Genular: Defining Cellular Identity and Function

Details for: Cyp1b1

Gene ID: 13078

Symbol: Cyp1b1

Ensembl ID: ENSMUSG00000024087

Description: cytochrome P450, family 1, subfamily b, polypeptide 1

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phase i - functionalization of compounds
(R-MMU-211945)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-MMU-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-MMU-2142670)
Angiogenesis
(GO:0001525)
Arachidonic acid metabolic process
(GO:0019369)
Aromatase activity
(GO:0070330)
Benzene-containing compound metabolic process
(GO:0042537)
Blood vessel endothelial cell migration
(GO:0043534)
Blood vessel morphogenesis
(GO:0048514)
Cell adhesion
(GO:0007155)
Cellular aromatic compound metabolic process
(GO:0006725)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to toxic substance
(GO:0097237)
Collagen fibril organization
(GO:0030199)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Dna modification
(GO:0006304)
Endoplasmic reticulum
(GO:0005783)
Endothelial cell-cell adhesion
(GO:0071603)
Endothelial cell migration
(GO:0043542)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Fatty acid metabolic process
(GO:0006631)
Heme binding
(GO:0020037)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Membrane lipid catabolic process
(GO:0046466)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Monooxygenase activity
(GO:0004497)
Negative regulation of cell adhesion mediated by integrin
(GO:0033629)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Nitric oxide biosynthetic process
(GO:0006809)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of translation
(GO:0045727)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to toxic substance
(GO:0009636)
Retinal blood vessel morphogenesis
(GO:0061304)
Retinal metabolic process
(GO:0042574)
Retina vasculature development in camera-type eye
(GO:0061298)
Retinol metabolic process
(GO:0042572)
Steroid metabolic process
(GO:0008202)
Toxin metabolic process
(GO:0009404)
Trabecular meshwork development
(GO:0002930)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

CYPIB1

Genular Protein ID: 1553638121

Symbol: CP1B1_MOUSE

Name: CYPIB1

UniProtKB Accession Codes:

Q64429 Q3UVA8 Q60593 Q64461

Database IDs:

Citations:

PubMed ID: 7772257

Title: cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1.

PubMed ID: 7772257

DOI: 10.1089/dna.1994.13.763

PubMed ID: 8195121

Title: Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.

PubMed ID: 8195121

DOI: 10.1016/s0021-9258(17)36551-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 7505439

Title: Identification of a cytochrome P450 gene by reverse transcription-PCR using degenerate primers containing inosine.

PubMed ID: 7505439

DOI: 10.1073/pnas.90.24.11483

PubMed ID: 15258110

Title: Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.

PubMed ID: 15258110

DOI: 10.1124/dmd.32.8.840

PubMed ID: 19005183

Title: CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression.

PubMed ID: 19005183

DOI: 10.1182/blood-2008-03-145219

PubMed ID: 20032512

Title: CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress.

PubMed ID: 20032512

DOI: 10.1152/ajpcell.00153.2009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23692925

Title: Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.

PubMed ID: 23692925

DOI: 10.1016/j.bbrc.2013.05.051

PubMed ID: 23568032

Title: Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells.

PubMed ID: 23568032

DOI: 10.1038/labinvest.2013.55

PubMed ID: 23979599

Title: Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.

PubMed ID: 23979599

DOI: 10.1128/mcb.00856-13

PubMed ID: 23821647

Title: Specificity determinants of CYP1B1 estradiol hydroxylation.

PubMed ID: 23821647

DOI: 10.1124/mol.113.087700

Sequence Information:

Length: 543
Mass: 60537
Checksum: 7C89B4312CB5BC4A
Sequence:

MATSLSADSP QQLSSLSTQQ TTLLLLFSVL AAVHLGQWLL RQWQRKPWSS PPGPFPWPLI 
GNAAAVGQAS HLYFARLARR YGDVFQIRLG SCPVVVLNGE SAIHQALVQQ GSIFADRPPF 
ASFRVVSGGR SLAFGHYSEH WKTQRRSAYS TMRAFSTRHP RSRGLLEGHA LAEARELVAV 
LVRRCAGGAF LDPTQPVIVA VANVMSAVCF GCRYNHDDAE FLELLSHNEE FGRTVGAGSL 
VDVLPWLQLF PNPVRTTFRK FEQLNRNFSN FVLDKFLRHR ESLVPGAAPR DMTDAFILSA 
EKKASGAPGD DSSGLDLEDV PATITDIFGA SQDTLSTALL WLLILFTRYP DVQARVQAEL 
DQVVGRDRLP CMSDQPNLPY VMAFLYESMR FSSFLPVTIP HATTANTFVL GYYIPKNTVV 
FVNQWSVNHD PAKWPNPEDF DPARFLDKDG FINKALASSV MIFSVGKRRC IGEELSKMLL 
FLFISILAHQ CNFKANQNES SNMSFSYGLT IKPKSFRIHV SLRESMELLD NAVKKLQTEE 
GCK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp1b1

Associated with

Other Information

cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1. PubMed ID: 7772257

Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. PubMed ID: 8195121

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Identification of a cytochrome P450 gene by reverse transcription-PCR using degenerate primers containing inosine. PubMed ID: 7505439

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. PubMed ID: 15258110

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression. PubMed ID: 19005183

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress. PubMed ID: 20032512

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. PubMed ID: 23692925

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells. PubMed ID: 23568032

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. PubMed ID: 23979599

Specificity determinants of CYP1B1 estradiol hydroxylation. PubMed ID: 23821647