Genular: Defining Cellular Identity and Function

Details for: Cyp27b1

Gene ID: 13115

Symbol: Cyp27b1

Ensembl ID: ENSMUSG00000006724

Description: cytochrome P450, family 27, subfamily b, polypeptide 1

Associated with

Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Phase i - functionalization of compounds
(R-MMU-211945)
Vitamin d (calciferol) metabolism
(R-MMU-196791)
Vitamins
(R-MMU-211916)
Calcidiol 1-monooxygenase activity
(GO:0004498)
Calcitriol biosynthetic process from calciol
(GO:0036378)
Calcium ion homeostasis
(GO:0055074)
Calcium ion transport
(GO:0006816)
Cytoplasm
(GO:0005737)
G1 to g0 transition
(GO:0070314)
Heme binding
(GO:0020037)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Monooxygenase activity
(GO:0004497)
Negative regulation of bone trabecula formation
(GO:1900155)
Negative regulation of calcidiol 1-monooxygenase activity
(GO:0010956)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of ossification
(GO:0030279)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of parathyroid hormone secretion
(GO:2000830)
Positive regulation of vitamin d 24-hydroxylase activity
(GO:0010980)
Positive regulation of vitamin d receptor signaling pathway
(GO:0070564)
Regulation of bone mineralization
(GO:0030500)
Response to camp
(GO:0051591)
Response to copper ion
(GO:0046688)
Response to insulin
(GO:0032868)
Response to lipopolysaccharide
(GO:0032496)
Response to prostaglandin e
(GO:0034695)
Response to type ii interferon
(GO:0034341)
Response to vitamin d
(GO:0033280)
Response to xenobiotic stimulus
(GO:0009410)
Secalciferol 1-monooxygenase activity
(GO:0062185)
Vitamin d catabolic process
(GO:0042369)
Vitamin d metabolic process
(GO:0042359)

Other Information

Proteins

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Q66JY8_MOUSE

Genular Protein ID: 3834967766

Symbol: CP27B_MOUSE

Name: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

UniProtKB Accession Codes:

O35084

Database IDs:

Citations:

PubMed ID: 9295274

Title: 25-hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis.

PubMed ID: 9295274

DOI: 10.1126/science.277.5333.1827

PubMed ID: 11149489

Title: 25-hydroxyvitamin D 1alpha-hydroxylase: structure of the mouse gene, chromosomal assignment, and developmental expression.

PubMed ID: 11149489

DOI: 10.1359/jbmr.2001.16.1.46

PubMed ID: 10092858

Title: Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli.

PubMed ID: 10092858

DOI: 10.1046/j.1432-1327.1999.00096.x

PubMed ID: 15972816

Title: Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1.

PubMed ID: 15972816

DOI: 10.1074/jbc.m505244200

Sequence Information:

Length: 507
Mass: 56225
Checksum: 0669B4478C461B83
Sequence:

MTQAVKLASR VFHRIHLPLQ LDASLGSRGS ESVLRSLSDI PGPSTLSFLA ELFCKGGLSR 
LHELQVHGAA RYGPIWSGSF GTLRTVYVAD PTLVEQLLRQ ESHCPERCSF SSWAEHRRRH 
QRACGLLTAD GEEWQRLRSL LAPLLLRPQA AAGYAGTLDN VVRDLVRRLR RQRGRGSGLP 
GLVLDVAGEF YKFGLESIGA VLLGSRLGCL EAEVPPDTET FIHAVGSVFV STLLTMAMPN 
WLHHLIPGPW ARLCRDWDQM FAFAQRHVEL REGEAAMRNQ GKPEEDMPSG HHLTHFLFRE 
KVSVQSIVGN VTELLLAGVD TVSNTLSWTL YELSRHPDVQ TALHSEITAG TRGSCAHPHG 
TALSQLPLLK AVIKEVLRLY PVVPGNSRVP DRDIRVGNYV IPQDTLVSLC HYATSRDPTQ 
FPDPNSFNPA RWLGEGPTPH PFASLPFGFG KRSCIGRRLA ELELQMALSQ ILTHFEVLPE 
PGALPIKPMT RTVLVPERSI NLQFVDR

Genular Protein ID: 368422478

Symbol: Q66JY8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q66JY8

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 448
Mass: 49901
Checksum: 547D36E3407775F3
Sequence:

MRRFSQVHGA ARYGPVWSGS FGTLRTVYVA DPTLVEQLLR QESHCPERCS FSSWAEHRRR 
HQRACGLLTA DGEEWQRLRS LLAPLLLRPQ AAAGYAGTLD NVVRDLVRRL RRQRGRGSGL 
PGLVLDVAGE FYKFGLESIG AVLLGSRLGC LEAEVPPDTE TFIHAVGSVS VSTLLTMAMP 
NWLHHLIPGP WARLCRDWDQ MFAFAQRHVE LREGEAAMRN QGKPEEDMPS GHHLTHFLFR 
EKVSVQSIVG NVTELLLAGV DTVSNTLSWT LYELSRHPDV QTALHSEITA GTRGSCAHPH 
GTALSQLPLL KAVIKEVLRL YPVVPGNSRV PDRDIRVGNY VIPQDTLVSL CHYATSRDPT 
QFPDPNSFNP ARWLGEGPTP HPFASLPFGF GKRSCIGRRL AELELQMALS QILTHFEVLP 
EPGALPIKPM TRTVLVPERS INLQFVDR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp27b1

Associated with

Other Information

25-hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. PubMed ID: 9295274

25-hydroxyvitamin D 1alpha-hydroxylase: structure of the mouse gene, chromosomal assignment, and developmental expression. PubMed ID: 11149489

Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli. PubMed ID: 10092858