Details for: AADAC
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: enterocyte of colon (CL1000347)
Fold Change: 7.67
Marker Score: 11,819 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.58
Marker Score: 7,571 - Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.56
Marker Score: 451 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.5
Marker Score: 9,564 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.37
Marker Score: 5,912 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.2
Marker Score: 7,730 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.18
Marker Score: 6,368 - Cell Name: precursor cell (CL0011115)
Fold Change: 1.18
Marker Score: 286 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,810 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,828 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,053 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1
Marker Score: 833 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.96
Marker Score: 1,551 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,337 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.85
Marker Score: 2,774 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.84
Marker Score: 1,902 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.82
Marker Score: 1,130 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.75
Marker Score: 745 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3,117 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.7
Marker Score: 1,133 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.66
Marker Score: 452 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 491 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6
Marker Score: 386 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.6
Marker Score: 1,267 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.6
Marker Score: 249 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.55
Marker Score: 585 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.54
Marker Score: 222 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.53
Marker Score: 211 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.52
Marker Score: 201 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.52
Marker Score: 3,371 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.52
Marker Score: 194 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.51
Marker Score: 961 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.5
Marker Score: 532 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277 - Cell Name: stem cell (CL0000034)
Fold Change: 0.45
Marker Score: 1,067 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.44
Marker Score: 891 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.38
Marker Score: 142 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.35
Marker Score: 977 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.35
Marker Score: 111 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.34
Marker Score: 89 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.34
Marker Score: 180 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.32
Marker Score: 119 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.31
Marker Score: 94 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.31
Marker Score: 4,817 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.31
Marker Score: 172 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3
Marker Score: 5,373 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.29
Marker Score: 91 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.29
Marker Score: 172 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.28
Marker Score: 452 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.28
Marker Score: 130 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.28
Marker Score: 276 - Cell Name: basal cell (CL0000646)
Fold Change: 0.27
Marker Score: 344 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.26
Marker Score: 96 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 89 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.25
Marker Score: 1,337 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.25
Marker Score: 4,066 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.25
Marker Score: 174 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.24
Marker Score: 53 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.24
Marker Score: 104 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.23
Marker Score: 221 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.22
Marker Score: 60 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.22
Marker Score: 454 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.2
Marker Score: 693 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.19
Marker Score: 58 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.19
Marker Score: 47 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.19
Marker Score: 185 - Cell Name: paneth cell (CL0000510)
Fold Change: 0.19
Marker Score: 130 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.19
Marker Score: 1,240 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.18
Marker Score: 187 - Cell Name: club cell (CL0000158)
Fold Change: 0.18
Marker Score: 207 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.18
Marker Score: 5,988 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.17
Marker Score: 58 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.17
Marker Score: 325 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.17
Marker Score: 124 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.17
Marker Score: 81 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.17
Marker Score: 112 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.16
Marker Score: 42 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.16
Marker Score: 292 - Cell Name: podocyte (CL0000653)
Fold Change: 0.15
Marker Score: 57 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.15
Marker Score: 1,327 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.15
Marker Score: 68 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.15
Marker Score: 150 - Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.15
Marker Score: 41 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.15
Marker Score: 69 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.15
Marker Score: 40 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.13
Marker Score: 33 - Cell Name: monocyte (CL0000576)
Fold Change: 0.13
Marker Score: 172 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.13
Marker Score: 100 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.13
Marker Score: 56
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4181350417
Symbol: AAAD_HUMAN
Name: Arylacetamide deacetylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8063807
Title: Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.
PubMed ID: 8063807
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2043131
Title: Purification and characterization of a human liver arylacetamide deacetylase.
PubMed ID: 2043131
PubMed ID: 17936933
Title: Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.
PubMed ID: 17936933
DOI: 10.1002/jbt.20178
PubMed ID: 19339378
Title: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.
PubMed ID: 19339378
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 22207054
Title: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.
PubMed ID: 22207054
PubMed ID: 22415931
Title: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.
PubMed ID: 22415931
PubMed ID: 24125761
Title: N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.
PubMed ID: 24125761
PubMed ID: 23542347
Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.
PubMed ID: 23542347
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 12721789
Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.
PubMed ID: 12721789
Sequence Information:
- Length: 399
- Mass: 45734
- Checksum: 34F9CB717DD7417A
- Sequence:
MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.