Details for: COL5A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 144.2182
Cell Significance Index: -36.5800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 104.1637
Cell Significance Index: -42.9100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 82.8785
Cell Significance Index: -33.6700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 79.7250
Cell Significance Index: -37.6400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.2556
Cell Significance Index: -33.6600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.2270
Cell Significance Index: -36.4100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 7.7588
Cell Significance Index: 52.5700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 6.9385
Cell Significance Index: 135.4200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.3054
Cell Significance Index: 111.0500 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.1209
Cell Significance Index: 25.5000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.9524
Cell Significance Index: 37.8100 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 2.7255
Cell Significance Index: 34.3200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.5311
Cell Significance Index: 72.2300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 2.1551
Cell Significance Index: 30.9500 - Cell Name: chondroblast (CL0000058)
Fold Change: 1.5417
Cell Significance Index: 9.0500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.5013
Cell Significance Index: 75.8700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.3410
Cell Significance Index: 42.9500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3316
Cell Significance Index: 38.1700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.2351
Cell Significance Index: 26.4000 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.2324
Cell Significance Index: 7.7500 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.8404
Cell Significance Index: 4.0200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.7873
Cell Significance Index: 12.1800 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.7815
Cell Significance Index: 11.8900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.7633
Cell Significance Index: 42.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7332
Cell Significance Index: 100.6900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6000
Cell Significance Index: 414.9700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5909
Cell Significance Index: 533.5300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5896
Cell Significance Index: 75.5800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4552
Cell Significance Index: 90.3300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.3847
Cell Significance Index: 43.9100 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.2780
Cell Significance Index: 1.2100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2708
Cell Significance Index: 54.3200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2684
Cell Significance Index: 43.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1512
Cell Significance Index: 28.7800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1456
Cell Significance Index: 14.4000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1374
Cell Significance Index: 2.3000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1260
Cell Significance Index: 232.3200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0970
Cell Significance Index: 42.9000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0774
Cell Significance Index: 49.1300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0737
Cell Significance Index: 8.0100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0693
Cell Significance Index: 24.8600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0612
Cell Significance Index: 2.1500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0455
Cell Significance Index: 1.3100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0296
Cell Significance Index: 55.6900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0112
Cell Significance Index: 17.2300 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0095
Cell Significance Index: -0.1600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0152
Cell Significance Index: -0.3800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0208
Cell Significance Index: -28.2400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0256
Cell Significance Index: -18.9600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0315
Cell Significance Index: -19.6800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0451
Cell Significance Index: -20.4600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0474
Cell Significance Index: -34.7800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0522
Cell Significance Index: -29.4300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0524
Cell Significance Index: -39.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0541
Cell Significance Index: -9.7500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0638
Cell Significance Index: -34.8600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0656
Cell Significance Index: -9.5400 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -0.0821
Cell Significance Index: -0.6300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1116
Cell Significance Index: -5.0600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1157
Cell Significance Index: -19.7600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1161
Cell Significance Index: -33.4000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1175
Cell Significance Index: -8.1300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1291
Cell Significance Index: -27.2000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1851
Cell Significance Index: -22.7600 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.1917
Cell Significance Index: -1.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2045
Cell Significance Index: -15.6900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2433
Cell Significance Index: -5.2700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2678
Cell Significance Index: -31.2100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3054
Cell Significance Index: -39.4600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3117
Cell Significance Index: -18.7100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3153
Cell Significance Index: -19.3300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3185
Cell Significance Index: -8.9000 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.3361
Cell Significance Index: -3.2400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3365
Cell Significance Index: -38.5500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3376
Cell Significance Index: -35.1500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3410
Cell Significance Index: -24.1200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3475
Cell Significance Index: -35.5000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3525
Cell Significance Index: -41.5700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3955
Cell Significance Index: -4.3000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4469
Cell Significance Index: -23.2800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4517
Cell Significance Index: -30.3700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4725
Cell Significance Index: -37.4200 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.5285
Cell Significance Index: -2.4400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5324
Cell Significance Index: -39.6800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5504
Cell Significance Index: -33.8300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5522
Cell Significance Index: -25.9600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5804
Cell Significance Index: -14.9200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6149
Cell Significance Index: -21.5400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6230
Cell Significance Index: -40.1900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6340
Cell Significance Index: -16.9300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7072
Cell Significance Index: -31.2800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.7154
Cell Significance Index: -14.8400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7369
Cell Significance Index: -38.6900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8082
Cell Significance Index: -25.7400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.8185
Cell Significance Index: -42.5200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8345
Cell Significance Index: -31.6000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8372
Cell Significance Index: -17.8300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8637
Cell Significance Index: -40.2700 - Cell Name: preosteoblast (CL0007010)
Fold Change: -0.9669
Cell Significance Index: -8.7800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9713
Cell Significance Index: -25.5400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2887960575
Symbol: CO5A2_HUMAN
Name: Collagen alpha-2(V) chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 2914927
Title: Amino-terminal propeptide of human pro-alpha 2(V) collagen conforms to the structural criteria of a fibrillar procollagen molecule.
PubMed ID: 2914927
PubMed ID: 11566270
Title: Genomic organization of the human COL3A1 and COL5A2 genes: COL5A2 has evolved differently than the other minor fibrillar collagen genes.
PubMed ID: 11566270
PubMed ID: 1820205
Title: Homology between alpha 2(V) and alpha 1(III) collagen promoters and evidence for negatively acting elements in the alpha 2(V) first intron and 5' flanking sequences.
PubMed ID: 1820205
PubMed ID: 1571108
Title: Isolation of the alpha 3-chain of human type V collagen and characterization by partial sequencing.
PubMed ID: 1571108
PubMed ID: 8181482
Title: Diversity in the processing events at the N-terminus of type-V collagen.
PubMed ID: 8181482
PubMed ID: 3029669
Title: The pro alpha 2(V) collagen gene is evolutionarily related to the major fibrillar-forming collagens.
PubMed ID: 3029669
DOI: 10.1093/nar/15.1.181
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2985598
Title: Partial covalent structure of the human alpha 2 type V collagen chain.
PubMed ID: 2985598
PubMed ID: 3858826
Title: Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2.
PubMed ID: 3858826
PubMed ID: 2411731
Title: Complete primary structure of the human alpha 2 type V procollagen COOH-terminal propeptide.
PubMed ID: 2411731
PubMed ID: 3224983
Title: Genetic distance of two fibrillar collagen loci, COL3A1 and COL5A2, located on the long arm of human chromosome 2.
PubMed ID: 3224983
PubMed ID: 9425231
Title: Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce Ehlers-Danlos syndrome type I.
PubMed ID: 9425231
DOI: 10.1093/hmg/7.2.249
PubMed ID: 21757687
Title: A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens.
PubMed ID: 21757687
PubMed ID: 9783710
Title: A single base mutation in COL5A2 causes Ehlers-Danlos syndrome type II.
PubMed ID: 9783710
PubMed ID: 11940702
Title: Sequence analysis of the COL5A2 gene in patients with spontaneous cervical artery dissections.
PubMed ID: 11940702
PubMed ID: 27656288
Title: A novel missense mutation of COL5A2 in a patient with Ehlers-Danlos syndrome.
PubMed ID: 27656288
DOI: 10.1038/hgv.2016.30
Sequence Information:
- Length: 1499
- Mass: 144910
- Checksum: E8C92BF5E749EC97
- Sequence:
MMANWAEARP LLILIVLLGQ FVSIKAQEED EDEGYGEEIA CTQNGQMYLN RDIWKPAPCQ ICVCDNGAIL CDKIECQDVL DCADPVTPPG ECCPVCSQTP GGGNTNFGRG RKGQKGEPGL VPVVTGIRGR PGPAGPPGSQ GPRGERGPKG RPGPRGPQGI DGEPGVPGQP GAPGPPGHPS HPGPDGLSRP FSAQMAGLDE KSGLGSQVGL MPGSVGPVGP RGPQGLQGQQ GGAGPTGPPG EPGDPGPMGP IGSRGPEGPP GKPGEDGEPG RNGNPGEVGF AGSPGARGFP GAPGLPGLKG HRGHKGLEGP KGEVGAPGSK GEAGPTGPMG AMGPLGPRGM PGERGRLGPQ GAPGQRGAHG MPGKPGPMGP LGIPGSSGFP GNPGMKGEAG PTGARGPEGP QGQRGETGPP GPVGSPGLPG AIGTDGTPGA KGPTGSPGTS GPPGSAGPPG SPGPQGSTGP QGIRGQPGDP GVPGFKGEAG PKGEPGPHGI QGPIGPPGEE GKRGPRGDPG TVGPPGPVGE RGAPGNRGFP GSDGLPGPKG AQGERGPVGS SGPKGSQGDP GRPGEPGLPG ARGLTGNPGV QGPEGKLGPL GAPGEDGRPG PPGSIGIRGQ PGSMGLPGPK GSSGDPGKPG EAGNAGVPGQ RGAPGKDGEV GPSGPVGPPG LAGERGEQGP PGPTGFQGLP GPPGPPGEGG KPGDQGVPGD PGAVGPLGPR GERGNPGERG EPGITGLPGE KGMAGGHGPD GPKGSPGPSG TPGDTGPPGL QGMPGERGIA GTPGPKGDRG GIGEKGAEGT AGNDGARGLP GPLGPPGPAG PTGEKGEPGP RGLVGPPGSR GNPGSRGENG PTGAVGFAGP QGPDGQPGVK GEPGEPGQKG DAGSPGPQGL AGSPGPHGPN GVPGLKGGRG TQGPPGATGF PGSAGRVGPP GPAGAPGPAG PLGEPGKEGP PGLRGDPGSH GRVGDRGPAG PPGGPGDKGD PGEDGQPGPD GPPGPAGTTG QRGIVGMPGQ RGERGMPGLP GPAGTPGKVG PTGATGDKGP PGPVGPPGSN GPVGEPGPEG PAGNDGTPGR DGAVGERGDR GDPGPAGLPG SQGAPGTPGP VGAPGDAGQR GDPGSRGPIG PPGRAGKRGL PGPQGPRGDK GDHGDRGDRG QKGHRGFTGL QGLPGPPGPN GEQGSAGIPG PFGPRGPPGP VGPSGKEGNP GPLGPIGPPG VRGSVGEAGP EGPPGEPGPP GPPGPPGHLT AALGDIMGHY DESMPDPLPE FTEDQAAPDD KNKTDPGVHA TLKSLSSQIE TMRSPDGSKK HPARTCDDLK LCHSAKQSGE YWIDPNQGSV EDAIKVYCNM ETGETCISAN PSSVPRKTWW ASKSPDNKPV WYGLDMNRGS QFAYGDHQSP NTAITQMTFL RLLSKEASQN ITYICKNSVG YMDDQAKNLK KAVVLKGAND LDIKAEGNIR FRYIVLQDTC SKRNGNVGKT VFEYRTQNVA RLPIIDLAPV DVGGTDQEFG VEIGPVCFV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.