Details for: COL4A4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 72.4548
Cell Significance Index: -11.2700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 44.4719
Cell Significance Index: -11.2800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 8.2889
Cell Significance Index: 119.0300 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 3.7694
Cell Significance Index: 60.8200 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.4488
Cell Significance Index: 37.2600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.0860
Cell Significance Index: 53.6200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.6439
Cell Significance Index: 40.1100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.5667
Cell Significance Index: 2889.2900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.5482
Cell Significance Index: 94.9200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.3185
Cell Significance Index: 28.8700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.1078
Cell Significance Index: 23.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.0768
Cell Significance Index: 1464.1800 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.9429
Cell Significance Index: 11.7000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6843
Cell Significance Index: 473.2600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6548
Cell Significance Index: 29.6800 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.6357
Cell Significance Index: 4.9000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5766
Cell Significance Index: 109.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.4599
Cell Significance Index: 708.0700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4253
Cell Significance Index: 42.0700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3921
Cell Significance Index: 6.7200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3735
Cell Significance Index: 7.9600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2909
Cell Significance Index: 7.6500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2673
Cell Significance Index: 241.3900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2157
Cell Significance Index: 35.0800 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.2077
Cell Significance Index: 2.5900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2064
Cell Significance Index: 22.4600 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.2007
Cell Significance Index: 3.2200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1852
Cell Significance Index: 348.7700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1804
Cell Significance Index: 10.8300 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.1664
Cell Significance Index: 1.2800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1637
Cell Significance Index: 103.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1131
Cell Significance Index: 40.5700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1123
Cell Significance Index: 50.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1067
Cell Significance Index: 21.1800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0790
Cell Significance Index: 6.0600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0738
Cell Significance Index: 1.5300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0651
Cell Significance Index: 4.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0605
Cell Significance Index: 12.1300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0548
Cell Significance Index: 1.3700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0546
Cell Significance Index: 40.0600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0532
Cell Significance Index: 1.8700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0531
Cell Significance Index: 1.5300 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.0372
Cell Significance Index: 0.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0217
Cell Significance Index: 3.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0176
Cell Significance Index: 3.0100 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0118
Cell Significance Index: 0.1300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0007
Cell Significance Index: -0.1000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0044
Cell Significance Index: -0.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0044
Cell Significance Index: -2.4300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0062
Cell Significance Index: -4.7200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0158
Cell Significance Index: -6.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0166
Cell Significance Index: -12.2700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0204
Cell Significance Index: -11.5100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0210
Cell Significance Index: -13.1000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0220
Cell Significance Index: -6.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0259
Cell Significance Index: -2.6500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0282
Cell Significance Index: -0.6100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0410
Cell Significance Index: -0.8000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0430
Cell Significance Index: -0.9300 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0457
Cell Significance Index: -0.3800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0486
Cell Significance Index: -6.6700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0502
Cell Significance Index: -5.9200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0516
Cell Significance Index: -6.6100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0614
Cell Significance Index: -12.9300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0625
Cell Significance Index: -7.2800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0642
Cell Significance Index: -7.9000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0646
Cell Significance Index: -2.0700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0744
Cell Significance Index: -7.7500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0755
Cell Significance Index: -0.9000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0817
Cell Significance Index: -1.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0829
Cell Significance Index: -9.5000 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0850
Cell Significance Index: -0.6500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0876
Cell Significance Index: -1.3200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0934
Cell Significance Index: -12.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0974
Cell Significance Index: -5.9900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0978
Cell Significance Index: -6.9200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1002
Cell Significance Index: -2.8000 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.1015
Cell Significance Index: -1.2300 - Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: -0.1159
Cell Significance Index: -1.4300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1181
Cell Significance Index: -5.9700 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.1245
Cell Significance Index: -1.3000 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.1263
Cell Significance Index: -1.8900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1356
Cell Significance Index: -10.7400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1390
Cell Significance Index: -7.3000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1402
Cell Significance Index: -9.4300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1407
Cell Significance Index: -7.3100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1561
Cell Significance Index: -2.1300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1615
Cell Significance Index: -12.0400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1642
Cell Significance Index: -9.2200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1761
Cell Significance Index: -5.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1810
Cell Significance Index: -8.4400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1850
Cell Significance Index: -5.0400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1887
Cell Significance Index: -9.8300 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1942
Cell Significance Index: -1.7500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1945
Cell Significance Index: -12.5500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1971
Cell Significance Index: -8.7200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2016
Cell Significance Index: -2.9000 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2175
Cell Significance Index: -3.4500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2245
Cell Significance Index: -9.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2254
Cell Significance Index: -10.6000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4233271545
Symbol: CO4A4_HUMAN
Name: Collagen alpha-4(IV) chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7523402
Title: Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains.
PubMed ID: 7523402
PubMed ID: 9792860
Title: Determination of the genomic structure of the COL4A4 gene and of novel mutations causing autosomal recessive Alport syndrome.
PubMed ID: 9792860
DOI: 10.1086/302106
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 9537506
Title: Two genes, COL4A3 and COL4A4 coding for the human alpha3(IV) and alpha4(IV) collagen chains are arranged head-to-head on chromosome 2q36.
PubMed ID: 9537506
PubMed ID: 8365481
Title: cDNA isolation and partial gene structure of the human alpha 4(IV) collagen chain.
PubMed ID: 8365481
PubMed ID: 1429714
Title: Isolation and sequencing of cDNAs and genomic DNAs encoding the alpha 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2.
PubMed ID: 1429714
PubMed ID: 8083201
Title: Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues.
PubMed ID: 8083201
PubMed ID: 12193605
Title: Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains.
PubMed ID: 12193605
PubMed ID: 29777959
Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.
PubMed ID: 29777959
PubMed ID: 9195222
Title: The clinical spectrum of type IV collagen mutations.
PubMed ID: 9195222
DOI: 10.1002/(sici)1098-1004(1997)9:6<477::aid-humu1>3.0.co;2-#
PubMed ID: 7987396
Title: Identification of mutations in the alpha 3(IV) and alpha 4(IV) collagen genes in autosomal recessive Alport syndrome.
PubMed ID: 7987396
DOI: 10.1038/ng0994-77
PubMed ID: 8787673
Title: Benign familial hematuria due to mutation of the type IV collagen alpha4 gene.
PubMed ID: 8787673
DOI: 10.1172/jci118893
PubMed ID: 11961012
Title: Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria.
PubMed ID: 11961012
DOI: 10.1681/asn.v1351248
PubMed ID: 12631110
Title: Mutations in the COL4A4 gene in thin basement membrane disease.
PubMed ID: 12631110
Sequence Information:
- Length: 1690
- Mass: 164038
- Checksum: C55711CDF14A57DB
- Sequence:
MWSLHIVLMR CSFRLTKSLA TGPWSLILIL FSVQYVYGSG KKYIGPCGGR DCSVCHCVPE KGSRGPPGPP GPQGPIGPLG APGPIGLSGE KGMRGDRGPP GAAGDKGDKG PTGVPGFPGL DGIPGHPGPP GPRGKPGMSG HNGSRGDPGF PGGRGALGPG GPLGHPGEKG EKGNSVFILG AVKGIQGDRG DPGLPGLPGS WGAGGPAGPT GYPGEPGLVG PPGQPGRPGL KGNPGVGVKG QMGDPGEVGQ QGSPGPTLLV EPPDFCLYKG EKGIKGIPGM VGLPGPPGRK GESGIGAKGE KGIPGFPGPR GDPGSYGSPG FPGLKGELGL VGDPGLFGLI GPKGDPGNRG HPGPPGVLVT PPLPLKGPPG DPGFPGRYGE TGDVGPPGPP GLLGRPGEAC AGMIGPPGPQ GFPGLPGLPG EAGIPGRPDS APGKPGKPGS PGLPGAPGLQ GLPGSSVIYC SVGNPGPQGI KGKVGPPGGR GPKGEKGNEG LCACEPGPMG PPGPPGLPGR QGSKGDLGLP GWLGTKGDPG PPGAEGPPGL PGKHGASGPP GNKGAKGDMV VSRVKGHKGE RGPDGPPGFP GQPGSHGRDG HAGEKGDPGP PGDHEDATPG GKGFPGPLGP PGKAGPVGPP GLGFPGPPGE RGHPGVPGHP GVRGPDGLKG QKGDTISCNV TYPGRHGPPG FDGPPGPKGF PGPQGAPGLS GSDGHKGRPG TPGTAEIPGP PGFRGDMGDP GFGGEKGSSP VGPPGPPGSP GVNGQKGIPG DPAFGHLGPP GKRGLSGVPG IKGPRGDPGC PGAEGPAGIP GFLGLKGPKG REGHAGFPGV PGPPGHSCER GAPGIPGQPG LPGYPGSPGA PGGKGQPGDV GPPGPAGMKG LPGLPGRPGA HGPPGLPGIP GPFGDDGLPG PPGPKGPRGL PGFPGFPGER GKPGAEGCPG AKGEPGEKGM SGLPGDRGLR GAKGAIGPPG DEGEMAIISQ KGTPGEPGPP GDDGFPGERG DKGTPGMQGR RGEPGRYGPP GFHRGEPGEK GQPGPPGPPG PPGSTGLRGF IGFPGLPGDQ GEPGSPGPPG FSGIDGARGP KGNKGDPASH FGPPGPKGEP GSPGCPGHFG ASGEQGLPGI QGPRGSPGRP GPPGSSGPPG CPGDHGMPGL RGQPGEMGDP GPRGLQGDPG IPGPPGIKGP SGSPGLNGLH GLKGQKGTKG ASGLHDVGPP GPVGIPGLKG ERGDPGSPGI SPPGPRGKKG PPGPPGSSGP PGPAGATGRA PKDIPDPGPP GDQGPPGPDG PRGAPGPPGL PGSVDLLRGE PGDCGLPGPP GPPGPPGPPG YKGFPGCDGK DGQKGPVGFP GPQGPHGFPG PPGEKGLPGP PGRKGPTGLP GPRGEPGPPA DVDDCPRIPG LPGAPGMRGP EGAMGLPGMR GPSGPGCKGE PGLDGRRGVD GVPGSPGPPG RKGDTGEDGY PGGPGPPGPI GDPGPKGFGP GYLGGFLLVL HSQTDQEPTC PLGMPRLWTG YSLLYLEGQE KAHNQDLGLA GSCLPVFSTL PFAYCNIHQV CHYAQRNDRS YWLASAAPLP MMPLSEEAIR PYVSRCAVCE APAQAVAVHS QDQSIPPCPQ TWRSLWIGYS FLMHTGAGDQ GGGQALMSPG SCLEDFRAAP FLECQGRQGT CHFFANKYSF WLTTVKADLQ FSSAPAPDTL KESQAQRQKI SRCQVCVKYS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.