Details for: ADH6

Gene ID: 130

Symbol: ADH6

Ensembl ID: ENSG00000172955

Description: alcohol dehydrogenase 6 (class V)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 4.3505
    Cell Significance Index: 32.9900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 3.3252
    Cell Significance Index: 30.8600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.3541
    Cell Significance Index: 6.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1834
    Cell Significance Index: 433.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6075
    Cell Significance Index: 46.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4893
    Cell Significance Index: 89.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3120
    Cell Significance Index: 142.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0523
    Cell Significance Index: -2.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0446
    Cell Significance Index: 22.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9902
    Cell Significance Index: 161.0400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8188
    Cell Significance Index: 8.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8175
    Cell Significance Index: 17.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7407
    Cell Significance Index: 51.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7139
    Cell Significance Index: 5.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6865
    Cell Significance Index: 14.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5753
    Cell Significance Index: 8.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5293
    Cell Significance Index: 13.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4355
    Cell Significance Index: 4.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4123
    Cell Significance Index: 18.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3663
    Cell Significance Index: 6.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3313
    Cell Significance Index: 4.8900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.3136
    Cell Significance Index: 2.2800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2509
    Cell Significance Index: 0.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2397
    Cell Significance Index: 216.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2386
    Cell Significance Index: 23.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1964
    Cell Significance Index: 6.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1824
    Cell Significance Index: 34.7100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0790
    Cell Significance Index: 0.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0764
    Cell Significance Index: 3.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0572
    Cell Significance Index: 2.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0446
    Cell Significance Index: 2.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0394
    Cell Significance Index: 7.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0209
    Cell Significance Index: 1.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0181
    Cell Significance Index: 1.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0108
    Cell Significance Index: 16.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0099
    Cell Significance Index: 18.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 16.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0082
    Cell Significance Index: 0.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0048
    Cell Significance Index: 0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0044
    Cell Significance Index: 0.4500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0041
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0038
    Cell Significance Index: 5.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0010
    Cell Significance Index: -0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0022
    Cell Significance Index: -0.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0026
    Cell Significance Index: -0.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0030
    Cell Significance Index: -2.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0048
    Cell Significance Index: -2.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0078
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0080
    Cell Significance Index: -2.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0084
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0105
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0113
    Cell Significance Index: -1.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0129
    Cell Significance Index: -1.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0159
    Cell Significance Index: -1.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0167
    Cell Significance Index: -1.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0239
    Cell Significance Index: -0.6400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0272
    Cell Significance Index: -0.2200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0274
    Cell Significance Index: -0.1700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0290
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0301
    Cell Significance Index: -0.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0308
    Cell Significance Index: -1.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0321
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0324
    Cell Significance Index: -1.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0341
    Cell Significance Index: -0.8500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0341
    Cell Significance Index: -0.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0378
    Cell Significance Index: -2.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0401
    Cell Significance Index: -1.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0434
    Cell Significance Index: -2.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0442
    Cell Significance Index: -0.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0450
    Cell Significance Index: -0.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0514
    Cell Significance Index: -0.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0515
    Cell Significance Index: -1.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0519
    Cell Significance Index: -2.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0535
    Cell Significance Index: -0.9000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0548
    Cell Significance Index: -0.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0581
    Cell Significance Index: -2.5700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0582
    Cell Significance Index: -0.5000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0601
    Cell Significance Index: -0.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0625
    Cell Significance Index: -2.1900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0635
    Cell Significance Index: -0.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0641
    Cell Significance Index: -2.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0645
    Cell Significance Index: -2.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0661
    Cell Significance Index: -1.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0684
    Cell Significance Index: -1.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0702
    Cell Significance Index: -2.6600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0712
    Cell Significance Index: -0.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0717
    Cell Significance Index: -1.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0756
    Cell Significance Index: -1.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0760
    Cell Significance Index: -2.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0760
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme classification:** ADH6 belongs to the class V of alcohol dehydrogenases, which are enzymes that catalyze the oxidation of alcohols to aldehydes or ketones. 2. **Substrate specificity:** ADH6 exhibits a broad substrate specificity, including the oxidation of ethanol, retinol, and retinoic acid. 3. **Zinc-dependent activity:** ADH6 is a zinc-dependent enzyme, which is essential for its catalytic activity. 4. **Tissue distribution:** ADH6 is expressed in various tissues, including the liver, brain, and gastrointestinal tract. **Pathways and Functions:** 1. **Alcohol metabolism:** ADH6 plays a crucial role in the metabolism of ethanol, the primary psychoactive ingredient in alcoholic beverages. The enzyme catalyzes the oxidation of ethanol to acetaldehyde, which is then further metabolized to acetate. 2. **Retinoid metabolism:** ADH6 is involved in the metabolism of retinoids, including retinol and retinoic acid. The enzyme catalyzes the oxidation of these compounds, which is essential for their conversion to more active forms. 3. **Biosynthesis of retinoids:** ADH6 is also involved in the biosynthesis of retinoids, including the oxidation of vitamin A precursors to retinoic acid. 4. **Response to ethanol:** ADH6 is induced by ethanol exposure, which is essential for the liver's ability to metabolize ethanol. **Clinical Significance:** 1. **Alcohol dependence:** ADH6 has been implicated in the development of alcohol dependence, as it plays a crucial role in the metabolism of ethanol. 2. **Liver disease:** ADH6 has been linked to liver disease, including alcoholic liver disease, as it is involved in the metabolism of ethanol and the production of reactive oxygen species. 3. **Neurological disorders:** ADH6 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, as it is involved in the metabolism of ethanol and the regulation of oxidative stress. 4. **Cancer:** ADH6 has been linked to cancer, including colorectal cancer, as it is involved in the metabolism of ethanol and the regulation of oxidative stress. In conclusion, ADH6 is a multifunctional enzyme that plays a crucial role in various metabolic pathways, including the metabolism of ethanol and retinoids. Its dysregulation has been implicated in various diseases, including alcohol dependence, liver disease, neurological disorders, and cancer. Further research is necessary to fully elucidate the role of ADH6 in maintaining metabolic homeostasis and responding to ethanol exposure.

Genular Protein ID: 3674275514

Symbol: ADH6_HUMAN

Name: Alcohol dehydrogenase 6

UniProtKB Accession Codes:

P28332 A0A0A0MS56 B3KS45 Q58F53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 22 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1881901

Title: A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme.

PubMed ID: 1881901

DOI: 10.1073/pnas.88.17.7610

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 1755855

Title: Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene.

PubMed ID: 1755855

DOI: 10.1016/0006-291x(91)91253-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 368
  • Mass: 39073
  • Checksum: EC8E81E9571E6241
  • Sequence:
    • MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE MKVLGSKHLD 
LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG ECTSCLNSEG NFCIQFKQSK 
TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY TVIKEISVAK IDAVAPLEKV CLISCGFSTG 
FGAAINTAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE 
CLNPQDLKKP IQEVLFDMTD AGIDFCFEAI GNLDVLAAAL ASCNESYGVC VVVGVLPASV 
QLKISGQLFF SGRSLKGSVF GGWKSRQHIP KLVADYMAEK LNLDPLITHT LNLDKINEAV 
ELMKTGKW

Genular Protein ID: 2884221735

Symbol: Q8IUN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IUN7 E9PBI1

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 RuleBase 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 295
  • Mass: 31299
  • Checksum: DE4720D0B3B91962
  • Sequence:
    • MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE MKVLGSKHLD 
LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG ECTSCLNSEG NFCIQFKQSK 
TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY TVIKEISVAK IDAVAPLEKV CLISCGFSTG 
FGAAINTAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE 
CLNPQDLKKP IQEVLFDMTD AGIDFCFEAI GNLDVLAGRA DSTSLNWLLI IWQRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.