Genular: Defining Cellular Identity and Function

Details for: Cryab

Gene ID: 12955

Symbol: Cryab

Ensembl ID: ENSMUSG00000032060

Description: crystallin, alpha B

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Hsf1-dependent transactivation
(R-MMU-3371571)
Actin filament bundle
(GO:0032432)
Amyloid-beta binding
(GO:0001540)
Apoptotic process involved in morphogenesis
(GO:0060561)
Axon
(GO:0030424)
Camera-type eye development
(GO:0043010)
Cardiac myofibril
(GO:0097512)
Cell surface
(GO:0009986)
Cellular response to gamma radiation
(GO:0071480)
Contractile fiber
(GO:0043292)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Extracellular region
(GO:0005576)
I band
(GO:0031674)
Identical protein binding
(GO:0042802)
Lens development in camera-type eye
(GO:0002088)
Lysosome
(GO:0005764)
M band
(GO:0031430)
Metal ion binding
(GO:0046872)
Microtubule binding
(GO:0008017)
Microtubule polymerization or depolymerization
(GO:0031109)
Mitochondrion
(GO:0005739)
Muscle organ development
(GO:0007517)
Myelin sheath
(GO:0043209)
Negative regulation of amyloid fibril formation
(GO:1905907)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of intracellular transport
(GO:0032387)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Nucleus
(GO:0005634)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein homodimerization activity
(GO:0042803)
Protein refolding
(GO:0042026)
Protein stabilization
(GO:0050821)
Regulation of programmed cell death
(GO:0043067)
Response to heat
(GO:0009408)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Stress-activated mapk cascade
(GO:0051403)
Structural constituent of eye lens
(GO:0005212)
Structural molecule activity
(GO:0005198)
Synaptic membrane
(GO:0097060)
Tubulin complex assembly
(GO:0007021)
Unfolded protein binding
(GO:0051082)
Z disc
(GO:0030018)

Other Information

Proteins

Alpha-crystallin B chain

Genular Protein ID: 1964270353

Symbol: CRYAB_MOUSE

Name: Alpha-crystallin B chain

UniProtKB Accession Codes:

P23927 Q64325

Database IDs:

Citations:

PubMed ID: 1846673

Title: Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.

PubMed ID: 1846673

DOI: 10.1128/mcb.11.2.803-812.1991

PubMed ID: 7838723

Title: Structure and alternate tissue-preferred transcription initiation of the mouse alpha B-crystallin/small heat shock protein gene.

PubMed ID: 7838723

DOI: 10.1093/nar/22.25.5686

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2725488

Title: Expression of the murine alpha B-crystallin gene is not restricted to the lens.

PubMed ID: 2725488

DOI: 10.1128/mcb.9.3.1083-1091.1989

PubMed ID: 10751411

Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.

PubMed ID: 10751411

DOI: 10.1074/jbc.m001981200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 31786107

Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.

PubMed ID: 31786107

DOI: 10.1016/j.bbagen.2019.129496

Sequence Information:

Length: 175
Mass: 20069
Checksum: 46702976C008EFD3
Sequence:

MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFST ATSLSPFYLR PPSFLRAPSW 
IDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR 
KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVA AAPKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cryab

Associated with

Other Information

Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts. PubMed ID: 1846673

Structure and alternate tissue-preferred transcription initiation of the mouse alpha B-crystallin/small heat shock protein gene. PubMed ID: 7838723

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of the murine alpha B-crystallin gene is not restricted to the lens. PubMed ID: 2725488

Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27. PubMed ID: 10751411

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens. PubMed ID: 31786107