ADH7 | ENSG00000196344 | NCBI 131

Details for: ADH7

Gene ID: 131

Symbol: ADH7

Ensembl ID: ENSG00000196344

Description: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Associated with

Biological oxidations
(R-HSA-211859)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Alcohol dehydrogenase (nad+) activity
(GO:0004022)
Alcohol dehydrogenase activity, zinc-dependent
(GO:0004024)
Aldehyde oxidase activity
(GO:0004031)
Cytosol
(GO:0005829)
Ethanol binding
(GO:0035276)
Ethanol oxidation
(GO:0006069)
Fatty acid omega-oxidation
(GO:0010430)
Nad-retinol dehydrogenase activity
(GO:0004745)
Omega-hydroxydecanoate dehydrogenase activity
(GO:0050153)
Plasma membrane
(GO:0005886)
Receptor antagonist activity
(GO:0048019)
Response to bacterium
(GO:0009617)
Response to ethanol
(GO:0045471)
Retinoic acid metabolic process
(GO:0042573)
Retinoid metabolic process
(GO:0001523)
Retinol binding
(GO:0019841)
Retinol metabolic process
(GO:0042572)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Alcohol dehydrogenase class 4 mu/sigma chain

Genular Protein ID: 2953191866

Symbol: ADH7_HUMAN

Name: Alcohol dehydrogenase class 4 mu/sigma chain

UniProtKB Accession Codes:

P40394 A2RRB6 A8MVN9 B2R760 B4DWV6 Q13713

Database IDs:

Citations:

PubMed ID: 7925371

Title: Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships.

PubMed ID: 7925371

DOI: 10.1111/j.1432-1033.1994.00549.x

PubMed ID: 8195208

Title: The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene.

PubMed ID: 8195208

DOI: 10.1016/s0021-9258(17)40724-1

PubMed ID: 7876191

Title: Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro.

PubMed ID: 7876191

DOI: 10.1074/jbc.270.9.4305

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8082805

Title: Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7).

PubMed ID: 8082805

DOI: 10.1016/0014-5793(94)00895-7

PubMed ID: 7876099

Title: Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes.

PubMed ID: 7876099

DOI: 10.1074/jbc.270.8.3625

PubMed ID: 8824810

Title: Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH.

PubMed ID: 8824810

DOI: 10.1006/geno.1996.0040

PubMed ID: 1592118

Title: Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class.

PubMed ID: 1592118

DOI: 10.1016/0014-5793(92)80479-z

PubMed ID: 7771649

Title: Human stomach class IV alcohol dehydrogenase: molecular genetic analysis.

PubMed ID: 7771649

DOI: 10.1111/j.1530-0277.1995.tb01490.x

PubMed ID: 9600267

Title: Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase.

PubMed ID: 9600267

DOI: 10.1016/s0014-5793(98)00374-3

PubMed ID: 15369820

Title: Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.

PubMed ID: 15369820

DOI: 10.1016/j.abb.2004.07.002

PubMed ID: 16787387

Title: Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.

PubMed ID: 16787387

DOI: 10.1042/bj20051988

PubMed ID: 9228021

Title: X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.

PubMed ID: 9228021

DOI: 10.1074/jbc.272.30.18558

PubMed ID: 10631979

Title: Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.

PubMed ID: 10631979

DOI: 10.1110/ps.8.12.2639

Sequence Information:

Length: 386
Mass: 41481
Checksum: E34C959778ED6817
Sequence:

MFAEIQIQDK DRMGTAGKVI KCKAAVLWEQ KQPFSIEEIE VAPPKTKEVR IKILATGICR 
TDDHVIKGTM VSKFPVIVGH EATGIVESIG EGVTTVKPGD KVIPLFLPQC RECNACRNPD 
GNLCIRSDIT GRGVLADGTT RFTCKGKPVH HFMNTSTFTE YTVVDESSVA KIDDAAPPEK 
VCLIGCGFST GYGAAVKTGK VKPGSTCVVF GLGGVGLSVI MGCKSAGASR IIGIDLNKDK 
FEKAMAVGAT ECISPKDSTK PISEVLSEMT GNNVGYTFEV IGHLETMIDA LASCHMNYGT 
SVVVGVPPSA KMLTYDPMLL FTGRTWKGCV FGGLKSRDDV PKLVTEFLAK KFDLDQLITH 
VLPFKKISEG FELLNSGQSI RTVLTF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADH7

Associated with

Other Information

Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. PubMed ID: 7925371

The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. PubMed ID: 8195208

Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. PubMed ID: 7876191

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7). PubMed ID: 8082805

Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes. PubMed ID: 7876099

Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH. PubMed ID: 8824810

Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class. PubMed ID: 1592118

Human stomach class IV alcohol dehydrogenase: molecular genetic analysis. PubMed ID: 7771649

Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase. PubMed ID: 9600267

Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80. PubMed ID: 15369820

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. PubMed ID: 16787387

X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity. PubMed ID: 9228021

Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase. PubMed ID: 10631979