Details for: COMT

Gene ID: 1312

Symbol: COMT

Ensembl ID: ENSG00000093010

Description: catechol-O-methyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.46
    Marker Score: 2098
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.39
    Marker Score: 2394
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.91
    Marker Score: 51738
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.63
    Marker Score: 7043
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.53
    Marker Score: 10524.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.49
    Marker Score: 19476.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.46
    Marker Score: 24726.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.4
    Marker Score: 10363
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.35
    Marker Score: 17505
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.35
    Marker Score: 60157
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.32
    Marker Score: 20033
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.32
    Marker Score: 9492
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.31
    Marker Score: 677
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.3
    Marker Score: 2453
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.28
    Marker Score: 6218
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.28
    Marker Score: 5759
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.28
    Marker Score: 3363
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.28
    Marker Score: 5568.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.28
    Marker Score: 127270
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.27
    Marker Score: 8917
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.19
    Marker Score: 2504
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.17
    Marker Score: 2303
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.16
    Marker Score: 1565
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.16
    Marker Score: 3466
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.08
    Marker Score: 4738
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.04
    Marker Score: 2455.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.03
    Marker Score: 13245
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.03
    Marker Score: 70205.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.02
    Marker Score: 2022
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.94
    Marker Score: 1070
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.94
    Marker Score: 10185
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.93
    Marker Score: 2081
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.91
    Marker Score: 1504
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.9
    Marker Score: 1590
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.9
    Marker Score: 1785
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.88
    Marker Score: 543
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.87
    Marker Score: 7227
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.87
    Marker Score: 11095.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.87
    Marker Score: 3641
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.86
    Marker Score: 4870
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.86
    Marker Score: 2629
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.86
    Marker Score: 978
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.85
    Marker Score: 18748
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.85
    Marker Score: 657
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.83
    Marker Score: 3251
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.83
    Marker Score: 1903
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.83
    Marker Score: 1008
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.82
    Marker Score: 4129
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.81
    Marker Score: 4310.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8
    Marker Score: 20278
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.8
    Marker Score: 1821
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.79
    Marker Score: 851
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.79
    Marker Score: 8787.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.76
    Marker Score: 1853.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.76
    Marker Score: 20448
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.76
    Marker Score: 563
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.75
    Marker Score: 10655
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.74
    Marker Score: 610
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.73
    Marker Score: 417
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.72
    Marker Score: 8259
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.72
    Marker Score: 1482
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.71
    Marker Score: 336
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.71
    Marker Score: 11128
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.71
    Marker Score: 1811
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.71
    Marker Score: 974
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.7
    Marker Score: 14742
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.69
    Marker Score: 709
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.68
    Marker Score: 2792
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.68
    Marker Score: 2332
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.67
    Marker Score: 834
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.66
    Marker Score: 676
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.64
    Marker Score: 10502
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.64
    Marker Score: 3074
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.64
    Marker Score: 764
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.63
    Marker Score: 731
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.63
    Marker Score: 4054
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.63
    Marker Score: 374
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.61
    Marker Score: 1075
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.61
    Marker Score: 1618
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.59
    Marker Score: 1419
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.59
    Marker Score: 929
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.58
    Marker Score: 657
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.57
    Marker Score: 369
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.56
    Marker Score: 1755
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.56
    Marker Score: 473
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.54
    Marker Score: 2533
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.53
    Marker Score: 1623
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.53
    Marker Score: 3056
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.52
    Marker Score: 1843
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.52
    Marker Score: 9703
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.51
    Marker Score: 1542
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.51
    Marker Score: 372
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.5
    Marker Score: 836
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.49
    Marker Score: 421
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.48
    Marker Score: 512
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.48
    Marker Score: 975
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.48
    Marker Score: 762
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.48
    Marker Score: 1701
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.46
    Marker Score: 349
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.45
    Marker Score: 3758

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Other Information

**Key characteristics:** * ComT is a member of the COMT family of O-methyltransferases, which are enzymes that transfer methyl groups to various substrates. * It is expressed in a variety of cell types, including myeloid dendritic cells, CD14-low and CD16-positive monocytes, cortical cells of the adrenal gland, kidney loop of Henle thick ascending limb epithelial cells, classical monocytes, stratified epithelial cells, granulosa cells, decidual cells, basal cells of the epithelium of the trachea, and alveolar macrophages. * It is a highly regulated protein, with its expression being influenced by various factors, including growth factors, cytokines, and neurotransmitters. **Pathways and functions:** * COMT is involved in several important pathways, including: * Dopamine clearance from the synaptic cleft: COMT is responsible for the O-methylation of tyrosine residues in the huntingtin and beta-amyloid precursor proteins, which are then degraded by the proteasome. * Neurotransmitter synthesis: COMT is involved in the synthesis of several neurotransmitters, including dopamine, norepinephrine, and serotonin. * Infection responses: COMT is expressed in immune cells, where it plays a role in the clearance of pathogens and the regulation of inflammation. **Clinical significance:** * Mutations in the COMT gene have been linked to several neurological and psychiatric disorders, including schizophrenia, depression, and Parkinson's disease. * COMT inhibitors are being investigated as potential therapeutics for these disorders, as they could be used to increase dopamine levels in the brain and improve symptoms. * COMT is a promising target for the treatment of neurodegenerative diseases characterized by abnormal dopamine metabolism, such as Parkinson's disease. **Additional information:** * The COMT gene is located on chromosome 15q21.1. * It is a highly conserved protein, with a similar gene found in humans, mice, and rats. * COMT is a well-characterized enzyme, with over 100 known substrates and cofactors.

Genular Protein ID: 893546733

Symbol: COMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P21964 A8MPV9 Q6IB07 Q6ICE6 Q9BWC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 47 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 26 DrugCentral 1 EC 1 EMBL 17 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 12 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 6 Rhea 14 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1707278

Title: Cloning and characterization of human placental catechol-O-methyltransferase cDNA.

PubMed ID: 1707278

DOI: 10.1089/dna.1991.10.181

PubMed ID: 1847521

Title: Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

PubMed ID: 1847521

DOI: 10.1073/pnas.88.4.1416

PubMed ID: 8055944

Title: Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters.

PubMed ID: 8055944

DOI: 10.1111/j.1432-1033.1994.tb19083.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020475

Title: Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding.

PubMed ID: 8020475

DOI: 10.1111/j.1432-1033.1994.tb18876.x

PubMed ID: 1993083

Title: Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme.

PubMed ID: 1993083

DOI: 10.1016/0006-291x(91)91517-g

PubMed ID: 1765063

Title: Cell-free synthesis of rat and human catechol O-methyltransferase. Insertion of the membrane-bound form into microsomal membranes in vitro.

PubMed ID: 1765063

DOI: 10.1111/j.1432-1033.1991.tb16464.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21846718

Title: Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development.

PubMed ID: 21846718

DOI: 10.1074/jbc.m111.262790

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18486144

Title: Crystal structures of human 108V and 108M catechol O-methyltransferase.

PubMed ID: 18486144

DOI: 10.1016/j.jmb.2008.04.040

PubMed ID: 8807664

Title: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

PubMed ID: 8807664

DOI: 10.1097/00008571-199606000-00007

PubMed ID: 10395222

Title: Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.

PubMed ID: 10395222

DOI: 10.1038/sj.mp.4000509

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11559542

Title: Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.

PubMed ID: 11559542

PubMed ID: 15645182

Title: Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.

PubMed ID: 15645182

DOI: 10.1007/s00439-004-1239-y

PubMed ID: 18474266

Title: The V108M mutation decreases the structural stability of catechol O-methyltransferase.

PubMed ID: 18474266

DOI: 10.1016/j.bbapap.2008.04.006

PubMed ID: 18442637

Title: Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.

PubMed ID: 18442637

DOI: 10.1016/j.metabol.2008.01.012

Sequence Information:

  • Length: 271
  • Mass: 30037
  • Checksum: D2547A1C399AC758
  • Sequence:
    • MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL 
NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG 
YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY 
DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE 
CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.