Details for: AADAC

Gene ID: 13

Symbol: AADAC

Ensembl ID: ENSG00000114771

Description: arylacetamide deacetylase

Associated with

Other Information

Genular Protein ID: 4181350417

Symbol: AAAD_HUMAN

Name: Arylacetamide deacetylase

UniProtKB Accession Codes:

P22760 A8K3L3 D3DNJ6 Q8N1A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8063807

Title: Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.

PubMed ID: 8063807

DOI: 10.1016/s0021-9258(17)31855-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2043131

Title: Purification and characterization of a human liver arylacetamide deacetylase.

PubMed ID: 2043131

DOI: 10.1016/0006-291x(91)92005-5

PubMed ID: 17936933

Title: Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.

PubMed ID: 17936933

DOI: 10.1002/jbt.20178

PubMed ID: 19339378

Title: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.

PubMed ID: 19339378

DOI: 10.1124/dmd.109.026567

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22207054

Title: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.

PubMed ID: 22207054

DOI: 10.1124/dmd.111.043067

PubMed ID: 22415931

Title: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.

PubMed ID: 22415931

DOI: 10.1124/dmd.112.044883

PubMed ID: 24125761

Title: N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.

PubMed ID: 24125761

DOI: 10.1016/j.bcp.2013.10.001

PubMed ID: 23542347

Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.

PubMed ID: 23542347

DOI: 10.1016/j.jhep.2013.03.022

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 399
  • Mass: 45734
  • Checksum: 34F9CB717DD7417A
  • Sequence:
    • MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD 
SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA 
ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP 
ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF 
LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP 
NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG 
VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.