AADAC - ENSG00000114771

Details for: AADAC

Gene ID: 13

Symbol: AADAC

Ensembl ID: ENSG00000114771

Description: arylacetamide deacetylase

Associated with

Biological oxidations (R-HSA-211859)
Metabolism (R-HSA-1430728)
Phase i - functionalization of compounds (R-HSA-211945)
Catalytic activity (GO:0003824)
Deacetylase activity (GO:0019213)
Endoplasmic reticulum membrane (GO:0005789)
Lipase activity (GO:0016298)
Lipid metabolic process (GO:0006629)
Positive regulation of triglyceride catabolic process (GO:0010898)
Protein binding (GO:0005515)
Serine hydrolase activity (GO:0017171)
Triglyceride lipase activity (GO:0004806)
Xenobiotic metabolic process (GO:0006805)

Cells (max top 100)

Cell Name: enterocyte of colon (CL1000347)
Fold Change: 7.67
Marker Score: 11819
Cell Name: enterocyte (CL0000584)
Fold Change: 1.58
Marker Score: 7571
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.56
Marker Score: 451
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.5
Marker Score: 9564
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.37
Marker Score: 5912
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.2
Marker Score: 7730
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.18
Marker Score: 6368
Cell Name: precursor cell (CL0011115)
Fold Change: 1.18
Marker Score: 286
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251810
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71828
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48053
Cell Name: keratinocyte (CL0000312)
Fold Change: 1
Marker Score: 832.5
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.96
Marker Score: 1551
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5337
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.85
Marker Score: 2774
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.84
Marker Score: 1902
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.82
Marker Score: 1130
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.75
Marker Score: 745
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3117
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.7
Marker Score: 1133
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.66
Marker Score: 452
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 491
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6
Marker Score: 386
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.6
Marker Score: 1267
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.6
Marker Score: 249
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.55
Marker Score: 584.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.54
Marker Score: 222
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.53
Marker Score: 211
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.52
Marker Score: 201
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.52
Marker Score: 3370.5
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.52
Marker Score: 194
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.51
Marker Score: 961
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.5
Marker Score: 532
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: stem cell (CL0000034)
Fold Change: 0.45
Marker Score: 1067
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.44
Marker Score: 891
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.38
Marker Score: 142
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.35
Marker Score: 977
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.35
Marker Score: 111
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.34
Marker Score: 89
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.34
Marker Score: 180
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.32
Marker Score: 119
Cell Name: ionocyte (CL0005006)
Fold Change: 0.31
Marker Score: 94
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.31
Marker Score: 4817
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.31
Marker Score: 172
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3
Marker Score: 5373
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.29
Marker Score: 91
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.29
Marker Score: 172
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.28
Marker Score: 452
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.28
Marker Score: 130
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.28
Marker Score: 276
Cell Name: basal cell (CL0000646)
Fold Change: 0.27
Marker Score: 344
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.26
Marker Score: 96
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 89
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.25
Marker Score: 1337
Cell Name: lactocyte (CL0002325)
Fold Change: 0.25
Marker Score: 4066
Cell Name: acinar cell (CL0000622)
Fold Change: 0.25
Marker Score: 174
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.24
Marker Score: 53
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.24
Marker Score: 104
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.23
Marker Score: 221
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.22
Marker Score: 60
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.22
Marker Score: 454
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.2
Marker Score: 693
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.19
Marker Score: 58
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.19
Marker Score: 47
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.19
Marker Score: 185
Cell Name: paneth cell (CL0000510)
Fold Change: 0.19
Marker Score: 130
Cell Name: goblet cell (CL0000160)
Fold Change: 0.19
Marker Score: 1240
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.18
Marker Score: 187
Cell Name: club cell (CL0000158)
Fold Change: 0.18
Marker Score: 207
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.18
Marker Score: 5988
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.17
Marker Score: 58
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.17
Marker Score: 325
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.17
Marker Score: 124
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.17
Marker Score: 81
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.17
Marker Score: 112
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.16
Marker Score: 42
Cell Name: secretory cell (CL0000151)
Fold Change: 0.16
Marker Score: 292
Cell Name: podocyte (CL0000653)
Fold Change: 0.15
Marker Score: 57
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.15
Marker Score: 1327
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.15
Marker Score: 68
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.15
Marker Score: 150
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.15
Marker Score: 41
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.15
Marker Score: 69
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.15
Marker Score: 40
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.13
Marker Score: 33
Cell Name: monocyte (CL0000576)
Fold Change: 0.13
Marker Score: 172
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.13
Marker Score: 100
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.13
Marker Score: 56

**Key characteristics:** * Gene name: AADAC * Ensembl ID: ENSG00000114771 * Pathway: Biological oxidations, Catalytic activity, Deacetylase activity, Endoplasmic reticulum membrane, Lipase activity, Lipid metabolic process, Metabolism, Phase i - functionalization of compounds, Positive regulation of triglyceride catabolic process, Protein binding, Serine hydrolase activity, Triglyceride lipase activity, Xenobiotic metabolic process * Significantly expressed cells: enterocyte of colon, enterocyte, enterocyte of epithelium proper of ileum, foveolar cell of stomach, midzonal region hepatocyte, centrilobular region hepatocyte, periportal region hepatocyte, precursor cell, fallopian tube secretory epithelial cell, cerebral cortex GABAergic interneuron **Pathways and functions:** * The AADAC gene is involved in multiple metabolic pathways, including biological oxidations, catalytic activity, deacetylase activity, and xenobiotic metabolic processes. * It plays a role in the regulation of triglyceride catabolism by deacetylating a key enzyme involved in this process. * It is also involved in the regulation of the endoplasmic reticulum membrane, where it may participate in the formation or remodeling of lipid droplets. * Additionally, it is involved in the regulation of protein binding, serine hydrolase activity, and triglyceride lipase activity. **Clinical significance:** Mutations in the AADAC gene have been linked to several diseases, including colorectal cancer, non-alcoholic fatty liver disease, and obesity. These mutations can lead to the accumulation of arylamines and arylketoaldehydes, which can damage cells and tissues.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.