Details for: COMT
Gene ID: 1312
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: COMT
Ensembl ID: ENSG00000093010
Description: catechol-O-methyltransferase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 71.43rCSI 57.76%PRS 21.11
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CSI 68.11rCSI 71.18%PRS 21.88
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CSI 67.96rCSI 45.17%PRS 25.12
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CSI 57.76rCSI 50.01%PRS 23.74
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CSI 45.6rCSI 70.46%PRS 19.61
-
CSI 43.41rCSI 36.39%PRS 24.95
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CSI 39.47rCSI 35.64%PRS 19.01
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CSI 39.28rCSI 37.87%PRS 15.24
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CSI 36.72rCSI 30.44%PRS 19.92
-
CSI 35.53rCSI 51.25%PRS 29.52
-
CSI 34.97rCSI 32.11%PRS 24.66
-
CSI 30.67rCSI 50.52%PRS 24.81
-
CSI 30.16rCSI 43.46%PRS 33.03
-
CSI 28.84rCSI 56.09%PRS 21.54
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CSI 26.8rCSI 28.07%PRS 19.62
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CSI 24.73rCSI 31.72%PRS 24.31
-
CSI 20.49rCSI 15.18%PRS 18.18
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CSI 19.74rCSI 30.15%PRS 21.17
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CSI 18.58rCSI 19.74%PRS 35.68
-
CSI 18.38rCSI 16.95%PRS 21.84
-
CSI 18rCSI 23.92%PRS 23.04
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CSI 17.34rCSI 21.76%PRS 27.23
-
CSI 16.3rCSI 47.18%PRS 23.68
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CSI 16.06rCSI 23.03%PRS 28.24
-
CSI 15.72rCSI 55.16%PRS 36.15
-
CSI 15.14rCSI 48.57%PRS 29.66
-
CSI 14.2rCSI 13.67%PRS 21.73
-
CSI 13.77rCSI 37.83%PRS 34.37
-
CSI 13.2rCSI 9.22%PRS 22.44
-
CSI 12.9rCSI 66.62%PRS 40.47
-
CSI 12.63rCSI 14.83%PRS 24.15
-
CSI 12.28rCSI 29.47%PRS 37.26
-
CSI 11.25rCSI 29.32%PRS 19.58
-
CSI 10.81rCSI 11.33%PRS 22.38
-
CSI 10.58rCSI 30.47%PRS 38.42
-
CSI 10.36rCSI 16.07%PRS 31.13
-
CSI 10.35rCSI 14.68%PRS 19.45
-
CSI 10.19rCSI 21.69%PRS 33.22
-
CSI 10rCSI 7.48%PRS 33.22
-
CSI 9.7rCSI 47.82%PRS 28.36
-
CSI 9.64rCSI 7.62%PRS 14.45
-
CSI 9.49rCSI 16.26%PRS 28.45
-
CSI 9.47rCSI 49.76%PRS 35.01
-
CSI 9.39rCSI 23.25%PRS 19.44
-
CSI 9.37rCSI 7.61%PRS 22.15
-
CSI 9.27rCSI 32.91%PRS 33.93
-
CSI 8.65rCSI 50.34%PRS 31.04
-
CSI 8.54rCSI 8.85%PRS 24.76
-
CSI 8.42rCSI 10.59%PRS 32.17
-
CSI 8.32rCSI 6.45%PRS 20.17
-
CSI 8.24rCSI 17.1%PRS 20.92
-
CSI 8.15rCSI 7.59%PRS 21.07
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CSI 8.11rCSI 26.1%PRS 21.92
-
CSI 7.9rCSI 12.13%PRS 28.59
-
CSI 7.85rCSI 9.67%PRS 56.77
-
CSI 7.49rCSI 32.38%PRS 38.11
-
CSI 7.4rCSI 10.25%PRS 29.5
-
CSI 7.25rCSI 6.37%PRS 15.29
-
CSI 6.89rCSI 30.61%PRS 20.51
-
CSI 6.88rCSI 18.11%PRS 40.56
-
CSI 6.83rCSI 16.04%PRS 30.31
-
CSI 6.83rCSI 19.43%PRS 23.95
-
CSI 6.68rCSI 4.65%PRS 25.2
-
CSI 6.67rCSI 10.59%PRS 27.01
-
CSI 6.55rCSI 10.5%PRS 54.71
-
CSI 6.46rCSI 11.67%PRS 50.88
-
CSI 6.41rCSI 8.77%PRS 20.9
-
CSI 6.37rCSI 8.52%PRS 23.05
-
CSI 6.37rCSI 9.32%PRS 23.93
-
CSI 6.26rCSI 8.21%PRS 30.03
-
CSI 6.19rCSI 20.74%PRS 15.07
-
CSI 6.13rCSI 66.7%PRS 39.7
-
CSI 6.09rCSI 4.37%PRS 28.95
-
CSI 6.07rCSI 5.03%PRS 21.34
-
CSI 6.02rCSI 7.5%PRS 29.75
-
CSI 5.97rCSI 6.89%PRS 18.36
-
CSI 5.95rCSI 10.82%PRS 63.87
-
CSI 5.92rCSI 11.74%PRS 54.31
-
CSI 5.84rCSI 57.39%PRS 52.53
-
CSI 5.8rCSI 7.75%PRS 39.63
-
CSI 5.7rCSI 18.49%PRS 25.24
-
CSI 5.59rCSI 39.43%PRS 55.13
-
CSI 5.58rCSI 11.52%PRS 31.15
-
CSI 5.55rCSI 4.86%PRS 28.03
-
CSI 5.53rCSI 5.93%PRS 19.34
-
CSI 5.49rCSI 4.58%PRS 52.28
-
CSI 5.42rCSI 13.23%PRS 20.66
-
CSI 5.41rCSI 3.77%PRS 29.65
-
CSI 5.32rCSI 5.24%PRS 22.69
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CSI 5.22rCSI 7.13%PRS 23.37
-
CSI 5.19rCSI 4.37%PRS 33.07
-
CSI 5.16rCSI 9.05%PRS 16.01
-
CSI 5.14rCSI 38.62%PRS 38.06
-
CSI 5.06rCSI 11.33%PRS 13.02
-
CSI 4.96rCSI 8.84%PRS 34.72
-
CSI 4.94rCSI 11.26%PRS 21.67
-
CSI 4.8rCSI 10.96%PRS 18.09
-
CSI 4.76rCSI 50.44%PRS 27.16
-
CSI 4.73rCSI 40.87%PRS 32.07
-
CSI 4.69rCSI 10.47%PRS 24.5
-
CSI -2.8rCSI -2.8%PRS 32.6%
-
CSI -2.2rCSI -1.6%PRS 22.3%
-
CSI 0.0rCSI 0.4%PRS 37.0%
-
CSI 0.1rCSI 1.2%PRS 10.9%
-
CSI 0.2rCSI 4.3%PRS 55.3%
-
CSI 0.2rCSI 0.5%PRS 16.2%
-
CSI 0.3rCSI 5.8%PRS 68.1%
-
CSI 0.3rCSI 3.1%PRS 52.2%
-
CSI 0.4rCSI 3.1%PRS 66.2%
-
CSI 0.4rCSI 0.9%PRS 15.0%
-
CSI 0.4rCSI 1.5%PRS 11.7%
-
CSI 0.4rCSI 3.8%PRS 72.9%
-
CSI 0.5rCSI 0.5%PRS 25.9%
-
CSI 0.5rCSI 2.6%PRS 59.5%
-
CSI 0.5rCSI 1.8%PRS 40.7%
-
CSI 0.5rCSI 0.8%PRS 16.1%
-
CSI 0.5rCSI 3.0%PRS 31.3%
-
CSI 0.6rCSI 12.8%PRS 87.2%
-
CSI 0.6rCSI 3.3%PRS 13.1%
-
CSI 0.6rCSI 3.1%PRS 35.8%
-
CSI 0.6rCSI 1.7%PRS 32.5%
-
CSI 0.6rCSI 0.5%PRS 26.4%
-
CSI 0.6rCSI 1.7%PRS 17.5%
-
CSI 0.6rCSI 4.1%PRS 59.3%
-
CSI 0.7rCSI 1.9%PRS 35.2%
-
CSI 0.7rCSI 1.7%PRS 19.6%
-
CSI 0.7rCSI 7.3%PRS 60.8%
-
CSI 0.7rCSI 1.6%PRS 26.0%
-
CSI 0.7rCSI 3.1%PRS 43.3%
-
CSI 0.7rCSI 1.3%PRS 40.6%
-
CSI 0.7rCSI 11.0%PRS 49.4%
-
CSI 0.7rCSI 5.7%PRS 41.1%
-
CSI 0.7rCSI 5.0%PRS 40.1%
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CSI 0.7rCSI 2.9%PRS 34.4%
-
CSI 0.8rCSI 1.9%PRS 15.9%
-
CSI 0.8rCSI 1.1%PRS 29.1%
-
CSI 0.8rCSI 5.1%PRS 51.4%
-
CSI 0.8rCSI 2.2%PRS 19.6%
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CSI 0.8rCSI 1.2%PRS 19.5%
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CSI 0.9rCSI 2.3%PRS 21.2%
-
CSI 0.9rCSI 2.8%PRS 13.3%
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CSI 0.9rCSI 1.3%PRS 40.9%
-
CSI 0.9rCSI 5.4%PRS 26.7%
-
CSI 1.0rCSI 5.1%PRS 36.8%
-
CSI 1.0rCSI 6.1%PRS 16.4%
-
CSI 1.0rCSI 3.5%PRS 60.0%
-
CSI 1.0rCSI 4.8%PRS 25.9%
-
CSI 1.0rCSI 2.4%PRS 31.2%
-
CSI 1.1rCSI 1.9%PRS 12.4%
-
CSI 1.1rCSI 4.3%PRS 43.5%
-
CSI 1.1rCSI 1.6%PRS 22.3%
-
CSI 1.1rCSI 2.7%PRS 30.9%
-
CSI 1.1rCSI 1.5%PRS 11.3%
-
CSI 1.1rCSI 9.2%PRS 21.0%
-
CSI 1.2rCSI 5.2%PRS 19.7%
-
CSI 1.2rCSI 5.1%PRS 36.3%
-
CSI 1.2rCSI 1.8%PRS 24.0%
-
CSI 1.2rCSI 0.9%PRS 19.5%
-
CSI 1.2rCSI 7.8%PRS 73.1%
-
CSI 1.2rCSI 2.1%PRS 19.5%
-
CSI 1.2rCSI 1.9%PRS 21.1%
-
CSI 1.2rCSI 3.6%PRS 43.9%
-
CSI 1.2rCSI 3.6%PRS 58.0%
-
CSI 1.3rCSI 5.8%PRS 50.8%
-
CSI 1.3rCSI 2.2%PRS 12.5%
-
CSI 1.3rCSI 2.1%PRS 16.2%
-
CSI 1.3rCSI 2.9%PRS 19.5%
-
CSI 1.3rCSI 3.5%PRS 27.2%
-
CSI 1.3rCSI 9.6%PRS 53.5%
-
CSI 1.3rCSI 5.1%PRS 28.7%
-
CSI 1.4rCSI 8.0%PRS 30.8%
-
CSI 1.4rCSI 2.2%PRS 25.2%
-
CSI 1.4rCSI 1.8%PRS 24.4%
-
CSI 1.4rCSI 4.0%PRS 27.9%
-
CSI 1.5rCSI 2.3%PRS 19.5%
-
CSI 1.6rCSI 1.6%PRS 30.0%
-
CSI 1.6rCSI 3.9%PRS 55.0%
-
CSI 1.6rCSI 7.8%PRS 27.8%
-
CSI 1.6rCSI 2.0%PRS 22.4%
-
CSI 1.6rCSI 4.1%PRS 21.1%
-
CSI 1.6rCSI 4.2%PRS 26.9%
-
CSI 1.6rCSI 1.2%PRS 30.8%
-
CSI 1.7rCSI 2.5%PRS 31.7%
-
CSI 1.7rCSI 1.0%PRS 29.4%
-
CSI 1.7rCSI 1.2%PRS 25.9%
-
CSI 1.8rCSI 7.7%PRS 38.4%
-
CSI 1.8rCSI 3.3%PRS 15.1%
-
CSI 1.8rCSI 7.5%PRS 49.5%
-
CSI 1.8rCSI 6.9%PRS 12.9%
-
CSI 1.9rCSI 9.6%PRS 65.1%
-
CSI 1.9rCSI 2.4%PRS 18.4%
-
CSI 1.9rCSI 3.4%PRS 27.4%
-
CSI 2.0rCSI 7.9%PRS 43.4%
-
CSI 2.0rCSI 2.9%PRS 16.3%
-
CSI 2.0rCSI 11.3%PRS 12.0%
-
CSI 2.0rCSI 3.0%PRS 24.0%
-
CSI 2.0rCSI 2.5%PRS 26.3%
-
CSI 2.1rCSI 6.0%PRS 36.7%
-
CSI 2.1rCSI 2.5%PRS 20.5%
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CSI 2.1rCSI 3.4%PRS 23.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 893546733
Symbol: COMT_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1707278
Title: Cloning and characterization of human placental catechol-O-methyltransferase cDNA.
PubMed ID: 1707278
PubMed ID: 1847521
Title: Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.
PubMed ID: 1847521
PubMed ID: 8055944
Title: Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters.
PubMed ID: 8055944
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8020475
Title: Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding.
PubMed ID: 8020475
PubMed ID: 1993083
Title: Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme.
PubMed ID: 1993083
PubMed ID: 1765063
Title: Cell-free synthesis of rat and human catechol O-methyltransferase. Insertion of the membrane-bound form into microsomal membranes in vitro.
PubMed ID: 1765063
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21846718
Title: Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development.
PubMed ID: 21846718
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 18486144
Title: Crystal structures of human 108V and 108M catechol O-methyltransferase.
PubMed ID: 18486144
PubMed ID: 8807664
Title: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
PubMed ID: 8807664
PubMed ID: 10395222
Title: Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.
PubMed ID: 10395222
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 11559542
Title: Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.
PubMed ID: 11559542
PubMed ID: 15645182
Title: Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.
PubMed ID: 15645182
PubMed ID: 18474266
Title: The V108M mutation decreases the structural stability of catechol O-methyltransferase.
PubMed ID: 18474266
PubMed ID: 18442637
Title: Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.
PubMed ID: 18442637
Sequence Information:
- Length: 271
- Mass: 30037
- Checksum: D2547A1C399AC758
- Sequence:
MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P