Genular: Defining Cellular Identity and Function

Details for: Celf1

Gene ID: 13046

Symbol: Celf1

Ensembl ID: ENSMUSG00000005506

Description: CUGBP, Elav-like family member 1

Associated with

Bre binding
(GO:0042835)
Cerebral cortex development
(GO:0021987)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Lncrna binding
(GO:0106222)
Male germ cell nucleus
(GO:0001673)
Mrna 3'-utr binding
(GO:0003730)
Mrna binding
(GO:0003729)
Mrna destabilization
(GO:0061157)
Mrna processing
(GO:0006397)
Mrna splice site recognition
(GO:0006376)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of gene expression
(GO:0010629)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinucleolar compartment
(GO:0097356)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of multicellular organism growth
(GO:0040018)
Post-transcriptional gene silencing
(GO:0016441)
Pre-mrna binding
(GO:0036002)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of cell cycle
(GO:0051726)
Regulation of inflammatory response
(GO:0050727)
Regulation of rna splicing
(GO:0043484)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Spermatid development
(GO:0007286)
Translation initiation factor binding
(GO:0031369)

Other Information

Proteins

CUGBP Elav-like family member 1

Genular Protein ID: 115902723

Symbol: CELF1_MOUSE

Name: CUGBP Elav-like family member 1

UniProtKB Accession Codes:

P28659 A2AFW9 A2AFX0 A2AFX1 A2AFX2 Q3U0N2 Q3UP93 Q3UY22 Q8R532 Q99PE1 Q9CXE5 Q9EPJ8 Q9JI37

Database IDs:

Citations:

PubMed ID: 11707455

Title: c-Jun ARE targets mRNA deadenylation by an EDEN-BP (embryo deadenylation element-binding protein)-dependent pathway.

PubMed ID: 11707455

DOI: 10.1074/jbc.m109362200

PubMed ID: 11686919

Title: Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells.

PubMed ID: 11686919

DOI: 10.1093/oxfordjournals.jbchem.a003022

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10893231

Title: A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.

PubMed ID: 10893231

DOI: 10.1074/jbc.m003083200

PubMed ID: 11158314

Title: The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.

PubMed ID: 11158314

DOI: 10.1128/mcb.21.4.1285-1296.2001

PubMed ID: 15082764

Title: Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells.

PubMed ID: 15082764

DOI: 10.1128/mcb.24.9.3682-3691.2004

PubMed ID: 15830352

Title: Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.

PubMed ID: 15830352

DOI: 10.1002/dvdy.20382

PubMed ID: 16931514

Title: Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.

PubMed ID: 16931514

DOI: 10.1074/jbc.m605701200

PubMed ID: 17130239

Title: Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice.

PubMed ID: 17130239

DOI: 10.1128/mcb.01009-06

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 486
Mass: 52107
Checksum: ABB22D331A62B584
Sequence:

MNGTLDHPDQ PDLDAIKMFV GQVPRTWSEK DLRELFEQYG AVYEINILRD RSQNPPQSKG 
CCFVTFYTRK AALEAQNALH NMKVLPGMHH PIQMKPADSE KNNAVEDRKL FIGMISKKCT 
ENDIRVMFSS FGQIEECRIL RGPDGLSRGC AFVTFTTRTM AQTAIKAMHQ AQTMEGCSSP 
MVVKFADTQK DKEQKRMAQQ LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAS 
SGNLNTLSSL HPMGGLNAMQ LQNLAALAAA ASAAQNTPSG TNALTTSSSP LSVLTSSGSS 
PSSSSSNSVN PIASLGALQT LAGATAGLNV GSLAGMAALN GGLGSSGLSN GTGSTMEALT 
QAYSGIQQYA AAALPTLYNQ NLLTQQSIGA AGSQKEGPEG ANLFIYHLPQ EFGDQDLLQM 
FMPFGNVVSA KVFIDKQTNL SKCFGFVSYD NPVSAQAAIQ SMNGFQIGMK RLKVQLKRSK 
NDSKPY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Celf1

Associated with

Other Information

c-Jun ARE targets mRNA deadenylation by an EDEN-BP (embryo deadenylation element-binding protein)-dependent pathway. PubMed ID: 11707455

Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells. PubMed ID: 11686919

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. PubMed ID: 10893231

The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. PubMed ID: 11158314

Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells. PubMed ID: 15082764

Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. PubMed ID: 15830352

Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. PubMed ID: 16931514

Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. PubMed ID: 17130239

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079