Cyp46a1 | ENSMUSG00000021259 | NCBI 13116

Details for: Cyp46a1

Gene ID: 13116

Symbol: Cyp46a1

Ensembl ID: ENSMUSG00000021259

Description: cytochrome P450, family 46, subfamily a, polypeptide 1

Associated with

Bile acid and bile salt metabolism
(R-MMU-194068)
Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Phase i - functionalization of compounds
(R-MMU-211945)
Synthesis of bile acids and bile salts
(R-MMU-192105)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(R-MMU-193775)
Cell projection
(GO:0042995)
Cholesterol 24-hydroxylase activity
(GO:0033781)
Cholesterol catabolic process
(GO:0006707)
Cholesterol metabolic process
(GO:0008203)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Progesterone metabolic process
(GO:0042448)
Protein localization to membrane raft
(GO:1903044)
Regulation of long-term synaptic potentiation
(GO:1900271)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Synapse
(GO:0045202)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cholesterol 24-monooxygenase

Genular Protein ID: 2273038362

Symbol: CP46A_MOUSE

Name: Cholesterol 24-monooxygenase

UniProtKB Accession Codes:

Q9WVK8

Database IDs:

Citations:

PubMed ID: 10377398

Title: cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.

PubMed ID: 10377398

DOI: 10.1073/pnas.96.13.7238

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16505352

Title: Brain cholesterol turnover required for geranylgeraniol production and learning in mice.

PubMed ID: 16505352

DOI: 10.1073/pnas.0600316103

PubMed ID: 18241055

Title: Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain.

PubMed ID: 18241055

DOI: 10.1002/cne.21605

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28190002

Title: Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.

PubMed ID: 28190002

DOI: 10.1074/jbc.m116.774760

Sequence Information:

Length: 500
Mass: 56814
Checksum: F0F178FA65820FF2
Sequence:

MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPYFW KKDEDCGRVL 
QDVFLDWAKK YGPVVRVNVF YKTSVIVTSP ESVKKFLMST KYNKDSKMYR ALQTVFGERL 
FGQGLVSECD YGRWYKQRKV MDLAFSRSSL VSLMETFNEK AEQLVEILEA KADGQTPVSM 
QDMLTCATID ILAKAAFGME TSMLLGAQKP LSQAVKVMLE GISASRNTLA KFMPGKRKQL 
REIRESIRLL RQVGKDWVQR RREALKRGED MPADILTQIL KAEEGAQDDE VLLDNFVTFF 
IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVVGSKR HLDYEDLGRL QYLSQVLKES 
LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR MDTYFEDPLT FNPDRFGPGA 
PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV MAKLLQRIEF RLVPGQRFGL QEQATLKPLD 
PVLCTLRPRG WQPAPPPPPC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp46a1

Associated with

Other Information

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. PubMed ID: 10377398

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Brain cholesterol turnover required for geranylgeraniol production and learning in mice. PubMed ID: 16505352

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. PubMed ID: 18241055

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079