Details for: ADH6

Gene ID: 130

Symbol: ADH6

Ensembl ID: ENSG00000172955

Description: alcohol dehydrogenase 6 (class V)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.73
    Marker Score: 8930
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.11
    Marker Score: 2128.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170088
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.32
    Marker Score: 8518
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.16
    Marker Score: 5015
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.14
    Marker Score: 6114
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 653
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.9
    Marker Score: 376
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.74
    Marker Score: 279
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1401
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3052
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.73
    Marker Score: 176
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 471
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.69
    Marker Score: 2444
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 464
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1159.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.53
    Marker Score: 2525
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.5
    Marker Score: 187
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.48
    Marker Score: 1663
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.48
    Marker Score: 462
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.47
    Marker Score: 432
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.46
    Marker Score: 489
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.45
    Marker Score: 3905
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 257
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.41
    Marker Score: 971
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.4
    Marker Score: 234
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.38
    Marker Score: 903
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5895
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.38
    Marker Score: 251
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.35
    Marker Score: 161
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.35
    Marker Score: 347
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.32
    Marker Score: 665
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 144
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3
    Marker Score: 111
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.29
    Marker Score: 452
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.29
    Marker Score: 72
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.29
    Marker Score: 151
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.28
    Marker Score: 531
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.25
    Marker Score: 255
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.25
    Marker Score: 76
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.25
    Marker Score: 137
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.24
    Marker Score: 124
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.23
    Marker Score: 161
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 359
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.22
    Marker Score: 922
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.21
    Marker Score: 80
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.21
    Marker Score: 204
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.19
    Marker Score: 91
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 82
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 186
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.18
    Marker Score: 242
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.17
    Marker Score: 535
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.17
    Marker Score: 108
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.17
    Marker Score: 705.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 145
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.17
    Marker Score: 175
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.16
    Marker Score: 194
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.15
    Marker Score: 346
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 793
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 101
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 20
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1
    Marker Score: 77
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 306
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.1
    Marker Score: 656

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Other Information

**Key characteristics:** * ADH6 is a protein of 153 amino acids. * It is encoded by the ADH6 gene. * It is expressed in a variety of cell types, including hepatocytes, endothelial cells, mural cells, and neurons. * It is a highly expressed protein in the liver, where it is responsible for the metabolism of ethanol. **Pathways and functions:** * ADH6 is involved in multiple metabolic pathways, including the metabolism of ethanol, the detoxification of reactive oxygen species, and the regulation of cell signaling. * It catalyzes the transfer of an hydrogen atom from ethanol to nicotinamide adenine dinucleotide (NAD+), resulting in the conversion of ADH6 to ADH5. * ADH6 is a key regulator of hepatic metabolism, and its activity is influenced by various factors, including blood alcohol concentration, nutrients, and hormones. **Clinical significance:** * Mutations in the ADH6 gene have been linked to several human diseases, including liver cirrhosis, liver failure, and brain tumors. * ADH6 inhibitors are being investigated as potential therapeutic agents for these diseases, as they could potentially protect liver cells from damage caused by ethanol and other toxins. **Additional information:** * The ADH6 gene is located on chromosome 15q21.1. * It is a single copy gene, with no known polymorphisms. * ADH6 is a highly conserved protein, with very similar sequences found in organisms from yeast to humans.

Genular Protein ID: 3674275514

Symbol: ADH6_HUMAN

Name: Alcohol dehydrogenase 6

UniProtKB Accession Codes:

P28332 A0A0A0MS56 B3KS45 Q58F53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 22 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1881901

Title: A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme.

PubMed ID: 1881901

DOI: 10.1073/pnas.88.17.7610

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 1755855

Title: Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene.

PubMed ID: 1755855

DOI: 10.1016/0006-291x(91)91253-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 368
  • Mass: 39073
  • Checksum: EC8E81E9571E6241
  • Sequence:
    • MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE MKVLGSKHLD 
LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG ECTSCLNSEG NFCIQFKQSK 
TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY TVIKEISVAK IDAVAPLEKV CLISCGFSTG 
FGAAINTAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE 
CLNPQDLKKP IQEVLFDMTD AGIDFCFEAI GNLDVLAAAL ASCNESYGVC VVVGVLPASV 
QLKISGQLFF SGRSLKGSVF GGWKSRQHIP KLVADYMAEK LNLDPLITHT LNLDKINEAV 
ELMKTGKW

Genular Protein ID: 2884221735

Symbol: Q8IUN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IUN7 E9PBI1

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 4 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 295
  • Mass: 31299
  • Checksum: DE4720D0B3B91962
  • Sequence:
    • MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE MKVLGSKHLD 
LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG ECTSCLNSEG NFCIQFKQSK 
TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY TVIKEISVAK IDAVAPLEKV CLISCGFSTG 
FGAAINTAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE 
CLNPQDLKKP IQEVLFDMTD AGIDFCFEAI GNLDVLAGRA DSTSLNWLLI IWQRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.