Genular: Defining Cellular Identity and Function

Details for: Dab1

Gene ID: 13131

Symbol: Dab1

Ensembl ID: ENSMUSG00000028519

Description: disabled 1

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Reelin signalling pathway
(R-MMU-8866376)
Adult walking behavior
(GO:0007628)
Apical part of cell
(GO:0045177)
Astrocyte differentiation
(GO:0048708)
Axonogenesis
(GO:0007409)
Brush border
(GO:0005903)
Cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
(GO:0021813)
Cell adhesion
(GO:0007155)
Cell differentiation
(GO:0030154)
Central nervous system development
(GO:0007417)
Cerebellum structural organization
(GO:0021589)
Cerebral cortex cell migration
(GO:0021795)
Cerebral cortex radially oriented cell migration
(GO:0021799)
Cytoplasm
(GO:0005737)
Dendrite development
(GO:0016358)
Golgi localization
(GO:0051645)
Hippocampus development
(GO:0021766)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Lateral motor column neuron migration
(GO:0097477)
Motor neuron migration
(GO:0097475)
Multicellular organism development
(GO:0007275)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of axonogenesis
(GO:0050771)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Nervous system development
(GO:0007399)
Neuronal cell body
(GO:0043025)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phospholipid binding
(GO:0005543)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of protein kinase activity
(GO:0045860)
Protein binding
(GO:0005515)
Radial glia-guided pyramidal neuron migration
(GO:0140650)
Radial glia guided migration of purkinje cell
(GO:0021942)
Receptor signaling pathway via jak-stat
(GO:0007259)
Sh2 domain binding
(GO:0042169)
Small gtpase-mediated signal transduction
(GO:0007264)
Ventral spinal cord development
(GO:0021517)

Other Information

Proteins

Disabled homolog 1
B2RRQ8_MOUSE

Genular Protein ID: 1770253656

Symbol: DAB1_MOUSE

Name: Disabled homolog 1

UniProtKB Accession Codes:

P97318 A2A963 A2A964 A2A965 A2A966 A2A967 A2A970 P97316 P97317 Q9DAP9

Database IDs:

Citations:

PubMed ID: 9009273

Title: Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.

PubMed ID: 9009273

DOI: 10.1093/emboj/16.1.121

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10959835

Title: Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.

PubMed ID: 10959835

DOI: 10.1016/s0960-9822(00)00608-4

PubMed ID: 11279201

Title: Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.

PubMed ID: 11279201

DOI: 10.1074/jbc.m101422200

PubMed ID: 12077184

Title: Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of reelin signaling.

PubMed ID: 12077184

DOI: 10.1523/jneurosci.22-12-04869.2002

PubMed ID: 12646221

Title: Inhibition of ubiquitin ligase Siah-1A by disabled-1.

PubMed ID: 12646221

DOI: 10.1016/s0006-291x(03)00247-x

PubMed ID: 15062102

Title: Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.

PubMed ID: 15062102

DOI: 10.1016/j.cub.2004.03.038

PubMed ID: 12826668

Title: Crystal structures of the Dab homology domains of mouse disabled 1 and 2.

PubMed ID: 12826668

DOI: 10.1074/jbc.m304384200

PubMed ID: 12737822

Title: Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes.

PubMed ID: 12737822

DOI: 10.1016/s0969-2126(03)00068-6

Sequence Information:

Length: 588
Mass: 63578
Checksum: 08404220792B1DB4
Sequence:

MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 
CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 
TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 
EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPN 
SQPLEDFESR FAAATPNRNL SMDFDELLEA TKVSAVTQLE LFGDMSTPPD ITSPPTPATP 
GDAFLPSSSQ TLPGSADVFG SMSFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQIAMGAQP 
PVAQVIPGAQ PIAWGQPGLF PATQQAWPTV AGQFPPAAFM PTQTVMPLAA AMFQGPLTPL 
ATVPGTNDSA RSSPQSDKPR QKMGKESFKD FQMVQPPPVP SRKPDQPSLT CTSEAFSSYF 
NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHVSDPTADD 
IFEEGFESPS KSEEQEAPDG SQASSTSDPF GEPSGEPSGD NISPQDGS

Genular Protein ID: 3664995616

Symbol: B2RRQ8_MOUSE

Name: N/A

UniProtKB Accession Codes:

B2RRQ8

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 555
Mass: 59838
Checksum: 57A7130311954FE0
Sequence:

MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 
CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 
TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 
EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV 
SAVTQLELFG DMSTPPDITS PPTPATPGDA FLPSSSQTLP GSADVFGSMS FGTAAVPSGY 
VAMGAVLPSF WGQQPLVQQQ IAMGAQPPVA QVIPGAQPIA WGQPGLFPAT QQAWPTVAGQ 
FPPAAFMPTQ TVMPLAAAMF QGPLTPLATV PGTNDSARSS PQSDKPRQKM GKESFKDFQM 
VQPPPVPSRK PDQPSLTCTS EAFSSYFNKV GVAQDTDDCD DFDISQLNLT PVTSTTPSTN 
SPPTPAPRQS SPSKSSASHV SDPTADDIFE EGFESPSKSE EQEAPDGSQA SSTSDPFGEP 
SGEPSGDNIS PQDGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dab1

Associated with

Other Information

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. PubMed ID: 9009273

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. PubMed ID: 10959835

Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. PubMed ID: 11279201

Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of reelin signaling. PubMed ID: 12077184

Inhibition of ubiquitin ligase Siah-1A by disabled-1. PubMed ID: 12646221

Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. PubMed ID: 15062102

Crystal structures of the Dab homology domains of mouse disabled 1 and 2. PubMed ID: 12826668

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. PubMed ID: 12737822

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334