Details for: COL6A2

Gene ID: 1292

Symbol: COL6A2

Ensembl ID: ENSG00000142173

Description: collagen type VI alpha 2 chain

Associated with

Other Information

Genular Protein ID: 1058156979

Symbol: CO6A2_HUMAN

Name: Collagen alpha-2(VI) chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1556127

Title: Human alpha 2(VI) collagen gene. Heterogeneity at the 5'-untranslated region generated by an alternate exon.

PubMed ID: 1556127

DOI: 10.1016/s0021-9258(18)42680-4

PubMed ID: 2551668

Title: Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2(VI) chain variants that differ in the carboxy terminus.

PubMed ID: 2551668

DOI: 10.1002/j.1460-2075.1989.tb03598.x

PubMed ID: 8168508

Title: Recombinant expression and structural and binding properties of alpha 1(VI) and alpha 2(VI) chains of human collagen type VI.

PubMed ID: 8168508

DOI: 10.1111/j.1432-1033.1994.tb18727.x

PubMed ID: 3665927

Title: Characterization of three constituent chains of collagen type VI by peptide sequences and cDNA clones.

PubMed ID: 3665927

DOI: 10.1111/j.1432-1033.1987.tb13422.x

PubMed ID: 1765372

Title: The exon organization of the triple-helical coding regions of the human alpha 1(VI) and alpha 2(VI) collagen genes is highly similar.

PubMed ID: 1765372

DOI: 10.1016/0888-7543(91)90111-q

PubMed ID: 6852033

Title: Further characterization of the three polypeptide chains of bovine and human short-chain collagen (intima collagen).

PubMed ID: 6852033

DOI: 10.1111/j.1432-1033.1983.tb07427.x

PubMed ID: 3198591

Title: Amino acid sequence of the triple-helical domain of human collagen type VI.

PubMed ID: 3198591

DOI: 10.1016/s0021-9258(18)37327-7

PubMed ID: 3348212

Title: Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen.

PubMed ID: 3348212

PubMed ID: 1690728

Title: Alternative splicing of the human alpha 2(VI) collagen gene generates multiple mRNA transcripts which predict three protein variants with distinct carboxyl termini.

PubMed ID: 1690728

DOI: 10.1016/s0021-9258(19)39351-2

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 8305732

Title: Expression of NG2 proteoglycan causes retention of type VI collagen on the cell surface.

PubMed ID: 8305732

DOI: 10.1091/mbc.4.11.1097

PubMed ID: 9099729

Title: The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein.

PubMed ID: 9099729

DOI: 10.1074/jbc.272.16.10769

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8782832

Title: Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures.

PubMed ID: 8782832

DOI: 10.1038/ng0996-113

PubMed ID: 11865138

Title: Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype.

PubMed ID: 11865138

DOI: 10.1212/wnl.58.4.593

PubMed ID: 15563506

Title: Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy.

PubMed ID: 15563506

DOI: 10.1093/hmg/ddi025

PubMed ID: 15689448

Title: Automated genomic sequence analysis of the three collagen VI genes: applications to Ullrich congenital muscular dystrophy and Bethlem myopathy.

PubMed ID: 15689448

DOI: 10.1136/jmg.2004.023754

PubMed ID: 17886299

Title: Molecular consequences of dominant Bethlem myopathy collagen VI mutations.

PubMed ID: 17886299

DOI: 10.1002/ana.21213

PubMed ID: 18852439

Title: Autosomal recessive myosclerosis myopathy is a collagen VI disorder.

PubMed ID: 18852439

DOI: 10.1212/01.wnl.0000327611.01687.5e

PubMed ID: 23040494

Title: An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects.

PubMed ID: 23040494

DOI: 10.1016/j.ajhg.2012.08.017

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 1019
  • Mass: 108579
  • Checksum: 6C513ADE46C1D111
  • Sequence:
  • MLQGTCSVLL LWGILGAIQA QQQEVISPDT TERNNNCPEK TDCPIHVYFV LDTSESVTMQ 
    SPTDILLFHM KQFVPQFISQ LQNEFYLDQV ALSWRYGGLH FSDQVEVFSP PGSDRASFIK 
    NLQGISSFRR GTFTDCALAN MTEQIRQDRS KGTVHFAVVI TDGHVTGSPC GGIKLQAERA 
    REEGIRLFAV APNQNLKEQG LRDIASTPHE LYRNDYATML PDSTEIDQDT INRIIKVMKH 
    EAYGECYKVS CLEIPGPSGP KGYRGQKGAK GNMGEPGEPG QKGRQGDPGI EGPIGFPGPK 
    GVPGFKGEKG EFGADGRKGA PGLAGKNGTD GQKGKLGRIG PPGCKGDPGN RGPDGYPGEA 
    GSPGERGDQG GKGDPGRPGR RGPPGEIGAK GSKGYQGNSG APGSPGVKGA KGGPGPRGPK 
    GEPGRRGDPG TKGSPGSDGP KGEKGDPGPE GPRGLAGEVG NKGAKGDRGL PGPRGPQGAL 
    GEPGKQGSRG DPGDAGPRGD SGQPGPKGDP GRPGFSYPGP RGAPGEKGEP GPRGPEGGRG 
    DFGLKGEPGR KGEKGEPADP GPPGEPGPRG PRGVPGPEGE PGPPGDPGLT ECDVMTYVRE 
    TCGCCDCEKR CGALDVVFVI DSSESIGYTN FTLEKNFVIN VVNRLGAIAK DPKSETGTRV 
    GVVQYSHEGT FEAIQLDDER IDSLSSFKEA VKNLEWIAGG TWTPSALKFA YDRLIKESRR 
    QKTRVFAVVI TDGRHDPRDD DLNLRALCDR DVTVTAIGIG DMFHEKHESE NLYSIACDKP 
    QQVRNMTLFS DLVAEKFIDD MEDVLCPDPQ IVCPDLPCQT ELSVAQCTQR PVDIVFLLDG 
    SERLGEQNFH KARRFVEQVA RRLTLARRDD DPLNARVALL QFGGPGEQQV AFPLSHNLTA 
    IHEALETTQY LNSFSHVGAG VVHAINAIVR SPRGGARRHA ELSFVFLTDG VTGNDSLHES 
    AHSMRKQNVV PTVLALGSDV DMDVLTTLSL GDRAAVFHEK DYDSLAQPGF FDRFIRWIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.