Details for: COL16A1

Gene ID: 1307

Symbol: COL16A1

Ensembl ID: ENSG00000084636

Description: collagen type XVI alpha 1 chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.82
    Marker Score: 6742
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.79
    Marker Score: 1177
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.67
    Marker Score: 474
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.59
    Marker Score: 1987
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.52
    Marker Score: 32437
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168560
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.43
    Marker Score: 2743
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.39
    Marker Score: 10638
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.36
    Marker Score: 8871
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.35
    Marker Score: 351
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.35
    Marker Score: 46022
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.25
    Marker Score: 1714
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2347.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2
    Marker Score: 4624
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18347
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.17
    Marker Score: 2791
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.14
    Marker Score: 1869
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.11
    Marker Score: 966
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.11
    Marker Score: 2915
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.07
    Marker Score: 596
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251779
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.03
    Marker Score: 876
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.96
    Marker Score: 1186
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.94
    Marker Score: 12335
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.93
    Marker Score: 387
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5117
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.88
    Marker Score: 554
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.87
    Marker Score: 1073
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5221
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.84
    Marker Score: 1297
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.84
    Marker Score: 1842
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.84
    Marker Score: 193
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.83
    Marker Score: 212
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.81
    Marker Score: 7673
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.73
    Marker Score: 45189
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 703
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 347
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.73
    Marker Score: 521
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.72
    Marker Score: 4258
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2978
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.7
    Marker Score: 172
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1390
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.66
    Marker Score: 494
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.64
    Marker Score: 285
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 982
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.64
    Marker Score: 1067
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.61
    Marker Score: 421
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.59
    Marker Score: 5099
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.59
    Marker Score: 2893.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.59
    Marker Score: 663
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.58
    Marker Score: 131
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.58
    Marker Score: 126
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.56
    Marker Score: 661
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.55
    Marker Score: 241
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.55
    Marker Score: 137
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.55
    Marker Score: 137
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.54
    Marker Score: 580
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.53
    Marker Score: 1837
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.52
    Marker Score: 191
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.52
    Marker Score: 630
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 312
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.49
    Marker Score: 222
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.48
    Marker Score: 1723
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.48
    Marker Score: 260
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.48
    Marker Score: 4198
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.48
    Marker Score: 117
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1122
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.48
    Marker Score: 180
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.46
    Marker Score: 560
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.45
    Marker Score: 431
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.45
    Marker Score: 411
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.43
    Marker Score: 788
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.42
    Marker Score: 449
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.42
    Marker Score: 237
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.41
    Marker Score: 196
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.41
    Marker Score: 968
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.41
    Marker Score: 139
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 393
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.4
    Marker Score: 172

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Other Information

**Key characteristics:** - Col16A1 is a type I collagen, which is a major component of the extracellular matrix. - It is expressed in high levels in various cell types, including epithelial cells, astrocytes, and cardiac neurons. - It is a key component of cell adhesion through integrin, which is a cell adhesion molecule. - It is involved in the regulation of cell migration and adhesion. - It is involved in the formation of the extracellular matrix. **Pathways and functions:** - COL16A1 is a key component of cell adhesion through integrin. - It is involved in the assembly of focal adhesions, which are cell-cell contacts that hold tissues together. - It is involved in the migration and adhesion of cells to extracellular matrix proteins. - It is involved in the formation of the extracellular matrix. **Clinical significance:** - Mutations in COL16A1 have been linked to a number of human diseases, including cerebral palsy, rheumatoid arthritis, and osteoporosis. - COL16A1 is a potential target for therapeutic intervention in these diseases. **Additional notes:** - COL16A1 is a highly conserved protein, with a similar sequence in humans, mice, and rats. - It is a secreted protein, which means that it is not incorporated into the cell's own extracellular matrix. - It is a major component of the extracellular matrix, which provides strength and elasticity to tissues.

Genular Protein ID: 850409386

Symbol: COGA1_HUMAN

Name: Collagen alpha-1(XVI) chain

UniProtKB Accession Codes:

Q07092 Q16593 Q59F89 Q71RG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1631157

Title: Cloning and chromosomal location of human alpha 1(XVI) collagen.

PubMed ID: 1631157

DOI: 10.1073/pnas.89.14.6565

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7882999

Title: Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain.

PubMed ID: 7882999

DOI: 10.1111/j.1432-1033.1995.tb20245.x

PubMed ID: 15165854

Title: Molecular structure and interaction of recombinant human type XVI collagen.

PubMed ID: 15165854

DOI: 10.1016/j.jmb.2004.03.042

PubMed ID: 1284248

Title: Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.

PubMed ID: 1284248

DOI: 10.1093/oxfordjournals.jbchem.a123989

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 9022684

Title: Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells.

PubMed ID: 9022684

DOI: 10.1111/j.1432-1033.1996.0576r.x

PubMed ID: 12782140

Title: Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.

PubMed ID: 12782140

DOI: 10.1016/s0945-053x(03)00008-8

PubMed ID: 16754661

Title: Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.

PubMed ID: 16754661

DOI: 10.1074/jbc.m509942200

Sequence Information:

  • Length: 1604
  • Mass: 157751
  • Checksum: 5FAA1950DFC6CA3C
  • Sequence:
    • MWVSWAPGLW LLGLWATFGH GANTGAQCPP SQQEGLKLEH SSSLPANVTG FNLIHRLSLM 
KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF ALVLTLLLKK HTHQKTWYLF 
QVTDANGYPQ ISLEVNSQER SLELRAQGQD GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA 
SVHVDCSSAS SQPLGPRRPM RPVGHVFLGL DAEQGKPVSF DLQQVHIYCD PELVLEEGCC 
EILPAGCPPE TSKARRDTQS NELIEINPQS EGKVYTRCFC LEEPQNSEVD AQLTGRISQK 
AERGAKVHQE TAADECPPCV HGARDSNVTL APSGPKGGKG ERGLPGPPGS KGEKGARGND 
CVRISPDAPL QCAEGPKGEK GESGALGPSG LPGSTGEKGQ KGEKGDGGIK GVPGKPGRDG 
RPGEICVIGP KGQKGDPGFV GPEGLAGEPG PPGLPGPPGI GLPGTPGDPG GPPGPKGDKG 
SSGIPGKEGP GGKPGKPGVK GEKGDPCEVC PTLPEGFQNF VGLPGKPGPK GEPGDPVPAR 
GDPGIQGIKG EKGEPCLSCS SVVGAQHLVS STGASGDVGS PGFGLPGLPG RAGVPGLKGE 
KGNFGEAGPA GSPGPPGPVG PAGIKGAKGE PCEPCPALSN LQDGDVRVVA LPGPSGEKGE 
PGPPGFGLPG KQGKAGERGL KGQKGDAGNP GDPGTPGTTG RPGLSGEPGV QGPAGPKGEK 
GDGCTACPSL QGTVTDMAGR PGQPGPKGEQ GPEGVGRPGK PGQPGLPGVQ GPPGLKGVQG 
EPGPPGRGVQ GPQGEPGAPG LPGIQGLPGP RGPPGPTGEK GAQGSPGVKG ATGPVGPPGA 
SVSGPPGRDG QQGQTGLRGT PGEKGPRGEK GEPGECSCPS QGDLIFSGMP GAPGLWMGSS 
WQPGPQGPPG IPGPPGPPGV PGLQGVPGNN GLPGQPGLTA ELGSLPIEQH LLKSICGDCV 
QGQRAHPGYL VEKGEKGDQG IPGVPGLDNC AQCFLSLERP RAEEARGDNS EGDPGCVGSP 
GLPGPPGLPG QRGEEGPPGM RGSPGPPGPI GPPGFPGAVG SPGLPGLQGE RGLTGLTGDK 
GEPGPPGQPG YPGATGPPGL PGIKGERGYT GSAGEKGEPG PPGSEGLPGP PGPAGPRGER 
GPQGNSGEKG DQGFQGQPGF PGPPGPPGFP GKVGSPGPPG PQAEKGSEGI RGPSGLPGSP 
GPPGPPGIQG PAGLDGLDGK DGKPGLRGDP GPAGPPGLMG PPGFKGKTGH PGLPGPKGDC 
GKPGPPGSTG RPGAEGEPGA MGPQGRPGPP GHVGPPGPPG QPGPAGISAV GLKGDRGATG 
ERGLAGLPGQ PGPPGHPGPP GEPGTDGAAG KEGPPGKQGF YGPPGPKGDP GAAGQKGQAG 
EKGRAGMPGG PGKSGSMGPV GPPGPAGERG HPGAPGPSGS PGLPGVPGSM GDMVNYDEIK 
RFIRQEIIKM FDERMAYYTS RMQFPMEMAA APGRPGPPGK DGAPGRPGAP GSPGLPGQIG 
REGRQGLPGV RGLPGTKGEK GDIGIGIAGE NGLPGPPGPQ GPPGYGKMGA TGPMGQQGIP 
GIPGPPGPMG QPGKAGHCNP SDCFGAMPME QQYPPMKTMK GPFG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.