Details for: COMP

Gene ID: 1311

Symbol: COMP

Ensembl ID: ENSG00000105664

Description: cartilage oligomeric matrix protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.06
    Marker Score: 2609
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 395.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.95
    Marker Score: 247
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.94
    Marker Score: 639
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 408
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.76
    Marker Score: 296
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1328
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.69
    Marker Score: 356
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1304
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 377
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.47
    Marker Score: 641
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 185
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.44
    Marker Score: 108
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.43
    Marker Score: 269
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.41
    Marker Score: 723
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6217
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.39
    Marker Score: 802
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.36
    Marker Score: 191
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 147
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.31
    Marker Score: 130
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.31
    Marker Score: 881
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 305
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 171
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.29
    Marker Score: 92.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.28
    Marker Score: 352
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 128
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.25
    Marker Score: 655
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 144
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 143
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.17
    Marker Score: 259
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.17
    Marker Score: 259
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 897
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 304
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 122
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.11
    Marker Score: 163
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.11
    Marker Score: 139
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 159
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.1
    Marker Score: 85
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1
    Marker Score: 51.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.07
    Marker Score: 486
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.07
    Marker Score: 94
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 18

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Other Information

**Key characteristics:** * The COMP gene is highly expressed in cartilage, particularly in the joints, bones, and cartilaginous tissues of the respiratory tract. * It is a secreted protein that forms a complex network of interactions with other ECM proteins and signaling molecules. * Studies have shown that COMP is essential for the survival, migration, and differentiation of chondrocytes, which are the cells responsible for cartilage formation and maintenance. * It also plays a role in the regulation of cell migration, proliferation, and apoptosis (programmed cell death). **Pathways and functions:** * COMP is a key regulator of cartilage development and remodeling. * It is involved in the formation of the embryonic cartilage field and maintains the integrity of mature cartilage tissues. * It is a major component of the extracellular matrix, where it forms complexes with other ECM proteins to form the structural scaffold of cartilage. * COMP signaling has been shown to play a role in cell migration, adhesion, and differentiation in cartilage. * It is also involved in the regulation of inflammation and pain sensation. **Clinical significance:** * Mutations in the COMP gene have been linked to various human diseases, including rheumatoid arthritis (RA), osteoarthritis, and cartilage defects. * Targeting COMP signaling has emerged as a potential therapeutic strategy for these diseases. * By blocking COMP signaling, it is possible to inhibit cartilage destruction and promote cartilage regeneration. **Additional notes:** * The COMP gene is also expressed in other tissues, such as the heart, lungs, and skin. * It is a highly conserved protein, with a similar gene found in mammals, birds, and reptiles. * The COMP protein is a multi-functional protein that can interact with various ECM proteins and signaling molecules.

Genular Protein ID: 1907263999

Symbol: COMP_HUMAN

Name: Thrombospondin-5

UniProtKB Accession Codes:

P49747 B4DKJ3 O14592 Q16388 Q16389 Q2NL86 Q8N4T2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7713493

Title: Characterization of human and mouse cartilage oligomeric matrix protein.

PubMed ID: 7713493

DOI: 10.1006/geno.1994.1649

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7670472

Title: Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.

PubMed ID: 7670472

DOI: 10.1038/ng0795-330

PubMed ID: 10852928

Title: Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes.

PubMed ID: 10852928

DOI: 10.1074/jbc.m909780199

PubMed ID: 11084047

Title: Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX.

PubMed ID: 11084047

DOI: 10.1074/jbc.m009512200

PubMed ID: 12225811

Title: Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin.

PubMed ID: 12225811

DOI: 10.1016/s0945-053x(02)00015-x

PubMed ID: 15075323

Title: Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.

PubMed ID: 15075323

DOI: 10.1074/jbc.m403778200

PubMed ID: 16051604

Title: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.

PubMed ID: 16051604

DOI: 10.1074/jbc.m504778200

PubMed ID: 16542502

Title: Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis.

PubMed ID: 16542502

DOI: 10.1186/ar1922

PubMed ID: 16611630

Title: ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.

PubMed ID: 16611630

DOI: 10.1074/jbc.m513433200

PubMed ID: 17588949

Title: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.

PubMed ID: 17588949

DOI: 10.1074/jbc.m611390200

PubMed ID: 17993464

Title: Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.

PubMed ID: 17993464

DOI: 10.1074/jbc.m704035200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19276170

Title: The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding.

PubMed ID: 19276170

DOI: 10.1096/fj.08-128090

PubMed ID: 7670471

Title: Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia.

PubMed ID: 7670471

DOI: 10.1038/ng0795-325

PubMed ID: 9021009

Title: Multiple epiphyseal dysplasia, ribbing type: a novel point mutation in the COMP gene in a South African family.

PubMed ID: 9021009

DOI: 10.1002/(sici)1096-8628(19970211)68:4<396::aid-ajmg4>3.3.co;2-r

PubMed ID: 9184241

Title: Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein.

PubMed ID: 9184241

DOI: 10.1111/j.1399-0004.1997.tb02458.x

PubMed ID: 9463320

Title: Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum.

PubMed ID: 9463320

DOI: 10.1086/301713

PubMed ID: 9921895

Title: Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in pseudoachondroplasia and multiple epiphyseal dysplasia.

PubMed ID: 9921895

DOI: 10.1007/s004390050883

PubMed ID: 9452026

Title: Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia.

PubMed ID: 9452026

DOI: 10.1002/humu.1380110105

PubMed ID: 9452063

Title: Pseudoachondroplasia due to the substitution of the highly conserved Asp482 by Gly in the seventh calmodulin-like repeat of cartilage oligomeric matrix protein.

PubMed ID: 9452063

DOI: 10.1002/humu.1380110142

PubMed ID: 11746045

Title: Double heterozygosity for pseudoachondroplasia and spondyloepiphyseal dysplasia congenita.

PubMed ID: 11746045

DOI: 10.1002/ajmg.10062

PubMed ID: 11746044

Title: Novel mutation in exon 18 of the cartilage oligomeric matrix protein gene causes a severe pseudoachondroplasia.

PubMed ID: 11746044

DOI: 10.1002/ajmg.10067

PubMed ID: 11565064

Title: A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity.

PubMed ID: 11565064

DOI: 10.1086/324023

PubMed ID: 21922596

Title: Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution.

PubMed ID: 21922596

DOI: 10.1002/humu.21611

PubMed ID: 32686688

Title: Mutations in COMP cause familial carpal tunnel syndrome.

PubMed ID: 32686688

DOI: 10.1038/s41467-020-17378-z

PubMed ID: 32747625

Title: Author Correction: Mutations in COMP cause familial carpal tunnel syndrome.

PubMed ID: 32747625

DOI: 10.1038/s41467-020-17845-7

Sequence Information:

  • Length: 757
  • Mass: 82860
  • Checksum: A0B73AADB39FBC7B
  • Sequence:
    • MVPDTACVLL LTLAALGASG QGQSPLGSDL GPQMLRELQE TNAALQDVRE LLRQQVREIT 
FLKNTVMECD ACGMQQSVRT GLPSVRPLLH CAPGFCFPGV ACIQTESGAR CGPCPAGFTG 
NGSHCTDVNE CNAHPCFPRV RCINTSPGFR CEACPPGYSG PTHQGVGLAF AKANKQVCTD 
INECETGQHN CVPNSVCINT RGSFQCGPCQ PGFVGDQASG CQRRAQRFCP DGSPSECHEH 
ADCVLERDGS RSCVCAVGWA GNGILCGRDT DLDGFPDEKL RCPERQCRKD NCVTVPNSGQ 
EDVDRDGIGD ACDPDADGDG VPNEKDNCPL VRNPDQRNTD EDKWGDACDN CRSQKNDDQK 
DTDQDGRGDA CDDDIDGDRI RNQADNCPRV PNSDQKDSDG DGIGDACDNC PQKSNPDQAD 
VDHDFVGDAC DSDQDQDGDG HQDSRDNCPT VPNSAQEDSD HDGQGDACDD DDDNDGVPDS 
RDNCRLVPNP GQEDADRDGV GDVCQDDFDA DKVVDKIDVC PENAEVTLTD FRAFQTVVLD 
PEGDAQIDPN WVVLNQGREI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDYAGFI 
FGYQDSSSFY VVMWKQMEQT YWQANPFRAV AEPGIQLKAV KSSTGPGEQL RNALWHTGDT 
ESQVRLLWKD PRNVGWKDKK SYRWFLQHRP QVGYIRVRFY EGPELVADSN VVLDTTMRGG 
RLGVFCFSQE NIIWANLRYR CNDTIPEDYE THQLRQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.