Details for: COPA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 463.7879
Cell Significance Index: -72.1400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 283.3900
Cell Significance Index: -71.8800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 162.8602
Cell Significance Index: -76.8900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 151.6773
Cell Significance Index: -61.6200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 139.7979
Cell Significance Index: -71.9100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 114.7652
Cell Significance Index: -77.0100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 64.6457
Cell Significance Index: -61.7200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 61.1620
Cell Significance Index: -75.4100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 26.3657
Cell Significance Index: -70.6300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.4118
Cell Significance Index: -76.6000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.5161
Cell Significance Index: -53.8000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 15.6265
Cell Significance Index: -34.2000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.3379
Cell Significance Index: 463.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.2383
Cell Significance Index: 59.7700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9989
Cell Significance Index: 400.9700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.7539
Cell Significance Index: 23.9300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0953
Cell Significance Index: 51.0700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0915
Cell Significance Index: 196.7700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0598
Cell Significance Index: 956.9100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0260
Cell Significance Index: 126.1600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9994
Cell Significance Index: 19.5100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9809
Cell Significance Index: 351.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9435
Cell Significance Index: 129.5700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8713
Cell Significance Index: 94.7800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7905
Cell Significance Index: 431.7400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7337
Cell Significance Index: 56.3000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6263
Cell Significance Index: 101.8600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5406
Cell Significance Index: 373.8900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5163
Cell Significance Index: 14.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4549
Cell Significance Index: 20.6200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4414
Cell Significance Index: 84.0000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4161
Cell Significance Index: 183.9700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4024
Cell Significance Index: 27.8300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3312
Cell Significance Index: 20.3600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3208
Cell Significance Index: 21.5700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2990
Cell Significance Index: 8.6200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2860
Cell Significance Index: 16.0500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2744
Cell Significance Index: 17.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2512
Cell Significance Index: 32.2000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2471
Cell Significance Index: 42.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2458
Cell Significance Index: 12.7700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2222
Cell Significance Index: 342.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2034
Cell Significance Index: 383.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1871
Cell Significance Index: 344.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1598
Cell Significance Index: 7.5100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1406
Cell Significance Index: 89.2800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1341
Cell Significance Index: 15.8200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0887
Cell Significance Index: 40.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0823
Cell Significance Index: 2.3000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0511
Cell Significance Index: 69.5300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0449
Cell Significance Index: 0.7700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0163
Cell Significance Index: -10.1700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0195
Cell Significance Index: -14.3200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0259
Cell Significance Index: -1.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0372
Cell Significance Index: -28.1300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0413
Cell Significance Index: -30.5600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0764
Cell Significance Index: -43.0700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1124
Cell Significance Index: -14.5200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1185
Cell Significance Index: -12.1100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1505
Cell Significance Index: -10.6500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1626
Cell Significance Index: -4.1800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1748
Cell Significance Index: -36.8200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1947
Cell Significance Index: -5.3000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2258
Cell Significance Index: -64.9700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2410
Cell Significance Index: -35.0300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2662
Cell Significance Index: -26.3300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2669
Cell Significance Index: -11.8100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2787
Cell Significance Index: -31.9300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3118
Cell Significance Index: -8.3600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3525
Cell Significance Index: -13.3500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3625
Cell Significance Index: -2.1900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4175
Cell Significance Index: -48.6500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4192
Cell Significance Index: -7.0100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4277
Cell Significance Index: -7.2100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4389
Cell Significance Index: -27.6600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4527
Cell Significance Index: -10.4600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5545
Cell Significance Index: -63.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6090
Cell Significance Index: -63.4200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6200
Cell Significance Index: -11.4600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6760
Cell Significance Index: -19.2900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.7136
Cell Significance Index: -18.7700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7347
Cell Significance Index: -38.2700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.7368
Cell Significance Index: -10.5800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7530
Cell Significance Index: -59.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8411
Cell Significance Index: -44.1600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8424
Cell Significance Index: -26.9800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9062
Cell Significance Index: -55.5600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.9124
Cell Significance Index: -7.4400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.9378
Cell Significance Index: -22.4900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.0067
Cell Significance Index: -50.8800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0650
Cell Significance Index: -15.7200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.0735
Cell Significance Index: -15.4400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0829
Cell Significance Index: -23.4600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.0854
Cell Significance Index: -22.7200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.1279
Cell Significance Index: -67.7100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1799
Cell Significance Index: -10.8700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.2015
Cell Significance Index: -32.1400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.2037
Cell Significance Index: -30.0900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2193
Cell Significance Index: -42.3700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2206
Cell Significance Index: -18.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1525681987
Symbol: COPA_HUMAN
Name: Coatomer subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8647451
Title: HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex.
PubMed ID: 8647451
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1429581
Title: Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion.
PubMed ID: 1429581
PubMed ID: 9365789
Title: Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin.
PubMed ID: 9365789
PubMed ID: 9533652
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21835166
Title: Genome-wide evaluation and discovery of vertebrate A-to-I RNA editing sites.
PubMed ID: 21835166
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25129144
Title: JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.
PubMed ID: 25129144
DOI: 10.1038/ng.3069
PubMed ID: 25894502
Title: COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
PubMed ID: 25894502
DOI: 10.1038/ng.3279
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30352685
Title: Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.
PubMed ID: 30352685
Sequence Information:
- Length: 1224
- Mass: 138346
- Checksum: 5A8BC35CE78F155D
- Sequence:
MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW NWQSRTCVCV LTGHNHYVMC AQFHPTEDLV VSASLDQTVR VWDISGLRKK NLSPGAVESD VRGITGVDLF GTTDAVVKHV LEGHDRGVNW AAFHPTMPLI VSGADDRQVK IWRMNESKAW EVDTCRGHYN NVSCAVFHPR QELILSNSED KSIRVWDMSK RTGVQTFRRD HDRFWVLAAH PNLNLFAAGH DGGMIVFKLE RERPAYAVHG NMLHYVKDRF LRQLDFNSSK DVAVMQLRSG SKFPVFNMSY NPAENAVLLC TRASNLENST YDLYTIPKDA DSQNPDAPEG KRSSGLTAVW VARNRFAVLD RMHSLLIKNL KNEITKKVQV PNCDEIFYAG TGNLLLRDAD SITLFDVQQK RTLASVKISK VKYVIWSADM SHVALLAKHA IVICNRKLDA LCNIHENIRV KSGAWDESGV FIYTTSNHIK YAVTTGDHGI IRTLDLPIYV TRVKGNNVYC LDRECRPRVL TIDPTEFKFK LALINRKYDE VLHMVRNAKL VGQSIIAYLQ KKGYPEVALH FVKDEKTRFS LALECGNIEI ALEAAKALDD KNCWEKLGEV ALLQGNHQIV EMCYQRTKNF DKLSFLYLIT GNLEKLRKMM KIAEIRKDMS GHYQNALYLG DVSERVRILK NCGQKSLAYL TAATHGLDEE AESLKETFDP EKETIPDIDP NAKLLQPPAP IMPLDTNWPL LTVSKGFFEG TIASKGKGGA LAADIDIDTV GTEGWGEDAE LQLDEDGFVE ATEGLGDDAL GKGQEEGGGW DVEEDLELPP ELDISPGAAG GAEDGFFVPP TKGTSPTQIW CNNSQLPVDH ILAGSFETAM RLLHDQVGVI QFGPYKQLFL QTYARGRTTY QALPCLPSMY GYPNRNWKDA GLKNGVPAVG LKLNDLIQRL QLCYQLTTVG KFEEAVEKFR SILLSVPLLV VDNKQEIAEA QQLITICREY IVGLSVETER KKLPKETLEQ QKRICEMAAY FTHSNLQPVH MILVLRTALN LFFKLKNFKT AATFARRLLE LGPKPEVAQQ TRKILSACEK NPTDAYQLNY DMHNPFDICA ASYRPIYRGK PVEKCPLSGA CYSPEFKGQI CRVTTVTEIG KDVIGLRISP LQFR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.