COMT | ENSG00000093010 | NCBI 1312

Details for: COMT

Gene ID: 1312

Symbol: COMT

Ensembl ID: ENSG00000093010

Description: catechol-O-methyltransferase

Associated with

Biological oxidations
(R-HSA-211859)
Disease
(R-HSA-1643685)
Dopamine clearance from the synaptic cleft
(R-HSA-379401)
Enzymatic degradation of dopamine by comt
(R-HSA-379397)
Enzymatic degradation of dopamine by monoamine oxidase
(R-HSA-379398)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter clearance
(R-HSA-112311)
Phase ii - conjugation of compounds
(R-HSA-156580)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Transmission across chemical synapses
(R-HSA-112315)
Viral infection pathways
(R-HSA-9824446)
Artery development
(GO:0060840)
Axon
(GO:0030424)
Behavioral fear response
(GO:0001662)
Catecholamine catabolic process
(GO:0042424)
Catechol o-methyltransferase activity
(GO:0016206)
Cellular response to cocaine
(GO:0071314)
Cellular response to phosphate starvation
(GO:0016036)
Cerebellar cortex morphogenesis
(GO:0021696)
Cholesterol efflux
(GO:0033344)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Developmental process
(GO:0032502)
Dopamine catabolic process
(GO:0042420)
Dopamine metabolic process
(GO:0042417)
Dopamine secretion
(GO:0014046)
Exploration behavior
(GO:0035640)
Extracellular exosome
(GO:0070062)
Gene expression
(GO:0010467)
Glomerulus development
(GO:0032835)
Glycogen metabolic process
(GO:0005977)
Habituation
(GO:0046959)
Intracellular membrane-bounded organelle
(GO:0043231)
L-dopa o-methyltransferase activity
(GO:0102084)
Magnesium ion binding
(GO:0000287)
Mastication
(GO:0071626)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Methylation
(GO:0032259)
Methyltransferase activity
(GO:0008168)
Multicellular organism growth
(GO:0035264)
Norepinephrine metabolic process
(GO:0042415)
Norepinephrine secretion
(GO:0048243)
O-methyltransferase activity
(GO:0008171)
Orcinol o-methyltransferase activity
(GO:0102938)
Plasma membrane
(GO:0005886)
Prostaglandin metabolic process
(GO:0006693)
Protein binding
(GO:0005515)
Renal albumin absorption
(GO:0097018)
Renal filtration
(GO:0097205)
Renal sodium excretion
(GO:0035812)
Renin secretion into blood stream
(GO:0002001)
Response to amphetamine
(GO:0001975)
Response to angiotensin
(GO:1990776)
Response to corticosterone
(GO:0051412)
Response to cytokine
(GO:0034097)
Response to dopamine
(GO:1903350)
Response to food
(GO:0032094)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to oxidative stress
(GO:0006979)
Response to toxic substance
(GO:0009636)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Startle response
(GO:0001964)
Synapse
(GO:0045202)
Synaptic transmission, dopaminergic
(GO:0001963)
Visual learning
(GO:0008542)

Other Information

Proteins

COMT_HUMAN

Genular Protein ID: 893546733

Symbol: COMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P21964 A8MPV9 Q6IB07 Q6ICE6 Q9BWC7

Database IDs:

Citations:

PubMed ID: 1707278

Title: Cloning and characterization of human placental catechol-O-methyltransferase cDNA.

PubMed ID: 1707278

DOI: 10.1089/dna.1991.10.181

PubMed ID: 1847521

Title: Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

PubMed ID: 1847521

DOI: 10.1073/pnas.88.4.1416

PubMed ID: 8055944

Title: Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters.

PubMed ID: 8055944

DOI: 10.1111/j.1432-1033.1994.tb19083.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020475

Title: Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding.

PubMed ID: 8020475

DOI: 10.1111/j.1432-1033.1994.tb18876.x

PubMed ID: 1993083

Title: Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme.

PubMed ID: 1993083

DOI: 10.1016/0006-291x(91)91517-g

PubMed ID: 1765063

Title: Cell-free synthesis of rat and human catechol O-methyltransferase. Insertion of the membrane-bound form into microsomal membranes in vitro.

PubMed ID: 1765063

DOI: 10.1111/j.1432-1033.1991.tb16464.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21846718

Title: Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development.

PubMed ID: 21846718

DOI: 10.1074/jbc.m111.262790

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18486144

Title: Crystal structures of human 108V and 108M catechol O-methyltransferase.

PubMed ID: 18486144

DOI: 10.1016/j.jmb.2008.04.040

PubMed ID: 8807664

Title: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

PubMed ID: 8807664

DOI: 10.1097/00008571-199606000-00007

PubMed ID: 10395222

Title: Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.

PubMed ID: 10395222

DOI: 10.1038/sj.mp.4000509

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11559542

Title: Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.

PubMed ID: 11559542

PubMed ID: 15645182

Title: Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.

PubMed ID: 15645182

DOI: 10.1007/s00439-004-1239-y

PubMed ID: 18474266

Title: The V108M mutation decreases the structural stability of catechol O-methyltransferase.

PubMed ID: 18474266

DOI: 10.1016/j.bbapap.2008.04.006

PubMed ID: 18442637

Title: Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.

PubMed ID: 18442637

DOI: 10.1016/j.metabol.2008.01.012

Sequence Information:

Length: 271
Mass: 30037
Checksum: D2547A1C399AC758
Sequence:

MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL 
NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG 
YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY 
DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE 
CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COMT

Associated with

Other Information

Cloning and characterization of human placental catechol-O-methyltransferase cDNA. PubMed ID: 1707278

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form. PubMed ID: 1847521

Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. PubMed ID: 8055944

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding. PubMed ID: 8020475

Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme. PubMed ID: 1993083

Cell-free synthesis of rat and human catechol O-methyltransferase. Insertion of the membrane-bound form into microsomal membranes in vitro. PubMed ID: 1765063

Initial characterization of the human central proteome. PubMed ID: 21269460

Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. PubMed ID: 21846718

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Crystal structures of human 108V and 108M catechol O-methyltransferase. PubMed ID: 18486144

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. PubMed ID: 8807664

Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. PubMed ID: 10395222

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. PubMed ID: 11559542

Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. PubMed ID: 15645182

The V108M mutation decreases the structural stability of catechol O-methyltransferase. PubMed ID: 18474266

Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. PubMed ID: 18442637