Genular: Defining Cellular Identity and Function

Details for: Cpe

Gene ID: 12876

Symbol: Cpe

Ensembl ID: ENSMUSG00000037852

Description: carboxypeptidase E

Associated with

Carboxypeptidase activity
(GO:0004180)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cell adhesion molecule binding
(GO:0050839)
Cobalt ion binding
(GO:0050897)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Dense core granule
(GO:0031045)
Enkephalin processing
(GO:0034230)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Insulin processing
(GO:0030070)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Metallocarboxypeptidase activity
(GO:0004181)
Metallopeptidase activity
(GO:0008237)
Negative regulation of branching morphogenesis of a nerve
(GO:2000173)
Neurexin family protein binding
(GO:0042043)
Neuronal cell body
(GO:0043025)
Peptidase activity
(GO:0008233)
Peptide catabolic process
(GO:0043171)
Peptide hormone secretion
(GO:0030072)
Peptide metabolic process
(GO:0006518)
Perikaryon
(GO:0043204)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization to membrane
(GO:0072657)
Protein localization to secretory granule
(GO:0033366)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Secretory granule
(GO:0030141)
Secretory granule membrane
(GO:0030667)
Synaptic membrane
(GO:0097060)
Wnt signaling pathway
(GO:0016055)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Carboxypeptidase E

Genular Protein ID: 3278289532

Symbol: CBPE_MOUSE

Name: Carboxypeptidase E

UniProtKB Accession Codes:

Q00493 Q64439

Database IDs:

Citations:

PubMed ID: 7663508

Title: Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.

PubMed ID: 7663508

DOI: 10.1038/ng0695-135

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10896946

Title: Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor.

PubMed ID: 10896946

DOI: 10.1074/jbc.m005364200

PubMed ID: 16219686

Title: Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.

PubMed ID: 16219686

DOI: 10.1242/jcs.02608

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 476
Mass: 53256
Checksum: 82C5318A12A17567
Sequence:

MAGRGGRVLL ALCAALVAGG WLLTAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR 
EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG 
RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS 
NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNLKKIVD QNSKLAPETK AVIHWIMDIP 
FVLSANLHGG DLVANYPYDE TRSGTAHEYS SCPDDAIFQS LARAYSSFNP VMSDPNRPPC 
RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKSYWED 
NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVDGIDH DVTSAKDGDY WRLLAPGNYK 
LTASAPGYLA ITKKVAVPFS PAVGVDFELE SFSERKEEEK EELMEWWKMM SETLNF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cpe

Associated with

Other Information

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. PubMed ID: 7663508

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor. PubMed ID: 10896946