Genular: Defining Cellular Identity and Function

Details for: Cybb

Gene ID: 13058

Symbol: Cybb

Ensembl ID: ENSMUSG00000015340

Description: cytochrome b-245, beta polypeptide

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cross-presentation of particulate exogenous antigens (phagosomes)
(R-MMU-1236973)
Detoxification of reactive oxygen species
(R-MMU-3299685)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Ros and rns production in phagocytes
(R-MMU-1222556)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Cytoplasm
(GO:0005737)
Defense response
(GO:0006952)
Dendrite
(GO:0030425)
Electron transfer activity
(GO:0009055)
Flavin adenine dinucleotide binding
(GO:0050660)
Heme binding
(GO:0020037)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hypoxia-inducible factor-1alpha signaling pathway
(GO:0097411)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Monoatomic ion channel complex
(GO:0034702)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nadph oxidase complex
(GO:0043020)
Neuronal cell body
(GO:0043025)
Nuclear envelope
(GO:0005635)
Oxidoreductase activity
(GO:0016491)
Perinuclear endoplasmic reticulum
(GO:0097038)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Respiratory burst
(GO:0045730)
Response to xenobiotic stimulus
(GO:0009410)
Superoxide-generating nad(p)h oxidase activity
(GO:0016175)
Superoxide anion generation
(GO:0042554)
Superoxide metabolic process
(GO:0006801)

Other Information

Proteins

Cytochrome b-245 heavy chain

Genular Protein ID: 2199124133

Symbol: CY24B_MOUSE

Name: Cytochrome b-245 heavy chain

UniProtKB Accession Codes:

Q61093

Database IDs:

Citations:

PubMed ID: 8634451

Title: Cloning of murine gp91phox cDNA and functional expression in a human X-linked chronic granulomatous disease cell line.

PubMed ID: 8634451

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21551061

Title: A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.

PubMed ID: 21551061

DOI: 10.1126/science.1201711

PubMed ID: 24739962

Title: NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.

PubMed ID: 24739962

DOI: 10.1038/nature13152

PubMed ID: 26194095

Title: Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

PubMed ID: 26194095

DOI: 10.1038/ncomms8838

PubMed ID: 28351984

Title: Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

PubMed ID: 28351984

DOI: 10.1084/jem.20161382

Sequence Information:

Length: 570
Mass: 65305
Checksum: 8816274E3D253DFA
Sequence:

MGNWAVNEGL SIFVILVWLG LNVFLFINYY KVYDDGPKYN YTRKLLGSAL ALARAPAACL 
NFNCMLILLP VCRNLLSFLR GSSACCSTRI RRQLDRNLTF HKMVAWMIAL HTAIHTIAHL 
FNVEWCVNAR VGISDRYSIA LSDIGDNENE EYLNFAREKI KNPEGGLYVA VTRLAGITGI 
VITLCLILII TSSTKTIRRS YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTAESLEEHN 
LDICADKIEE WGKIKECPVP KFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV 
VTHPFKTIEL QMKKKGFKME VGQYIFVKCP KVSKLEWHPF TLTSAPEEDF FSIHIRIVGD 
WTEGLFNACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS YEVVMLVGAG IGVTPFASIL 
KSVWYKYCDN ATSLKLKKIY FYWLCRDTHA FEWFADLLQL LETQMQERNN ANFLSYNIYL 
TGWDESQANH FAVHHDEEKD VITGLKQKTL YGRPNWDNEF KTIASEHPNT TIGVFLCGPE 
ALAETLSKQS ISNSESGPRG VHFIFNKENF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cybb

Associated with

Other Information

Cloning of murine gp91phox cDNA and functional expression in a human X-linked chronic granulomatous disease cell line. PubMed ID: 8634451

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. PubMed ID: 21551061

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. PubMed ID: 24739962

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. PubMed ID: 26194095

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. PubMed ID: 28351984