Genular: Defining Cellular Identity and Function

Details for: Ctsl

Gene ID: 13039

Symbol: Ctsl

Ensembl ID: ENSMUSG00000021477

Description: cathepsin L

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Adaptive immune system
(R-MMU-1280218)
Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Collagen formation
(R-MMU-1474290)
Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Mhc class ii antigen presentation
(R-MMU-2132295)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-MMU-8939242)
Toll-like receptor cascades
(R-MMU-168898)
Trafficking and processing of endosomal tlr
(R-MMU-1679131)
Transcriptional regulation by runx1
(R-MMU-8878171)
Aminopeptidase activity
(GO:0004177)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Apical part of cell
(GO:0045177)
Catagen
(GO:0042637)
Cd4-positive, alpha-beta t cell lineage commitment
(GO:0043373)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type carboxypeptidase activity
(GO:0016807)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasmic vesicle
(GO:0031410)
Decidualization
(GO:0046697)
Elastin catabolic process
(GO:0060309)
Endopeptidase activity
(GO:0004175)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Golgi apparatus
(GO:0005794)
Hair follicle morphogenesis
(GO:0031069)
Histone binding
(GO:0042393)
Hydrolase activity
(GO:0016787)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Keratinocyte proliferation
(GO:0043616)
Kininogen binding
(GO:0030984)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Multivesicular body
(GO:0005771)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Peptide binding
(GO:0042277)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of peptidase activity
(GO:0010952)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Secretory granule
(GO:0030141)
Serpin family protein binding
(GO:0097655)
Thyroid hormone generation
(GO:0006590)

Other Information

Proteins

Cathepsin L1

Genular Protein ID: 1409891243

Symbol: CATL1_MOUSE

Name: Cathepsin L1

UniProtKB Accession Codes:

P06797 Q91UZ0

Database IDs:

Citations:

PubMed ID: 3689328

Title: Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.

PubMed ID: 3689328

DOI: 10.1042/bj2460731

PubMed ID: 2835398

Title: Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

PubMed ID: 2835398

DOI: 10.1172/jci113497

PubMed ID: 3533924

Title: Cloning and characterization of a mouse cysteine proteinase.

PubMed ID: 3533924

DOI: 10.1016/s0021-9258(18)66927-3

PubMed ID: 2275556

Title: Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.

PubMed ID: 2275556

DOI: 10.1016/0003-9861(90)90666-m

PubMed ID: 10516062

Title: Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.

PubMed ID: 10516062

DOI: 10.1128/jvi.73.11.9532-9543.1999

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8554545

Title: Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L.

PubMed ID: 8554545

DOI: 10.1042/bj3120961

PubMed ID: 3755373

Title: Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

PubMed ID: 3755373

PubMed ID: 9545226

Title: Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.

PubMed ID: 9545226

DOI: 10.1126/science.280.5362.450

PubMed ID: 10716919

Title: Secreted cathepsin L generates endostatin from collagen XVIII.

PubMed ID: 10716919

DOI: 10.1093/emboj/19.6.1187

PubMed ID: 11483509

Title: The p41 isoform of invariant chain is a chaperone for cathepsin L.

PubMed ID: 11483509

DOI: 10.1093/emboj/20.15.4055

PubMed ID: 12163394

Title: Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.

PubMed ID: 12163394

DOI: 10.1016/s0002-9440(10)64225-3

PubMed ID: 12021314

Title: Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands.

PubMed ID: 12021314

DOI: 10.1084/jem.20011904

PubMed ID: 12417635

Title: Invariant chain controls the activity of extracellular cathepsin L.

PubMed ID: 12417635

DOI: 10.1084/jem.20020762

PubMed ID: 11972068

Title: Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

PubMed ID: 11972068

DOI: 10.1073/pnas.092637699

PubMed ID: 12782676

Title: Thyroid functions of mouse cathepsins B, K, and L.

PubMed ID: 12782676

DOI: 10.1172/jci15990

PubMed ID: 12869695

Title: Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

PubMed ID: 12869695

DOI: 10.1073/pnas.1531542100

PubMed ID: 15099520

Title: A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

PubMed ID: 15099520

DOI: 10.1016/s1097-2765(04)00209-6

PubMed ID: 16170054

Title: High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.

PubMed ID: 16170054

DOI: 10.1074/mcp.m500203-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 334
Mass: 37547
Checksum: FE6747043307AD98
Sequence:

MNLLLLLAVL CLGTALATPK FDQTFSAEWH QWKSTHRRLY GTNEEEWRRA IWEKNMRMIQ 
LHNGEYSNGQ HGFSMEMNAF GDMTNEEFRQ VVNGYRHQKH KKGRLFQEPL MLKIPKSVDW 
REKGCVTPVK NQGQCGSCWA FSASGCLEGQ MFLKTGKLIS LSEQNLVDCS HAQGNQGCNG 
GLMDFAFQYI KENGGLDSEE SYPYEAKDGS CKYRAEFAVA NDTGFVDIPQ QEKALMKAVA 
TVGPISVAMD ASHPSLQFYS SGIYYEPNCS SKNLDHGVLL VGYGYEGTDS NKNKYWLVKN 
SWGSEWGMEG YIKIAKDRDN HCGLATAASY PVVN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ctsl

Associated with

Other Information

Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin. PubMed ID: 3689328

Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. PubMed ID: 2835398

Cloning and characterization of a mouse cysteine proteinase. PubMed ID: 3533924

Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. PubMed ID: 2275556

Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly. PubMed ID: 10516062

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L. PubMed ID: 8554545

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins. PubMed ID: 3755373

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. PubMed ID: 9545226

Secreted cathepsin L generates endostatin from collagen XVIII. PubMed ID: 10716919

The p41 isoform of invariant chain is a chaperone for cathepsin L. PubMed ID: 11483509

Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. PubMed ID: 12163394

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. PubMed ID: 12021314

Invariant chain controls the activity of extracellular cathepsin L. PubMed ID: 12417635

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. PubMed ID: 11972068

Thyroid functions of mouse cathepsins B, K, and L. PubMed ID: 12782676

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. PubMed ID: 12869695

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. PubMed ID: 15099520

High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. PubMed ID: 16170054

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079