Genular: Defining Cellular Identity and Function

Details for: Cyp1a1

Gene ID: 13076

Symbol: Cyp1a1

Ensembl ID: ENSMUSG00000032315

Description: cytochrome P450, family 1, subfamily a, polypeptide 1

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biological oxidations
(R-MMU-211859)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of protectins
(R-MMU-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phase i - functionalization of compounds
(R-MMU-211945)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-MMU-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-MMU-2142670)
Xenobiotics
(R-MMU-211981)
9-cis-retinoic acid biosynthetic process
(GO:0042904)
Amine metabolic process
(GO:0009308)
Arachidonic acid monooxygenase activity
(GO:0008391)
Aromatase activity
(GO:0070330)
Catalytic activity
(GO:0003824)
Cellular response to organic cyclic compound
(GO:0071407)
Coumarin metabolic process
(GO:0009804)
Cytoplasm
(GO:0005737)
Demethylase activity
(GO:0032451)
Dibenzo-p-dioxin catabolic process
(GO:0019341)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Fatty acid metabolic process
(GO:0006631)
Flavonoid 3'-monooxygenase activity
(GO:0016711)
Flavonoid metabolic process
(GO:0009812)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Insecticide metabolic process
(GO:0017143)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Lipid metabolic process
(GO:0006629)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid omega-1 hydroxylase activity
(GO:0120319)
Long-chain fatty acid omega-hydroxylase activity
(GO:0102033)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Monooxygenase activity
(GO:0004497)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on diphenols and related substances as donors
(GO:0016679)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Porphyrin-containing compound metabolic process
(GO:0006778)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Response to toxic substance
(GO:0009636)
Retinol metabolic process
(GO:0042572)
Steroid biosynthetic process
(GO:0006694)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Toxin metabolic process
(GO:0009404)
Vitamin d 24-hydroxylase activity
(GO:0070576)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 1A1

Genular Protein ID: 3516355176

Symbol: CP1A1_MOUSE

Name: Cytochrome P450 1A1

UniProtKB Accession Codes:

P00184 Q61455

Database IDs:

Citations:

PubMed ID: 6547952

Title: The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

PubMed ID: 6547952

DOI: 10.1016/s0021-9258(18)90569-7

PubMed ID: 3988744

Title: Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

PubMed ID: 3988744

DOI: 10.1016/s0021-9258(18)89176-1

PubMed ID: 3308449

Title: Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.

PubMed ID: 3308449

DOI: 10.1002/j.1460-2075.1987.tb02453.x

PubMed ID: 6548461

Title: Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450.

PubMed ID: 6548461

DOI: 10.1016/0378-1119(84)90057-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 3718958

Title: Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450.

PubMed ID: 3718958

DOI: 10.1021/bi00357a015

PubMed ID: 2425809

Title: Methylation differences in the murine P-1-450 and P-3-450 genes in wild-type and mutant hepatoma cell culture.

PubMed ID: 2425809

DOI: 10.1016/0006-2952(86)90577-0

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 524
Mass: 59230
Checksum: E31D9E9CBA7B2B02
Sequence:

MPSMYGLPAF VSATELLLAV TVFCLGFWVV RATRTWVPKG LKTPPGPWGL PFIGHMLTVG 
KNPHLSLTRL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL VRQGDDFKGR PDLYSFTLIT 
NGKSMTFNPD SGPVWAARRR LAQNALKSFS IASDPTSASS CYLEEHVSKE ANYLVSKLQK 
VMAEVGHFDP YKYLVVSVAN VICAICFGQR YDHDDQELLS IVNLSNEFGE VTGSGYPADF 
IPVLRYLPNS SLDAFKDLND KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRKLDE 
NANVQLSDDK VITIVLDLFG AGFDTVTTAI SWSLMYLVTN PRVQRKIQEE LDTVIGRDRQ 
PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTTRDTSL NGFYIPKGCC VFVNQWQVNH 
DRELWGDPNE FRPERFLTPS GTLDKRLSEK VTLFGLGKRK CIGETIGRSE VFLFLAILLQ 
QIEFKVSPGE KVDMTPTYGL TLKHARCEHF QVQMRSSGPQ HLQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp1a1

Associated with

Other Information

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. PubMed ID: 6547952

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. PubMed ID: 3988744

Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast. PubMed ID: 3308449

Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. PubMed ID: 6548461

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. PubMed ID: 3718958

Methylation differences in the murine P-1-450 and P-3-450 genes in wild-type and mutant hepatoma cell culture. PubMed ID: 2425809

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079