Details for: COL6A2

Gene ID: 1292

Symbol: COL6A2

Ensembl ID: ENSG00000142173

Description: collagen type VI alpha 2 chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.7940
    Cell Significance Index: -36.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.1143
    Cell Significance Index: -36.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.3465
    Cell Significance Index: -28.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.8637
    Cell Significance Index: -32.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6258
    Cell Significance Index: -28.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.3685
    Cell Significance Index: -36.2100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 14.6085
    Cell Significance Index: 85.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 13.8279
    Cell Significance Index: 177.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.7745
    Cell Significance Index: -36.9000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 12.8557
    Cell Significance Index: 79.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.7030
    Cell Significance Index: 306.8100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 10.1350
    Cell Significance Index: 68.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9887
    Cell Significance Index: -35.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8171
    Cell Significance Index: -24.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.4436
    Cell Significance Index: 125.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.1126
    Cell Significance Index: 839.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.0798
    Cell Significance Index: 127.2600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 4.6474
    Cell Significance Index: 24.4600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 4.2895
    Cell Significance Index: 26.9800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.7592
    Cell Significance Index: 12.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6150
    Cell Significance Index: 83.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5032
    Cell Significance Index: 117.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.2353
    Cell Significance Index: 32.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2207
    Cell Significance Index: 284.6800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.1900
    Cell Significance Index: 12.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9516
    Cell Significance Index: 48.7900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.8572
    Cell Significance Index: 15.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.7341
    Cell Significance Index: 87.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6848
    Cell Significance Index: 87.7600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.6765
    Cell Significance Index: 8.0200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.5094
    Cell Significance Index: 8.8600
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.2148
    Cell Significance Index: 2.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8941
    Cell Significance Index: 9.7200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8697
    Cell Significance Index: 9.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.8494
    Cell Significance Index: 14.2200
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.7432
    Cell Significance Index: 7.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5561
    Cell Significance Index: 105.8200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.4460
    Cell Significance Index: 2.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4298
    Cell Significance Index: 55.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3890
    Cell Significance Index: 2.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3509
    Cell Significance Index: 316.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3192
    Cell Significance Index: 5.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2831
    Cell Significance Index: 125.1700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.2266
    Cell Significance Index: 1.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1780
    Cell Significance Index: 3.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1757
    Cell Significance Index: 13.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1622
    Cell Significance Index: 26.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1574
    Cell Significance Index: 4.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1408
    Cell Significance Index: 63.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1227
    Cell Significance Index: 12.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1197
    Cell Significance Index: 4.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0917
    Cell Significance Index: 0.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0887
    Cell Significance Index: 6.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0576
    Cell Significance Index: 108.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0441
    Cell Significance Index: 2.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0407
    Cell Significance Index: 8.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0209
    Cell Significance Index: -38.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0219
    Cell Significance Index: -33.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0231
    Cell Significance Index: -0.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0233
    Cell Significance Index: -12.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0256
    Cell Significance Index: -18.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0276
    Cell Significance Index: -37.5100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0304
    Cell Significance Index: -0.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0318
    Cell Significance Index: -3.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0417
    Cell Significance Index: -31.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0419
    Cell Significance Index: -30.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0473
    Cell Significance Index: -26.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0524
    Cell Significance Index: -1.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0543
    Cell Significance Index: -0.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0730
    Cell Significance Index: -26.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0750
    Cell Significance Index: -13.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0954
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1074
    Cell Significance Index: -22.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1167
    Cell Significance Index: -19.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1212
    Cell Significance Index: -34.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1335
    Cell Significance Index: -6.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1459
    Cell Significance Index: -21.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1564
    Cell Significance Index: -31.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1637
    Cell Significance Index: -20.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1757
    Cell Significance Index: -20.4800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1784
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1961
    Cell Significance Index: -22.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1992
    Cell Significance Index: -20.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2385
    Cell Significance Index: -2.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2468
    Cell Significance Index: -25.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2616
    Cell Significance Index: -29.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2650
    Cell Significance Index: -18.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2658
    Cell Significance Index: -19.8100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2824
    Cell Significance Index: -1.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2948
    Cell Significance Index: -4.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3031
    Cell Significance Index: -35.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3037
    Cell Significance Index: -6.5800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3286
    Cell Significance Index: -3.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3842
    Cell Significance Index: -10.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3999
    Cell Significance Index: -24.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4476
    Cell Significance Index: -23.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4560
    Cell Significance Index: -25.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4926
    Cell Significance Index: -30.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: The COL6A2 gene encodes a single polypeptide chain, the alpha-2 subunit of collagen type VI, which is a non-fibrillar collagen molecule. 2. **Expression**: COL6A2 is significantly expressed in endocardial cells, fibroblasts, and mesodermal cells, indicating its role in cardiovascular, connective tissue, and immune system development. 3. **Function**: COL6A2 plays a crucial role in regulating cell adhesion, migration, and differentiation, as well as modulating the ECM's mechanical properties and signaling pathways. **Pathways and Functions** 1. **Assembly of collagen fibrils and other multimeric structures**: COL6A2 is involved in the formation of non-fibrillar collagen networks, which provide mechanical strength and stability to tissues. 2. **Axon guidance**: COL6A2 interacts with Ncam1 and other molecules to regulate axon guidance and neuronal development. 3. **Cell adhesion**: COL6A2 mediates cell-cell and cell-matrix interactions, influencing cell migration, differentiation, and survival. 4. **Collagen biosynthesis and modifying enzymes**: COL6A2 interacts with collagen biosynthetic enzymes, such as prolyl hydroxylase and lysyl oxidase, to regulate collagen synthesis and degradation. 5. **Signaling pathways**: COL6A2 is involved in various signaling pathways, including phosphatidylinositol 3-kinase/protein kinase B, receptor tyrosine kinase, and PDGF signaling, which regulate cellular behavior and tissue homeostasis. **Clinical Significance** 1. **Cardiovascular diseases**: Alterations in COL6A2 expression have been linked to cardiovascular diseases, such as aortic aneurysms and heart failure. 2. **Connective tissue disorders**: COL6A2 mutations have been associated with connective tissue disorders, such as Ehlers-Danlos syndrome and Marfan syndrome. 3. **Cancer**: COL6A2 expression is altered in various cancers, including breast, lung, and colon cancer, suggesting its role in tumorigenesis and metastasis. 4. **Neurological disorders**: COL6A2 is involved in the regulation of neuronal development and function, and alterations in its expression have been linked to neurological disorders, such as autism and Alzheimer's disease. In conclusion, the COL6A2 gene plays a multifaceted role in regulating cellular behavior, tissue development, and immune responses. Its involvement in various signaling pathways and its expression in multiple cell types highlight its importance in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the functions of COL6A2 and its role in human disease.

Genular Protein ID: 1058156979

Symbol: CO6A2_HUMAN

Name: Collagen alpha-2(VI) chain

UniProtKB Accession Codes:

P12110 Q13909 Q13910 Q13911 Q14048 Q14049 Q16259 Q16597 Q6P0Q1 Q9UML3 Q9Y4S8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 32 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1556127

Title: Human alpha 2(VI) collagen gene. Heterogeneity at the 5'-untranslated region generated by an alternate exon.

PubMed ID: 1556127

DOI: 10.1016/s0021-9258(18)42680-4

PubMed ID: 2551668

Title: Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2(VI) chain variants that differ in the carboxy terminus.

PubMed ID: 2551668

DOI: 10.1002/j.1460-2075.1989.tb03598.x

PubMed ID: 8168508

Title: Recombinant expression and structural and binding properties of alpha 1(VI) and alpha 2(VI) chains of human collagen type VI.

PubMed ID: 8168508

DOI: 10.1111/j.1432-1033.1994.tb18727.x

PubMed ID: 3665927

Title: Characterization of three constituent chains of collagen type VI by peptide sequences and cDNA clones.

PubMed ID: 3665927

DOI: 10.1111/j.1432-1033.1987.tb13422.x

PubMed ID: 1765372

Title: The exon organization of the triple-helical coding regions of the human alpha 1(VI) and alpha 2(VI) collagen genes is highly similar.

PubMed ID: 1765372

DOI: 10.1016/0888-7543(91)90111-q

PubMed ID: 6852033

Title: Further characterization of the three polypeptide chains of bovine and human short-chain collagen (intima collagen).

PubMed ID: 6852033

DOI: 10.1111/j.1432-1033.1983.tb07427.x

PubMed ID: 3198591

Title: Amino acid sequence of the triple-helical domain of human collagen type VI.

PubMed ID: 3198591

DOI: 10.1016/s0021-9258(18)37327-7

PubMed ID: 3348212

Title: Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen.

PubMed ID: 3348212

PubMed ID: 1690728

Title: Alternative splicing of the human alpha 2(VI) collagen gene generates multiple mRNA transcripts which predict three protein variants with distinct carboxyl termini.

PubMed ID: 1690728

DOI: 10.1016/s0021-9258(19)39351-2

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 8305732

Title: Expression of NG2 proteoglycan causes retention of type VI collagen on the cell surface.

PubMed ID: 8305732

DOI: 10.1091/mbc.4.11.1097

PubMed ID: 9099729

Title: The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein.

PubMed ID: 9099729

DOI: 10.1074/jbc.272.16.10769

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8782832

Title: Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures.

PubMed ID: 8782832

DOI: 10.1038/ng0996-113

PubMed ID: 11865138

Title: Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype.

PubMed ID: 11865138

DOI: 10.1212/wnl.58.4.593

PubMed ID: 15563506

Title: Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy.

PubMed ID: 15563506

DOI: 10.1093/hmg/ddi025

PubMed ID: 15689448

Title: Automated genomic sequence analysis of the three collagen VI genes: applications to Ullrich congenital muscular dystrophy and Bethlem myopathy.

PubMed ID: 15689448

DOI: 10.1136/jmg.2004.023754

PubMed ID: 17886299

Title: Molecular consequences of dominant Bethlem myopathy collagen VI mutations.

PubMed ID: 17886299

DOI: 10.1002/ana.21213

PubMed ID: 18852439

Title: Autosomal recessive myosclerosis myopathy is a collagen VI disorder.

PubMed ID: 18852439

DOI: 10.1212/01.wnl.0000327611.01687.5e

PubMed ID: 23040494

Title: An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects.

PubMed ID: 23040494

DOI: 10.1016/j.ajhg.2012.08.017

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 1019
  • Mass: 108579
  • Checksum: 6C513ADE46C1D111
  • Sequence:
    • MLQGTCSVLL LWGILGAIQA QQQEVISPDT TERNNNCPEK TDCPIHVYFV LDTSESVTMQ 
SPTDILLFHM KQFVPQFISQ LQNEFYLDQV ALSWRYGGLH FSDQVEVFSP PGSDRASFIK 
NLQGISSFRR GTFTDCALAN MTEQIRQDRS KGTVHFAVVI TDGHVTGSPC GGIKLQAERA 
REEGIRLFAV APNQNLKEQG LRDIASTPHE LYRNDYATML PDSTEIDQDT INRIIKVMKH 
EAYGECYKVS CLEIPGPSGP KGYRGQKGAK GNMGEPGEPG QKGRQGDPGI EGPIGFPGPK 
GVPGFKGEKG EFGADGRKGA PGLAGKNGTD GQKGKLGRIG PPGCKGDPGN RGPDGYPGEA 
GSPGERGDQG GKGDPGRPGR RGPPGEIGAK GSKGYQGNSG APGSPGVKGA KGGPGPRGPK 
GEPGRRGDPG TKGSPGSDGP KGEKGDPGPE GPRGLAGEVG NKGAKGDRGL PGPRGPQGAL 
GEPGKQGSRG DPGDAGPRGD SGQPGPKGDP GRPGFSYPGP RGAPGEKGEP GPRGPEGGRG 
DFGLKGEPGR KGEKGEPADP GPPGEPGPRG PRGVPGPEGE PGPPGDPGLT ECDVMTYVRE 
TCGCCDCEKR CGALDVVFVI DSSESIGYTN FTLEKNFVIN VVNRLGAIAK DPKSETGTRV 
GVVQYSHEGT FEAIQLDDER IDSLSSFKEA VKNLEWIAGG TWTPSALKFA YDRLIKESRR 
QKTRVFAVVI TDGRHDPRDD DLNLRALCDR DVTVTAIGIG DMFHEKHESE NLYSIACDKP 
QQVRNMTLFS DLVAEKFIDD MEDVLCPDPQ IVCPDLPCQT ELSVAQCTQR PVDIVFLLDG 
SERLGEQNFH KARRFVEQVA RRLTLARRDD DPLNARVALL QFGGPGEQQV AFPLSHNLTA 
IHEALETTQY LNSFSHVGAG VVHAINAIVR SPRGGARRHA ELSFVFLTDG VTGNDSLHES 
AHSMRKQNVV PTVLALGSDV DMDVLTTLSL GDRAAVFHEK DYDSLAQPGF FDRFIRWIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.