Genular: Defining Cellular Identity and Function

Details for: Cpeb1

Gene ID: 12877

Symbol: Cpeb1

Ensembl ID: ENSMUSG00000025586

Description: cytoplasmic polyadenylation element binding protein 1

Associated with

Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glutamatergic synapse
(GO:0098978)
Growth cone
(GO:0030426)
Meiotic spindle
(GO:0072687)
Membrane
(GO:0016020)
Messenger ribonucleoprotein complex
(GO:1990124)
Metal ion binding
(GO:0046872)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna 3'-utr binding
(GO:0003730)
Mrna binding
(GO:0003729)
Mrna processing
(GO:0006397)
Mrna regulatory element binding translation repressor activity
(GO:0000900)
Mrna transport
(GO:0051028)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cytoplasmic translation
(GO:2000766)
Negative regulation of translation
(GO:0017148)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of translation
(GO:0045727)
Postsynapse
(GO:0098794)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Regulation of mrna 3'-end processing
(GO:0031440)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of translation
(GO:0006417)
Regulation of translation at synapse, modulating synaptic transmission
(GO:0099547)
Ribonucleoprotein complex
(GO:1990904)
Ribosome binding
(GO:0043022)
Rna binding
(GO:0003723)
Synapse
(GO:0045202)
Synaptonemal complex assembly
(GO:0007130)
Translation factor activity, rna binding
(GO:0008135)
Translation regulator activity
(GO:0045182)

Other Information

Proteins

Cytoplasmic polyadenylation element-binding protein 1
Q059Z2_MOUSE

Genular Protein ID: 310931293

Symbol: CPEB1_MOUSE

Name: Cytoplasmic polyadenylation element-binding protein 1

UniProtKB Accession Codes:

P70166 Q8C5P9

Database IDs:

Citations:

PubMed ID: 8962099

Title: Mouse cytoplasmic polyadenylation element binding protein: an evolutionarily conserved protein that interacts with the cytoplasmic polyadenylation elements of c-mos mRNA.

PubMed ID: 8962099

DOI: 10.1073/pnas.93.25.14602

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9856468

Title: CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses.

PubMed ID: 9856468

DOI: 10.1016/s0896-6273(00)80630-3

PubMed ID: 11526086

Title: CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.

PubMed ID: 11526086

DOI: 10.1242/dev.128.14.2815

PubMed ID: 11980711

Title: N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.

PubMed ID: 11980711

DOI: 10.1093/emboj/21.9.2139

PubMed ID: 12629046

Title: Facilitation of dendritic mRNA transport by CPEB.

PubMed ID: 12629046

DOI: 10.1101/gad.1053003

PubMed ID: 12815066

Title: Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation.

PubMed ID: 12815066

DOI: 10.1101/gad.1071403

PubMed ID: 12871996

Title: Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.

PubMed ID: 12871996

DOI: 10.1073/pnas.1133424100

PubMed ID: 15175389

Title: Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II.

PubMed ID: 15175389

DOI: 10.1523/jneurosci.0854-04.2004

PubMed ID: 15944388

Title: Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation.

PubMed ID: 15944388

DOI: 10.1523/jneurosci.5051-04.2005

PubMed ID: 16314516

Title: Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.

PubMed ID: 16314516

DOI: 10.1128/mcb.25.24.10930-10939.2005

PubMed ID: 16705177

Title: Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein.

PubMed ID: 16705177

DOI: 10.1128/mcb.02470-05

PubMed ID: 17927953

Title: Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.

PubMed ID: 17927953

DOI: 10.1016/j.bbrc.2007.09.096

Sequence Information:

Length: 561
Mass: 61917
Checksum: CB7958885AB13FF6
Sequence:

MAFSLEEAAG RIKDCWDNQE VPALSTCSNA NIFRRINAIL DDSLDFSKVC TTPINRGIHD 
QLPDFQDSEE TVTSRMLFPT SAQESPRGLP DANGLCLGLQ SLSLTGWDRP WSTQDSDSSA 
QSSTQSVLSM LQNPLGNVLG KAPLSFLSLD PLGSDLDKFP APSVRGSRLD TRPILDSRSS 
SPSDSDTSGF SSGSDHLSDL ISSLRISPPL PFLSMTGNGP RDPLKMGVGS RMDQEQAALA 
AVAPSPTSAP KRWPGASVWP SWDLLGAPKD PFSIEREARL HRQAAAVNEA TCTWSGQLPP 
RNYKNPIYSC KVFLGGVPWD ITEAGLVNTF RVFGSLSVEW PGKDGKHPRC PPKGNMPKGY 
VYLVFELEKS VRALLQACSH DPLSPDGLSE YYFKMSSRRM RCKEVQVIPW VLADSNFVWS 
PSQRLDPSRT VFVGALHGML NAEALAAILN DLFGGVVYAG IDTDKHKYPI GSGRVTFNNQ 
RSYLKAVTAA FVEIKTTKFT KKVQIDPYLE DSLCLICSSQ PGPFFCRDQV CFKYFCRSCW 
HWRHSMEGLR HHSPLMRNQK N

Genular Protein ID: 53868220

Symbol: Q059Z2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q059Z2

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 562
Mass: 61988
Checksum: 779AFC41AEE78238
Sequence:

MAFSLEEAAG RIKDCWDNQE VPALSTCSNA NIFRRINAIL DDSLDFSKVC TTPINRGIHD 
QLPADFQDSE ETVTSRMLFP TSAQESPRGL PDANGLCLGL QSLSLTGWDR PWSTQDSDSS 
AQSSTQSVLS MLQNPLGNVL GKAPLSFLSL DPLGSDLDKF PAPSVRGSRL DTRPILDSRS 
SSPSDSDTSG FSSGSDHLSD LISSLRISPP LPFLSMTGNG PRDPLKMGVG SRMDQEQAAL 
AAVAPSPTSA PKRWPGASVW PSWDLLGAPK DPFSIEREAR LHRQAAAVNE ATCTWSGQLP 
PRNYKNPIYS CKVFLGGVPW DITEAGLVNT FRVFGSLSVE WPGKDGKHPR CPPKGNMPKG 
YVYLVFELEK SVRALLQACS HDPLSPDGLS EYYFKMSSRR MRCKEVQVIP WVLADSNFVW 
SPSQRLDPSR TVFVGALHGM LNAEALAAIL NDLFGGVVYA GIDTDKHKYP IGSGRVTFNN 
QRSYLKAVTA AFVEIKTTKF TKKVQIDPYL EDSLCLICSS QPGPFFCRDQ VCFKYFCRSC 
WHWRHSMEGL RHHSPLMRNQ KN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cpeb1

Associated with

Other Information

Mouse cytoplasmic polyadenylation element binding protein: an evolutionarily conserved protein that interacts with the cytoplasmic polyadenylation elements of c-mos mRNA. PubMed ID: 8962099

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses. PubMed ID: 9856468

CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes. PubMed ID: 11526086

N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. PubMed ID: 11980711

Facilitation of dendritic mRNA transport by CPEB. PubMed ID: 12629046

Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. PubMed ID: 12815066

Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus. PubMed ID: 12871996

Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II. PubMed ID: 15175389

Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation. PubMed ID: 15944388

Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. PubMed ID: 16314516

Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. PubMed ID: 16705177

Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells. PubMed ID: 17927953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303