Genular: Defining Cellular Identity and Function

Details for: Smc3

Gene ID: 13006

Symbol: Smc3

Ensembl ID: ENSMUSG00000024974

Description: structural maintenance of chromosomes 3

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Cohesin loading onto chromatin
(R-MMU-2470946)
Establishment of sister chromatid cohesion
(R-MMU-2468052)
Metabolism of proteins
(R-MMU-392499)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic telophase/cytokinesis
(R-MMU-68884)
M phase
(R-MMU-68886)
Post-translational protein modification
(R-MMU-597592)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Separation of sister chromatids
(R-MMU-2467813)
S phase
(R-MMU-69242)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basement membrane
(GO:0005604)
Beta-tubulin binding
(GO:0048487)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome organization
(GO:0051276)
Cohesin complex
(GO:0008278)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Double-stranded dna binding
(GO:0003690)
Dynein complex binding
(GO:0070840)
Lateral element
(GO:0000800)
Mediator complex binding
(GO:0036033)
Meiotic cell cycle
(GO:0051321)
Meiotic cohesin complex
(GO:0030893)
Mitotic cohesin complex
(GO:0030892)
Mitotic sister chromatid cohesion
(GO:0007064)
Mitotic spindle assembly
(GO:0090307)
Mitotic spindle pole
(GO:0097431)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dna replication
(GO:0006275)
Sister chromatid cohesion
(GO:0007062)
Stem cell population maintenance
(GO:0019827)
Synaptonemal complex
(GO:0000795)

Other Information

Proteins

Structural maintenance of chromosomes protein 3
Q3TMK9_MOUSE

Genular Protein ID: 2949820958

Symbol: SMC3_MOUSE

Name: Structural maintenance of chromosomes protein 3

UniProtKB Accession Codes:

Q9CW03 O35667 Q9QUS3

Database IDs:

Citations:

PubMed ID: 10358101

Title: Complete cDNA cloning, genomic organization, chromosomal assignment, functional characterization of the promoter, and expression of the murine Bamacan gene.

PubMed ID: 10358101

DOI: 10.1074/jbc.274.24.17384

PubMed ID: 10375619

Title: Characterization of the components of the putative mammalian sister chromatid cohesion complex.

PubMed ID: 10375619

DOI: 10.1016/s0378-1119(99)00160-2

PubMed ID: 9528857

Title: Mmip1: a novel leucine zipper protein that reverses the suppressive effects of mad family members on C-myc.

PubMed ID: 9528857

DOI: 10.1038/sj.onc.1201634

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11483963

Title: Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I.

PubMed ID: 11483963

DOI: 10.1038/35087082

PubMed ID: 11564881

Title: Novel meiosis-specific isoform of mammalian SMC1.

PubMed ID: 11564881

DOI: 10.1128/mcb.21.20.6984-6998.2001

PubMed ID: 15378723

Title: Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry.

PubMed ID: 15378723

DOI: 10.1002/rcm.1604

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22346761

Title: Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.

PubMed ID: 22346761

DOI: 10.1371/journal.pgen.1002485

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24287868

Title: Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.

PubMed ID: 24287868

DOI: 10.1007/s00412-013-0444-7

Sequence Information:

Length: 1217
Mass: 141556
Checksum: 11FF55165BE6A88E
Sequence:

MYIKQVIIQG FRSYRDQTIV DPFSSKHNVI VGRNGSGKSN FFYAIQFVLS DEFSHLRPEQ 
RLALLHEGTG PRVISAFVEI IFDNSDNRLP IDKEEVSLRR VIGAKKDQYF LDKKMVTKND 
VMNLLESAGF SRSNPYYIVK QGKINQMATA PDSQRLKLLR EVAGTRVYDE RKEESISLMK 
ETEGKREKIN ELLKYIEERL HTLEEEKEEL AQYQKWDKMR RALEYTIYNQ ELNETRAKLD 
ELSAKRETSG EKSRQLRDAQ QDARDKMEDI ERQVRELKTK ISAMKEEKEQ LSAERQEQIK 
QRTKLELKAK DLQDELAGNS EQRKRLLKER QKLLEKIEEK QKELAETEPK FNSVKEKEER 
GIARLAQATQ ERTDLYAKQG RGSQFTSKEE RDKWIKKELK SLDQAINDKK RQIAAIHKDL 
EDTEANKEKN LEQYNKLDQD LNEVKARVEE LDRKYYEVKN KKDELQSERN YLWREENAEQ 
QALAAKREDL EKKQQLLRAA TGKAILNGID SINKVLEHFR RKGINQHVQN GYHGIVMNNF 
ECEPAFYTCV EVTAGNRLFY HIVDSDEVST KILMEFNKMN LPGEVTFLPL NKLDVRDTAY 
PETNDAIPMI SKLRYNPRFD KAFKHVFGKT LICRSMEVST QLARAFTMDC ITLEGDQVSH 
RGALTGGYYD TRKSRLELQK DVRKAEEELG ELEAKLNENL RRNIERINNE IDQLMNQMQQ 
IETQQRKFKA SRDSILSEMK MLKEKRQQSE KTFMPKQRSL QSLEASLHAM ESTRESLKAE 
LGTDLLSQLS LEDQKRVDAL NDEIRQLQQE NRQLLNERIK LEGIITRVET YLNENLRKRL 
DQVEQELNEL RETEGGTVLT ATTSELEAIN KRVKDTMARS EDLDNSIDKT EAGIKELQKS 
MERWKNMEKE HMDAINHDTK ELEKMTNRQG MLLKKKEECM KKIRELGSLP QEAFEKYQTL 
SLKQLFRKLE QCNTELKKYS HVNKKALDQF VNFSEQKEKL IKRQEELDRG YKSIMELMNV 
LELRKYEAIQ LTFKQVSKNF SEVFQKLVPG GKATLVMKKG DVEGSQSQDE GEGSGESERG 
SGSQSSVPSV DQFTGVGIRV SFTGKQGEMR EMQQLSGGQK SLVALALIFA IQKCDPAPFY 
LFDEIDQALD AQHRKAVSDM IMELAVHAQF ITTTFRPELL ESADKFYGVK FRNKVSHIDV 
ITAEMAKDFV EDDTTHG

Genular Protein ID: 1802649001

Symbol: Q3TMK9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TMK9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 171
Mass: 19678
Checksum: 58EF3F6C861743FE
Sequence:

MYIKQVIIQG FRSYRDQTIV DPFSSKHNVI VGRNGSGKSN FFYAIQFVLS DEFSHLRPEQ 
RLALLHEGTG PRVISAFVEI IFDNSDNRLP IDKEEVSLRR VIGAKKDQYF LDKKMVTKND 
VMNLLESAGF SRSNPYYIVK QGKINQMATA PDSQRLKLLR EVAGTRVYDE R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smc3

Associated with

Other Information

Complete cDNA cloning, genomic organization, chromosomal assignment, functional characterization of the promoter, and expression of the murine Bamacan gene. PubMed ID: 10358101

Characterization of the components of the putative mammalian sister chromatid cohesion complex. PubMed ID: 10375619

Mmip1: a novel leucine zipper protein that reverses the suppressive effects of mad family members on C-myc. PubMed ID: 9528857

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I. PubMed ID: 11483963

Novel meiosis-specific isoform of mammalian SMC1. PubMed ID: 11564881

Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. PubMed ID: 15378723

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PubMed ID: 22346761

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I. PubMed ID: 24287868

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073