Genular: Defining Cellular Identity and Function

Details for: Ctcf

Gene ID: 13018

Symbol: Ctcf

Ensembl ID: ENSMUSG00000005698

Description: CCCTC-binding factor

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii transcription
(R-MMU-73857)
Chromatin binding
(GO:0003682)
Chromatin insulator sequence binding
(GO:0043035)
Chromatin looping
(GO:0140588)
Chromatin organization
(GO:0006325)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome segregation
(GO:0007059)
Condensed chromosome
(GO:0000793)
Dense fibrillar component
(GO:0001651)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna methylation
(GO:0006306)
Epigenetic regulation of gene expression
(GO:0040029)
Genomic imprinting
(GO:0071514)
Granular component
(GO:0001652)
Male germ cell nucleus
(GO:0001673)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of gene expression via cpg island methylation
(GO:0044027)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to chromosome, centromeric region
(GO:0071459)
Random inactivation of x chromosome
(GO:0060816)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)

Other Information

Proteins

Transcriptional repressor CTCF

Genular Protein ID: 1872333703

Symbol: CTCF_MOUSE

Name: Transcriptional repressor CTCF

UniProtKB Accession Codes:

Q61164

Database IDs:

Citations:

PubMed ID: 8649389

Title: An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.

PubMed ID: 8649389

DOI: 10.1128/mcb.16.6.2802

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11743158

Title: CTCF, a candidate trans-acting factor for X-inactivation choice.

PubMed ID: 11743158

DOI: 10.1126/science.1065982

PubMed ID: 15669143

Title: Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.

PubMed ID: 15669143

DOI: 10.1016/j.devcel.2004.10.018

PubMed ID: 16951251

Title: CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus.

PubMed ID: 16951251

DOI: 10.1101/gad.399506

PubMed ID: 16949368

Title: CTCF-dependent chromatin insulator is linked to epigenetic remodeling.

PubMed ID: 16949368

DOI: 10.1016/j.molcel.2006.08.008

PubMed ID: 16614224

Title: CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1.

PubMed ID: 16614224

DOI: 10.1126/science.1123191

PubMed ID: 17329968

Title: CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain.

PubMed ID: 17329968

DOI: 10.4161/cc.6.4.3854

PubMed ID: 17952071

Title: Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein.

PubMed ID: 17952071

DOI: 10.1038/ng.2007.5

PubMed ID: 18614575

Title: Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development.

PubMed ID: 18614575

DOI: 10.1242/dev.024539

PubMed ID: 19029252

Title: The CTCF insulator protein is posttranslationally modified by SUMO.

PubMed ID: 19029252

DOI: 10.1128/mcb.00825-08

PubMed ID: 26961175

Title: A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.

PubMed ID: 26961175

DOI: 10.1038/srep22892

Sequence Information:

Length: 736
Mass: 83745
Checksum: 7C49D4A7BDCFEFA1
Sequence:

MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV VQDVNSSVQM 
VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV VNMEEQPINI GELQLVQVPV 
PVTVPVATTS VEELQGAYEN EVSKEGLAES EPMICHTLPL PEGFQVVKVG ANGEVETLEQ 
GELPPQEDSS WQKDPDYQPP AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV 
NAEKVVGNMK PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG 
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP FKCSMCDYAS 
VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT HSGEKPYECY ICHARFTQSG 
TMKMHILQKH TENVAKFHCP HCDTVIARKS DLGVHLRKQH SYIEQGKKCR YCDAVFHERY 
ALIQHQKSHK NEKRFKCDQC DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM 
HFKRYHDPNF VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR 
KMRSKKEDSS DSEENAEPDL DDNEEEEEPA VEIEPEPEPQ PQPPPPPQPV APAPPPAKKR 
RGRPPGRTNQ PKQNQPTAII QVEDQNTGAI ENIIVEVKKE PDAEPAEGEE EEAQAATTDA 
PNGDLTPEMI LSMMDR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ctcf

Associated with

Other Information

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. PubMed ID: 8649389

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

CTCF, a candidate trans-acting factor for X-inactivation choice. PubMed ID: 11743158

Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. PubMed ID: 15669143

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. PubMed ID: 16951251

CTCF-dependent chromatin insulator is linked to epigenetic remodeling. PubMed ID: 16949368

CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. PubMed ID: 16614224

CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain. PubMed ID: 17329968

Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. PubMed ID: 17952071

Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. PubMed ID: 18614575

The CTCF insulator protein is posttranslationally modified by SUMO. PubMed ID: 19029252

A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. PubMed ID: 26961175