Genular: Defining Cellular Identity and Function

Details for: Cpox

Gene ID: 12892

Symbol: Cpox

Ensembl ID: ENSMUSG00000022742

Description: coproporphyrinogen oxidase

Associated with

Heme biosynthesis
(R-MMU-189451)
Metabolism
(R-MMU-1430728)
Metabolism of porphyrins
(R-MMU-189445)
Coproporphyrinogen oxidase activity
(GO:0004109)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Heme a biosynthetic process
(GO:0006784)
Heme b biosynthetic process
(GO:0006785)
Heme biosynthetic process
(GO:0006783)
Heme o biosynthetic process
(GO:0048034)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial intermembrane space
(GO:0005758)
Mitochondrion
(GO:0005739)
Oxidoreductase activity
(GO:0016491)
P-type sodium:potassium-exchanging transporter activity
(GO:0005391)
Porphyrin-containing compound biosynthetic process
(GO:0006779)
Potassium ion transport
(GO:0006813)
Protein homodimerization activity
(GO:0042803)
Protoporphyrinogen ix biosynthetic process
(GO:0006782)
Sodium ion transport
(GO:0006814)
Structural constituent of eye lens
(GO:0005212)

Other Information

Proteins

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Genular Protein ID: 217198039

Symbol: HEM6_MOUSE

Name: Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

UniProtKB Accession Codes:

P36552 Q7TQ36 Q8VD08

Database IDs:

Citations:

PubMed ID: 8407975

Title: Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation.

PubMed ID: 8407975

DOI: 10.1016/s0021-9258(19)36931-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15482256

Title: Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase.

PubMed ID: 15482256

DOI: 10.1042/bj20040570

PubMed ID: 12862310

Title: The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria.

PubMed ID: 12862310

DOI: 10.1620/tjem.200.39

PubMed ID: 8159699

Title: Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase.

PubMed ID: 8159699

DOI: 10.1073/pnas.91.8.3024

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 443
Mass: 49715
Checksum: 9F3D5E8E420645F0
Sequence:

MALRLGRLGS DPWWRAVLGD YAQLRAASPR CASARVCQLP GTAGPQPRRG LGYGPWARGG 
SGLGTRLAAT LAGLAGLAAA AFGHVQRAEM VPKSSGARSP SPGRREEDGD ELARRCSTFM 
SSPVTELREL RRRPEDMKTK MELMIMETQA QVCRALAQVD GVADFTVDRW ERKEGGGGIT 
CVLQDGRVFE KAGVSISVVH GNLSEEAANQ MRGRGKTLKT KDSKLPFTAM GVSSVIHPKN 
PYAPTMHFNY RYFEVEEADG NTHWWFGGGC DLTPTYLNQE DAVHFHRTLK EACDQHGPDI 
YPKFKKWCDD YFFIVHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 
HCDDSYTPRD KLWQQLRRGR YVEFNLLYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 
SPPENSKEAE ILEVLRHPKD WVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cpox

Associated with

Other Information

Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation. PubMed ID: 8407975

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase. PubMed ID: 15482256

The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria. PubMed ID: 12862310

Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase. PubMed ID: 8159699

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753