Genular: Defining Cellular Identity and Function

Details for: Creb1

Gene ID: 12912

Symbol: Creb1

Ensembl ID: ENSMUSG00000025958

Description: cAMP responsive element binding protein 1

Associated with

Activation of nmda receptors and postsynaptic events
(R-MMU-442755)
Akt phosphorylates targets in the nucleus
(R-MMU-198693)
Axon guidance
(R-MMU-422475)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-MMU-442742)
Creb phosphorylation
(R-MMU-199920)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-MMU-9634638)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
G alpha (q) signalling events
(R-MMU-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-MMU-881907)
Gpcr downstream signalling
(R-MMU-388396)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Map kinase activation
(R-MMU-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-MMU-450282)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Ncam signaling for neurite out-growth
(R-MMU-375165)
Nervous system development
(R-MMU-9675108)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Ngf-stimulated transcription
(R-MMU-9031628)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Pip3 activates akt signaling
(R-MMU-1257604)
Post nmda receptor activation events
(R-MMU-438064)
Signaling by gpcr
(R-MMU-372790)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Transmission across chemical synapses
(R-MMU-112315)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Arrestin family protein binding
(GO:1990763)
Axonogenesis
(GO:0007409)
Camp-mediated signaling
(GO:0019933)
Camp response element binding
(GO:0035497)
Cell differentiation
(GO:0030154)
Circadian rhythm
(GO:0007623)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
Histone acetyltransferase binding
(GO:0035035)
Hsp70 protein binding
(GO:0030544)
Identical protein binding
(GO:0042802)
Lactation
(GO:0007595)
Mammary gland development
(GO:0030879)
Memory
(GO:0007613)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Osteoclast differentiation
(GO:0030316)
Pituitary gland development
(GO:0021983)
Positive regulation of transforming growth factor beta3 production
(GO:0032916)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Regulation of cell size
(GO:0008361)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to inorganic substance
(GO:0010035)
Response to organic substance
(GO:0010033)
Response to purine-containing compound
(GO:0014074)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Secretory granule organization
(GO:0033363)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Visual learning
(GO:0008542)

Other Information

Proteins

Genular Protein ID: 3503032500

Symbol: CREB1_MOUSE

Name: Cyclic AMP-responsive element-binding protein 1

UniProtKB Accession Codes:

Q01147

Database IDs:

Citations:

PubMed ID: 1532935

Title: Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

PubMed ID: 1532935

DOI: 10.1002/j.1460-2075.1992.tb05195.x

PubMed ID: 1387109

Title: The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization.

PubMed ID: 1387109

DOI: 10.1016/0888-7543(92)90010-p

PubMed ID: 8552098

Title: Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.

PubMed ID: 8552098

DOI: 10.1128/mcb.16.2.694

PubMed ID: 11970866

Title: Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.

PubMed ID: 11970866

DOI: 10.1016/s0896-6273(02)00656-6

PubMed ID: 18690222

Title: The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling.

PubMed ID: 18690222

DOI: 10.1038/ni.1644

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20852621

Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

PubMed ID: 20852621

DOI: 10.1038/nm.2214

PubMed ID: 21728997

Title: CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes.

PubMed ID: 21728997

DOI: 10.1042/bj20101475

PubMed ID: 30566056

Title: Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.

PubMed ID: 30566056

DOI: 10.1161/circresaha.118.313777

PubMed ID: 34914893

Title: TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.

PubMed ID: 34914893

DOI: 10.1016/j.cmet.2021.11.013

PubMed ID: 10952992

Title: The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.

PubMed ID: 10952992

DOI: 10.1074/jbc.m007293200

Sequence Information:

Length: 327
Mass: 35122
Checksum: 00D1F26B00D48442
Sequence:

MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES VDSVTDSQKR REILSRRPSY 
RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA 
NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL VPSNQVVVQA ASGDVQTYQI 
RTAPTSTIAP GVVMASSPAL PTQPAEEAAR KREVRLMKNR EAARECRRKK KEYVKCLENR 
VAVLENQNKT LIEELKALKD LYCHKSD

Genular Protein ID: 2719418887

Symbol: Q547S9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q547S9

Database IDs:

Sequence Information:

Length: 341
Mass: 36674
Checksum: CF2958DE9174968A
Sequence:

MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD 
SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG 
QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV 
VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D

Genular Protein ID: 1295550113

Symbol: Q62347_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q62347

Database IDs:

Citations:

PubMed ID: 8605879

Title: Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.

PubMed ID: 8605879

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 287
Mass: 30960
Checksum: 2228CB72B8991381
Sequence:

MPAAHATSSA PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES 
VDSVTDSQKR REILSRRPSY RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI 
YQTSSGQYIA ITQGGAIQLA NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL 
VPSNQVVVQA ASGDVQTYQI RTAPTSTIAP GVVMASSPAL PTQPAEEAAR KREVRLMKNR 
EAARECRRKK KEYVKCLENR VAVLENQNKT LIEELKALKD LYCHKSD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Creb1

Associated with

Other Information

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. PubMed ID: 1532935

The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization. PubMed ID: 1387109

Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. PubMed ID: 8552098

Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. PubMed ID: 11970866

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. PubMed ID: 18690222

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. PubMed ID: 20852621

CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. PubMed ID: 21728997

Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury. PubMed ID: 30566056

TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. PubMed ID: 34914893

The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. PubMed ID: 10952992

Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. PubMed ID: 8605879

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 1532935

PubMed ID: 1387109

PubMed ID: 8552098

PubMed ID: 11970866

PubMed ID: 18690222

PubMed ID: 21183079

PubMed ID: 20852621

PubMed ID: 21728997

PubMed ID: 30566056

PubMed ID: 34914893

PubMed ID: 10952992

PubMed ID: 8605879

PubMed ID: 19468303

PubMed ID: 21183079