Details for: COL12A1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 52.1475
Cell Significance Index: -24.6200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 50.2391
Cell Significance Index: -20.4100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.3880
Cell Significance Index: -20.4200 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 7.5729
Cell Significance Index: 51.3100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.8119
Cell Significance Index: -26.8800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 4.5104
Cell Significance Index: 88.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.1837
Cell Significance Index: 66.6400 - Cell Name: chondroblast (CL0000058)
Fold Change: 2.5792
Cell Significance Index: 15.1400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.3232
Cell Significance Index: 66.6000 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.8017
Cell Significance Index: 11.3300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.0327
Cell Significance Index: 52.1900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9558
Cell Significance Index: 20.4300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7896
Cell Significance Index: 283.2300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7026
Cell Significance Index: 96.4800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.7012
Cell Significance Index: 8.8300 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.6826
Cell Significance Index: 6.2000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.6762
Cell Significance Index: 9.7100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6266
Cell Significance Index: 125.6900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5638
Cell Significance Index: 29.3700 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.5437
Cell Significance Index: 4.3900 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.3878
Cell Significance Index: 5.9000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2862
Cell Significance Index: 20.2400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2570
Cell Significance Index: 113.6300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2088
Cell Significance Index: 144.4200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1867
Cell Significance Index: 2.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1142
Cell Significance Index: 13.3100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0999
Cell Significance Index: 18.0000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0988
Cell Significance Index: 53.9300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0407
Cell Significance Index: 0.6300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0395
Cell Significance Index: 24.6600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0002
Cell Significance Index: -0.4100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0008
Cell Significance Index: -1.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0101
Cell Significance Index: -7.4500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0165
Cell Significance Index: -9.3200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0176
Cell Significance Index: -32.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0214
Cell Significance Index: -32.9000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0319
Cell Significance Index: -24.1700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0331
Cell Significance Index: -24.2900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0341
Cell Significance Index: -21.6600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0356
Cell Significance Index: -7.4900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0370
Cell Significance Index: -0.6200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0373
Cell Significance Index: -0.6200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0480
Cell Significance Index: -21.7800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0617
Cell Significance Index: -7.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0685
Cell Significance Index: -11.7000 - Cell Name: theca cell (CL0000503)
Fold Change: -0.0698
Cell Significance Index: -0.4100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0706
Cell Significance Index: -20.3300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0733
Cell Significance Index: -8.3700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0961
Cell Significance Index: -2.0400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1062
Cell Significance Index: -21.0700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1084
Cell Significance Index: -13.9000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1594
Cell Significance Index: -23.1700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1773
Cell Significance Index: -13.6100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1824
Cell Significance Index: -23.5700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1964
Cell Significance Index: -4.9000 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.2106
Cell Significance Index: -2.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2272
Cell Significance Index: -26.0400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2401
Cell Significance Index: -4.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2407
Cell Significance Index: -24.5900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2452
Cell Significance Index: -7.8100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2539
Cell Significance Index: -11.9400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2549
Cell Significance Index: -15.6700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2581
Cell Significance Index: -8.4500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2583
Cell Significance Index: -26.9000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2605
Cell Significance Index: -3.7300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2606
Cell Significance Index: -19.4200 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.2712
Cell Significance Index: -5.6600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2780
Cell Significance Index: -7.7700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.2864
Cell Significance Index: -4.6000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3095
Cell Significance Index: -24.5100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3236
Cell Significance Index: -7.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3589
Cell Significance Index: -24.1300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3599
Cell Significance Index: -5.7100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3949
Cell Significance Index: -17.1700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4011
Cell Significance Index: -24.5900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4253
Cell Significance Index: -14.9000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4317
Cell Significance Index: -20.1300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4632
Cell Significance Index: -25.9900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4680
Cell Significance Index: -12.0300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4999
Cell Significance Index: -22.1100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5017
Cell Significance Index: -5.7000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5273
Cell Significance Index: -27.3900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5341
Cell Significance Index: -28.0400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5458
Cell Significance Index: -6.9900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5470
Cell Significance Index: -15.6100 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.5703
Cell Significance Index: -3.5700 - Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.5763
Cell Significance Index: -3.5300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5841
Cell Significance Index: -22.1200 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.5990
Cell Significance Index: -11.7900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.6155
Cell Significance Index: -14.9100 - Cell Name: fibroblast of the aortic adventitia (CL0002547)
Fold Change: -0.6897
Cell Significance Index: -6.9600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6918
Cell Significance Index: -24.0400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7245
Cell Significance Index: -21.3400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7478
Cell Significance Index: -27.4500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.7667
Cell Significance Index: -24.2500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.7898
Cell Significance Index: -21.0900 - Cell Name: Langerhans cell (CL0000453)
Fold Change: -0.8192
Cell Significance Index: -7.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8397
Cell Significance Index: -22.5000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8589
Cell Significance Index: -30.1800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.8600
Cell Significance Index: -19.8700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 594818025
Symbol: COCA1_HUMAN
Name: Collagen alpha-1(XII) chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9143499
Title: Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13.
PubMed ID: 9143499
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 9826181
Title: The chick and human collagen alpha1(XII) gene promoter -- activity of highly conserved regions around the first exon and in the first intron.
PubMed ID: 9826181
PubMed ID: 9344363
Title: Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices.
PubMed ID: 9344363
PubMed ID: 1427837
Title: The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6.
PubMed ID: 1427837
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24334604
Title: Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in humans and mice.
PubMed ID: 24334604
DOI: 10.1093/hmg/ddt627
PubMed ID: 24334769
Title: Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy.
PubMed ID: 24334769
DOI: 10.1093/hmg/ddt637
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 32337544
Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.
PubMed ID: 32337544
Sequence Information:
- Length: 3063
- Mass: 333147
- Checksum: EA38CAFECE8393D2
- Sequence:
MRSRLPPALA ALGAALLLSS IEAEVDPPSD LNFKIIDENT VHMSWAKPVD PIVGYRITVD PTTDGPTKEF TLSASTTETL LSELVPETEY VVTITSYDEV EESVPVIGQL TIQTGSSTKP VEKKPGKTEI QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIAALVSAF DIGEEKTRVG VVQYSSDTRT EFNLNQYYQR DELLAAIKKI PYKGGNTMTG DAIDYLVKNT FTESAGARVG FPKVAIIITD GKSQDEVEIP ARELRNVGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVVEPPSNL IAMEVSSKYV KLNWNPSPSP VTGYKVILTP MTAGSRQHAL SVGPQTTTLS VRDLSADTEY QISVSAMKGM TSSEPISIME KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLVKSF EISPNRVQIS LVQYSRDPHT EFTLKKFTKV EDIIEAINTF PYRGGSTNTG KAMTYVREKI FVPSKGSRSN VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLSF SEVTSYGFKT NWSPAGENVF SYHITYKEAA GDDEVTVVEP ASSTSVVLSS LKPETLYLVN VTAEYEDGFS IPLAGEETTE EVKGAPRNLK VTDETTDSFK ITWTQAPGRV LRYRIIYRPV AGGESREVTT PPNQRRRTLE NLIPDTKYEV SVIPEYFSGP GTPLTGNAAT EEVRGNPRDL RVSDPTTSTM KLSWSGAPGK VKQYLVTYTP VAGGETQEVT VRGDTTNTVL QGLKEGTQYA LSVTALYASG AGDALFGEGT TLEERGSPQD LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDVDTGE KNLPEDAIHT MIENLQPETK YRISVFATYS SGEGEPLTGD ATTELSQDSK TLKVDEETEN TMRVTWKPAP GKVVNYRVVY RPHGRGKQMV AKVPPTVTST VLKRLQPQTT YDITVLPIYK MGEGKLRQGS GTTASRFKSP RNLKTSDPTM SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVVGPYDN TVVLEELRAG TTYKVNVFGM FDGGESSPLV GQEMTTLSDT TVMPILSSGM ECLTRAEADI VLLVDGSWSI GRANFRTVRS FISRIVEVFD IGPKRVQIAL AQYSGDPRTE WQLNAHRDKK SLLQAVANLP YKGGNTLTGM ALNFIRQQNF RTQAGMRPRA RKIGVLITDG KSQDDVEAPS KKLKDEGVEL FAIGIKNADE VELKMIATDP DDTHAYNVAD FESLSRIVDD LTINLCNSVK GPGDLEAPSN LVISERTHRS FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRMETSTV LKDLKPETEY VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA TGYILSYKPV KDTEPTRPKE VRLGPTVNDM QLTDLVPNTE YAVTVQAVLH DLTSEPVTVR EVTLPLPRPQ DLKLRDVTHS TMNVFWEPVP GKVRKYIVRY KTPEEDVKEV EVDRSETSTS LKDLFSQTLY TVSVSAVHDE GESPPVTAQE TTRPVPAPTN LKITEVTSEG FRGTWDHGAS DVSLYRITWA PFGSSDKMET ILNGDENTLV FENLNPNTIY EVSITAIYPD ESESDDLIGS ERTLPILTTQ APKSGPRNLQ VYNATSNSLT VKWDPASGRV QKYRITYQPS TGEGNEQTTT IGGRQNSVVL QKLKPDTPYT ITVSSLYPDG EGGRMTGRGK TKPLNTVRNL RVYDPSTSTL NVRWDHAEGN PRQYKLFYAP AAGGPEELVP IPGNTNYAIL RNLQPDTSYT VTVVPVYTEG DGGRTSDTGR TLMRGLARNV QVYNPTPNSL DVRWDPAPGP VLQYRVVYSP VDGTRPSESI VVPGNTRMVH LERLIPDTLY SVNLVALYSD GEGNPSPAQG RTLPRSGPRN LRVFGETTNS LSVAWDHADG PVQQYRIIYS PTVGDPIDEY TTVPGRRNNV ILQPLQPDTP YKITVIAVYE DGDGGHLTGN GRTVGLLPPQ NIHISDEWYT RFRVSWDPSP SPVLGYKIVY KPVGSNEPME AFVGEMTSYT LHNLNPSTTY DVNVYAQYDS GLSVPLTDQG TTLYLNVTDL KTYQIGWDTF CVKWSPHRAA TSYRLKLSPA DGTRGQEITV RGSETSHCFT GLSPDTDYGV TVFVQTPNLE GPGVSVKEHT TVKPTEAPTE PPTPPPPPTI PPARDVCKGA KADIVFLTDA SWSIGDDNFN KVVKFIFNTV GGFDEISPAG IQVSFVQYSD EVKSEFKLNT YNDKALALGA LQNIRYRGGN TRTGKALTFI KEKVLTWESG MRKNVPKVLV VVTDGRSQDE VKKAALVIQQ SGFSVFVVGV ADVDYNELAN IASKPSERHV FIVDDFESFE KIEDNLITFV CETATSSCPL IYLDGYTSPG FKMLEAYNLT EKNFASVQGV SLESGSFPSY SAYRIQKNAF VNQPTADLHP NGLPPSYTII LLFRLLPETP SDPFAIWQIT DRDYKPQVGV IADPSSKTLS FFNKDTRGEV QTVTFDTEEV KTLFYGSFHK VHIVVTSKSV KIYIDCYEII EKDIKEAGNI TTDGYEILGK LLKGERKSAA FQIQSFDIVC SPVWTSRDRC CDIPSRRDEG KCPAFPNSCT CTQDSVGPPG PPGPAGGPGA KGPRGERGIS GAIGPPGPRG DIGPPGPQGP PGPQGPNGLS IPGEQGRQGM KGDAGEPGLP GRTGTPGLPG PPGPMGPPGD RGFTGKDGAM GPRGPPGPPG SPGSPGVTGP SGKPGKPGDH GRPGPSGLKG EKGDRGDIAS QNMMRAVARQ VCEQLISGQM NRFNQMLNQI PNDYQSSRNQ PGPPGPPGPP GSAGARGEPG PGGRPGFPGT PGMQGPPGER GLPGEKGERG TGSSGPRGLP GPPGPQGESR TGPPGSTGSR GPPGPPGRPG NSGIRGPPGP PGYCDSSQCA SIPYNGQGYP GSG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.