Genular: Defining Cellular Identity and Function

Details for: Cyp7b1

Gene ID: 13123

Symbol: Cyp7b1

Ensembl ID: ENSMUSG00000039519

Description: cytochrome P450, family 7, subfamily b, polypeptide 1

Associated with

Bile acid and bile salt metabolism
(R-MMU-194068)
Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Phase i - functionalization of compounds
(R-MMU-211945)
Synthesis of bile acids and bile salts
(R-MMU-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-MMU-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-MMU-193807)
24-hydroxycholesterol 7alpha-hydroxylase activity
(GO:0033782)
25-hydroxycholesterol 7alpha-hydroxylase activity
(GO:0033783)
27-hydroxycholesterol 7-alpha-monooxygenase activity
(GO:0047092)
B cell chemotaxis
(GO:0035754)
Bile acid biosynthetic process
(GO:0006699)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Circadian rhythm
(GO:0007623)
Digestion
(GO:0007586)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell proliferation
(GO:0050673)
Heme binding
(GO:0020037)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Negative regulation of intracellular estrogen receptor signaling pathway
(GO:0033147)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Oxysterol 7-alpha-hydroxylase activity
(GO:0008396)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Prostate gland epithelium morphogenesis
(GO:0060740)
Steroid biosynthetic process
(GO:0006694)
Steroid metabolic process
(GO:0008202)

Other Information

Proteins

Cytochrome P450 7B1
Q3USU4_MOUSE

Genular Protein ID: 506424004

Symbol: CP7B1_MOUSE

Name: Cytochrome P450 7B1

UniProtKB Accession Codes:

Q60991 Q9CZ39

Database IDs:

Citations:

PubMed ID: 8530364

Title: A novel cytochrome P450 expressed primarily in brain.

PubMed ID: 8530364

DOI: 10.1074/jbc.270.50.29739

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9295351

Title: Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.

PubMed ID: 9295351

DOI: 10.1074/jbc.272.38.23995

PubMed ID: 9144166

Title: Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.

PubMed ID: 9144166

DOI: 10.1073/pnas.94.10.4925

PubMed ID: 10748047

Title: Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.

PubMed ID: 10748047

DOI: 10.1074/jbc.m001810200

PubMed ID: 11067870

Title: The bile acid synthetic gene 3beta-hydroxy-delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.

PubMed ID: 11067870

DOI: 10.1172/jci10902

PubMed ID: 22999953

Title: Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.

PubMed ID: 22999953

DOI: 10.1016/j.immuni.2012.06.015

Sequence Information:

Length: 507
Mass: 58470
Checksum: 628A0D3270C04DA4
Sequence:

MQGATTLDAA SPGPLALLGL LFAATLLLSA LFLLTRRTRR PREPPLIKGW LPYLGMALKF 
FKDPLTFLKT LQRQHGDTFT VFLVGKYITF VLNPFQYQYV TKNPKQLSFQ KFSSRLSAKA 
FSVKKLLTDD DLNEDVHRAY LLLQGKPLDA LLETMIQEVK ELFESQLLKI TDWNTERIFA 
FCGSLVFEIT FATLYGKILA GNKKQIISEL RDDFFKFDDM FPYLVSDIPI QLLRNEESMQ 
KKIIKCLTSE KVAQMQGQSK IVQERQDLLK RYYRHDDPEI GAHHLGFLWA SLANTIPAMF 
WAMYYILRHP EAMEALRDEI DSFLQSTGQK KGPGISVHFT REQLDSLVCL ESTILEVLRL 
CSYSSIIREV QEDMNLSLES KSFSLRKGDF VALFPPLIHN DPEIFDAPKE FRFDRFIEDG 
KKKSTFFKGG KKLKTYVMPF GLGTSKCPGR YFAVNEMKLL LIMLLTYFDL EIIDRKPIGL 
NHSRMFLGIQ HPDSAVSFRY KAKSWRS

Genular Protein ID: 2064772797

Symbol: Q3USU4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3USU4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 507
Mass: 58490
Checksum: 12DDEF8C36EEE8E0
Sequence:

MQGATTLDAA SPGPLALLGL LFAATLLLSA LFLLTRRTRR PCEPPLIKGW LPYLGMALKF 
FKDPLTFLKT LQRQHGDTFT VFLVGKYITF VLNPFQYQYV TKNPKQLSFQ KFSSRLSAKA 
FSVKKLLTDD DLNEDVHRAY LLLQGKPWDA LLETMIQEVK ELFESQLLKI TDWNTERIFA 
FCGSLVFEIT FATLYGKILA GNKKQIISEL RDDFFKFDDM FPYLVSDIPI QLLRNEESMQ 
KKIIKCLTSE KVAQMQGQSK IVQERQDLLK RYYRHDDPEI GAHHLGFLWA SLANTIPAMF 
WAMYYILRHP EAMEALRDEI DSFLQSTGQK KGPGISVHFT REQLDSLVCL ESTILEVLRL 
CSYSSIIREV QEDMNLSLES KSFSLRKGDF VALFPPLIHN DPEIFDAPKE FRFDRFIEDG 
KKKSTFFKGG KKLKTYVMPF GLGTSKCPGR YFAVNEMKLL LIMLLTYFDL EIIDRKPIGL 
NHSRMFLGIQ HPDSAVSFRY KAKSWRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp7b1

Associated with

Other Information

A novel cytochrome P450 expressed primarily in brain. PubMed ID: 8530364

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. PubMed ID: 9295351

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. PubMed ID: 9144166

Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. PubMed ID: 10748047

The bile acid synthetic gene 3beta-hydroxy-delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. PubMed ID: 11067870

Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. PubMed ID: 22999953

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073