Details for: Crem

Gene ID: 12916

Symbol: Crem

Ensembl ID: ENSMUSG00000063889

Description: cAMP responsive element modulator

Associated with

  • Atf4-creb1 transcription factor complex
    (GO:1990589)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Circadian rhythm
    (GO:0007623)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Glycosphingolipid metabolic process
    (GO:0006687)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to camp
    (GO:0051591)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spermatogenesis
    (GO:0007283)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 1836612012

Symbol: CREM_MOUSE

Name: cAMP-responsive element modulator

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8252624

Title: Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor.

PubMed ID: 8252624

DOI: 10.1016/0092-8674(93)90532-u

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 1847666

Title: CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription.

PubMed ID: 1847666

DOI: 10.1016/0092-8674(91)90503-q

PubMed ID: 16059773

Title: Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts.

PubMed ID: 16059773

DOI: 10.1007/s00223-005-0003-1

PubMed ID: 1370576

Title: Developmental switch of CREM function during spermatogenesis: from antagonist to activator.

PubMed ID: 1370576

DOI: 10.1038/355080a0

PubMed ID: 10086359

Title: CBP-independent activation of CREM and CREB by the LIM-only protein ACT.

PubMed ID: 10086359

DOI: 10.1038/18237

PubMed ID: 16595651

Title: Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation.

PubMed ID: 16595651

DOI: 10.1074/jbc.m602051200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23443664

Title: Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.

PubMed ID: 23443664

DOI: 10.1074/jbc.m112.445692

PubMed ID: 26940607

Title: Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117.

PubMed ID: 26940607

DOI: 10.1080/09168451.2016.1146067

Sequence Information:

  • Length: 357
  • Mass: 38516
  • Checksum: 0B387B7247113088
  • Sequence:
  • MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS 
    GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID 
    SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG 
    QYIAIAQGGT IQISNPGSDG VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS 
    QVVVQDEETD LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR 
    KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD ICSPKTD

Genular Protein ID: 637587489

Symbol: Q9CQ87_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 124
  • Mass: 13685
  • Checksum: B2339E81F7D322CD
  • Sequence:
  • MTMETVESQQ DRSVTRSVAE HSSAHMQTGQ ISVPTLAQVA TIAETDDSAD SEVIDSHKRR 
    EILSRRPSYR KILNELSSDV PGIPKIEEEK SEEEGTPPNI ATMAVPTSIY QTSTGQYSMY 
    AMIP

Genular Protein ID: 371512973

Symbol: F6QWT6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 125
  • Mass: 14036
  • Checksum: 23A57A8236614AA1
  • Sequence:
  • MQKPNMAVTG DETDEETDLA PSHMAAATGD MPTYQIRAPT TALPQGVVMA ASPGSLHSPQ 
    QLAEEATRKR ELRLMKNREA ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY 
    CHKAE

Genular Protein ID: 131253377

Symbol: E9PV35_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 304
  • Mass: 32538
  • Checksum: 166073651D77B37D
  • Sequence:
  • MVSVAGSGTG RGSPAVTLVQ LPSGQTVQVQ GVIQTPHPSV IQSPQIQTVQ VATIAETDDS 
    ADSEVIDSHK RREILSRRPS YRKILNELSS DVPGIPKIEE EKSEEEGTPP NIATMAVPTS 
    IYQTSTGQYI AIAQGGTIQI SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ 
    QFFVPGSQVV VQDEETDLAP SHMAAATGDM PTYQIRAPTT ALPQGVVMAA SPGSLHSPQQ 
    LAEEATRKRE LRLMKNREAA KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS 
    PKTD

Genular Protein ID: 1722587532

Symbol: F6VJ22_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 113
  • Mass: 12739
  • Checksum: 489EC3A7402670E0
  • Sequence:
  • MQKPNMAVTG DETAATGDMP TYQIRAPTTA LPQGVVMAAS PGSLHSPQQL AEEATRKREL 
    RLMKNREAAR ECRRKKKEYV KCLENRVAVL ENQNKTLIEE LKALKDLYCH KAE

Genular Protein ID: 3917472426

Symbol: D3Z6A5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 119
  • Mass: 13541
  • Checksum: 0ADF8B428BEEA79E
  • Sequence:
  • MMYPHFTDEE TDLAPSHMAA ATGDMPTYQI RAPTTALPQG VVMAASPGSL HSPQQLAEEA 
    TRKRELRLMK NREAARECRR KKKEYVKCLE NRVAVLENQN KTLIEELKAL KDLYCHKAE

Genular Protein ID: 2088815865

Symbol: D3YXV5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 296
  • Mass: 32317
  • Checksum: EB734414DC9AB851
  • Sequence:
  • MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVATIAE 
    TDDSADSEVI DSHKRREILS RRPSYRKILN ELSSDVPGIP KIEEEKSEEE GTPPNIATMA 
    VPTSIYQTST GQYIAIAQGG TIQISNPGSD GVQGLQALTM TNSGAPPPGA TIVQYAAQSA 
    DGTQQFFVPG SQVVVQAATG DMPTYQIRAP TTALPQGVVM AASPGSLHSP QQLAEEATRK 
    RELRLMKNRE AAKECRRRKK EYVKCLESRV AVLEVQNKKL IEELETLKDI CSPKTD

Genular Protein ID: 2276290391

Symbol: D3Z011_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 280
  • Mass: 30750
  • Checksum: EA0C8DD28C0D0068
  • Sequence:
  • MWWHQQNLCF RHPIEEDYSS GDLDKKVATI AETDDSADSE VIDSHKRREI LSRRPSYRKI 
    LNELSSDVPG IPKIEEEKSE EEGTPPNIAT MAVPTSIYQT STGQYIAIAQ GGTIQISNPG 
    SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV PGSQVVVQDE ETDLAPSHMA 
    AATGDMPTYQ IRAPTTALPQ GVVMAASPGS LHSPQQLAEE ATRKRELRLM KNREAAKECR 
    RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD

Genular Protein ID: 2569003229

Symbol: Q78Z98_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8252624

Title: Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor.

PubMed ID: 8252624

DOI: 10.1016/0092-8674(93)90532-U

Sequence Information:

  • Length: 108
  • Mass: 12140
  • Checksum: 4BCA53CAA903255A
  • Sequence:
  • MAVTGDETAA TGDMPTYQIR APTTALPQGV VMAASPGSLH SPQQLAEEAT RKRELRLMKN 
    REAARECRRK KKEYVKCLEN RVAVLENQNK TLIEELKALK DLYCHKAE

Genular Protein ID: 2361816196

Symbol: D3Z326_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 102
  • Mass: 11537
  • Checksum: 1CB90597177DF995
  • Sequence:
  • MAAATGDMPT YQIRAPTTAL PQGVVMAASP GSLHSPQQLA EEATRKRELR LMKNREAARE 
    CRRKKKEYVK CLENRVAVLE NQNKTLIEEL KALKDLYCHK AE

Genular Protein ID: 2872193803

Symbol: E9PWV9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 304
  • Mass: 32622
  • Checksum: 4B377FB1E39C0ECF
  • Sequence:
  • MVSVAGSGTG RGSPAVTLVQ LPSGQTVQVQ GVIQTPHPSV IQSPQIQTVQ VATIAETDDS 
    ADSEVIDSHK RREILSRRPS YRKILNELSS DVPGIPKIEE EKSEEEGTPP NIATMAVPTS 
    IYQTSTGQYI AIAQGGTIQI SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ 
    QFFVPGSQVV VQDEETDLAP SHMAAATGDM PTYQIRAPTT ALPQGVVMAA SPGSLHSPQQ 
    LAEEATRKRE LRLMKNREAA RECRRKKKEY VKCLENRVAV LENQNKTLIE ELKALKDLYC 
    HKAE

Genular Protein ID: 7686619

Symbol: Q9D599_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 196
  • Mass: 20488
  • Checksum: B41D4EFFE61496AC
  • Sequence:
  • MVSVAGSGTG RGSPAVTLVQ LPSGQTVQVQ GVIQTPHPSV IQSPQIQTVQ VATIAETDDS 
    ADSEVIDSHK RREILSRRPS YRKILNELSS DVPGIPKIEE EKSEEEGTPP NIATMAVPTS 
    IYQTSTGQYI AIAQGGTIQI SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ 
    QFFVPGSQVV VQGIFY

Genular Protein ID: 1878753870

Symbol: Q3TTH6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 173
  • Mass: 18588
  • Checksum: 86DCE3BF439F28A9
  • Sequence:
  • MTMETVESQQ DRSVTRSVAE HSSAHMQTGQ ISVPTLAQVS VAGSGTGRGS PAVTLVQLPS 
    GQTVQVQGVI QTPHPSVIQS PQIQTVQVAT IAETDDSADS EVIDSHKRRE ILSRRPSYRK 
    ILNELSSDVP GIPKIEEEKS EEEGTPPNIA TMAVPTSIYQ TSTGQYSMYA MIP

Genular Protein ID: 372893331

Symbol: D3Z7M6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 329
  • Mass: 35736
  • Checksum: 0970C01DCFFB2B21
  • Sequence:
  • MWWHQQNLCF RHPIEEDYSS GDLDKKVSVA GSGTGRGSPA VTLVQLPSGQ TVQVQGVIQT 
    PHPSVIQSPQ IQTVQVATIA ETDDSADSEV IDSHKRREIL SRRPSYRKIL NELSSDVPGI 
    PKIEEEKSEE EGTPPNIATM AVPTSIYQTS TGQYIAIAQG GTIQISNPGS DGVQGLQALT 
    MTNSGAPPPG ATIVQYAAQS ADGTQQFFVP GSQVVVQDEE TDLAPSHMAA ATGDMPTYQI 
    RAPTTALPQG VVMAASPGSL HSPQQLAEEA TRKRELRLMK NREAARECRR KKKEYVKCLE 
    NRVAVLENQN KTLIEELKAL KDLYCHKAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.