Details for: COL4A5

Gene ID: 1287

Symbol: COL4A5

Ensembl ID: ENSG00000188153

Description: collagen type IV alpha 5 chain

Associated with

Other Information

Genular Protein ID: 2185934490

Symbol: CO4A5_HUMAN

Name: Collagen alpha-5(IV) chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8120014

Title: Structure of the human type IV collagen COL4A5 gene.

PubMed ID: 8120014

DOI: 10.1016/s0021-9258(17)37416-1

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 1352287

Title: Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient.

PubMed ID: 1352287

DOI: 10.1016/s0021-9258(18)42301-0

PubMed ID: 2380186

Title: Complete primary structure of the triple-helical region and the carboxyl-terminal domain of a new type IV collagen chain, alpha 5(IV).

PubMed ID: 2380186

DOI: 10.1016/s0021-9258(18)77414-0

PubMed ID: 2004755

Title: Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome.

PubMed ID: 2004755

DOI: 10.1016/0888-7543(91)90214-y

PubMed ID: 1689491

Title: Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome.

PubMed ID: 1689491

DOI: 10.1073/pnas.87.4.1606

PubMed ID: 2339699

Title: Molecular cloning of alpha 5(IV) collagen and assignment of the gene to the region of the X chromosome containing the Alport syndrome locus.

PubMed ID: 2339699

PubMed ID: 8301933

Title: Differential splicing of COL4A5 mRNA in kidney and white blood cells: a complex mutation in the COL4A5 gene of an Alport patient deletes the NC1 domain.

PubMed ID: 8301933

DOI: 10.1038/ki.1993.384

PubMed ID: 7853788

Title: Mutations in the COL4A5 gene in Alport syndrome: a possible mutation in primordial germ cells.

PubMed ID: 7853788

DOI: 10.1038/ki.1994.399

PubMed ID: 9195222

Title: The clinical spectrum of type IV collagen mutations.

PubMed ID: 9195222

DOI: 10.1002/(sici)1098-1004(1997)9:6<477::aid-humu1>3.0.co;2-#

PubMed ID: 1672282

Title: Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome.

PubMed ID: 1672282

DOI: 10.1016/0888-7543(91)90215-z

PubMed ID: 1376965

Title: Substitution of arginine for glycine 325 in the collagen alpha 5 (IV) chain associated with X-linked Alport syndrome: characterization of the mutation by direct sequencing of PCR-amplified lymphoblast cDNA fragments.

PubMed ID: 1376965

PubMed ID: 1363780

Title: De novo mutation in the COL4A5 gene converting glycine 325 to glutamic acid in Alport syndrome.

PubMed ID: 1363780

DOI: 10.1093/hmg/1.2.127

PubMed ID: 8406498

Title: Identification of four novel mutations in the COL4A5 gene of patients with Alport syndrome.

PubMed ID: 8406498

DOI: 10.1006/geno.1993.1351

PubMed ID: 8356449

Title: Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors.

PubMed ID: 8356449

DOI: 10.1126/science.8356449

PubMed ID: 7599631

Title: Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients.

PubMed ID: 7599631

DOI: 10.1002/humu.1380050303

PubMed ID: 8651292

Title: A mutation causing Alport syndrome with tardive hearing loss is common in the western United States.

PubMed ID: 8651292

PubMed ID: 8651296

Title: X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene.

PubMed ID: 8651296

PubMed ID: 8940267

Title: Spectrum of mutations in the COL4A5 collagen gene in X-linked Alport syndrome.

PubMed ID: 8940267

PubMed ID: 8829632

Title: Substitution of A1498D in noncollagen domain of a5(IV) collagen chain associated with adult-onset X-linked Alport syndrome.

PubMed ID: 8829632

DOI: 10.1002/(sici)1098-1004(1996)7:2<149::aid-humu9>3.0.co;2-7

PubMed ID: 9150741

Title: Common ancestry of three Ashkenazi-American families with Alport syndrome and COL4A5 R1677Q.

PubMed ID: 9150741

DOI: 10.1007/s004390050429

PubMed ID: 9452056

Title: Missense mutations in the COL4A5 gene in patients with X-linked Alport syndrome.

PubMed ID: 9452056

DOI: 10.1002/humu.1380110135

PubMed ID: 9848783

Title: High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing.

PubMed ID: 9848783

DOI: 10.1681/asn.v9122291

PubMed ID: 10561141

Title: Detection of mutations in the COL4A5 gene in over 90% of male patients with X-linked Alport's syndrome by RT-PCR and direct sequencing.

PubMed ID: 10561141

DOI: 10.1016/s0272-6386(99)70042-9

PubMed ID: 10563487

Title: Three novel mutations in the COL4A5 gene in Mexican Alport syndrome patients.

PubMed ID: 10563487

DOI: 10.1034/j.1399-0004.1999.560312.x

PubMed ID: 10094548

Title: Detection of mutations in COL4A5 in patients with Alport syndrome.

PubMed ID: 10094548

DOI: 10.1002/(sici)1098-1004(1999)13:2<124::aid-humu4>3.0.co;2-z

PubMed ID: 11004279

Title: Dot-and-fleck retinopathy in Alport syndrome caused by a novel mutation in the COL4A5 gene.

PubMed ID: 11004279

DOI: 10.1016/s0002-9394(00)00466-9

PubMed ID: 10862091

Title: Spectrum of COL4A5 mutations in Finnish Alport syndrome patients.

PubMed ID: 10862091

DOI: 10.1002/1098-1004(200006)15:6<579::aid-humu13>3.0.co;2-k

PubMed ID: 10684360

Title: Mutational analysis of COL4A5 gene in Korean Alport syndrome.

PubMed ID: 10684360

DOI: 10.1007/s004670050025

PubMed ID: 11223851

Title: Efficient detection of Alport syndrome COL4A5 mutations with multiplex genomic PCR-SSCP.

PubMed ID: 11223851

DOI: 10.1002/1096-8628(20010115)98:2<148::aid-ajmg1024>3.0.co;2-w

PubMed ID: 12784310

Title: Alport syndrome with diffuse leiomyomatosis.

PubMed ID: 12784310

DOI: 10.1002/ajmg.a.20019

PubMed ID: 24522658

Title: Identification of a novel COL4A5 mutation in a Chinese family with X-linked Alport syndrome using exome sequencing.

PubMed ID: 24522658

DOI: 10.1007/s11033-014-3227-1

Sequence Information:

  • Length: 1685
  • Mass: 161044
  • Checksum: 4450A6762F12A626
  • Sequence:
  • MKLRGVSLAA GLFLLALSLW GQPAEAAACY GCSPGSKCDC SGIKGEKGER GFPGLEGHPG 
    LPGFPGPEGP PGPRGQKGDD GIPGPPGPKG IRGPPGLPGF PGTPGLPGMP GHDGAPGPQG 
    IPGCNGTKGE RGFPGSPGFP GLQGPPGPPG IPGMKGEPGS IIMSSLPGPK GNPGYPGPPG 
    IQGLPGPTGI PGPIGPPGPP GLMGPPGPPG LPGPKGNMGL NFQGPKGEKG EQGLQGPPGP 
    PGQISEQKRP IDVEFQKGDQ GLPGDRGPPG PPGIRGPPGP PGGEKGEKGE QGEPGKRGKP 
    GKDGENGQPG IPGLPGDPGY PGEPGRDGEK GQKGDTGPPG PPGLVIPRPG TGITIGEKGN 
    IGLPGLPGEK GERGFPGIQG PPGLPGPPGA AVMGPPGPPG FPGERGQKGD EGPPGISIPG 
    PPGLDGQPGA PGLPGPPGPA GPHIPPSDEI CEPGPPGPPG SPGDKGLQGE QGVKGDKGDT 
    CFNCIGTGIS GPPGQPGLPG LPGPPGSLGF PGQKGEKGQA GATGPKGLPG IPGAPGAPGF 
    PGSKGEPGDI LTFPGMKGDK GELGSPGAPG LPGLPGTPGQ DGLPGLPGPK GEPGGITFKG 
    ERGPPGNPGL PGLPGNIGPM GPPGFGPPGP VGEKGIQGVA GNPGQPGIPG PKGDPGQTIT 
    QPGKPGLPGN PGRDGDVGLP GDPGLPGQPG LPGIPGSKGE PGIPGIGLPG PPGPKGFPGI 
    PGPPGAPGTP GRIGLEGPPG PPGFPGPKGE PGFALPGPPG PPGLPGFKGA LGPKGDRGFP 
    GPPGPPGRTG LDGLPGPKGD VGPNGQPGPM GPPGLPGIGV QGPPGPPGIP GPIGQPGLHG 
    IPGEKGDPGP PGLDVPGPPG ERGSPGIPGA PGPIGPPGSP GLPGKAGASG FPGTKGEMGM 
    MGPPGPPGPL GIPGRSGVPG LKGDDGLQGQ PGLPGPTGEK GSKGEPGLPG PPGPMDPNLL 
    GSKGEKGEPG LPGIPGVSGP KGYQGLPGDP GQPGLSGQPG LPGPPGPKGN PGLPGQPGLI 
    GPPGLKGTIG DMGFPGPQGV EGPPGPSGVP GQPGSPGLPG QKGDKGDPGI SSIGLPGLPG 
    PKGEPGLPGY PGNPGIKGSV GDPGLPGLPG TPGAKGQPGL PGFPGTPGPP GPKGISGPPG 
    NPGLPGEPGP VGGGGHPGQP GPPGEKGKPG QDGIPGPAGQ KGEPGQPGFG NPGPPGLPGL 
    SGQKGDGGLP GIPGNPGLPG PKGEPGFHGF PGVQGPPGPP GSPGPALEGP KGNPGPQGPP 
    GRPGLPGPEG PPGLPGNGGI KGEKGNPGQP GLPGLPGLKG DQGPPGLQGN PGRPGLNGMK 
    GDPGLPGVPG FPGMKGPSGV PGSAGPEGEP GLIGPPGPPG LPGPSGQSII IKGDAGPPGI 
    PGQPGLKGLP GPQGPQGLPG PTGPPGDPGR NGLPGFDGAG GRKGDPGLPG QPGTRGLDGP 
    PGPDGLQGPP GPPGTSSVAH GFLITRHSQT TDAPQCPQGT LQVYEGFSLL YVQGNKRAHG 
    QDLGTAGSCL RRFSTMPFMF CNINNVCNFA SRNDYSYWLS TPEPMPMSMQ PLKGQSIQPF 
    ISRCAVCEAP AVVIAVHSQT IQIPHCPQGW DSLWIGYSFM MHTSAGAEGS GQALASPGSC 
    LEEFRSAPFI ECHGRGTCNY YANSYSFWLA TVDVSDMFSK PQSETLKAGD LRTRISRCQV 
    CMKRT

Genular Protein ID: 3043529338

Symbol: Q49AM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 695
  • Mass: 64324
  • Checksum: 91FAB53FB30A3120
  • Sequence:
  • MGPPGPPGFP GERGQKGDEG PPGISIPGPP GLDGQPGAPG LPGPPGPAGP HIPPSDEICE 
    PGPPGPPGSP GDKGLQGEQG VKGDKGDTCF NCIGTGISGP PGQPGLPGLP GPPGSLGFPG 
    QKGEKGQAGA TGPKGLPGIP GAPGAPGFPG SKGEPGDILT FPGMKGDKGE LGSPGAPGLP 
    GLPGTPGQDG LPGLPGPKGE PGGITFKGER GPPGNPGLPG LPGNIGPMGP PGFGPPGPVG 
    EKGIQGVAGN PGQPGIPGPK GDPGQTITQP GKPGLPGNPG RDGDVGLPGD PGLPGQPGLP 
    GIPGSKGEPG IPGIGLPGPP GPKGFPGIPG PPGAPGTPGR IGLEGPPGPP GFPGPKGEPG 
    FALPGPPGPP GLPGFKGALG PKGDRGFPGP PGPPGRTGLD GLPGPKGDVG PNGQPGPMGP 
    PGLPGIGVQG PPGPPGIPGP IGQPGLHGIP GEKGDPGPPG LDVPGPPGER GSPGIPGAPG 
    PIGPPGSPGL PGKAGASGFP GTKGEMGMMG PPGPPGPLGI PGRSGVPGLK GDDGLQGQPG 
    LPGPTGEKGS KGEPGLPGPP GPMDPNLLGS KGEKGEPGLP GIPGVSGPKG YQGLPGDPGQ 
    PGLSGQPGLP GPPGPKGNPG LPGQPGLIGP PGLKGTIGDM GFPGPQGVEG PPGPSGVPGQ 
    PGSPGLPGQK GDKGDPGISS IGLPGLPGPK VIFGI

Genular Protein ID: 993533887

Symbol: A7MBN3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1691
  • Mass: 161790
  • Checksum: 8241484AE676D9AB
  • Sequence:
  • MKLRGVSLAA GLFLLALSLW GQPAEAAACY GCSPGSKCDC SGIKGEKGER GFPGLEGHPG 
    LPGFPGPEGP PGPRGQKGDD GIPGPPGPKG IRGPPGLPGF PGTPGLPGMP GHDGAPGPQG 
    IPGCNGTKGE RGFPGSPGFP GLQGPPGPPG IPGMKGEPGS IIMSSLPGPK GNPGYPGPPG 
    IQGLPGPTGI PGPIGPPGPP GLMGPPGPPG LPGPKGNMGL NFQGPKGEKG EQGLQGPPGP 
    PGQISEQKRP IDVEFQKGDQ GLPGDRGPPG PPGIRGPPGP PGGEKGEKGE QGEPGKRGKP 
    GKDGENGQPG IPGLPGDPGY PGEPGRDGEK GQKGDTGPPG PPGLVIPRPG TGITIGEKGN 
    IGLPGLPGEK GERGFPGIQG PPGLPGPPGA AVMGPPGPPG FPGERGQKGD EGPPGISIPG 
    PPGLDGQPGA PGLPGPPGPA GPHIPPSDEI CEPGPPGPPG SPGDKGLQGE QGVKGDKGDT 
    CFNCIGTGIS GPPGQPGLPG LPGPPGSLGF PGQKGEKGQA GATGPKGLPG IPGAPGAPGF 
    PGSKGEPGDI LTFPGMKGDK GELGSPGAPG LPGLPGTPGQ DGLPGLPGPK GEPGGITFKG 
    ERGPPGNPGL PGLPGNIGPM GPPGFGPPGP VGEKGIQGVA GNPGQPGIPG PKGDPGQTIT 
    QPGKPGLPGN PGRDGDVGLP GDPGLPGQPG LPGIPGSKGE PGIPGIGLHG PPGPKGFPGI 
    PGPPGAPGTP GRIGLEGPPG PPGFPGPKGE PGFALPGPPG PPGLPGFKGA LGPKGDRGFP 
    GPPGPPGRTG LDGLPGPKGD VGPNGQPGPM GPPGLPGIGV QGPPGPPGIP GPIGQPGLHG 
    IPGEKGDPGP PGLDVPGPPG ERGSRGIPGA PGPIGPPGSP GLPGKAGASG FPGTKGEMGM 
    MGPPGPPGPL GIPGRSGVPG LKGDDGLQGQ PGLPGPTGEK GSKGERGLPG PPGPMDPNLL 
    GSKGEKGEPG LPGIPGVSGP KGYQGLPGDP GQPGLSGQPG LPGPPGPKGN PGLPGQPGLI 
    GPPGLKGTIG DMGFPGPQGV EGPPGPSGVP GQPGSPGLPG QKGDKGDPGI SSIGLPGLPG 
    PKGEPGLPGY PGNPGIKGSV GDPGLPGLPG TPGAKGQPGL PGFPGTPGPP GPKGISGPPG 
    NPGLPGEPGP VGGGGHPGQP GPPGEKGKPG QDGIPGPAGQ KGEPGQPGFG NPGPPGLPGL 
    SGQKGDGGLP GIPGNPGLPG PKGEPGFHGF PGVQGPPGPP GSPGPALEGP KGNPGPQGPP 
    GRPGPTGFQG LPGPEGPPGL PGNGGIKGEK GNPGQPGLPG LPGLKGDQGP PGLQGNPGRP 
    GLNGMKGDPG LPGVPGFPGM KGPSGVPGSA GPEGEPGLIG PPGPPGLPGP SGQSIIIKGD 
    AGPPGIPGQP GLKGLPGPQG PQGLPGPTGP PGDPGRNGLP GFDGAGGRKG DPGLPGQPGT 
    RGLDGPPGPD GLQGPPGPPG TSSVAHGFLI TRHSQTTDAP QCPQGTLQVY EGFSLLYVQG 
    NKRAHGQDLG TAGSCLRRFS TMPFMFCNIN NVCNFASRND YSYWLSTPEP MPMSMQPLKG 
    QSIQPFISRC AVCEAPAVVI AVHSQTIQIP HCPQGWDSLW IGYSFMMHTS AGAEGSGQAL 
    ASPGSCLEEF RSAPFIECHG RGTCNYYANS YSFWLATVDV SDMFSKPQSE TLKAGDLRTR 
    ISRCQVCMKR T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.