Genular: Defining Cellular Identity and Function

Details for: Csk

Gene ID: 12988

Symbol: Csk

Ensembl ID: ENSMUSG00000032312

Description: c-src tyrosine kinase

Associated with

Adaptive immune system
(R-MMU-1280218)
Costimulation by the cd28 family
(R-MMU-388841)
Cytokine signaling in immune system
(R-MMU-1280215)
Flt3 signaling
(R-MMU-9607240)
Gab1 signalosome
(R-MMU-180292)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Integrin signaling
(R-MMU-354192)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of flt3
(R-MMU-9706369)
Pd-1 signaling
(R-MMU-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-MMU-202427)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Raf/map kinase cascade
(R-MMU-5673001)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Signaling by egfr
(R-MMU-177929)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Tcr signaling
(R-MMU-202403)
Adaptive immune response
(GO:0002250)
Adherens junction organization
(GO:0034332)
Atp binding
(GO:0005524)
Cell-cell junction
(GO:0005911)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cytoplasm
(GO:0005737)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of bone resorption
(GO:0045779)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of golgi to plasma membrane protein transport
(GO:0042997)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of low-density lipoprotein particle clearance
(GO:0010989)
Negative regulation of phagocytosis
(GO:0050765)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein kinase activity
(GO:0004672)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060368)
Regulation of t cell activation
(GO:0050863)
Transferase activity
(GO:0016740)

Other Information

Proteins

Tyrosine-protein kinase CSK

Genular Protein ID: 2037732540

Symbol: CSK_MOUSE

Name: Tyrosine-protein kinase CSK

UniProtKB Accession Codes:

P41241 Q03143 Q80WU4 Q8VCW1

Database IDs:

Citations:

PubMed ID: 7511815

Title: Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.

PubMed ID: 7511815

DOI: 10.1073/pnas.91.7.2597

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1281307

Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.

PubMed ID: 1281307

PubMed ID: 7685657

Title: Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.

PubMed ID: 7685657

DOI: 10.1016/0092-8674(93)90641-3

PubMed ID: 8890164

Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.

PubMed ID: 8890164

DOI: 10.1002/j.1460-2075.1996.tb00871.x

PubMed ID: 9858471

Title: Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.

PubMed ID: 9858471

DOI: 10.1242/jcs.112.2.181

PubMed ID: 12218089

Title: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

PubMed ID: 12218089

DOI: 10.4049/jimmunol.169.6.2813

PubMed ID: 12612075

Title: Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.

PubMed ID: 12612075

DOI: 10.1128/mcb.23.6.2017-2028.2003

PubMed ID: 16166631

Title: Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development.

PubMed ID: 16166631

DOI: 10.1128/mcb.25.19.8486-8495.2005

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23526378

Title: Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

PubMed ID: 23526378

DOI: 10.1002/jbmr.1935

PubMed ID: 28290451

Title: Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.

PubMed ID: 28290451

DOI: 10.1038/icb.2017.10

PubMed ID: 11685249

Title: A novel, specific interaction involving the Csk SH3 domain and its natural ligand.

PubMed ID: 11685249

DOI: 10.1038/nsb1101-998

Sequence Information:

Length: 450
Mass: 50716
Checksum: E8D3EC9357B86277
Sequence:

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCEGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAATR PTFLQLREQL EHIKTHELHL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Csk

Associated with

Other Information

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family. PubMed ID: 7511815

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. PubMed ID: 1281307

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. PubMed ID: 7685657

Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. PubMed ID: 8890164

Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin. PubMed ID: 9858471

Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. PubMed ID: 12218089

Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. PubMed ID: 12612075

Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development. PubMed ID: 16166631

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. PubMed ID: 23526378

Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP. PubMed ID: 28290451

A novel, specific interaction involving the Csk SH3 domain and its natural ligand. PubMed ID: 11685249