Details for: AADAC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: precursor cell (CL0011115)
Fold Change: 11.6998
Cell Significance Index: 88.7200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.2491
Cell Significance Index: -10.7400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.7518
Cell Significance Index: 170.0600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 3.2860
Cell Significance Index: 625.3400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.2670
Cell Significance Index: 94.1300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.1211
Cell Significance Index: 35.7300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.9750
Cell Significance Index: 52.9200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.7653
Cell Significance Index: 105.9800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.4091
Cell Significance Index: 1272.3100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3438
Cell Significance Index: 146.1600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.2687
Cell Significance Index: 27.0200 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.1464
Cell Significance Index: 7.6100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9310
Cell Significance Index: 151.4100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7985
Cell Significance Index: 17.3000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7937
Cell Significance Index: 54.8900 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.7577
Cell Significance Index: 4.9400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7114
Cell Significance Index: 70.3700 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.5851
Cell Significance Index: 5.4300 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.5803
Cell Significance Index: 9.7600 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.5444
Cell Significance Index: 3.1400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.5181
Cell Significance Index: 12.5500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.4763
Cell Significance Index: 7.0300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4362
Cell Significance Index: 10.9100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4259
Cell Significance Index: 84.5300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4036
Cell Significance Index: 68.9300 - Cell Name: colonocyte (CL1000347)
Fold Change: 0.3770
Cell Significance Index: 2.3300 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.2627
Cell Significance Index: 2.6500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2357
Cell Significance Index: 4.6000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1087
Cell Significance Index: 12.6700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0616
Cell Significance Index: 38.4800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0471
Cell Significance Index: 2.3800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0358
Cell Significance Index: 6.4600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0225
Cell Significance Index: 17.0000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0188
Cell Significance Index: 0.6600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0069
Cell Significance Index: -13.0800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0073
Cell Significance Index: -5.4400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0092
Cell Significance Index: -17.0200 - Cell Name: epidermal cell (CL0000362)
Fold Change: -0.0096
Cell Significance Index: -0.0200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0100
Cell Significance Index: -1.2300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0112
Cell Significance Index: -17.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0124
Cell Significance Index: -6.9700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0128
Cell Significance Index: -17.4200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0209
Cell Significance Index: -13.2500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0224
Cell Significance Index: -12.2200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0306
Cell Significance Index: -13.9000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0338
Cell Significance Index: -12.1400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0339
Cell Significance Index: -3.8700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0348
Cell Significance Index: -7.3200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0430
Cell Significance Index: -0.4500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0455
Cell Significance Index: -13.1000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0478
Cell Significance Index: -1.5300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0479
Cell Significance Index: -5.4900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0633
Cell Significance Index: -2.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0636
Cell Significance Index: -12.7500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0721
Cell Significance Index: -3.3600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0775
Cell Significance Index: -2.1600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0807
Cell Significance Index: -4.9500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0816
Cell Significance Index: -2.1000 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0858
Cell Significance Index: -0.9400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0905
Cell Significance Index: -13.1600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1015
Cell Significance Index: -13.9400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1062
Cell Significance Index: -13.7200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1209
Cell Significance Index: -1.8700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1306
Cell Significance Index: -13.6000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1338
Cell Significance Index: -13.6700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1619
Cell Significance Index: -7.6100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1636
Cell Significance Index: -4.6900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1826
Cell Significance Index: -13.6100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1890
Cell Significance Index: -12.7100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1915
Cell Significance Index: -9.9500 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.1991
Cell Significance Index: -0.7500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2035
Cell Significance Index: -10.6000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2070
Cell Significance Index: -3.1200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2074
Cell Significance Index: -3.2900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2155
Cell Significance Index: -4.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2217
Cell Significance Index: -17.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2244
Cell Significance Index: -13.7900 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2945
Cell Significance Index: -7.3600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3126
Cell Significance Index: -17.5400 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.3294
Cell Significance Index: -4.6800 - Cell Name: tendon cell (CL0000388)
Fold Change: -0.3375
Cell Significance Index: -4.5900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3533
Cell Significance Index: -12.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3562
Cell Significance Index: -9.5100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3701
Cell Significance Index: -4.2100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3839
Cell Significance Index: -16.9800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3874
Cell Significance Index: -13.5700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3881
Cell Significance Index: -8.0500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3919
Cell Significance Index: -13.6200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4059
Cell Significance Index: -13.2900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.4124
Cell Significance Index: -2.7900 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.4164
Cell Significance Index: -4.6000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4211
Cell Significance Index: -13.4100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4376
Cell Significance Index: -11.9100 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: -0.4397
Cell Significance Index: -1.1600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4460
Cell Significance Index: -16.8900 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.4481
Cell Significance Index: -2.7800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4482
Cell Significance Index: -12.7900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4597
Cell Significance Index: -13.5400 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.4752
Cell Significance Index: -6.5900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4902
Cell Significance Index: -12.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4181350417
Symbol: AAAD_HUMAN
Name: Arylacetamide deacetylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8063807
Title: Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.
PubMed ID: 8063807
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2043131
Title: Purification and characterization of a human liver arylacetamide deacetylase.
PubMed ID: 2043131
PubMed ID: 17936933
Title: Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.
PubMed ID: 17936933
DOI: 10.1002/jbt.20178
PubMed ID: 19339378
Title: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.
PubMed ID: 19339378
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 22207054
Title: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.
PubMed ID: 22207054
PubMed ID: 22415931
Title: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.
PubMed ID: 22415931
PubMed ID: 24125761
Title: N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.
PubMed ID: 24125761
PubMed ID: 23542347
Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.
PubMed ID: 23542347
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 12721789
Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.
PubMed ID: 12721789
Sequence Information:
- Length: 399
- Mass: 45734
- Checksum: 34F9CB717DD7417A
- Sequence:
MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.