Details for: COMT

Gene ID: 1312

Symbol: COMT

Ensembl ID: ENSG00000093010

Description: catechol-O-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 410.7166
    Cell Significance Index: -63.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 180.7262
    Cell Significance Index: -45.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 153.9430
    Cell Significance Index: -72.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 133.3922
    Cell Significance Index: -68.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 108.1186
    Cell Significance Index: -72.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.9614
    Cell Significance Index: -67.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.2371
    Cell Significance Index: -59.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.4808
    Cell Significance Index: -68.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.6375
    Cell Significance Index: -48.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4800
    Cell Significance Index: -25.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.0486
    Cell Significance Index: 55.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.5076
    Cell Significance Index: 61.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9101
    Cell Significance Index: 106.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.7515
    Cell Significance Index: 100.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.7028
    Cell Significance Index: 667.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.2803
    Cell Significance Index: 170.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.0221
    Cell Significance Index: 371.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.8244
    Cell Significance Index: 169.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.7968
    Cell Significance Index: 74.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5480
    Cell Significance Index: 118.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4369
    Cell Significance Index: 172.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1055
    Cell Significance Index: 55.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8133
    Cell Significance Index: 249.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7718
    Cell Significance Index: 47.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7025
    Cell Significance Index: 80.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5513
    Cell Significance Index: 100.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5489
    Cell Significance Index: 251.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5362
    Cell Significance Index: 679.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5234
    Cell Significance Index: 831.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4677
    Cell Significance Index: 189.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4404
    Cell Significance Index: 184.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4050
    Cell Significance Index: 104.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1757
    Cell Significance Index: 1061.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9547
    Cell Significance Index: 189.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8922
    Cell Significance Index: 178.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8664
    Cell Significance Index: 18.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8016
    Cell Significance Index: 152.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6290
    Cell Significance Index: 225.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5529
    Cell Significance Index: 382.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5424
    Cell Significance Index: 15.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5216
    Cell Significance Index: 40.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4559
    Cell Significance Index: 52.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3582
    Cell Significance Index: 6.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2381
    Cell Significance Index: 40.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1159
    Cell Significance Index: 87.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1118
    Cell Significance Index: 81.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1041
    Cell Significance Index: 2.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0842
    Cell Significance Index: 129.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0794
    Cell Significance Index: 7.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0694
    Cell Significance Index: 128.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0663
    Cell Significance Index: 124.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0560
    Cell Significance Index: 6.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0394
    Cell Significance Index: 53.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0044
    Cell Significance Index: 0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0041
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0239
    Cell Significance Index: -2.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0274
    Cell Significance Index: -1.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0275
    Cell Significance Index: -17.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0525
    Cell Significance Index: -32.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0626
    Cell Significance Index: -28.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0713
    Cell Significance Index: -40.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1132
    Cell Significance Index: -2.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1590
    Cell Significance Index: -10.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1593
    Cell Significance Index: -9.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1678
    Cell Significance Index: -35.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2015
    Cell Significance Index: -5.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2103
    Cell Significance Index: -60.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2574
    Cell Significance Index: -7.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2739
    Cell Significance Index: -39.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2850
    Cell Significance Index: -7.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3358
    Cell Significance Index: -5.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3723
    Cell Significance Index: -29.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3830
    Cell Significance Index: -44.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3875
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3962
    Cell Significance Index: -45.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5120
    Cell Significance Index: -23.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5980
    Cell Significance Index: -40.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5985
    Cell Significance Index: -62.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6189
    Cell Significance Index: -17.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6219
    Cell Significance Index: -21.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6918
    Cell Significance Index: -4.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7169
    Cell Significance Index: -12.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7400
    Cell Significance Index: -23.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8302
    Cell Significance Index: -17.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8976
    Cell Significance Index: -13.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0025
    Cell Significance Index: -11.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0221
    Cell Significance Index: -25.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.0744
    Cell Significance Index: -16.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0748
    Cell Significance Index: -13.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1515
    Cell Significance Index: -50.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1528
    Cell Significance Index: -70.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2302
    Cell Significance Index: -36.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.3108
    Cell Significance Index: -66.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4194
    Cell Significance Index: -53.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5048
    Cell Significance Index: -29.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5122
    Cell Significance Index: -55.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.5623
    Cell Significance Index: -38.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5844
    Cell Significance Index: -12.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.5933
    Cell Significance Index: -28.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzymatic Activity**: COMT is a cytosolic enzyme that catalyzes the transfer of a methyl group from SAM to the catecholamine, resulting in the formation of inactive metabolites. 2. **Tissue Expression**: COMT is highly expressed in the adrenal glands, kidney, and brain, where it regulates dopamine levels and influences neural function, behavior, and physiological responses. 3. **Genetic Variability**: The COMT gene has several polymorphisms, including the Val158Met and Thr158Ala variants, which affect enzyme activity and have been associated with various diseases, such as attention-deficit/hyperactivity disorder (ADHD) and schizophrenia. 4. **Regulation**: COMT is regulated by various factors, including transcriptional and post-transcriptional mechanisms, which ensure optimal enzyme activity in response to changing physiological demands. **Pathways and Functions** 1. **Catecholamine Catabolic Process**: COMT is the final enzyme in the catecholamine catabolic pathway, responsible for the degradation of dopamine, norepinephrine, and epinephrine. 2. **Neurotransmitter Clearance**: COMT regulates the clearance of dopamine from the synaptic cleft, influencing neural function, behavior, and learning. 3. **Dopamine Metabolism**: COMT is involved in the regulation of dopamine metabolism, including the breakdown of dopamine into inactive metabolites, such as homovanillic acid (HVA). 4. **Physiological Responses**: COMT influences various physiological responses, including the regulation of blood pressure, heart rate, and body temperature. **Clinical Significance** 1. **Attention-Deficit/Hyperactivity Disorder (ADHD)**: Variants of the COMT gene, such as the Val158Met variant, have been associated with ADHD and may influence treatment outcomes. 2. **Schizophrenia**: COMT has been implicated in the pathophysiology of schizophrenia, and genetic variations may contribute to the development of the disorder. 3. **Neurodegenerative Diseases**: COMT has been studied as a potential therapeutic target for neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. 4. **Cancer**: COMT has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly for kidney cancer. 5. **Infectious Diseases**: COMT has been involved in the regulation of the immune response to infections, such as SARS-CoV-2. In conclusion, the COMT gene plays a critical role in regulating dopamine metabolism and influencing various physiological and pathological processes. Further research is needed to fully understand the mechanisms underlying COMT function and its clinical significance.

Genular Protein ID: 893546733

Symbol: COMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P21964 A8MPV9 Q6IB07 Q6ICE6 Q9BWC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 47 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 26 DrugCentral 1 EC 1 EMBL 17 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 6 Rhea 14 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1707278

Title: Cloning and characterization of human placental catechol-O-methyltransferase cDNA.

PubMed ID: 1707278

DOI: 10.1089/dna.1991.10.181

PubMed ID: 1847521

Title: Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

PubMed ID: 1847521

DOI: 10.1073/pnas.88.4.1416

PubMed ID: 8055944

Title: Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters.

PubMed ID: 8055944

DOI: 10.1111/j.1432-1033.1994.tb19083.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020475

Title: Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding.

PubMed ID: 8020475

DOI: 10.1111/j.1432-1033.1994.tb18876.x

PubMed ID: 1993083

Title: Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme.

PubMed ID: 1993083

DOI: 10.1016/0006-291x(91)91517-g

PubMed ID: 1765063

Title: Cell-free synthesis of rat and human catechol O-methyltransferase. Insertion of the membrane-bound form into microsomal membranes in vitro.

PubMed ID: 1765063

DOI: 10.1111/j.1432-1033.1991.tb16464.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21846718

Title: Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development.

PubMed ID: 21846718

DOI: 10.1074/jbc.m111.262790

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18486144

Title: Crystal structures of human 108V and 108M catechol O-methyltransferase.

PubMed ID: 18486144

DOI: 10.1016/j.jmb.2008.04.040

PubMed ID: 8807664

Title: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

PubMed ID: 8807664

DOI: 10.1097/00008571-199606000-00007

PubMed ID: 10395222

Title: Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.

PubMed ID: 10395222

DOI: 10.1038/sj.mp.4000509

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11559542

Title: Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.

PubMed ID: 11559542

PubMed ID: 15645182

Title: Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.

PubMed ID: 15645182

DOI: 10.1007/s00439-004-1239-y

PubMed ID: 18474266

Title: The V108M mutation decreases the structural stability of catechol O-methyltransferase.

PubMed ID: 18474266

DOI: 10.1016/j.bbapap.2008.04.006

PubMed ID: 18442637

Title: Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.

PubMed ID: 18442637

DOI: 10.1016/j.metabol.2008.01.012

Sequence Information:

  • Length: 271
  • Mass: 30037
  • Checksum: D2547A1C399AC758
  • Sequence:
    • MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL 
NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG 
YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY 
DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE 
CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.