Genular: Defining Cellular Identity and Function

Details for: Dapk3

Gene ID: 13144

Symbol: Dapk3

Ensembl ID: ENSMUSG00000034974

Description: death-associated protein kinase 3

Associated with

Actin filament
(GO:0005884)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Atp binding
(GO:0005524)
Cellular response to type ii interferon
(GO:0071346)
Chromatin organization
(GO:0006325)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Leucine zipper domain binding
(GO:0043522)
Membrane raft
(GO:0045121)
Negative regulation of translation
(GO:0017148)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Pml body
(GO:0016605)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001241)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell shape
(GO:0008360)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of myosin ii filament organization
(GO:0043519)
Small gtpase binding
(GO:0031267)
Transferase activity
(GO:0016740)

Other Information

Proteins

Death-associated protein kinase 3

Genular Protein ID: 3175951220

Symbol: DAPK3_MOUSE

Name: Death-associated protein kinase 3

UniProtKB Accession Codes:

O54784

Database IDs:

Citations:

PubMed ID: 9488481

Title: ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.

PubMed ID: 9488481

DOI: 10.1128/mcb.18.3.1642

PubMed ID: 12917339

Title: ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.

PubMed ID: 12917339

DOI: 10.1128/mcb.23.17.6174-6186.2003

PubMed ID: 15096528

Title: ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts.

PubMed ID: 15096528

DOI: 10.1083/jcb.200309056

PubMed ID: 16219639

Title: Physical and functional interactions between STAT3 and ZIP kinase.

PubMed ID: 16219639

DOI: 10.1093/intimm/dxh331

PubMed ID: 16325270

Title: Phosphorylation of threonine-265 in zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.

PubMed ID: 16325270

DOI: 10.1016/j.imlet.2005.10.015

PubMed ID: 18515077

Title: Physical and functional interactions between ZIP kinase and UbcH5.

PubMed ID: 18515077

DOI: 10.1016/j.bbrc.2008.05.113

PubMed ID: 20854903

Title: Phosphorylation-dependent control of ZIPK nuclear import is species specific.

PubMed ID: 20854903

DOI: 10.1016/j.cellsig.2010.09.016

PubMed ID: 21454679

Title: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).

PubMed ID: 21454679

DOI: 10.1074/jbc.m110.189829

PubMed ID: 23071094

Title: Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.

PubMed ID: 23071094

DOI: 10.1128/mcb.01168-12

Sequence Information:

Length: 448
Mass: 51422
Checksum: DA32EF3EB1F20EFC
Sequence:

MSTFRQEDVE DHYEMGEELG SGQFAIVRKC QQKGTGMEYA AKFIKKRRLP SSRRGVSREE 
IEREVSILRE IRHPNIITLH DVFENKTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL 
KQILDGVHYL HSKRIAHFDL KPENIMLLDK HAASPRIKLI DFGIAHRIEA GSEFKNIFGT 
PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY 
FSSTSELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKVRRR EDGARKPERR RLRAARLREY 
SLKSHSSMPR NTSYASFERF SRVLEDVAAA EQGLRELQRG RRQCRERVCA LRAAAEQREA 
RCRDGSAGLG RDLRRLRTEL GRTEALRTRA QEEARAALLG AGGLKRRLCR LENRYDALAA 
QVAAEVQFVR DLVRALEQER LQAECGVR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dapk3

Associated with

Other Information

ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. PubMed ID: 9488481

ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. PubMed ID: 12917339

ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts. PubMed ID: 15096528

Physical and functional interactions between STAT3 and ZIP kinase. PubMed ID: 16219639

Phosphorylation of threonine-265 in zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines. PubMed ID: 16325270

Physical and functional interactions between ZIP kinase and UbcH5. PubMed ID: 18515077

Phosphorylation-dependent control of ZIPK nuclear import is species specific. PubMed ID: 20854903

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4). PubMed ID: 21454679

Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. PubMed ID: 23071094