Genular: Defining Cellular Identity and Function

Details for: Cyp1a2

Gene ID: 13077

Symbol: Cyp1a2

Ensembl ID: ENSMUSG00000032310

Description: cytochrome P450, family 1, subfamily a, polypeptide 2

Associated with

Aflatoxin activation and detoxification
(R-MMU-5423646)
Arachidonic acid metabolism
(R-MMU-2142753)
Aromatic amines can be n-hydroxylated or n-dealkylated by cyp1a2
(R-MMU-211957)
Biological oxidations
(R-MMU-211859)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of maresin-like spms
(R-MMU-9027307)
Biosynthesis of maresins
(R-MMU-9018682)
Biosynthesis of protectins
(R-MMU-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Methylation
(R-MMU-156581)
Phase i - functionalization of compounds
(R-MMU-211945)
Phase ii - conjugation of compounds
(R-MMU-156580)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-MMU-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-MMU-2142670)
Xenobiotics
(R-MMU-211981)
Alkaloid metabolic process
(GO:0009820)
Aromatase activity
(GO:0070330)
Caffeine oxidase activity
(GO:0034875)
Cellular aromatic compound metabolic process
(GO:0006725)
Cellular respiration
(GO:0045333)
Cellular response to cadmium ion
(GO:0071276)
Demethylase activity
(GO:0032451)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Fatty acid metabolic process
(GO:0006631)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Lung development
(GO:0030324)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monocarboxylic acid metabolic process
(GO:0032787)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Porphyrin-containing compound metabolic process
(GO:0006778)
Post-embryonic development
(GO:0009791)
Regulation of gene expression
(GO:0010468)
Retinol metabolic process
(GO:0042572)
Steroid catabolic process
(GO:0006706)
Steroid metabolic process
(GO:0008202)
Toxin biosynthetic process
(GO:0009403)
Toxin metabolic process
(GO:0009404)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 1A2

Genular Protein ID: 1691208737

Symbol: CP1A2_MOUSE

Name: Cytochrome P450 1A2

UniProtKB Accession Codes:

P00186 Q9QWJ4

Database IDs:

Citations:

PubMed ID: 6547952

Title: The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

PubMed ID: 6547952

DOI: 10.1016/s0021-9258(18)90569-7

PubMed ID: 6324134

Title: Mouse cytochrome P3-450: complete cDNA and amino acid sequence.

PubMed ID: 6324134

DOI: 10.1093/nar/12.6.2917

PubMed ID: 3988744

Title: Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

PubMed ID: 3988744

DOI: 10.1016/s0021-9258(18)89176-1

PubMed ID: 6548461

Title: Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450.

PubMed ID: 6548461

DOI: 10.1016/0378-1119(84)90057-x

PubMed ID: 3755821

Title: cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene.

PubMed ID: 3755821

DOI: 10.1093/nar/14.16.6765

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3718958

Title: Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450.

PubMed ID: 3718958

DOI: 10.1021/bi00357a015

PubMed ID: 2425809

Title: Methylation differences in the murine P-1-450 and P-3-450 genes in wild-type and mutant hepatoma cell culture.

PubMed ID: 2425809

DOI: 10.1016/0006-2952(86)90577-0

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 513
Mass: 58184
Checksum: DC2D7D976B126E3B
Sequence:

MAFSQYISLA PELLLATAIF CLVFWMVRAS RTQVPKGLKN PPGPWGLPFI GHMLTVGKNP 
HLSLTRLSQQ YGDVLQIRIG STPVVVLSGL NTIKQALVRQ GDDFKGRPDL YSFTLITNGK 
SMTFNPDSGP VWAARRRLAQ DALKSFSIAS DPTSASSCYL EEHVSKEANH LVSKLQKAMA 
EVGHFEPVSQ VVESVANVIG AMCFGKNFPR KSEEMLNIVN NSKDFVENVT SGNAVDFFPV 
LRYLPNPALK RFKTFNDNFV LFLQKTVQEH YQDFNKNSIQ DITSALFKHS ENYKDNGGLI 
PEEKIVNIVN DIFGAGFDTV TTAITWSILL LVTWPNVQRK IHEELDTVVG RDRQPRLSDR 
PQLPYLEAFI LEIYRYTSFV PFTIPHSTTR DTSLNGFHIP KERCIYINQW QVNHDEKQWK 
DPFVFRPERF LTNNNSAIDK TQSEKVMLFG LGKRRCIGEI PAKWEVFLFL AILLQHLEFS 
VPPGVKVDLT PNYGLTMKPG TCEHVQAWPR FSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp1a2

Associated with

Other Information

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. PubMed ID: 6547952

Mouse cytochrome P3-450: complete cDNA and amino acid sequence. PubMed ID: 6324134

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. PubMed ID: 3988744

Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. PubMed ID: 6548461

cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene. PubMed ID: 3755821

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. PubMed ID: 3718958

Methylation differences in the murine P-1-450 and P-3-450 genes in wild-type and mutant hepatoma cell culture. PubMed ID: 2425809

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079