Genular: Defining Cellular Identity and Function

Details for: Cyp7a1

Gene ID: 13122

Symbol: Cyp7a1

Ensembl ID: ENSMUSG00000028240

Description: cytochrome P450, family 7, subfamily a, polypeptide 1

Associated with

Bile acid and bile salt metabolism
(R-MMU-194068)
Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Phase i - functionalization of compounds
(R-MMU-211945)
Synthesis of bile acids and bile salts
(R-MMU-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-MMU-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-MMU-193807)
24-hydroxycholesterol 7alpha-hydroxylase activity
(GO:0033782)
Bile acid biosynthetic process
(GO:0006699)
Cellular response to cholesterol
(GO:0071397)
Cellular response to glucose stimulus
(GO:0071333)
Cholesterol 7-alpha-monooxygenase activity
(GO:0008123)
Cholesterol catabolic process
(GO:0006707)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Endoplasmic reticulum
(GO:0005783)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of fatty acid biosynthetic process
(GO:0045717)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Positive regulation of bile acid biosynthetic process
(GO:0070859)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Regulation of bile acid biosynthetic process
(GO:0070857)
Steroid metabolic process
(GO:0008202)

Other Information

Proteins

CYPVII

Genular Protein ID: 3965998519

Symbol: CP7A1_MOUSE

Name: CYPVII

UniProtKB Accession Codes:

Q64505 Q8BFR7

Database IDs:

Citations:

PubMed ID: 8088795

Title: Structure of the mouse cholesterol 7 alpha-hydroxylase gene.

PubMed ID: 8088795

DOI: 10.1006/geno.1994.1250

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 14522988

Title: PGC-1alpha activates CYP7A1 and bile acid biosynthesis.

PubMed ID: 14522988

DOI: 10.1074/jbc.m309736200

PubMed ID: 17636037

Title: Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.

PubMed ID: 17636037

DOI: 10.1210/me.2007-0196

Sequence Information:

Length: 503
Mass: 57262
Checksum: F7F8BC2CDD2C43D1
Sequence:

MMSISLIWGI AVVVSCCIWF IIGIRRRKVG EPPLDNGLIP YLGCALKFGS NPLEFLRAKQ 
RKHGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HYTTSAKAFG HRSIDPSDGN 
TTENINKTFN KTLQGDALCS LSEAMMQNLQ SVMRPPGLPK SKSAVWVTEG MYAFCYRVMF 
EAGYLTLFGK DISKTDSQRA FIQNNLDSFK QFDQVFPALV AGVPIHLFKT AHKARERLAE 
SLKHKNLYMR DQVSELIRLR MFLNDTLSTF DDMEKAKTHL VILWASQANT IPATFWSLFQ 
MIRSPEAMKA ASEEVNGALQ SAGQELSSGG NAIYLDQEQL NNLPVLDSII KEALRLSSAS 
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDESGKAK 
TTFYRNGNKL KYFYMPFGSG ATICPGRLFA VQEIKQFLIL MLSYFELELV ESHTKCPPLD 
QSRAGLGILP PLNDIEFKYK LKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp7a1

Associated with

Other Information

Structure of the mouse cholesterol 7 alpha-hydroxylase gene. PubMed ID: 8088795

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303