Details for: COL10A1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.9214
Cell Significance Index: 13.6000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5409
Cell Significance Index: 107.3500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5338
Cell Significance Index: 107.0700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4395
Cell Significance Index: 33.7300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3728
Cell Significance Index: 10.7400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.2985
Cell Significance Index: 18.3000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2786
Cell Significance Index: 5.9600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2772
Cell Significance Index: 12.2600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2699
Cell Significance Index: 10.2200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1144
Cell Significance Index: 79.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0706
Cell Significance Index: 63.7300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0582
Cell Significance Index: 107.3400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0529
Cell Significance Index: 15.2400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0510
Cell Significance Index: 7.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0501
Cell Significance Index: 77.1700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0344
Cell Significance Index: 64.7600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0334
Cell Significance Index: 6.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0179
Cell Significance Index: 0.4800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0074
Cell Significance Index: 10.0700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0067
Cell Significance Index: 0.3100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0060
Cell Significance Index: 0.3000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0058
Cell Significance Index: 0.5800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0013
Cell Significance Index: 0.0200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0008
Cell Significance Index: 0.3000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0035
Cell Significance Index: -2.2100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0096
Cell Significance Index: -4.3400 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0187
Cell Significance Index: -0.2400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0197
Cell Significance Index: -14.5700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0253
Cell Significance Index: -13.7900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0273
Cell Significance Index: -1.5300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0274
Cell Significance Index: -15.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0280
Cell Significance Index: -17.4900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0351
Cell Significance Index: -5.7100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0373
Cell Significance Index: -4.7800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0412
Cell Significance Index: -1.0600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0455
Cell Significance Index: -8.6500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0612
Cell Significance Index: -7.5300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0782
Cell Significance Index: -16.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0963
Cell Significance Index: -16.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0985
Cell Significance Index: -13.5300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1072
Cell Significance Index: -11.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1124
Cell Significance Index: -3.9500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1152
Cell Significance Index: -3.2200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1250
Cell Significance Index: -5.8300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1257
Cell Significance Index: -16.2400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1481
Cell Significance Index: -16.9700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1586
Cell Significance Index: -16.2100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1673
Cell Significance Index: -2.4700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1833
Cell Significance Index: -6.0000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1918
Cell Significance Index: -6.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1926
Cell Significance Index: -12.9500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2012
Cell Significance Index: -8.7500 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2085
Cell Significance Index: -2.6000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2088
Cell Significance Index: -4.3700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2148
Cell Significance Index: -13.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2178
Cell Significance Index: -16.2300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2198
Cell Significance Index: -7.7000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2313
Cell Significance Index: -4.9100 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.2350
Cell Significance Index: -2.2500 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2364
Cell Significance Index: -3.7500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2454
Cell Significance Index: -12.7500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2585
Cell Significance Index: -13.5700 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.2616
Cell Significance Index: -3.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2743
Cell Significance Index: -12.8900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.2765
Cell Significance Index: -3.4900 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.3065
Cell Significance Index: -4.3600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3128
Cell Significance Index: -6.2800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3231
Cell Significance Index: -10.2200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3477
Cell Significance Index: -14.2500 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -0.3629
Cell Significance Index: -3.8300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3760
Cell Significance Index: -9.3800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3820
Cell Significance Index: -5.4700 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.3870
Cell Significance Index: -5.0000 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.3896
Cell Significance Index: -4.0300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3900
Cell Significance Index: -4.2400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3966
Cell Significance Index: -7.7400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4018
Cell Significance Index: -10.0200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4119
Cell Significance Index: -15.1200 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4168
Cell Significance Index: -8.7000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.4205
Cell Significance Index: -7.2700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4208
Cell Significance Index: -11.2400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4243
Cell Significance Index: -8.3900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4258
Cell Significance Index: -9.2000 - Cell Name: neuron (CL0000540)
Fold Change: -0.4294
Cell Significance Index: -4.0700 - Cell Name: myoblast (CL0000056)
Fold Change: -0.4346
Cell Significance Index: -4.2700 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.4394
Cell Significance Index: -8.9400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4537
Cell Significance Index: -6.1900 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4571
Cell Significance Index: -5.9200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4586
Cell Significance Index: -5.2100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4627
Cell Significance Index: -7.9300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4632
Cell Significance Index: -11.2200 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4657
Cell Significance Index: -6.6300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4830
Cell Significance Index: -11.7900 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.4876
Cell Significance Index: -6.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4929
Cell Significance Index: -14.0700 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.4931
Cell Significance Index: -5.8100 - Cell Name: group 3 innate lymphoid cell, human (CL0001078)
Fold Change: -0.4974
Cell Significance Index: -4.6600 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.4992
Cell Significance Index: -3.9200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5133
Cell Significance Index: -12.8300 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.5147
Cell Significance Index: -10.1300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 403753198
Symbol: COAA1_HUMAN
Name: Collagen alpha-1(X) chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1764025
Title: The human collagen X gene. Complete primary translated sequence and chromosomal localization.
PubMed ID: 1764025
DOI: 10.1042/bj2800617
PubMed ID: 1397333
Title: Genomic organization and full-length cDNA sequence of human collagen X.
PubMed ID: 1397333
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1587271
Title: Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10.
PubMed ID: 1587271
PubMed ID: 2037056
Title: Cloning of human alpha 1(X) collagen DNA and localization of the COL10A1 gene to the q21-q22 region of human chromosome 6.
PubMed ID: 2037056
PubMed ID: 1743401
Title: In situ hybridization studies on the expression of type X collagen in fetal human cartilage.
PubMed ID: 1743401
PubMed ID: 11839302
Title: Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer.
PubMed ID: 11839302
PubMed ID: 9101290
Title: Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels.
PubMed ID: 9101290
DOI: 10.1002/(sici)1098-1004(1997)9:4<300::aid-humu2>3.0.co;2-9
PubMed ID: 8304336
Title: Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid.
PubMed ID: 8304336
PubMed ID: 8004099
Title: Additional mutations of type X collagen confirm COL10A1 as the Schmid metaphyseal chondrodysplasia locus.
PubMed ID: 8004099
DOI: 10.1093/hmg/3.2.303
PubMed ID: 7876225
Title: Type X collagen multimer assembly in vitro is prevented by a Gly618 to Val mutation in the alpha 1(X) NC1 domain resulting in Schmid metaphyseal chondrodysplasia.
PubMed ID: 7876225
PubMed ID: 7607655
Title: Mutations in three subdomains of the carboxy-terminal region of collagen type X account for most of the Schmid metaphyseal dysplasias.
PubMed ID: 7607655
DOI: 10.1007/bf00214187
PubMed ID: 8782043
Title: Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia.
PubMed ID: 8782043
DOI: 10.1136/jmg.33.6.450
PubMed ID: 9067753
Title: Mutations in the N-terminal globular domain of the type X collagen gene (COL10A1) in patients with schmid metaphyseal chondrodysplasia.
PubMed ID: 9067753
DOI: 10.1002/(sici)1098-1004(1997)9:2<131::aid-humu5>3.0.co;2-c
PubMed ID: 9837818
Title: Mutation of the type X collagen gene 'COL10A1' causes spondylometaphyseal dysplasia.
PubMed ID: 9837818
DOI: 10.1086/302158
PubMed ID: 9852679
Title: Novel missense mutation resulting in the substitution of tyrosine by cysteine at codon 597 of the type X collagen gene associated with Schmid metaphyseal chondrodysplasia.
PubMed ID: 9852679
PubMed ID: 15880705
Title: Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia.
PubMed ID: 15880705
DOI: 10.1002/humu.20183
Sequence Information:
- Length: 680
- Mass: 66158
- Checksum: E2F98E53E7882459
- Sequence:
MLPQIPFLLL VSLNLVHGVF YAERYQMPTG IKGPLPNTKT QFFIPYTIKS KGIAVRGEQG TPGPPGPAGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP GPSAVGKPGV PGLPGKPGER GPYGPKGDVG PAGLPGPRGP PGPPGIPGPA GISVPGKPGQ QGPTGAPGPR GFPGEKGAPG VPGMNGQKGE MGYGAPGRPG ERGLPGPQGP TGPSGPPGVG KRGENGVPGQ PGIKGDRGFP GEMGPIGPPG PQGPPGERGP EGIGKPGAAG APGQPGIPGT KGLPGAPGIA GPPGPPGFGK PGLPGLKGER GPAGLPGGPG AKGEQGPAGL PGKPGLTGPP GNMGPQGPKG IPGSHGLPGP KGETGPAGPA GYPGAKGERG SPGSDGKPGY PGKPGLDGPK GNPGLPGPKG DPGVGGPPGL PGPVGPAGAK GMPGHNGEAG PRGAPGIPGT RGPIGPPGIP GFPGSKGDPG SPGPPGPAGI ATKGLNGPTG PPGPPGPRGH SGEPGLPGPP GPPGPPGQAV MPEGFIKAGQ RPSLSGTPLV SANQGVTGMP VSAFTVILSK AYPAIGTPIP FDKILYNRQQ HYDPRTGIFT CQIPGIYYFS YHVHVKGTHV WVGLYKNGTP VMYTYDEYTK GYLDQASGSA IIDLTENDQV WLQLPNAESN GLYSSEYVHS SFSGFLVAPM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.