Details for: ADH7

Gene ID: 131

Symbol: ADH7

Ensembl ID: ENSG00000196344

Description: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53062
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6842
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 3.48
    Marker Score: 2910
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.17
    Marker Score: 16168
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.11
    Marker Score: 18163
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.84
    Marker Score: 2029
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.73
    Marker Score: 1158
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.7
    Marker Score: 13311
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.68
    Marker Score: 1488
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.44
    Marker Score: 1520
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.31
    Marker Score: 1488
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.28
    Marker Score: 1432
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.14
    Marker Score: 1475
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.13
    Marker Score: 2059
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1815.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.93
    Marker Score: 8118
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.83
    Marker Score: 390
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.83
    Marker Score: 2868
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.81
    Marker Score: 233
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1284
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.79
    Marker Score: 456
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1436
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 524
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.61
    Marker Score: 715
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 366
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8873.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.5
    Marker Score: 341
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.5
    Marker Score: 6668
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.48
    Marker Score: 3093
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.45
    Marker Score: 220
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.44
    Marker Score: 1255
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.4
    Marker Score: 211
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.37
    Marker Score: 2492
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 174
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.36
    Marker Score: 1028
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.35
    Marker Score: 730
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.32
    Marker Score: 985
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.31
    Marker Score: 76
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.3
    Marker Score: 175.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.28
    Marker Score: 443
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.27
    Marker Score: 168
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 282
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.23
    Marker Score: 433
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.2
    Marker Score: 96
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.19
    Marker Score: 164
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 215
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.15
    Marker Score: 104.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.14
    Marker Score: 121
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.1
    Marker Score: 312
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.09
    Marker Score: 1262.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 158
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 14

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Other Information

**Key characteristics:** * ADH7 is a protein of approximately 140 kDa. * It is expressed in a variety of cell types, including progenitor cells, microglial cells, keratinocytes, basal cells of the epithelium of the trachea, epithelial cells of the esophagus, corneal epithelial cells, nasal mucosa goblet cells, stratified epithelial cells, basal epithelial cells of the prostatic duct, conjunctival epithelial cells. * It is a regulator of the cellular response to bacteria and retinoic acid. **Pathways and functions:** * ADH7 is involved in multiple pathways, including: * Alcohol dehydrogenase (NAD+) activity * Alcohol dehydrogenase activity * Zinc-dependent * Aldehyde oxidase activity * Biological oxidations * Ethanol binding * Ethanol oxidation * Fatty acid omega-oxidation * Metabolism * Nad-retinol dehydrogenase activity * Omega-hydroxydecanoate dehydrogenase activity * Phase I - functionalization of compounds * It plays a role in the regulation of cellular metabolism and response to various stimuli. **Clinical significance:** * Mutations in the ADH7 gene have been linked to several human diseases, including: * Aldehyde dehydrogenase deficiency * Alcohol use disorders * Retinoid-induced skin cancer * ADH7 inhibitors are being investigated as potential therapeutic agents for these diseases.

Genular Protein ID: 2953191866

Symbol: ADH7_HUMAN

Name: Alcohol dehydrogenase class 4 mu/sigma chain

UniProtKB Accession Codes:

P40394 A2RRB6 A8MVN9 B2R760 B4DWV6 Q13713

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 76 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 20 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 27 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7925371

Title: Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships.

PubMed ID: 7925371

DOI: 10.1111/j.1432-1033.1994.00549.x

PubMed ID: 8195208

Title: The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene.

PubMed ID: 8195208

DOI: 10.1016/s0021-9258(17)40724-1

PubMed ID: 7876191

Title: Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro.

PubMed ID: 7876191

DOI: 10.1074/jbc.270.9.4305

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8082805

Title: Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7).

PubMed ID: 8082805

DOI: 10.1016/0014-5793(94)00895-7

PubMed ID: 7876099

Title: Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes.

PubMed ID: 7876099

DOI: 10.1074/jbc.270.8.3625

PubMed ID: 8824810

Title: Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH.

PubMed ID: 8824810

DOI: 10.1006/geno.1996.0040

PubMed ID: 1592118

Title: Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class.

PubMed ID: 1592118

DOI: 10.1016/0014-5793(92)80479-z

PubMed ID: 7771649

Title: Human stomach class IV alcohol dehydrogenase: molecular genetic analysis.

PubMed ID: 7771649

DOI: 10.1111/j.1530-0277.1995.tb01490.x

PubMed ID: 9600267

Title: Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase.

PubMed ID: 9600267

DOI: 10.1016/s0014-5793(98)00374-3

PubMed ID: 15369820

Title: Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.

PubMed ID: 15369820

DOI: 10.1016/j.abb.2004.07.002

PubMed ID: 16787387

Title: Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.

PubMed ID: 16787387

DOI: 10.1042/bj20051988

PubMed ID: 9228021

Title: X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.

PubMed ID: 9228021

DOI: 10.1074/jbc.272.30.18558

PubMed ID: 10631979

Title: Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.

PubMed ID: 10631979

DOI: 10.1110/ps.8.12.2639

Sequence Information:

  • Length: 386
  • Mass: 41481
  • Checksum: E34C959778ED6817
  • Sequence:
    • MFAEIQIQDK DRMGTAGKVI KCKAAVLWEQ KQPFSIEEIE VAPPKTKEVR IKILATGICR 
TDDHVIKGTM VSKFPVIVGH EATGIVESIG EGVTTVKPGD KVIPLFLPQC RECNACRNPD 
GNLCIRSDIT GRGVLADGTT RFTCKGKPVH HFMNTSTFTE YTVVDESSVA KIDDAAPPEK 
VCLIGCGFST GYGAAVKTGK VKPGSTCVVF GLGGVGLSVI MGCKSAGASR IIGIDLNKDK 
FEKAMAVGAT ECISPKDSTK PISEVLSEMT GNNVGYTFEV IGHLETMIDA LASCHMNYGT 
SVVVGVPPSA KMLTYDPMLL FTGRTWKGCV FGGLKSRDDV PKLVTEFLAK KFDLDQLITH 
VLPFKKISEG FELLNSGQSI RTVLTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.