Genular: Defining Cellular Identity and Function

Details for: Ctsd

Gene ID: 13033

Symbol: Ctsd

Ensembl ID: ENSMUSG00000007891

Description: cathepsin D

Associated with

Adaptive immune system
(R-MMU-1280218)
Collagen degradation
(R-MMU-1442490)
Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of angiotensinogen to angiotensins
(R-MMU-2022377)
Metabolism of proteins
(R-MMU-392499)
Mhc class ii antigen presentation
(R-MMU-2132295)
Neutrophil degranulation
(R-MMU-6798695)
Peptide hormone metabolism
(R-MMU-2980736)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Aspartic-type endopeptidase activity
(GO:0004190)
Aspartic-type peptidase activity
(GO:0070001)
Autophagosome assembly
(GO:0000045)
Collagen-containing extracellular matrix
(GO:0062023)
Endopeptidase activity
(GO:0004175)
Endosome lumen
(GO:0031904)
Endosome membrane
(GO:0010008)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gaba-ergic synapse
(GO:0098982)
Hydrolase activity
(GO:0016787)
Insulin catabolic process
(GO:1901143)
Insulin receptor recycling
(GO:0038020)
Lipoprotein catabolic process
(GO:0042159)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Membrane raft
(GO:0045121)
Mitochondrion
(GO:0005739)
Peptidase activity
(GO:0008233)
Peptide binding
(GO:0042277)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Presynaptic endosome
(GO:0098830)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Proteolysis
(GO:0006508)
Regulation of establishment of protein localization
(GO:0070201)

Other Information

Proteins

Cathepsin D

Genular Protein ID: 1868401767

Symbol: CATD_MOUSE

Name: Cathepsin D

UniProtKB Accession Codes:

P18242

Database IDs:

Citations:

PubMed ID: 2263503

Title: Nucleotide sequence of a cDNA encoding mouse cathepsin D.

PubMed ID: 2263503

DOI: 10.1093/nar/18.23.7184

PubMed ID: 2374732

Title: Molecular cloning of mouse cathepsin D.

PubMed ID: 2374732

DOI: 10.1093/nar/18.13.4008

PubMed ID: 8011168

Title: Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.

PubMed ID: 8011168

DOI: 10.1089/dna.1994.13.419

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16170054

Title: High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.

PubMed ID: 16170054

DOI: 10.1074/mcp.m500203-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28453791

Title: Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.

PubMed ID: 28453791

DOI: 10.1093/hmg/ddx162

Sequence Information:

Length: 410
Mass: 44954
Checksum: DC4928EC46928BF0
Sequence:

MKTPGVLLLI LGLLASSSFA IIRIPLRKFT SIRRTMTEVG GSVEDLILKG PITKYSMQSS 
PKTTEPVSEL LKNYLDAQYY GDIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KILDIACWVH 
HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSDQSKARGI KVEKQIFGEA 
TKQPGIVFVA AKFDGILGMG YPHISVNNVL PVFDNLMQQK LVDKNIFSFY LNRDPEGQPG 
GELMLGGTDS KYYHGELSYL NVTRKAYWQV HMDQLEVGNE LTLCKGGCEA IVDTGTSLLV 
GPVEEVKELQ KAIGAVPLIQ GEYMIPCEKV SSLPTVYLKL GGKNYELHPD KYILKVSQGG 
KTICLSGFMG MDIPPPSGPL WILGDVFIGS YYTVFDRDNN RVGFANAVVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ctsd

Associated with

Other Information

Nucleotide sequence of a cDNA encoding mouse cathepsin D. PubMed ID: 2263503

Molecular cloning of mouse cathepsin D. PubMed ID: 2374732

Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization. PubMed ID: 8011168

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. PubMed ID: 16170054

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo. PubMed ID: 28453791