Genular: Defining Cellular Identity and Function

Details for: Csf2

Gene ID: 12981

Symbol: Csf2

Ensembl ID: ENSMUSG00000018916

Description: colony stimulating factor 2 (granulocyte-macrophage)

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin receptor shc signaling
(R-MMU-912526)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Raf/map kinase cascade
(R-MMU-5673001)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Cell population proliferation
(GO:0008283)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus
(GO:0097011)
Cytokine activity
(GO:0005125)
Dendritic cell differentiation
(GO:0097028)
Embryonic placenta development
(GO:0001892)
Epithelial fluid transport
(GO:0042045)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Granulocyte-macrophage colony-stimulating factor signaling pathway
(GO:0038157)
Granulocyte macrophage colony-stimulating factor receptor binding
(GO:0005129)
Granulocyte macrophage colony-stimulating factor receptor complex
(GO:0030526)
Growth factor activity
(GO:0008083)
Histamine secretion
(GO:0001821)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Macrophage differentiation
(GO:0030225)
Monocyte differentiation
(GO:0030224)
Myeloid cell differentiation
(GO:0030099)
Myeloid dendritic cell differentiation
(GO:0043011)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Neutrophil differentiation
(GO:0030223)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-23 production
(GO:0032747)
Positive regulation of leukocyte proliferation
(GO:0070665)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of podosome assembly
(GO:0071803)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell population proliferation
(GO:0042127)
Regulation of circadian sleep/wake cycle, sleep
(GO:0045187)
Regulation of gene expression
(GO:0010468)

Other Information

Proteins

Granulocyte-macrophage colony-stimulating factor

Genular Protein ID: 2467109681

Symbol: CSF2_MOUSE

Name: Granulocyte-macrophage colony-stimulating factor

UniProtKB Accession Codes:

P01587

Database IDs:

Citations:

PubMed ID: 3876930

Title: Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

PubMed ID: 3876930

DOI: 10.1002/j.1460-2075.1985.tb03971.x

PubMed ID: 3876931

Title: The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters.

PubMed ID: 3876931

DOI: 10.1002/j.1460-2075.1985.tb03972.x

PubMed ID: 3902470

Title: Recombinant murine GM-CSF from E. coli has biological activity and is neutralized by a specific antiserum.

PubMed ID: 3902470

DOI: 10.1002/j.1460-2075.1985.tb03973.x

PubMed ID: 3874057

Title: Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor.

PubMed ID: 3874057

DOI: 10.1002/j.1460-2075.1985.tb03678.x

PubMed ID: 6610831

Title: Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor.

PubMed ID: 6610831

DOI: 10.1038/309763a0

PubMed ID: 3898082

Title: Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.

PubMed ID: 3898082

DOI: 10.1073/pnas.82.18.6250

PubMed ID: 3871523

Title: Purification and partial amino acid sequence of asialo murine granulocyte-macrophage colony stimulating factor.

PubMed ID: 3871523

DOI: 10.1073/pnas.82.2.292

PubMed ID: 3318813

Title: Characterization of human and mouse granulocyte-macrophage-colony-stimulating factors derived from Escherichia coli.

PubMed ID: 3318813

DOI: 10.1042/bj2470195

PubMed ID: 2002066

Title: Single proline substitutions in predicted alpha-helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylation.

PubMed ID: 2002066

DOI: 10.1016/s0021-9258(19)67792-6

Sequence Information:

Length: 141
Mass: 16091
Checksum: 209C7CBB4FF77349
Sequence:

MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL NEEVEVVSNE 
FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT YCPPTPETDC ETQVTTYADF 
IDSLKTFLTD IPFECKKPGQ K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Csf2

Associated with

Other Information

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. PubMed ID: 3876930

The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters. PubMed ID: 3876931

Recombinant murine GM-CSF from E. coli has biological activity and is neutralized by a specific antiserum. PubMed ID: 3902470

Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. PubMed ID: 3874057

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. PubMed ID: 6610831

Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. PubMed ID: 3898082

Purification and partial amino acid sequence of asialo murine granulocyte-macrophage colony stimulating factor. PubMed ID: 3871523

Characterization of human and mouse granulocyte-macrophage-colony-stimulating factors derived from Escherichia coli. PubMed ID: 3318813

Single proline substitutions in predicted alpha-helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylation. PubMed ID: 2002066