Details for: Cry2

Gene ID: 12953

Symbol: Cry2

Ensembl ID: ENSMUSG00000068742

Description: cryptochrome circadian regulator 2

Associated with

Other Information

Genular Protein ID: 3683503771

Symbol: CRY2_MOUSE

Name: Cryptochrome-2

UniProtKB Accession Codes:

Q9R194 O08706 Q6A024

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChEBI 6 ComplexPortal 3 DIP 1 EMBL 7 EPD 1 Ensembl 2 GO 33 Gene3D 3 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 10 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 10428031

Title: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.

PubMed ID: 10428031

DOI: 10.1016/s0092-8674(00)81014-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15368895

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 15368895

DOI: 10.1093/dnares/11.3.205

PubMed ID: 9801304

Title: Characterization of photolyase/blue-light receptor homologs in mouse and human cells.

PubMed ID: 9801304

DOI: 10.1093/nar/26.22.5086

PubMed ID: 10521578

Title: Circadian regulation of cryptochrome genes in the mouse.

PubMed ID: 10521578

DOI: 10.1016/s0169-328x(99)00192-8

PubMed ID: 11779462

Title: Posttranslational mechanisms regulate the mammalian circadian clock.

PubMed ID: 11779462

DOI: 10.1016/s0092-8674(01)00610-9

PubMed ID: 15298678

Title: Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase.

PubMed ID: 15298678

DOI: 10.1111/j.1356-9597.2004.00758.x

PubMed ID: 11875063

Title: The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.

PubMed ID: 11875063

DOI: 10.1074/jbc.m111466200

PubMed ID: 14701732

Title: Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.

PubMed ID: 14701732

DOI: 10.1128/mcb.24.2.584-594.2004

PubMed ID: 15980066

Title: Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.

PubMed ID: 15980066

DOI: 10.1074/jbc.m506225200

PubMed ID: 16628007

Title: Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES.

PubMed ID: 16628007

DOI: 10.4161/cc.5.8.2684

PubMed ID: 16717091

Title: The polycomb group protein EZH2 is required for mammalian circadian clock function.

PubMed ID: 16717091

DOI: 10.1074/jbc.m603722200

PubMed ID: 17274955

Title: The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2.

PubMed ID: 17274955

DOI: 10.1016/j.bbrc.2007.01.084

PubMed ID: 17462724

Title: Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.

PubMed ID: 17462724

DOI: 10.1016/j.cell.2007.04.030

PubMed ID: 17310242

Title: CIPC is a mammalian circadian clock protein without invertebrate homologues.

PubMed ID: 17310242

DOI: 10.1038/ncb1539

PubMed ID: 19917250

Title: Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism.

PubMed ID: 19917250

DOI: 10.1016/j.molcel.2009.10.012

PubMed ID: 19299583

Title: Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

PubMed ID: 19299583

DOI: 10.1126/science.1171641

PubMed ID: 20840750

Title: Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction.

PubMed ID: 20840750

DOI: 10.1186/1471-2199-11-69

PubMed ID: 20123978

Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.

PubMed ID: 20123978

DOI: 10.1128/mcb.01047-09

PubMed ID: 20852621

Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

PubMed ID: 20852621

DOI: 10.1038/nm.2214

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 22798407

Title: Identification of small molecule activators of cryptochrome.

PubMed ID: 22798407

DOI: 10.1126/science.1223710

PubMed ID: 24154698

Title: A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.

PubMed ID: 24154698

DOI: 10.1152/ajprenal.00472.2013

PubMed ID: 23531614

Title: High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.

PubMed ID: 23531614

DOI: 10.1152/ajpendo.00512.2012

PubMed ID: 23452855

Title: Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

PubMed ID: 23452855

DOI: 10.1016/j.cell.2013.01.055

PubMed ID: 23452856

Title: FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.

PubMed ID: 23452856

DOI: 10.1016/j.cell.2013.01.054

PubMed ID: 24158435

Title: Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.

PubMed ID: 24158435

DOI: 10.1074/jbc.m113.509604

PubMed ID: 23616524

Title: Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.

PubMed ID: 23616524

DOI: 10.1523/jneurosci.4950-12.2013

PubMed ID: 23575670

Title: Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus.

PubMed ID: 23575670

DOI: 10.1038/ncomms2670

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 24736997

Title: A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.

PubMed ID: 24736997

DOI: 10.1371/journal.pbio.1001839

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 26776516

Title: Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function.

PubMed ID: 26776516

DOI: 10.1016/j.celrep.2015.12.076

PubMed ID: 27123980

Title: USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock.

PubMed ID: 27123980

DOI: 10.1371/journal.pone.0154263

PubMed ID: 28683290

Title: CRY1/2 selectively repress PPARdelta and limit exercise capacity.

PubMed ID: 28683290

DOI: 10.1016/j.cmet.2017.06.002

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 29561690

Title: Differential roles for cryptochromes in the mammalian retinal clock.

PubMed ID: 29561690

DOI: 10.1096/fj.201701165rr

PubMed ID: 24080726

Title: Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase.

PubMed ID: 24080726

DOI: 10.1038/cr.2013.136

PubMed ID: 23503662

Title: SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.

PubMed ID: 23503662

DOI: 10.1038/nature11964

Sequence Information:

  • Length: 592
  • Mass: 66850
  • Checksum: 4D6E7B199C392CBB
  • Sequence:
    • MAAAAVVAAT VPAQSMGADG ASSVHWFRKG LRLHDNPALL AAVRGARCVR CVYILDPWFA 
ASSSVGINRW RFLLQSLEDL DTSLRKLNSR LFVVRGQPAD VFPRLFKEWG VTRLTFEYDS 
EPFGKERDAA IMKMAKEAGV EVVTENSHTL YDLDRIIELN GQKPPLTYKR FQALISRMEL 
PKKPAVAVSS QQMESCRAEI QENHDDTYGV PSLEELGFPT EGLGPAVWQG GETEALARLD 
KHLERKAWVA NYERPRMNAN SLLASPTGLS PYLRFGCLSC RLFYYRLWDL YKKVKRNSTP 
PLSLFGQLLW REFFYTAATN NPRFDRMEGN PICIQIPWDR NPEALAKWAE GKTGFPWIDA 
IMTQLRQEGW IHHLARHAVA CFLTRGDLWV SWESGVRVFD ELLLDADFSV NAGSWMWLSC 
SAFFQQFFHC YCPVGFGRRT DPSGDYIRRY LPKLKGFPSR YIYEPWNAPE SVQKAAKCII 
GVDYPRPIVN HAETSRLNIE RMKQIYQQLS RYRGLCLLAS VPSCVEDLSH PVAEPGSSQA 
GSISNTGPRA LSSGPASPKR KLEAAEEPPG EELTKRARVT EMPTQEPASK DS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.