Details for: AADAC

Gene ID: 13

Symbol: AADAC

Ensembl ID: ENSG00000114771

Description: arylacetamide deacetylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 11.6998
    Cell Significance Index: 88.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.2491
    Cell Significance Index: -10.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.7518
    Cell Significance Index: 170.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.2860
    Cell Significance Index: 625.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.2670
    Cell Significance Index: 94.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1211
    Cell Significance Index: 35.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9750
    Cell Significance Index: 52.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7653
    Cell Significance Index: 105.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4091
    Cell Significance Index: 1272.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3438
    Cell Significance Index: 146.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2687
    Cell Significance Index: 27.0200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.1464
    Cell Significance Index: 7.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9310
    Cell Significance Index: 151.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7985
    Cell Significance Index: 17.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7937
    Cell Significance Index: 54.8900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.7577
    Cell Significance Index: 4.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7114
    Cell Significance Index: 70.3700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.5851
    Cell Significance Index: 5.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5803
    Cell Significance Index: 9.7600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.5444
    Cell Significance Index: 3.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5181
    Cell Significance Index: 12.5500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4763
    Cell Significance Index: 7.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4362
    Cell Significance Index: 10.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4259
    Cell Significance Index: 84.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4036
    Cell Significance Index: 68.9300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.3770
    Cell Significance Index: 2.3300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2627
    Cell Significance Index: 2.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2357
    Cell Significance Index: 4.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1087
    Cell Significance Index: 12.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0616
    Cell Significance Index: 38.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0471
    Cell Significance Index: 2.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0358
    Cell Significance Index: 6.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0225
    Cell Significance Index: 17.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0069
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -17.0200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0096
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0100
    Cell Significance Index: -1.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0128
    Cell Significance Index: -17.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0224
    Cell Significance Index: -12.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0306
    Cell Significance Index: -13.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0338
    Cell Significance Index: -12.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0339
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0348
    Cell Significance Index: -7.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0430
    Cell Significance Index: -0.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0455
    Cell Significance Index: -13.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0478
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0479
    Cell Significance Index: -5.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0633
    Cell Significance Index: -2.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0636
    Cell Significance Index: -12.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0721
    Cell Significance Index: -3.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0775
    Cell Significance Index: -2.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0807
    Cell Significance Index: -4.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0816
    Cell Significance Index: -2.1000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0858
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0905
    Cell Significance Index: -13.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1015
    Cell Significance Index: -13.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1062
    Cell Significance Index: -13.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1209
    Cell Significance Index: -1.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1306
    Cell Significance Index: -13.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1338
    Cell Significance Index: -13.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1619
    Cell Significance Index: -7.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1636
    Cell Significance Index: -4.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1826
    Cell Significance Index: -13.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1890
    Cell Significance Index: -12.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1915
    Cell Significance Index: -9.9500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1991
    Cell Significance Index: -0.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2035
    Cell Significance Index: -10.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2070
    Cell Significance Index: -3.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2074
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2155
    Cell Significance Index: -4.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2217
    Cell Significance Index: -17.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2244
    Cell Significance Index: -13.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2945
    Cell Significance Index: -7.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3126
    Cell Significance Index: -17.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3294
    Cell Significance Index: -4.6800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3375
    Cell Significance Index: -4.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3533
    Cell Significance Index: -12.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3562
    Cell Significance Index: -9.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3701
    Cell Significance Index: -4.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3839
    Cell Significance Index: -16.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3874
    Cell Significance Index: -13.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3881
    Cell Significance Index: -8.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3919
    Cell Significance Index: -13.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4059
    Cell Significance Index: -13.2900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4124
    Cell Significance Index: -2.7900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.4164
    Cell Significance Index: -4.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4211
    Cell Significance Index: -13.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4376
    Cell Significance Index: -11.9100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.4397
    Cell Significance Index: -1.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4460
    Cell Significance Index: -16.8900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.4481
    Cell Significance Index: -2.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4482
    Cell Significance Index: -12.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4597
    Cell Significance Index: -13.5400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4752
    Cell Significance Index: -6.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4902
    Cell Significance Index: -12.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AADAC is a serine hydrolase enzyme that exhibits deacetylase activity, which involves the removal of an acetyl group from arylacetamides. This reaction is catalyzed by a metalloprotease center, which is essential for the enzyme's activity. AADAC is also involved in the regulation of triglyceride catabolic processes, suggesting its potential role in lipid metabolism. The enzyme's expression in various tissues and its involvement in xenobiotic metabolism make it a valuable tool for studying the processing of drugs and other foreign compounds in the body. **Pathways and Functions** AADAC is involved in several cellular pathways, including: 1. **Biological oxidations**: AADAC participates in the oxidation of arylacetamides, which is a critical step in the metabolism of these compounds. 2. **Catalytic activity**: The enzyme's metalloprotease center is essential for its catalytic activity, allowing it to remove an acetyl group from arylacetamides. 3. **Deacetylase activity**: AADAC is a deacetylase enzyme, which involves the removal of an acetyl group from arylacetamides. 4. **Endoplasmic reticulum membrane**: AADAC is localized to the endoplasmic reticulum membrane, suggesting its involvement in lipid metabolism and xenobiotic processing. 5. **Lipase activity**: The enzyme's involvement in triglyceride catabolic processes suggests its potential role in lipid metabolism. 6. **Lipid metabolic process**: AADAC's expression in enterocytes and its involvement in triglyceride catabolic processes highlight its potential role in lipid metabolism. 7. **Metabolism**: The enzyme's involvement in xenobiotic metabolism and its expression in various tissues make it a valuable tool for studying the processing of drugs and other foreign compounds in the body. **Clinical Significance** AADAC's expression in various tissues and its involvement in xenobiotic metabolism make it a potential biomarker for the processing of drugs and other foreign compounds in the body. The enzyme's role in lipid metabolism and triglyceride catabolic processes also make it a potential target for the treatment of metabolic disorders, such as obesity and hyperlipidemia. Additionally, AADAC's involvement in the regulation of GABAergic neurotransmission in the brain suggests its potential role in the treatment of neurological disorders, such as anxiety and insomnia. In conclusion, AADAC is a serine hydrolase enzyme that plays a crucial role in various cellular processes, including protein and lipid metabolism. Its expression in various tissues and its involvement in xenobiotic metabolism make it a valuable tool for studying the processing of drugs and other foreign compounds in the body. Further research is needed to fully understand the clinical significance of AADAC and its potential applications in the treatment of metabolic and neurological disorders.

Genular Protein ID: 4181350417

Symbol: AAAD_HUMAN

Name: Arylacetamide deacetylase

UniProtKB Accession Codes:

P22760 A8K3L3 D3DNJ6 Q8N1A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8063807

Title: Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.

PubMed ID: 8063807

DOI: 10.1016/s0021-9258(17)31855-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2043131

Title: Purification and characterization of a human liver arylacetamide deacetylase.

PubMed ID: 2043131

DOI: 10.1016/0006-291x(91)92005-5

PubMed ID: 17936933

Title: Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.

PubMed ID: 17936933

DOI: 10.1002/jbt.20178

PubMed ID: 19339378

Title: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.

PubMed ID: 19339378

DOI: 10.1124/dmd.109.026567

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22207054

Title: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.

PubMed ID: 22207054

DOI: 10.1124/dmd.111.043067

PubMed ID: 22415931

Title: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.

PubMed ID: 22415931

DOI: 10.1124/dmd.112.044883

PubMed ID: 24125761

Title: N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.

PubMed ID: 24125761

DOI: 10.1016/j.bcp.2013.10.001

PubMed ID: 23542347

Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.

PubMed ID: 23542347

DOI: 10.1016/j.jhep.2013.03.022

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 399
  • Mass: 45734
  • Checksum: 34F9CB717DD7417A
  • Sequence:
    • MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD 
SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA 
ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP 
ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF 
LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP 
NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG 
VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.