Details for: COL16A1

Gene ID: 1307

Symbol: COL16A1

Ensembl ID: ENSG00000084636

Description: collagen type XVI alpha 1 chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.1871
    Cell Significance Index: -26.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.7190
    Cell Significance Index: -23.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.0871
    Cell Significance Index: -26.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.6187
    Cell Significance Index: -26.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.0015
    Cell Significance Index: -23.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7511
    Cell Significance Index: -26.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1997
    Cell Significance Index: 32.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4531
    Cell Significance Index: 18.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1174
    Cell Significance Index: 32.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0735
    Cell Significance Index: 22.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8270
    Cell Significance Index: 16.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8269
    Cell Significance Index: 296.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7930
    Cell Significance Index: 128.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7830
    Cell Significance Index: 85.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7011
    Cell Significance Index: 20.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5994
    Cell Significance Index: 30.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5607
    Cell Significance Index: 33.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5509
    Cell Significance Index: 38.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5038
    Cell Significance Index: 14.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4114
    Cell Significance Index: 82.5200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3863
    Cell Significance Index: 3.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2323
    Cell Significance Index: 31.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2023
    Cell Significance Index: 3.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1991
    Cell Significance Index: 88.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1969
    Cell Significance Index: 2.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1944
    Cell Significance Index: 19.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1880
    Cell Significance Index: 35.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0867
    Cell Significance Index: 78.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0637
    Cell Significance Index: 8.1600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0452
    Cell Significance Index: 0.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0075
    Cell Significance Index: 3.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0033
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0032
    Cell Significance Index: 2.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0027
    Cell Significance Index: 0.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0023
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0105
    Cell Significance Index: -16.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0155
    Cell Significance Index: -11.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0176
    Cell Significance Index: -23.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0318
    Cell Significance Index: -17.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0329
    Cell Significance Index: -20.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0334
    Cell Significance Index: -25.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0361
    Cell Significance Index: -20.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0363
    Cell Significance Index: -26.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0397
    Cell Significance Index: -3.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0403
    Cell Significance Index: -5.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0637
    Cell Significance Index: -12.6500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0672
    Cell Significance Index: -1.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0809
    Cell Significance Index: -23.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0904
    Cell Significance Index: -16.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0954
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1032
    Cell Significance Index: -21.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1084
    Cell Significance Index: -15.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1140
    Cell Significance Index: -19.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1171
    Cell Significance Index: -3.7500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1244
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1271
    Cell Significance Index: -14.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1451
    Cell Significance Index: -5.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1534
    Cell Significance Index: -18.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1749
    Cell Significance Index: -20.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1896
    Cell Significance Index: -19.3700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1901
    Cell Significance Index: -1.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1930
    Cell Significance Index: -4.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1935
    Cell Significance Index: -8.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2082
    Cell Significance Index: -2.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2132
    Cell Significance Index: -15.8900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2175
    Cell Significance Index: -3.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2186
    Cell Significance Index: -10.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2300
    Cell Significance Index: -6.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2331
    Cell Significance Index: -24.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2452
    Cell Significance Index: -28.9200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2774
    Cell Significance Index: -1.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3399
    Cell Significance Index: -26.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3505
    Cell Significance Index: -23.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4013
    Cell Significance Index: -22.5200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.4065
    Cell Significance Index: -2.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4320
    Cell Significance Index: -27.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4323
    Cell Significance Index: -22.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4333
    Cell Significance Index: -22.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4420
    Cell Significance Index: -27.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4449
    Cell Significance Index: -23.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4520
    Cell Significance Index: -6.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4685
    Cell Significance Index: -7.0600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4699
    Cell Significance Index: -4.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5081
    Cell Significance Index: -23.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5193
    Cell Significance Index: -11.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5249
    Cell Significance Index: -9.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5287
    Cell Significance Index: -20.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5311
    Cell Significance Index: -23.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5424
    Cell Significance Index: -17.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5749
    Cell Significance Index: -20.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6213
    Cell Significance Index: -20.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6464
    Cell Significance Index: -16.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6984
    Cell Significance Index: -19.9300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7109
    Cell Significance Index: -4.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7226
    Cell Significance Index: -7.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7294
    Cell Significance Index: -15.1300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.7347
    Cell Significance Index: -4.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** COL16A1 is expressed in a wide range of cell types, including cortical thymic epithelial cells, mature astrocytes, preosteoblasts, cardiac neurons, and granulocyte monocyte progenitor cells. 2. **Cellular Functions:** COL16A1 is involved in cell adhesion, migration, and differentiation, and plays a crucial role in maintaining the integrity of the ECM. 3. **ECM Organization:** COL16A1 is a key component of the ECM, contributing to its organization and structure. 4. **Signaling Pathways:** COL16A1 is involved in integrin-mediated signaling pathways, which regulate cell adhesion and migration. **Pathways and Functions:** 1. **Cell Adhesion:** COL16A1 interacts with integrins, which are transmembrane receptors that facilitate cell adhesion to the ECM. 2. **ECM Organization:** COL16A1 contributes to the organization and structure of the ECM, influencing the assembly and function of collagen fibrils. 3. **Collagen Degradation:** COL16A1 is involved in the regulation of collagen degradation, which is essential for tissue remodeling and repair. 4. **Integrin Activation:** COL16A1 is a ligand for integrins, which are activated by binding to COL16A1, leading to changes in cell adhesion and migration. **Clinical Significance:** 1. **Cancer Metastasis:** Alterations in COL16A1 expression have been implicated in cancer metastasis, suggesting its potential as a therapeutic target. 2. **Neurological Disorders:** COL16A1 has been linked to neurological disorders, such as Alzheimer's disease and multiple sclerosis, highlighting its importance in maintaining neural tissue integrity. 3. **Cardiovascular Disease:** COL16A1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac fibrosis, suggesting its potential as a therapeutic target. 4. **Musculoskeletal Disorders:** COL16A1 has been linked to musculoskeletal disorders, such as osteoarthritis and fibrosis, highlighting its importance in maintaining tissue structure and function. In conclusion, COL16A1 is a critical component of the ECM and plays a significant role in cell adhesion, migration, and differentiation. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the functions and clinical significance of COL16A1.

Genular Protein ID: 850409386

Symbol: COGA1_HUMAN

Name: Collagen alpha-1(XVI) chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1631157

Title: Cloning and chromosomal location of human alpha 1(XVI) collagen.

PubMed ID: 1631157

DOI: 10.1073/pnas.89.14.6565

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7882999

Title: Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain.

PubMed ID: 7882999

DOI: 10.1111/j.1432-1033.1995.tb20245.x

PubMed ID: 15165854

Title: Molecular structure and interaction of recombinant human type XVI collagen.

PubMed ID: 15165854

DOI: 10.1016/j.jmb.2004.03.042

PubMed ID: 1284248

Title: Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.

PubMed ID: 1284248

DOI: 10.1093/oxfordjournals.jbchem.a123989

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 9022684

Title: Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells.

PubMed ID: 9022684

DOI: 10.1111/j.1432-1033.1996.0576r.x

PubMed ID: 12782140

Title: Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.

PubMed ID: 12782140

DOI: 10.1016/s0945-053x(03)00008-8

PubMed ID: 16754661

Title: Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.

PubMed ID: 16754661

DOI: 10.1074/jbc.m509942200

Sequence Information:

  • Length: 1604
  • Mass: 157751
  • Checksum: 5FAA1950DFC6CA3C
  • Sequence:
  • MWVSWAPGLW LLGLWATFGH GANTGAQCPP SQQEGLKLEH SSSLPANVTG FNLIHRLSLM 
    KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF ALVLTLLLKK HTHQKTWYLF 
    QVTDANGYPQ ISLEVNSQER SLELRAQGQD GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA 
    SVHVDCSSAS SQPLGPRRPM RPVGHVFLGL DAEQGKPVSF DLQQVHIYCD PELVLEEGCC 
    EILPAGCPPE TSKARRDTQS NELIEINPQS EGKVYTRCFC LEEPQNSEVD AQLTGRISQK 
    AERGAKVHQE TAADECPPCV HGARDSNVTL APSGPKGGKG ERGLPGPPGS KGEKGARGND 
    CVRISPDAPL QCAEGPKGEK GESGALGPSG LPGSTGEKGQ KGEKGDGGIK GVPGKPGRDG 
    RPGEICVIGP KGQKGDPGFV GPEGLAGEPG PPGLPGPPGI GLPGTPGDPG GPPGPKGDKG 
    SSGIPGKEGP GGKPGKPGVK GEKGDPCEVC PTLPEGFQNF VGLPGKPGPK GEPGDPVPAR 
    GDPGIQGIKG EKGEPCLSCS SVVGAQHLVS STGASGDVGS PGFGLPGLPG RAGVPGLKGE 
    KGNFGEAGPA GSPGPPGPVG PAGIKGAKGE PCEPCPALSN LQDGDVRVVA LPGPSGEKGE 
    PGPPGFGLPG KQGKAGERGL KGQKGDAGNP GDPGTPGTTG RPGLSGEPGV QGPAGPKGEK 
    GDGCTACPSL QGTVTDMAGR PGQPGPKGEQ GPEGVGRPGK PGQPGLPGVQ GPPGLKGVQG 
    EPGPPGRGVQ GPQGEPGAPG LPGIQGLPGP RGPPGPTGEK GAQGSPGVKG ATGPVGPPGA 
    SVSGPPGRDG QQGQTGLRGT PGEKGPRGEK GEPGECSCPS QGDLIFSGMP GAPGLWMGSS 
    WQPGPQGPPG IPGPPGPPGV PGLQGVPGNN GLPGQPGLTA ELGSLPIEQH LLKSICGDCV 
    QGQRAHPGYL VEKGEKGDQG IPGVPGLDNC AQCFLSLERP RAEEARGDNS EGDPGCVGSP 
    GLPGPPGLPG QRGEEGPPGM RGSPGPPGPI GPPGFPGAVG SPGLPGLQGE RGLTGLTGDK 
    GEPGPPGQPG YPGATGPPGL PGIKGERGYT GSAGEKGEPG PPGSEGLPGP PGPAGPRGER 
    GPQGNSGEKG DQGFQGQPGF PGPPGPPGFP GKVGSPGPPG PQAEKGSEGI RGPSGLPGSP 
    GPPGPPGIQG PAGLDGLDGK DGKPGLRGDP GPAGPPGLMG PPGFKGKTGH PGLPGPKGDC 
    GKPGPPGSTG RPGAEGEPGA MGPQGRPGPP GHVGPPGPPG QPGPAGISAV GLKGDRGATG 
    ERGLAGLPGQ PGPPGHPGPP GEPGTDGAAG KEGPPGKQGF YGPPGPKGDP GAAGQKGQAG 
    EKGRAGMPGG PGKSGSMGPV GPPGPAGERG HPGAPGPSGS PGLPGVPGSM GDMVNYDEIK 
    RFIRQEIIKM FDERMAYYTS RMQFPMEMAA APGRPGPPGK DGAPGRPGAP GSPGLPGQIG 
    REGRQGLPGV RGLPGTKGEK GDIGIGIAGE NGLPGPPGPQ GPPGYGKMGA TGPMGQQGIP 
    GIPGPPGPMG QPGKAGHCNP SDCFGAMPME QQYPPMKTMK GPFG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.