Genular: Defining Cellular Identity and Function

Details for: Cyp51

Gene ID: 13121

Symbol: Cyp51

Ensembl ID: ENSMUSG00000001467

Description: cytochrome P450, family 51

Associated with

Biological oxidations
(R-MMU-211859)
Cholesterol biosynthesis
(R-MMU-191273)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Phase i - functionalization of compounds
(R-MMU-211945)
Acrosomal vesicle
(GO:0001669)
Cholesterol biosynthetic process
(GO:0006695)
Cholesterol biosynthetic process via 24,25-dihydrolanosterol
(GO:0033488)
Cholesterol metabolic process
(GO:0008203)
Endoplasmic reticulum
(GO:0005783)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Negative regulation of amyloid-beta clearance
(GO:1900222)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of protein secretion
(GO:0050709)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Positive regulation of oocyte development
(GO:0060282)
Steroid biosynthetic process
(GO:0006694)
Steroid metabolic process
(GO:0008202)
Sterol 14-demethylase activity
(GO:0008398)
Sterol biosynthetic process
(GO:0016126)
Sterol metabolic process
(GO:0016125)

Other Information

Proteins

CYPLI

Genular Protein ID: 3303479646

Symbol: CP51A_MOUSE

Name: CYPLI

UniProtKB Accession Codes:

Q8K0C4 Q8BSQ7 Q9JIP8 Q9JIY3

Database IDs:

Citations:

PubMed ID: 10864439

Title: Characterization of the mouse lanosterol 14alpha-demethylase (CYP51), a new member of the evolutionarily most conserved cytochrome P450 family.

PubMed ID: 10864439

DOI: 10.1006/abbi.2000.1859

PubMed ID: 10653123

Title: Molecular cloning and partial characterisation of the mouse Cyp51 cDNA.

PubMed ID: 10653123

DOI: 10.1007/s004240000070

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21705796

Title: Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome.

PubMed ID: 21705796

DOI: 10.1074/jbc.m111.253245

Sequence Information:

Length: 503
Mass: 56776
Checksum: 6A4BBA350F1D85C7
Sequence:

MVLLGLLQSG GWVLGQAMEQ VTGGNLLSTL LIACAFTLSL VYLFRLAVGH MVQLPAGAKS 
PPHIYSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM VGKTFTYLLG SDAAALLFNS 
KNEDLNAEEV YGRLTTPVFG KGVAYDVPNA IFLEQKKIIK SGLNIAHFKQ YVPIIEKEAK 
EYFQSWGESG ERNVFEALSE LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFTHAAWL 
LPAWLPLPSF RRRDRAHREI KNIFYKAIQK RRLSKEPAED ILQTLLDSTY KDGRPLTDEE 
ISGMLIGLLL AGQHTSSTTS AWMGFFLAKD KPLQEKCYLE QKAVCGEDLP PLTYDQLKDL 
NLLDRCIKET LRLRPPIMTM MRMAKTPQTV AGYTIPPGHQ VCVSPTVNQR LKDSWAERLD 
FNPDRYLQDN PASGEKFAYV PFGAGRHRCV GENFAYVQIK TIWSTMLRLY EFDLINGYFP 
TVNYTTMIHT PENPVIRYKR RSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp51

Associated with

Other Information

Characterization of the mouse lanosterol 14alpha-demethylase (CYP51), a new member of the evolutionarily most conserved cytochrome P450 family. PubMed ID: 10864439

Molecular cloning and partial characterisation of the mouse Cyp51 cDNA. PubMed ID: 10653123

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079