Details for: COL19A1

Gene ID: 1310

Symbol: COL19A1

Ensembl ID: ENSG00000082293

Description: collagen type XIX alpha 1 chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.64
    Marker Score: 2529
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 5.14
    Marker Score: 4931
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.93
    Marker Score: 11292
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.99
    Marker Score: 17986
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.24
    Marker Score: 1089
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.94
    Marker Score: 5535
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.91
    Marker Score: 37994
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15660
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.79
    Marker Score: 39919
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.73
    Marker Score: 3278
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.71
    Marker Score: 17697
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.67
    Marker Score: 5927
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.6
    Marker Score: 809
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.57
    Marker Score: 579
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.54
    Marker Score: 1631
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.48
    Marker Score: 2455
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.46
    Marker Score: 1576
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.44
    Marker Score: 3010
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.4
    Marker Score: 3296
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.35
    Marker Score: 1917
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3
    Marker Score: 2649
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.3
    Marker Score: 855
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18180
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42709
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1777
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.12
    Marker Score: 707.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.11
    Marker Score: 2143
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.09
    Marker Score: 67277
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.06
    Marker Score: 1046
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 637
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.01
    Marker Score: 6695
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1
    Marker Score: 558
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71794
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48019
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.98
    Marker Score: 9343
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.89
    Marker Score: 791
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.87
    Marker Score: 3558
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.87
    Marker Score: 2183
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.86
    Marker Score: 348
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.83
    Marker Score: 481
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.8
    Marker Score: 1388
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.79
    Marker Score: 360
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.79
    Marker Score: 979
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.78
    Marker Score: 780
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.77
    Marker Score: 29357
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.77
    Marker Score: 290
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.77
    Marker Score: 177
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 236
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.7
    Marker Score: 2407.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.69
    Marker Score: 250
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.68
    Marker Score: 248
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.67
    Marker Score: 2381
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.66
    Marker Score: 371
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.66
    Marker Score: 451
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.66
    Marker Score: 144
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.65
    Marker Score: 251
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.63
    Marker Score: 1154
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.63
    Marker Score: 564
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 193
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.61
    Marker Score: 2276
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.61
    Marker Score: 400
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 289
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6
    Marker Score: 1002
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.59
    Marker Score: 343
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 457
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.57
    Marker Score: 935
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 147
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.56
    Marker Score: 2349
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.55
    Marker Score: 141
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.54
    Marker Score: 471
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.54
    Marker Score: 946.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.53
    Marker Score: 691
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.52
    Marker Score: 384
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.52
    Marker Score: 574
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.52
    Marker Score: 584
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.51
    Marker Score: 4805
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.5
    Marker Score: 1272
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.5
    Marker Score: 620
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.48
    Marker Score: 7651
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.47
    Marker Score: 450
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.46
    Marker Score: 592
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.45
    Marker Score: 243
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.45
    Marker Score: 155
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.45
    Marker Score: 484.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.43
    Marker Score: 1240

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Other Information

**Key characteristics:** * Type: Collagen type XIX * Ensembl ID: ENSG00000082293 * Protein length: 121 amino acids * Molecular weight: 250 kDa * Sequence: COL19A1 is a secreted protein **Pathways and functions:** * Cell-cell adhesion: COL19A1 is a key component of cell-cell adhesion complexes, where it helps to strengthen and maintain tissue integrity. * Cell adhesion: COL19A1 is also involved in cell adhesion between epithelial cells, endothelial cells, and cardiac cells. * Cell differentiation: COL19A1 is a key regulator of cell differentiation, as it is expressed in various cell types during development. * Collagen biosynthesis and modifying enzymes: COL19A1 is a key component of the extracellular matrix (ECM), where it is synthesized by fibroblasts and secreted by endothelial cells. It is also a substrate for a variety of collagen modifying enzymes. * Collagen chain trimerization: COL19A1 is a major component of the extracellular matrix trimer, a complex network of collagen fibers that provides structural support and elasticity to tissues. * Collagen degradation: COL19A1 is also involved in the degradation of the extracellular matrix, where it is cleaved by proteases to release collagen fragments that can be used by other cells. * Extracellular matrix structural constituent: COL19A1 is a major component of the extracellular matrix, where it provides strength and elasticity. * Extracellular region: COL19A1 is a component of the extracellular matrix structural constituent, which is responsible for the mechanical properties of tissues. * Extracellular space: The extracellular space is a space between cells and between the ECM and the underlying tissue. **Clinical significance:** Mutations in COL19A1 have been linked to a number of human diseases, including pulmonary fibrosis, rheumatoid arthritis, and osteoporosis. These diseases are characterized by the formation of abnormal ECMs, which can lead to tissue damage and dysfunction. Therefore, COL19A1 is an important target for the treatment of these diseases.

Genular Protein ID: 2503171493

Symbol: COJA1_HUMAN

Name: Collagen alpha-1(XIX) chain

UniProtKB Accession Codes:

Q14993 Q00559 Q05850 Q12885 Q13676 Q14DH1 Q5JUF0 Q5T424 Q9H572 Q9NPZ2 Q9NQP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7775380

Title: The mRNA for alpha 1(XIX) collagen chain, a new member of FACITs, contains a long unusual 3' untranslated region and displays many unique splicing variants.

PubMed ID: 7775380

DOI: 10.1093/oxfordjournals.jbchem.a124700

PubMed ID: 9344653

Title: Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family.

PubMed ID: 9344653

DOI: 10.1006/geno.1997.4921

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639419

Title: Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans.

PubMed ID: 1639419

DOI: 10.1016/0888-7543(92)90176-s

PubMed ID: 7916703

Title: Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain.

PubMed ID: 7916703

DOI: 10.1016/0378-1119(93)90126-n

PubMed ID: 8034603

Title: The triple-helical region of human type XIX collagen consists of multiple collagenous subdomains and exhibits limited sequence homology to alpha 1(XVI).

PubMed ID: 8034603

DOI: 10.1016/s0021-9258(17)32344-x

PubMed ID: 12788917

Title: Type XIX collagen purified from human umbilical cord is characterized by multiple sharp kinks delineating collagenous subdomains and by intermolecular aggregates via globular, disulfide-linked, and heparin-binding amino termini.

PubMed ID: 12788917

DOI: 10.1074/jbc.m304629200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1142
  • Mass: 115221
  • Checksum: F1153CE751387943
  • Sequence:
    • MRLTGPWKLW LWMSIFLLPA STSVTVRDKT EESCPILRIE GHQLTYDNIN KLEVSGFDLG 
DSFSLRRAFC ESDKTCFKLG SALLIRDTIK IFPKGLPEEY SVAAMFRVRR NAKKERWFLW 
QVLNQQNIPQ ISIVVDGGKK VVEFMFQATE GDVLNYIFRN RELRPLFDRQ WHKLGISIQS 
QVISLYMDCN LIARRQTDEK DTVDFHGRTV IATRASDGKP VDIELHQLKI YCSANLIAQE 
TCCEISDTKC PEQDGFGNIA SSWVTAHASK MSSYLPAKQE LKDQCQCIPN KGEAGLPGAP 
GSPGQKGHKG EPGENGLHGA PGFPGQKGEQ GFEGSKGETG EKGEQGEKGD PALAGLNGEN 
GLKGDLGPHG PPGPKGEKGD TGPPGPPALP GSLGIQGPQG PPGKEGQRGR RGKTGPPGKP 
GPPGPPGPPG IQGIHQTLGG YYNKDNKGND EHEAGGLKGD KGETGLPGFP GSVGPKGQKG 
EPGEPFTKGE KGDRGEPGVI GSQGVKGEPG DPGPPGLIGS PGLKGQQGSA GSMGPRGPPG 
DVGLPGEHGI PGKQGIKGEK GDPGGIIGPP GLPGPKGEAG PPGKSLPGEP GLDGNPGAPG 
PRGPKGERGL PGVHGSPGDI GPQGIGIPGR TGAQGPAGEP GIQGPRGLPG LPGTPGTPGN 
DGVPGRDGKP GLPGPPGDPI ALPLLGDIGA LLKNFCGNCQ ASVPGLKSNK GEEGGAGEPG 
KYDSMARKGD IGPRGPPGIP GREGPKGSKG ERGYPGIPGE KGDEGLQGIP GIPGAPGPTG 
PPGLMGRTGH PGPTGAKGEK GSDGPPGKPG PPGPPGIPFN ERNGMSSLYK IKGGVNVPSY 
PGPPGPPGPK GDPGPVGEPG AMGLPGLEGF PGVKGDRGPA GPPGIAGMSG KPGAPGPPGV 
PGEPGERGPV GDIGFPGPEG PSGKPGINGK DGIPGAQGIM GKPGDRGPKG ERGDQGIPGD 
RGSQGERGKP GLTGMKGAIG PMGPPGNKGS MGSPGHQGPP GSPGIPGIPA DAVSFEEIKK 
YINQEVLRIF EERMAVFLSQ LKLPAAMLAA QAYGRPGPPG KDGLPGPPGD PGPQGYRGQK 
GERGEPGIGL PGSPGLPGTS ALGLPGSPGA PGPQGPPGPS GRCNPEDCLY PVSHAHQRTG 
GN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.