Details for: AADAC

Gene ID: 13

Symbol: AADAC

Ensembl ID: ENSG00000114771

Description: arylacetamide deacetylase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 7.67
    Marker Score: 11819
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.58
    Marker Score: 7571
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.56
    Marker Score: 451
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.5
    Marker Score: 9564
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.37
    Marker Score: 5912
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7730
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.18
    Marker Score: 6368
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.18
    Marker Score: 286
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251810
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1
    Marker Score: 832.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1551
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.85
    Marker Score: 2774
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.84
    Marker Score: 1902
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.82
    Marker Score: 1130
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.75
    Marker Score: 745
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3117
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.7
    Marker Score: 1133
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.66
    Marker Score: 452
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 491
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6
    Marker Score: 1267
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6
    Marker Score: 249
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.55
    Marker Score: 584.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 222
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.53
    Marker Score: 211
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.52
    Marker Score: 201
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.52
    Marker Score: 3370.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 961
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.5
    Marker Score: 532
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.45
    Marker Score: 1067
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 891
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.35
    Marker Score: 977
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.34
    Marker Score: 180
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.32
    Marker Score: 119
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4817
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.31
    Marker Score: 172
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3
    Marker Score: 5373
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.28
    Marker Score: 452
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.28
    Marker Score: 276
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.27
    Marker Score: 344
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.25
    Marker Score: 1337
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.25
    Marker Score: 4066
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.25
    Marker Score: 174
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.24
    Marker Score: 53
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 104
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.22
    Marker Score: 60
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 454
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.2
    Marker Score: 693
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 185
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1240
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 187
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.18
    Marker Score: 207
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.18
    Marker Score: 5988
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.17
    Marker Score: 325
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.17
    Marker Score: 124
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.16
    Marker Score: 292
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.15
    Marker Score: 1327
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 172
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 100
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 56

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Other Information

**Key characteristics:** * Gene name: AADAC * Ensembl ID: ENSG00000114771 * Pathway: Biological oxidations, Catalytic activity, Deacetylase activity, Endoplasmic reticulum membrane, Lipase activity, Lipid metabolic process, Metabolism, Phase i - functionalization of compounds, Positive regulation of triglyceride catabolic process, Protein binding, Serine hydrolase activity, Triglyceride lipase activity, Xenobiotic metabolic process * Significantly expressed cells: enterocyte of colon, enterocyte, enterocyte of epithelium proper of ileum, foveolar cell of stomach, midzonal region hepatocyte, centrilobular region hepatocyte, periportal region hepatocyte, precursor cell, fallopian tube secretory epithelial cell, cerebral cortex GABAergic interneuron **Pathways and functions:** * The AADAC gene is involved in multiple metabolic pathways, including biological oxidations, catalytic activity, deacetylase activity, and xenobiotic metabolic processes. * It plays a role in the regulation of triglyceride catabolism by deacetylating a key enzyme involved in this process. * It is also involved in the regulation of the endoplasmic reticulum membrane, where it may participate in the formation or remodeling of lipid droplets. * Additionally, it is involved in the regulation of protein binding, serine hydrolase activity, and triglyceride lipase activity. **Clinical significance:** Mutations in the AADAC gene have been linked to several diseases, including colorectal cancer, non-alcoholic fatty liver disease, and obesity. These mutations can lead to the accumulation of arylamines and arylketoaldehydes, which can damage cells and tissues.

Genular Protein ID: 4181350417

Symbol: AAAD_HUMAN

Name: Arylacetamide deacetylase

UniProtKB Accession Codes:

P22760 A8K3L3 D3DNJ6 Q8N1A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8063807

Title: Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.

PubMed ID: 8063807

DOI: 10.1016/s0021-9258(17)31855-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2043131

Title: Purification and characterization of a human liver arylacetamide deacetylase.

PubMed ID: 2043131

DOI: 10.1016/0006-291x(91)92005-5

PubMed ID: 17936933

Title: Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.

PubMed ID: 17936933

DOI: 10.1002/jbt.20178

PubMed ID: 19339378

Title: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.

PubMed ID: 19339378

DOI: 10.1124/dmd.109.026567

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22207054

Title: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.

PubMed ID: 22207054

DOI: 10.1124/dmd.111.043067

PubMed ID: 22415931

Title: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.

PubMed ID: 22415931

DOI: 10.1124/dmd.112.044883

PubMed ID: 24125761

Title: N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.

PubMed ID: 24125761

DOI: 10.1016/j.bcp.2013.10.001

PubMed ID: 23542347

Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.

PubMed ID: 23542347

DOI: 10.1016/j.jhep.2013.03.022

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 399
  • Mass: 45734
  • Checksum: 34F9CB717DD7417A
  • Sequence:
    • MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD 
SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA 
ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP 
ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF 
LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP 
NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG 
VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.