Details for: COL4A4
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.15
Marker Score: 5,587 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 3.14
Marker Score: 1,831 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.89
Marker Score: 5,563 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.79
Marker Score: 1,634 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.62
Marker Score: 3,172 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.46
Marker Score: 2,495 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.45
Marker Score: 1,292 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.85
Marker Score: 773 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.73
Marker Score: 2,085 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.61
Marker Score: 4,313 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.53
Marker Score: 742 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.48
Marker Score: 1,705 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,933 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.47
Marker Score: 3,231 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.45
Marker Score: 395 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.38
Marker Score: 402 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 864 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.27
Marker Score: 2,984 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.25
Marker Score: 5,250 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 849 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.24
Marker Score: 1,316 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.23
Marker Score: 893 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.22
Marker Score: 3,067 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.17
Marker Score: 1,450 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 482 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,805 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.11
Marker Score: 351 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.1
Marker Score: 17,590 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.08
Marker Score: 498 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 791 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,812 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,037 - Cell Name: podocyte (CL0000653)
Fold Change: 1
Marker Score: 368 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.98
Marker Score: 335 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.97
Marker Score: 352 - Cell Name: fat cell (CL0000136)
Fold Change: 0.96
Marker Score: 539 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,734 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.91
Marker Score: 407 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5,124 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.88
Marker Score: 835 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,280 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.86
Marker Score: 202 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.85
Marker Score: 5,114 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.83
Marker Score: 895 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.81
Marker Score: 423 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.8
Marker Score: 1,327 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,255 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.77
Marker Score: 3,213 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.76
Marker Score: 950 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.76
Marker Score: 197 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393 - Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 689 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.75
Marker Score: 152 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.75
Marker Score: 829 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.74
Marker Score: 11,525 - Cell Name: interneuron (CL0000099)
Fold Change: 0.73
Marker Score: 335 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.71
Marker Score: 228 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.7
Marker Score: 221 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.69
Marker Score: 591 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.69
Marker Score: 7,074 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.68
Marker Score: 968 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.68
Marker Score: 177 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.66
Marker Score: 2,341 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.65
Marker Score: 498 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.64
Marker Score: 1,302 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.62
Marker Score: 158 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.62
Marker Score: 370 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.61
Marker Score: 9,096 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.57
Marker Score: 146 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 230 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.53
Marker Score: 3,432 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.53
Marker Score: 4,026 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.52
Marker Score: 164 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5
Marker Score: 6,627 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.49
Marker Score: 294 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.45
Marker Score: 733 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.44
Marker Score: 411 - Cell Name: monocyte (CL0000576)
Fold Change: 0.43
Marker Score: 560 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.43
Marker Score: 203 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.42
Marker Score: 111 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.4
Marker Score: 2,116 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4
Marker Score: 13,583 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.4
Marker Score: 162 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.4
Marker Score: 1,006 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.4
Marker Score: 121 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.39
Marker Score: 122 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.38
Marker Score: 191 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 368 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.36
Marker Score: 402
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4233271545
Symbol: CO4A4_HUMAN
Name: Collagen alpha-4(IV) chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7523402
Title: Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains.
PubMed ID: 7523402
PubMed ID: 9792860
Title: Determination of the genomic structure of the COL4A4 gene and of novel mutations causing autosomal recessive Alport syndrome.
PubMed ID: 9792860
DOI: 10.1086/302106
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 9537506
Title: Two genes, COL4A3 and COL4A4 coding for the human alpha3(IV) and alpha4(IV) collagen chains are arranged head-to-head on chromosome 2q36.
PubMed ID: 9537506
PubMed ID: 8365481
Title: cDNA isolation and partial gene structure of the human alpha 4(IV) collagen chain.
PubMed ID: 8365481
PubMed ID: 1429714
Title: Isolation and sequencing of cDNAs and genomic DNAs encoding the alpha 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2.
PubMed ID: 1429714
PubMed ID: 8083201
Title: Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues.
PubMed ID: 8083201
PubMed ID: 12193605
Title: Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains.
PubMed ID: 12193605
PubMed ID: 29777959
Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.
PubMed ID: 29777959
PubMed ID: 9195222
Title: The clinical spectrum of type IV collagen mutations.
PubMed ID: 9195222
DOI: 10.1002/(sici)1098-1004(1997)9:6<477::aid-humu1>3.0.co;2-#
PubMed ID: 7987396
Title: Identification of mutations in the alpha 3(IV) and alpha 4(IV) collagen genes in autosomal recessive Alport syndrome.
PubMed ID: 7987396
DOI: 10.1038/ng0994-77
PubMed ID: 8787673
Title: Benign familial hematuria due to mutation of the type IV collagen alpha4 gene.
PubMed ID: 8787673
DOI: 10.1172/jci118893
PubMed ID: 11961012
Title: Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria.
PubMed ID: 11961012
DOI: 10.1681/asn.v1351248
PubMed ID: 12631110
Title: Mutations in the COL4A4 gene in thin basement membrane disease.
PubMed ID: 12631110
Sequence Information:
- Length: 1690
- Mass: 164038
- Checksum: C55711CDF14A57DB
- Sequence:
MWSLHIVLMR CSFRLTKSLA TGPWSLILIL FSVQYVYGSG KKYIGPCGGR DCSVCHCVPE KGSRGPPGPP GPQGPIGPLG APGPIGLSGE KGMRGDRGPP GAAGDKGDKG PTGVPGFPGL DGIPGHPGPP GPRGKPGMSG HNGSRGDPGF PGGRGALGPG GPLGHPGEKG EKGNSVFILG AVKGIQGDRG DPGLPGLPGS WGAGGPAGPT GYPGEPGLVG PPGQPGRPGL KGNPGVGVKG QMGDPGEVGQ QGSPGPTLLV EPPDFCLYKG EKGIKGIPGM VGLPGPPGRK GESGIGAKGE KGIPGFPGPR GDPGSYGSPG FPGLKGELGL VGDPGLFGLI GPKGDPGNRG HPGPPGVLVT PPLPLKGPPG DPGFPGRYGE TGDVGPPGPP GLLGRPGEAC AGMIGPPGPQ GFPGLPGLPG EAGIPGRPDS APGKPGKPGS PGLPGAPGLQ GLPGSSVIYC SVGNPGPQGI KGKVGPPGGR GPKGEKGNEG LCACEPGPMG PPGPPGLPGR QGSKGDLGLP GWLGTKGDPG PPGAEGPPGL PGKHGASGPP GNKGAKGDMV VSRVKGHKGE RGPDGPPGFP GQPGSHGRDG HAGEKGDPGP PGDHEDATPG GKGFPGPLGP PGKAGPVGPP GLGFPGPPGE RGHPGVPGHP GVRGPDGLKG QKGDTISCNV TYPGRHGPPG FDGPPGPKGF PGPQGAPGLS GSDGHKGRPG TPGTAEIPGP PGFRGDMGDP GFGGEKGSSP VGPPGPPGSP GVNGQKGIPG DPAFGHLGPP GKRGLSGVPG IKGPRGDPGC PGAEGPAGIP GFLGLKGPKG REGHAGFPGV PGPPGHSCER GAPGIPGQPG LPGYPGSPGA PGGKGQPGDV GPPGPAGMKG LPGLPGRPGA HGPPGLPGIP GPFGDDGLPG PPGPKGPRGL PGFPGFPGER GKPGAEGCPG AKGEPGEKGM SGLPGDRGLR GAKGAIGPPG DEGEMAIISQ KGTPGEPGPP GDDGFPGERG DKGTPGMQGR RGEPGRYGPP GFHRGEPGEK GQPGPPGPPG PPGSTGLRGF IGFPGLPGDQ GEPGSPGPPG FSGIDGARGP KGNKGDPASH FGPPGPKGEP GSPGCPGHFG ASGEQGLPGI QGPRGSPGRP GPPGSSGPPG CPGDHGMPGL RGQPGEMGDP GPRGLQGDPG IPGPPGIKGP SGSPGLNGLH GLKGQKGTKG ASGLHDVGPP GPVGIPGLKG ERGDPGSPGI SPPGPRGKKG PPGPPGSSGP PGPAGATGRA PKDIPDPGPP GDQGPPGPDG PRGAPGPPGL PGSVDLLRGE PGDCGLPGPP GPPGPPGPPG YKGFPGCDGK DGQKGPVGFP GPQGPHGFPG PPGEKGLPGP PGRKGPTGLP GPRGEPGPPA DVDDCPRIPG LPGAPGMRGP EGAMGLPGMR GPSGPGCKGE PGLDGRRGVD GVPGSPGPPG RKGDTGEDGY PGGPGPPGPI GDPGPKGFGP GYLGGFLLVL HSQTDQEPTC PLGMPRLWTG YSLLYLEGQE KAHNQDLGLA GSCLPVFSTL PFAYCNIHQV CHYAQRNDRS YWLASAAPLP MMPLSEEAIR PYVSRCAVCE APAQAVAVHS QDQSIPPCPQ TWRSLWIGYS FLMHTGAGDQ GGGQALMSPG SCLEDFRAAP FLECQGRQGT CHFFANKYSF WLTTVKADLQ FSSAPAPDTL KESQAQRQKI SRCQVCVKYS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.