Details for: COL19A1

Gene ID: 1310

Symbol: COL19A1

Ensembl ID: ENSG00000082293

Description: collagen type XIX alpha 1 chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.5280
    Cell Significance Index: 156.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.4638
    Cell Significance Index: 59.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.4235
    Cell Significance Index: 230.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3253
    Cell Significance Index: 125.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3126
    Cell Significance Index: -7.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.1870
    Cell Significance Index: 77.7600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.7477
    Cell Significance Index: 34.6000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.4716
    Cell Significance Index: 39.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7852
    Cell Significance Index: 354.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.7798
    Cell Significance Index: 50.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6410
    Cell Significance Index: 329.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3485
    Cell Significance Index: 932.6900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.2901
    Cell Significance Index: 16.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9652
    Cell Significance Index: 6.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9375
    Cell Significance Index: 71.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7839
    Cell Significance Index: 15.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7796
    Cell Significance Index: 10.4000
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.7782
    Cell Significance Index: 7.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6711
    Cell Significance Index: 17.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5793
    Cell Significance Index: 16.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3465
    Cell Significance Index: 8.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2440
    Cell Significance Index: 15.0000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2065
    Cell Significance Index: 2.9700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1302
    Cell Significance Index: 1.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0914
    Cell Significance Index: 32.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0840
    Cell Significance Index: 1.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0013
    Cell Significance Index: 1.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0126
    Cell Significance Index: -8.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0221
    Cell Significance Index: -16.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0243
    Cell Significance Index: -3.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0288
    Cell Significance Index: -21.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0292
    Cell Significance Index: -13.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0349
    Cell Significance Index: -0.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0381
    Cell Significance Index: -21.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0443
    Cell Significance Index: -0.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0455
    Cell Significance Index: -0.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0496
    Cell Significance Index: -14.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0506
    Cell Significance Index: -7.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0644
    Cell Significance Index: -11.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0657
    Cell Significance Index: -2.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0660
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0668
    Cell Significance Index: -11.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0839
    Cell Significance Index: -4.7100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0965
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1032
    Cell Significance Index: -21.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1125
    Cell Significance Index: -13.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1171
    Cell Significance Index: -16.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1190
    Cell Significance Index: -14.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1375
    Cell Significance Index: -17.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1385
    Cell Significance Index: -2.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1545
    Cell Significance Index: -15.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1554
    Cell Significance Index: -17.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1613
    Cell Significance Index: -16.8000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1682
    Cell Significance Index: -1.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1749
    Cell Significance Index: -20.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2047
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2062
    Cell Significance Index: -16.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2092
    Cell Significance Index: -4.2000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2217
    Cell Significance Index: -0.9700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2269
    Cell Significance Index: -2.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2436
    Cell Significance Index: -11.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2449
    Cell Significance Index: -15.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2647
    Cell Significance Index: -16.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2954
    Cell Significance Index: -15.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2969
    Cell Significance Index: -3.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2987
    Cell Significance Index: -10.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3203
    Cell Significance Index: -3.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3252
    Cell Significance Index: -16.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3372
    Cell Significance Index: -4.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3496
    Cell Significance Index: -16.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3602
    Cell Significance Index: -18.7100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3640
    Cell Significance Index: -3.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3700
    Cell Significance Index: -9.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3969
    Cell Significance Index: -17.9900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4132
    Cell Significance Index: -4.8200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4263
    Cell Significance Index: -5.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4346
    Cell Significance Index: -9.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4384
    Cell Significance Index: -6.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4413
    Cell Significance Index: -16.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4585
    Cell Significance Index: -16.1100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.4599
    Cell Significance Index: -5.1100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.4665
    Cell Significance Index: -6.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4675
    Cell Significance Index: -10.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4828
    Cell Significance Index: -13.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5347
    Cell Significance Index: -15.7500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.5391
    Cell Significance Index: -5.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5397
    Cell Significance Index: -17.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5748
    Cell Significance Index: -6.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5775
    Cell Significance Index: -15.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5790
    Cell Significance Index: -14.0300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5929
    Cell Significance Index: -4.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6104
    Cell Significance Index: -26.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6269
    Cell Significance Index: -17.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6304
    Cell Significance Index: -10.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6349
    Cell Significance Index: -13.1700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6358
    Cell Significance Index: -4.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COL19A1 is a member of the collagen family, specifically a type XIX collagen, which is characterized by its unique structure and function. It is composed of three alpha chains (α1, α2, and α3) and is expressed in various tissues, including epithelial cells, fibroblasts, and endothelial cells. COL19A1 is predominantly found in the ECM, where it interacts with other ECM components, such as collagen type I and IV, to form a stable and dynamic network. **Pathways and Functions:** COL19A1 is involved in various cellular processes, including cell-cell adhesion, differentiation, and ECM organization. It interacts with other ECM components to form a complex network that regulates cell migration, proliferation, and survival. COL19A1 also plays a role in collagen chain trimerization, which is essential for the formation of a stable ECM. Furthermore, COL19A1 is involved in the degradation and remodeling of the ECM, which is critical for tissue homeostasis and repair. **Clinical Significance:** Dysregulation of COL19A1 has been implicated in various diseases, including: 1. **Lung diseases:** COL19A1 is significantly expressed in epithelial cells of the alveolus, where it plays a crucial role in maintaining alveolar structure and function. Mutations in COL19A1 have been associated with lung diseases, such as pulmonary fibrosis and emphysema. 2. **Skin diseases:** COL19A1 is expressed in fibroblasts and endothelial cells, where it contributes to skin ECM organization and integrity. Mutations in COL19A1 have been linked to skin disorders, including epidermolysis bullosa simplex. 3. **Cardiovascular diseases:** COL19A1 is expressed in cardiac tissue, where it plays a role in maintaining cardiac ECM organization and function. Mutations in COL19A1 have been associated with cardiac arrhythmias and cardiomyopathy. In conclusion, COL19A1 is a critical component of the ECM that plays a pivotal role in maintaining tissue integrity and function. Its dysregulation has been implicated in various diseases, emphasizing the importance of understanding its immunological significance. Further research is needed to elucidate the mechanisms underlying COL19A1's role in disease and to develop novel therapeutic strategies for the treatment of COL19A1-related disorders. **References:** * [Insert relevant references to support the discussion] **Author's Note:** As an expert immunologist, it is essential to acknowledge the limitations of this review and to emphasize the need for further research to fully understand the immunological significance of COL19A1. This review aims to provide a comprehensive overview of COL19A1's role in maintaining tissue integrity and its clinical implications, but it is by no means exhaustive.

Genular Protein ID: 2503171493

Symbol: COJA1_HUMAN

Name: Collagen alpha-1(XIX) chain

UniProtKB Accession Codes:

Q14993 Q00559 Q05850 Q12885 Q13676 Q14DH1 Q5JUF0 Q5T424 Q9H572 Q9NPZ2 Q9NQP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7775380

Title: The mRNA for alpha 1(XIX) collagen chain, a new member of FACITs, contains a long unusual 3' untranslated region and displays many unique splicing variants.

PubMed ID: 7775380

DOI: 10.1093/oxfordjournals.jbchem.a124700

PubMed ID: 9344653

Title: Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family.

PubMed ID: 9344653

DOI: 10.1006/geno.1997.4921

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639419

Title: Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans.

PubMed ID: 1639419

DOI: 10.1016/0888-7543(92)90176-s

PubMed ID: 7916703

Title: Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain.

PubMed ID: 7916703

DOI: 10.1016/0378-1119(93)90126-n

PubMed ID: 8034603

Title: The triple-helical region of human type XIX collagen consists of multiple collagenous subdomains and exhibits limited sequence homology to alpha 1(XVI).

PubMed ID: 8034603

DOI: 10.1016/s0021-9258(17)32344-x

PubMed ID: 12788917

Title: Type XIX collagen purified from human umbilical cord is characterized by multiple sharp kinks delineating collagenous subdomains and by intermolecular aggregates via globular, disulfide-linked, and heparin-binding amino termini.

PubMed ID: 12788917

DOI: 10.1074/jbc.m304629200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1142
  • Mass: 115221
  • Checksum: F1153CE751387943
  • Sequence:
    • MRLTGPWKLW LWMSIFLLPA STSVTVRDKT EESCPILRIE GHQLTYDNIN KLEVSGFDLG 
DSFSLRRAFC ESDKTCFKLG SALLIRDTIK IFPKGLPEEY SVAAMFRVRR NAKKERWFLW 
QVLNQQNIPQ ISIVVDGGKK VVEFMFQATE GDVLNYIFRN RELRPLFDRQ WHKLGISIQS 
QVISLYMDCN LIARRQTDEK DTVDFHGRTV IATRASDGKP VDIELHQLKI YCSANLIAQE 
TCCEISDTKC PEQDGFGNIA SSWVTAHASK MSSYLPAKQE LKDQCQCIPN KGEAGLPGAP 
GSPGQKGHKG EPGENGLHGA PGFPGQKGEQ GFEGSKGETG EKGEQGEKGD PALAGLNGEN 
GLKGDLGPHG PPGPKGEKGD TGPPGPPALP GSLGIQGPQG PPGKEGQRGR RGKTGPPGKP 
GPPGPPGPPG IQGIHQTLGG YYNKDNKGND EHEAGGLKGD KGETGLPGFP GSVGPKGQKG 
EPGEPFTKGE KGDRGEPGVI GSQGVKGEPG DPGPPGLIGS PGLKGQQGSA GSMGPRGPPG 
DVGLPGEHGI PGKQGIKGEK GDPGGIIGPP GLPGPKGEAG PPGKSLPGEP GLDGNPGAPG 
PRGPKGERGL PGVHGSPGDI GPQGIGIPGR TGAQGPAGEP GIQGPRGLPG LPGTPGTPGN 
DGVPGRDGKP GLPGPPGDPI ALPLLGDIGA LLKNFCGNCQ ASVPGLKSNK GEEGGAGEPG 
KYDSMARKGD IGPRGPPGIP GREGPKGSKG ERGYPGIPGE KGDEGLQGIP GIPGAPGPTG 
PPGLMGRTGH PGPTGAKGEK GSDGPPGKPG PPGPPGIPFN ERNGMSSLYK IKGGVNVPSY 
PGPPGPPGPK GDPGPVGEPG AMGLPGLEGF PGVKGDRGPA GPPGIAGMSG KPGAPGPPGV 
PGEPGERGPV GDIGFPGPEG PSGKPGINGK DGIPGAQGIM GKPGDRGPKG ERGDQGIPGD 
RGSQGERGKP GLTGMKGAIG PMGPPGNKGS MGSPGHQGPP GSPGIPGIPA DAVSFEEIKK 
YINQEVLRIF EERMAVFLSQ LKLPAAMLAA QAYGRPGPPG KDGLPGPPGD PGPQGYRGQK 
GERGEPGIGL PGSPGLPGTS ALGLPGSPGA PGPQGPPGPS GRCNPEDCLY PVSHAHQRTG 
GN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.