Details for: Cry1

Gene ID: 12952

Symbol: Cry1

Ensembl ID: ENSMUSG00000020038

Description: cryptochrome circadian regulator 1

Associated with

Other Information

Genular Protein ID: 3209282927

Symbol: CRY1_MOUSE

Name: Cryptochrome-1

UniProtKB Accession Codes:

P97784

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 DisProt 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneTree 1 Genevisible 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 14 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9801304

Title: Characterization of photolyase/blue-light receptor homologs in mouse and human cells.

PubMed ID: 9801304

DOI: 10.1093/nar/26.22.5086

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9600923

Title: Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals.

PubMed ID: 9600923

DOI: 10.1073/pnas.95.11.6097

PubMed ID: 10428031

Title: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.

PubMed ID: 10428031

DOI: 10.1016/s0092-8674(00)81014-4

PubMed ID: 10521578

Title: Circadian regulation of cryptochrome genes in the mouse.

PubMed ID: 10521578

DOI: 10.1016/s0169-328x(99)00192-8

PubMed ID: 11779462

Title: Posttranslational mechanisms regulate the mammalian circadian clock.

PubMed ID: 11779462

DOI: 10.1016/s0092-8674(01)00610-9

PubMed ID: 11889036

Title: Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.

PubMed ID: 11889036

DOI: 10.1093/emboj/21.6.1301

PubMed ID: 11875063

Title: The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.

PubMed ID: 11875063

DOI: 10.1074/jbc.m111466200

PubMed ID: 15298678

Title: Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase.

PubMed ID: 15298678

DOI: 10.1111/j.1356-9597.2004.00758.x

PubMed ID: 14701732

Title: Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.

PubMed ID: 14701732

DOI: 10.1128/mcb.24.2.584-594.2004

PubMed ID: 15226430

Title: Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation.

PubMed ID: 15226430

DOI: 10.1128/mcb.24.14.6278-6287.2004

PubMed ID: 16628007

Title: Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES.

PubMed ID: 16628007

DOI: 10.4161/cc.5.8.2684

PubMed ID: 16717091

Title: The polycomb group protein EZH2 is required for mammalian circadian clock function.

PubMed ID: 16717091

DOI: 10.1074/jbc.m603722200

PubMed ID: 16478995

Title: Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

PubMed ID: 16478995

DOI: 10.1128/mcb.26.5.1743-1753.2006

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 17462724

Title: Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.

PubMed ID: 17462724

DOI: 10.1016/j.cell.2007.04.030

PubMed ID: 17310242

Title: CIPC is a mammalian circadian clock protein without invertebrate homologues.

PubMed ID: 17310242

DOI: 10.1038/ncb1539

PubMed ID: 18953409

Title: Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals.

PubMed ID: 18953409

DOI: 10.1371/journal.pone.0003530

PubMed ID: 19917250

Title: Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism.

PubMed ID: 19917250

DOI: 10.1016/j.molcel.2009.10.012

PubMed ID: 19129230

Title: Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.

PubMed ID: 19129230

DOI: 10.1093/nar/gkn1013

PubMed ID: 19833968

Title: AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.

PubMed ID: 19833968

DOI: 10.1126/science.1172156

PubMed ID: 19299583

Title: Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

PubMed ID: 19299583

DOI: 10.1126/science.1171641

PubMed ID: 20159955

Title: The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors.

PubMed ID: 20159955

DOI: 10.1101/gad.564110

PubMed ID: 20385766

Title: Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver.

PubMed ID: 20385766

DOI: 10.1128/mcb.01141-09

PubMed ID: 20852621

Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

PubMed ID: 20852621

DOI: 10.1038/nm.2214

PubMed ID: 21236481

Title: Delay in feedback repression by cryptochrome 1 is required for circadian clock function.

PubMed ID: 21236481

DOI: 10.1016/j.cell.2010.12.019

PubMed ID: 21613214

Title: Biochemical analysis of the canonical model for the mammalian circadian clock.

PubMed ID: 21613214

DOI: 10.1074/jbc.m111.254680

PubMed ID: 21768648

Title: cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.

PubMed ID: 21768648

DOI: 10.1074/jbc.m111.258970

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 23133559

Title: Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.

PubMed ID: 23133559

DOI: 10.1371/journal.pone.0048152

PubMed ID: 22798407

Title: Identification of small molecule activators of cryptochrome.

PubMed ID: 22798407

DOI: 10.1126/science.1223710

PubMed ID: 23531614

Title: High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.

PubMed ID: 23531614

DOI: 10.1152/ajpendo.00512.2012

PubMed ID: 23452855

Title: Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

PubMed ID: 23452855

DOI: 10.1016/j.cell.2013.01.055

PubMed ID: 23452856

Title: FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.

PubMed ID: 23452856

DOI: 10.1016/j.cell.2013.01.054

PubMed ID: 24158435

Title: Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.

PubMed ID: 24158435

DOI: 10.1074/jbc.m113.509604

PubMed ID: 23616524

Title: Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.

PubMed ID: 23616524

DOI: 10.1523/jneurosci.4950-12.2013

PubMed ID: 23575670

Title: Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus.

PubMed ID: 23575670

DOI: 10.1038/ncomms2670

PubMed ID: 24089055

Title: Metastasis-associated protein 1 is an integral component of the circadian molecular machinery.

PubMed ID: 24089055

DOI: 10.1038/ncomms3545

PubMed ID: 23418588

Title: Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

PubMed ID: 23418588

DOI: 10.1371/journal.pone.0056623

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 24385426

Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.

PubMed ID: 24385426

DOI: 10.1074/jbc.m113.534651

PubMed ID: 24378737

Title: Modulation of glucocorticoid receptor induction properties by core circadian clock proteins.

PubMed ID: 24378737

DOI: 10.1016/j.mce.2013.12.013

PubMed ID: 24489120

Title: Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1.

PubMed ID: 24489120

DOI: 10.1093/nar/gku094

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 26776516

Title: Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function.

PubMed ID: 26776516

DOI: 10.1016/j.celrep.2015.12.076

PubMed ID: 27123980

Title: USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock.

PubMed ID: 27123980

DOI: 10.1371/journal.pone.0154263

PubMed ID: 28683290

Title: CRY1/2 selectively repress PPARdelta and limit exercise capacity.

PubMed ID: 28683290

DOI: 10.1016/j.cmet.2017.06.002

PubMed ID: 28790135

Title: DDB1-mediated CRY1 degradation promotes FOXO1-driven gluconeogenesis in liver.

PubMed ID: 28790135

DOI: 10.2337/db16-1600

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 29561690

Title: Differential roles for cryptochromes in the mammalian retinal clock.

PubMed ID: 29561690

DOI: 10.1096/fj.201701165rr

PubMed ID: 30500822

Title: JMJD5 links CRY1 function and proteasomal degradation.

PubMed ID: 30500822

DOI: 10.1371/journal.pbio.2006145

PubMed ID: 29937374

Title: Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.

PubMed ID: 29937374

DOI: 10.1016/j.cmet.2018.05.023

PubMed ID: 23746849

Title: Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function.

PubMed ID: 23746849

DOI: 10.1016/j.cell.2013.05.011

Sequence Information:

  • Length: 606
  • Mass: 68001
  • Checksum: 2F2B8DD53F0A9AF9
  • Sequence:
    • MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE 
DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA 
GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLVSKM EPLEMPADTI TSDVIGKCMT 
PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN 
ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA 
TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA 
VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR 
RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN 
IERMKQIYQQ LSRYRGLGLL ASVPSNSNGN GGLMGYAPGE NVPSCSSSGN GGLMGYAPGE 
NVPSCSGGNC SQGSGILHYA HGDSQQTHSL KQGRSSAGTG LSSGKRPSQE EDAQSVGPKV 
QRQSSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.