Details for: AADAC

Gene ID: 13

Symbol: AADAC

Ensembl ID: ENSG00000114771

Description: arylacetamide deacetylase

Associated with

Cells (max top 100)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 7.67
    Marker Score: 11819
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.58
    Marker Score: 7571
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.56
    Marker Score: 451
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.5
    Marker Score: 9564
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.37
    Marker Score: 5912
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7730
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.18
    Marker Score: 6368
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.18
    Marker Score: 286
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251810
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1
    Marker Score: 832.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1551
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.85
    Marker Score: 2774
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.84
    Marker Score: 1902
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.82
    Marker Score: 1130
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.75
    Marker Score: 745
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3117
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.7
    Marker Score: 1133
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.66
    Marker Score: 452
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 491
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6
    Marker Score: 1267
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6
    Marker Score: 249
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.55
    Marker Score: 584.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 222
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.53
    Marker Score: 211
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.52
    Marker Score: 201
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.52
    Marker Score: 3370.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 961
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.5
    Marker Score: 532
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.45
    Marker Score: 1067
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 891
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.35
    Marker Score: 977
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.34
    Marker Score: 180
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.32
    Marker Score: 119
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4817
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.31
    Marker Score: 172
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3
    Marker Score: 5373
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.28
    Marker Score: 452
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.28
    Marker Score: 276
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.27
    Marker Score: 344
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.25
    Marker Score: 1337
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.25
    Marker Score: 4066
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.25
    Marker Score: 174
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.24
    Marker Score: 53
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 104
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.22
    Marker Score: 60
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 454
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.2
    Marker Score: 693
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 185
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1240
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 187
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.18
    Marker Score: 207
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.18
    Marker Score: 5988
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.17
    Marker Score: 325
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.17
    Marker Score: 124
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.16
    Marker Score: 292
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.15
    Marker Score: 1327
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 172
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 100
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 56
**Key characteristics:** * Gene name: AADAC * Ensembl ID: ENSG00000114771 * Pathway: Biological oxidations, Catalytic activity, Deacetylase activity, Endoplasmic reticulum membrane, Lipase activity, Lipid metabolic process, Metabolism, Phase i - functionalization of compounds, Positive regulation of triglyceride catabolic process, Protein binding, Serine hydrolase activity, Triglyceride lipase activity, Xenobiotic metabolic process * Significantly expressed cells: enterocyte of colon, enterocyte, enterocyte of epithelium proper of ileum, foveolar cell of stomach, midzonal region hepatocyte, centrilobular region hepatocyte, periportal region hepatocyte, precursor cell, fallopian tube secretory epithelial cell, cerebral cortex GABAergic interneuron **Pathways and functions:** * The AADAC gene is involved in multiple metabolic pathways, including biological oxidations, catalytic activity, deacetylase activity, and xenobiotic metabolic processes. * It plays a role in the regulation of triglyceride catabolism by deacetylating a key enzyme involved in this process. * It is also involved in the regulation of the endoplasmic reticulum membrane, where it may participate in the formation or remodeling of lipid droplets. * Additionally, it is involved in the regulation of protein binding, serine hydrolase activity, and triglyceride lipase activity. **Clinical significance:** Mutations in the AADAC gene have been linked to several diseases, including colorectal cancer, non-alcoholic fatty liver disease, and obesity. These mutations can lead to the accumulation of arylamines and arylketoaldehydes, which can damage cells and tissues.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.