Details for: ADH7

Gene ID: 131

Symbol: ADH7

Ensembl ID: ENSG00000196344

Description: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5474
    Cell Significance Index: 48.4000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.6245
    Cell Significance Index: 37.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1302
    Cell Significance Index: 59.5300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.9621
    Cell Significance Index: 20.2400
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.3048
    Cell Significance Index: 9.3900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.8718
    Cell Significance Index: 7.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8149
    Cell Significance Index: 19.7400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2456
    Cell Significance Index: 1.6300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.2359
    Cell Significance Index: 1.9500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1488
    Cell Significance Index: 0.9700
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.1246
    Cell Significance Index: 0.9200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1194
    Cell Significance Index: 1.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0177
    Cell Significance Index: 2.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0040
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0071
    Cell Significance Index: -3.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0078
    Cell Significance Index: -3.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0088
    Cell Significance Index: -3.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0102
    Cell Significance Index: -2.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0104
    Cell Significance Index: -1.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0125
    Cell Significance Index: -1.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0130
    Cell Significance Index: -2.6100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0146
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0151
    Cell Significance Index: -2.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0171
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0173
    Cell Significance Index: -2.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0175
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0223
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0275
    Cell Significance Index: -3.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0312
    Cell Significance Index: -0.8500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0352
    Cell Significance Index: -3.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0380
    Cell Significance Index: -0.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0431
    Cell Significance Index: -2.6500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0462
    Cell Significance Index: -0.5000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0473
    Cell Significance Index: -0.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0492
    Cell Significance Index: -0.7000
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0496
    Cell Significance Index: -0.5900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0500
    Cell Significance Index: -0.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0509
    Cell Significance Index: -3.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0550
    Cell Significance Index: -4.2200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0551
    Cell Significance Index: -0.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0569
    Cell Significance Index: -0.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0588
    Cell Significance Index: -2.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0694
    Cell Significance Index: -4.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0702
    Cell Significance Index: -0.7400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0720
    Cell Significance Index: -0.7100
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0752
    Cell Significance Index: -0.6800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0818
    Cell Significance Index: -1.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0821
    Cell Significance Index: -2.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0875
    Cell Significance Index: -2.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0881
    Cell Significance Index: -1.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0881
    Cell Significance Index: -2.8100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0915
    Cell Significance Index: -0.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0928
    Cell Significance Index: -5.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0931
    Cell Significance Index: -2.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0958
    Cell Significance Index: -0.6500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0985
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0986
    Cell Significance Index: -1.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1010
    Cell Significance Index: -2.5200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1034
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1076
    Cell Significance Index: -3.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1078
    Cell Significance Index: -3.4100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1118
    Cell Significance Index: -1.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1131
    Cell Significance Index: -2.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1139
    Cell Significance Index: -5.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1144
    Cell Significance Index: -3.3700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1163
    Cell Significance Index: -0.7200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1186
    Cell Significance Index: -1.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1191
    Cell Significance Index: -6.1900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1211
    Cell Significance Index: -0.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1250
    Cell Significance Index: -5.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1265
    Cell Significance Index: -3.6100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1283
    Cell Significance Index: -1.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1287
    Cell Significance Index: -3.6900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1299
    Cell Significance Index: -2.5900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1311
    Cell Significance Index: -2.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1316
    Cell Significance Index: -0.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1328
    Cell Significance Index: -5.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1350
    Cell Significance Index: -2.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1363
    Cell Significance Index: -2.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1365
    Cell Significance Index: -2.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1391
    Cell Significance Index: -2.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1439
    Cell Significance Index: -3.4500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1450
    Cell Significance Index: -2.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1479
    Cell Significance Index: -2.9700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1482
    Cell Significance Index: -2.9300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1497
    Cell Significance Index: -3.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1510
    Cell Significance Index: -1.6500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1539
    Cell Significance Index: -1.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1547
    Cell Significance Index: -2.8600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1573
    Cell Significance Index: -2.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ADH7 gene exhibits several key characteristics, including: 1. **Class IV ADH enzyme**: ADH7 is a member of the class IV ADH family, which is distinct from other ADH classes. This class is characterized by the presence of a mu/sigma polypeptide chain. 2. **Ethanol oxidation**: ADH7 is primarily involved in the oxidation of ethanol, converting it into acetaldehyde, which is then further metabolized by other enzymes. 3. **Zinc-dependent activity**: ADH7 exhibits zinc-dependent activity, indicating that zinc ions play a crucial role in the enzyme's catalytic function. 4. **Expression in various tissues**: ADH7 is expressed in multiple tissues, including progenitor cells, microglial cells, keratinocytes, and epithelial cells of the trachea, esophagus, and other organs. **Pathways and Functions** ADH7 is involved in several metabolic pathways, including: 1. **Alcohol metabolism**: ADH7 plays a key role in the oxidation of ethanol, which is a critical step in the metabolism of alcohol. 2. **Biological oxidations**: ADH7 is involved in the oxidation of various substances, including aldehydes and fatty acids. 3. **Fatty acid omega-oxidation**: ADH7 is also involved in the oxidation of fatty acids, which is an essential process for the production of energy. 4. **Retinoid metabolism**: ADH7 is involved in the metabolism of retinoids, which are essential for vision, cell growth, and differentiation. **Clinical Significance** The ADH7 gene has several clinical implications, including: 1. **Alcohol metabolism disorders**: Variations in the ADH7 gene can lead to impaired ethanol metabolism, resulting in alcohol dependence and related disorders. 2. **Ethanol sensitivity**: Individuals with ADH7 variations may exhibit increased sensitivity to ethanol, leading to adverse effects at lower doses. 3. **Cancer risk**: The expression of ADH7 in certain tissues may be associated with an increased risk of cancer, particularly in the context of ethanol metabolism. 4. **Neurological disorders**: ADH7 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, which may be related to impaired ethanol metabolism. In conclusion, the ADH7 gene plays a critical role in the metabolism of ethanol and other substances, and its dysregulation can lead to various clinical disorders. Further research is needed to fully understand the mechanisms underlying ADH7 function and its clinical significance.

Genular Protein ID: 2953191866

Symbol: ADH7_HUMAN

Name: Alcohol dehydrogenase class 4 mu/sigma chain

UniProtKB Accession Codes:

P40394 A2RRB6 A8MVN9 B2R760 B4DWV6 Q13713

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 76 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 20 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 27 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7925371

Title: Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships.

PubMed ID: 7925371

DOI: 10.1111/j.1432-1033.1994.00549.x

PubMed ID: 8195208

Title: The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene.

PubMed ID: 8195208

DOI: 10.1016/s0021-9258(17)40724-1

PubMed ID: 7876191

Title: Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro.

PubMed ID: 7876191

DOI: 10.1074/jbc.270.9.4305

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8082805

Title: Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7).

PubMed ID: 8082805

DOI: 10.1016/0014-5793(94)00895-7

PubMed ID: 7876099

Title: Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes.

PubMed ID: 7876099

DOI: 10.1074/jbc.270.8.3625

PubMed ID: 8824810

Title: Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH.

PubMed ID: 8824810

DOI: 10.1006/geno.1996.0040

PubMed ID: 1592118

Title: Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class.

PubMed ID: 1592118

DOI: 10.1016/0014-5793(92)80479-z

PubMed ID: 7771649

Title: Human stomach class IV alcohol dehydrogenase: molecular genetic analysis.

PubMed ID: 7771649

DOI: 10.1111/j.1530-0277.1995.tb01490.x

PubMed ID: 9600267

Title: Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase.

PubMed ID: 9600267

DOI: 10.1016/s0014-5793(98)00374-3

PubMed ID: 15369820

Title: Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.

PubMed ID: 15369820

DOI: 10.1016/j.abb.2004.07.002

PubMed ID: 16787387

Title: Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.

PubMed ID: 16787387

DOI: 10.1042/bj20051988

PubMed ID: 9228021

Title: X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.

PubMed ID: 9228021

DOI: 10.1074/jbc.272.30.18558

PubMed ID: 10631979

Title: Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.

PubMed ID: 10631979

DOI: 10.1110/ps.8.12.2639

Sequence Information:

  • Length: 386
  • Mass: 41481
  • Checksum: E34C959778ED6817
  • Sequence:
    • MFAEIQIQDK DRMGTAGKVI KCKAAVLWEQ KQPFSIEEIE VAPPKTKEVR IKILATGICR 
TDDHVIKGTM VSKFPVIVGH EATGIVESIG EGVTTVKPGD KVIPLFLPQC RECNACRNPD 
GNLCIRSDIT GRGVLADGTT RFTCKGKPVH HFMNTSTFTE YTVVDESSVA KIDDAAPPEK 
VCLIGCGFST GYGAAVKTGK VKPGSTCVVF GLGGVGLSVI MGCKSAGASR IIGIDLNKDK 
FEKAMAVGAT ECISPKDSTK PISEVLSEMT GNNVGYTFEV IGHLETMIDA LASCHMNYGT 
SVVVGVPPSA KMLTYDPMLL FTGRTWKGCV FGGLKSRDDV PKLVTEFLAK KFDLDQLITH 
VLPFKKISEG FELLNSGQSI RTVLTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.