Genular: Defining Cellular Identity and Function

Details for: Csf1

Gene ID: 12977

Symbol: Csf1

Ensembl ID: ENSMUSG00000014599

Description: colony stimulating factor 1 (macrophage)

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Metabolism of proteins
(R-MMU-392499)
Other interleukin signaling
(R-MMU-449836)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Signaling by interleukins
(R-MMU-449147)
Branching involved in mammary gland duct morphogenesis
(GO:0060444)
Csf1-csf1r complex
(GO:1990682)
Cytokine activity
(GO:0005125)
Developmental process involved in reproduction
(GO:0003006)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Homeostasis of number of cells within a tissue
(GO:0048873)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Macrophage colony-stimulating factor receptor binding
(GO:0005157)
Macrophage colony-stimulating factor signaling pathway
(GO:0038145)
Macrophage differentiation
(GO:0030225)
Macrophage homeostasis
(GO:0061519)
Mammary duct terminal end bud growth
(GO:0060763)
Mammary gland fat development
(GO:0060611)
Membrane
(GO:0016020)
Microglial cell proliferation
(GO:0061518)
Monocyte differentiation
(GO:0030224)
Monocyte homeostasis
(GO:0035702)
Myeloid leukocyte migration
(GO:0097529)
Neutrophil homeostasis
(GO:0001780)
Nuclear body
(GO:0016604)
Ossification
(GO:0001503)
Osteoclast differentiation
(GO:0030316)
Osteoclast proliferation
(GO:0002158)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of macrophage colony-stimulating factor signaling pathway
(GO:1902228)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of macrophage migration
(GO:1905523)
Positive regulation of macrophage proliferation
(GO:0120041)
Positive regulation of microglial cell migration
(GO:1904141)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of mononuclear cell migration
(GO:0071677)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of odontogenesis of dentin-containing tooth
(GO:0042488)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of ras protein signal transduction
(GO:0046579)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Ras protein signal transduction
(GO:0007265)
Regulation of ossification
(GO:0030278)
Response to ischemia
(GO:0002931)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Macrophage colony-stimulating factor 1

Genular Protein ID: 170167659

Symbol: CSF1_MOUSE

Name: Macrophage colony-stimulating factor 1

UniProtKB Accession Codes:

P07141 Q3U395 Q8R3C8

Database IDs:

Citations:

PubMed ID: 3494232

Title: Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF).

PubMed ID: 3494232

DOI: 10.1093/nar/15.5.2389

PubMed ID: 2457916

Title: cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells.

PubMed ID: 2457916

DOI: 10.1073/pnas.85.18.6706

PubMed ID: 8357831

Title: Isolation and characterization of a cDNA clone encoding for rat CSF-1 gene. Post-transcriptional repression occurs in myogenic differentiation.

PubMed ID: 8357831

DOI: 10.1016/0167-4781(93)90108-p

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3493488

Title: Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA.

PubMed ID: 3493488

DOI: 10.1073/pnas.84.5.1157

PubMed ID: 3925458

Title: Amino-terminal amino acid sequence of murine colony-stimulating factor 1.

PubMed ID: 3925458

DOI: 10.1073/pnas.82.13.4486

PubMed ID: 1874443

Title: Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene.

PubMed ID: 1874443

DOI: 10.1016/0378-1119(91)90074-l

PubMed ID: 12074592

Title: Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat.

PubMed ID: 12074592

DOI: 10.1016/s0006-291x(02)00598-3

PubMed ID: 12379742

Title: The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification.

PubMed ID: 12379742

DOI: 10.1073/pnas.202332999

PubMed ID: 1733926

Title: The predominant form of secreted colony stimulating factor-1 is a proteoglycan.

PubMed ID: 1733926

DOI: 10.1016/s0021-9258(18)45861-9

PubMed ID: 2188141

Title: The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene.

PubMed ID: 2188141

DOI: 10.1038/345442a0

PubMed ID: 19017797

Title: Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.

PubMed ID: 19017797

DOI: 10.1073/pnas.0807762105

Sequence Information:

Length: 552
Mass: 60649
Checksum: 3886D72D70E770AF
Sequence:

MTARGAAGRC PSSTWLGSRL LLVCLLMSRS IAKEVSEHCS HMIGNGHLKV LQQLIDSQME 
TSCQIAFEFV DQEQLDDPVC YLKKAFFLVQ DIIDETMRFK DNTPNANATE RLQELSNNLN 
SCFTKDYEEQ NKACVRTFHE TPLQLLEKIK NFFNETKNLL EKDWNIFTKN CNNSFAKCSS 
RDVVTKPDCN CLYPKATPSS DPASASPHQP PAPSMAPLAG LAWDDSQRTE GSSLLPSELP 
LRIEDPGSAK QRPPRSTCQT LESTEQPNHG DRLTEDSQPH PSAGGPVPGV EDILESSLGT 
NWVLEEASGE ASEGFLTQEA KFSPSTPVGG SIQAETDRPR ALSASPFPKS TEDQKPVDIT 
DRPLTEVNPM RPIGQTQNNT PEKTDGTSTL REDHQEPGSP HIATPNPQRV SNSATPVAQL 
LLPKSHSWGI VLPLGELEGK RSTRDRRSPA ELEGGSASEG AARPVARFNS IPLTDTGHVE 
QHEGSSDPQI PESVFHLLVP GIILVLLTVG GLLFYKWKWR SHRDPQTLDS SVGRPEDSSL 
TQDEDRQVEL PV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Csf1

Associated with

Other Information

Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF). PubMed ID: 3494232

cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells. PubMed ID: 2457916

Isolation and characterization of a cDNA clone encoding for rat CSF-1 gene. Post-transcriptional repression occurs in myogenic differentiation. PubMed ID: 8357831

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. PubMed ID: 3493488

Amino-terminal amino acid sequence of murine colony-stimulating factor 1. PubMed ID: 3925458

Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene. PubMed ID: 1874443

Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat. PubMed ID: 12074592

The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. PubMed ID: 12379742

The predominant form of secreted colony stimulating factor-1 is a proteoglycan. PubMed ID: 1733926

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. PubMed ID: 2188141

Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. PubMed ID: 19017797