Details for: COPB1
Gene ID: 1315
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: COPB1
Ensembl ID: ENSG00000129083
Description: COPI coat complex subunit beta 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 11.2rCSI 17.3%PRS 20.71
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CSI 10.1rCSI 24.02%PRS 32.82
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CSI 10.05rCSI 40.01%PRS 37.43
-
CSI 10.03rCSI 17.14%PRS 44.15
-
CSI 9.19rCSI 11.37%PRS 19.42
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CSI 8.27rCSI 40.75%PRS 29.87
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CSI 8.12rCSI 88.94%PRS 38.62
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CSI 8.01rCSI 10.65%PRS 24.33
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CSI 7.19rCSI 8.32%PRS 16.38
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CSI 6.65rCSI 7.81%PRS 25.41
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CSI 5.79rCSI 25.43%PRS 40.29
-
CSI 5.45rCSI 6.79%PRS 31.2
-
CSI 5.36rCSI 7.92%PRS 34.49
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CSI 5.25rCSI 7.57%PRS 34.78
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CSI 5.19rCSI 15.4%PRS 31.02
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CSI 4.77rCSI 3.63%PRS 29.31
-
CSI 4.74rCSI 21.06%PRS 21.57
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CSI 4.73rCSI 9.21%PRS 22.78
-
CSI 4.6rCSI 3.62%PRS 26.85
-
CSI 4.45rCSI 3.91%PRS 16.14
-
CSI 4.36rCSI 4.29%PRS 23.86
-
CSI 4.33rCSI 8.18%PRS 28.04
-
CSI 3.94rCSI 3.15%PRS 39.24
-
CSI 3.87rCSI 5.95%PRS 29.87
-
CSI 3.82rCSI 5.1%PRS 28.5
-
CSI 3.8rCSI 5.5%PRS 33.61
-
CSI 3.66rCSI 2.71%PRS 19.12
-
CSI 3.53rCSI 7.74%PRS 29.63
-
CSI 3.52rCSI 3.39%PRS 22.97
-
CSI 3.51rCSI 11.78%PRS 15.95
-
CSI 3.28rCSI 18.92%PRS 27.97
-
CSI 3.16rCSI 2.8%PRS 22.36
-
CSI 3.08rCSI 8.24%PRS 18.5
-
CSI 3.08rCSI 2.14%PRS 26.73
-
CSI 3.07rCSI 6.79%PRS 20.49
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CSI 3.05rCSI 71%PRS 40.91
-
CSI 3.02rCSI 6.2%PRS 21.73
-
CSI 3.01rCSI 4.02%PRS 41.63
-
CSI 3.01rCSI 10.69%PRS 62.09
-
CSI 2.96rCSI 2.96%PRS 18.97
-
CSI 2.93rCSI 16.79%PRS 32.76
-
CSI 2.87rCSI 2.22%PRS 21.38
-
CSI 2.86rCSI 4.18%PRS 23.51
-
CSI 2.79rCSI 2.35%PRS 34.89
-
CSI 2.75rCSI 14.22%PRS 42.5
-
CSI 2.72rCSI 17.86%PRS 61.23
-
CSI 2.7rCSI 3.69%PRS 25.05
-
CSI 2.65rCSI 3.23%PRS 27.74
-
CSI 2.62rCSI 4.3%PRS 16.99
-
CSI 2.56rCSI 1.78%PRS 31.32
-
CSI 2.55rCSI 2.62%PRS 35.62
-
CSI 2.53rCSI 2.32%PRS 26.11
-
CSI 2.51rCSI 2.82%PRS 35.17
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CSI 2.47rCSI 3.78%PRS 22.36
-
CSI 2.46rCSI 5.69%PRS 17.89
-
CSI 2.46rCSI 1.84%PRS 37.18
-
CSI 2.44rCSI 5.38%PRS 25.41
-
CSI 2.43rCSI 26.42%PRS 41.79
-
CSI 2.42rCSI 14.09%PRS 32.6
-
CSI 2.42rCSI 2.47%PRS 40.25
-
CSI 2.4rCSI 6.07%PRS 27.28
-
CSI 2.38rCSI 10.57%PRS 72.28
-
CSI 2.32rCSI 5.89%PRS 16.8
-
CSI 2.27rCSI 1.72%PRS 30.43
-
CSI 2.26rCSI 2.06%PRS 33.85
-
CSI 2.24rCSI 1.86%PRS 21.06
-
CSI 2.23rCSI 3.6%PRS 16.92
-
CSI 2.23rCSI 2.08%PRS 22.24
-
CSI 2.22rCSI 2.06%PRS 39.76
-
CSI 2.21rCSI 2.17%PRS 34.4
-
CSI 2.15rCSI 3.42%PRS 18.71
-
CSI 2.11rCSI 5.36%PRS 22.13
-
CSI 2.08rCSI 3.37%PRS 22.35
-
CSI 2.04rCSI 6.03%PRS 26.11
-
CSI 2.03rCSI 10.21%PRS 29.27
-
CSI 2.01rCSI 2.78%PRS 30.81
-
CSI 2rCSI 1.89%PRS 23.32
-
CSI 1.96rCSI 4.6%PRS 31.73
-
CSI 1.96rCSI 5.67%PRS 24.96
-
CSI 1.95rCSI 1.58%PRS 23.32
-
CSI 1.94rCSI 5.13%PRS 26.47
-
CSI 1.94rCSI 2.48%PRS 21.24
-
CSI 1.89rCSI 4.91%PRS 20.62
-
CSI 1.88rCSI 9.01%PRS 18.03
-
CSI 1.86rCSI 2.37%PRS 25.63
-
CSI 1.86rCSI 2.38%PRS 25.71
-
CSI 1.82rCSI 1.35%PRS 32.59
-
CSI 1.81rCSI 1.89%PRS 22.76
-
CSI 1.8rCSI 1.43%PRS 39.43
-
CSI 1.79rCSI 5.14%PRS 33.3
-
CSI 1.79rCSI 1.25%PRS 23.66
-
CSI 1.72rCSI 3.44%PRS 16.32
-
CSI 1.71rCSI 2.15%PRS 28.75
-
CSI 1.7rCSI 1.78%PRS 23.54
-
CSI 1.68rCSI 1.95%PRS 31.87
-
CSI 1.67rCSI 3.97%PRS 25.21
-
CSI 1.65rCSI 1.42%PRS 33.95
-
CSI 1.65rCSI 1.37%PRS 22.54
-
CSI 1.63rCSI 1.43%PRS 29.53
-
CSI 1.6rCSI 1.67%PRS 57.95
-
CSI -0.2rCSI -1.3%PRS 17.3%
-
CSI -0.2rCSI -0.8%PRS 38.4%
-
CSI 0.0rCSI 0.0%PRS 24.3%
-
CSI 0.1rCSI 0.2%PRS 34.4%
-
CSI 0.1rCSI 0.8%PRS 11.8%
-
CSI 0.1rCSI 0.8%PRS 42.0%
-
CSI 0.1rCSI 0.8%PRS 32.6%
-
CSI 0.2rCSI 2.1%PRS 60.4%
-
CSI 0.2rCSI 3.5%PRS 59.3%
-
CSI 0.2rCSI 0.6%PRS 17.0%
-
CSI 0.2rCSI 1.7%PRS 13.5%
-
CSI 0.2rCSI 1.0%PRS 51.5%
-
CSI 0.2rCSI 2.4%PRS 54.6%
-
CSI 0.3rCSI 6.0%PRS 88.0%
-
CSI 0.3rCSI 3.9%PRS 17.4%
-
CSI 0.3rCSI 1.2%PRS 40.0%
-
CSI 0.3rCSI 1.8%PRS 53.4%
-
CSI 0.3rCSI 0.6%PRS 42.4%
-
CSI 0.3rCSI 1.7%PRS 37.2%
-
CSI 0.3rCSI 0.9%PRS 36.9%
-
CSI 0.3rCSI 0.3%PRS 27.9%
-
CSI 0.3rCSI 1.5%PRS 38.1%
-
CSI 0.3rCSI 1.2%PRS 35.8%
-
CSI 0.4rCSI 0.4%PRS 27.0%
-
CSI 0.4rCSI 0.7%PRS 13.0%
-
CSI 0.4rCSI 0.7%PRS 42.2%
-
CSI 0.4rCSI 0.6%PRS 28.5%
-
CSI 0.4rCSI 3.1%PRS 40.2%
-
CSI 0.4rCSI 2.5%PRS 52.0%
-
CSI 0.4rCSI 10.5%PRS 12.6%
-
CSI 0.5rCSI 1.1%PRS 14.9%
-
CSI 0.5rCSI 2.2%PRS 52.7%
-
CSI 0.5rCSI 0.9%PRS 42.5%
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CSI 0.5rCSI 3.0%PRS 62.4%
-
CSI 0.5rCSI 1.4%PRS 36.1%
-
CSI 0.5rCSI 5.6%PRS 62.9%
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CSI 0.5rCSI 1.2%PRS 22.8%
-
CSI 0.5rCSI 1.0%PRS 45.8%
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CSI 0.6rCSI 3.3%PRS 13.8%
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CSI 0.6rCSI 2.6%PRS 45.0%
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CSI 0.6rCSI 1.4%PRS 35.1%
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CSI 0.6rCSI 1.6%PRS 22.5%
-
CSI 0.6rCSI 2.5%PRS 31.5%
-
CSI 0.6rCSI 2.2%PRS 38.0%
-
CSI 0.6rCSI 1.5%PRS 39.1%
-
CSI 0.6rCSI 0.8%PRS 38.4%
-
CSI 0.6rCSI 2.1%PRS 27.0%
-
CSI 0.6rCSI 1.5%PRS 32.4%
-
CSI 0.6rCSI 2.5%PRS 42.4%
-
CSI 0.7rCSI 1.0%PRS 25.3%
-
CSI 0.7rCSI 20.1%PRS 46.4%
-
CSI 0.7rCSI 0.8%PRS 21.6%
-
CSI 0.7rCSI 1.8%PRS 28.8%
-
CSI 0.7rCSI 1.8%PRS 20.6%
-
CSI 0.7rCSI 2.2%PRS 18.1%
-
CSI 0.7rCSI 1.0%PRS 30.8%
-
CSI 0.7rCSI 3.4%PRS 27.3%
-
CSI 0.7rCSI 0.8%PRS 44.0%
-
CSI 0.7rCSI 0.5%PRS 27.4%
-
CSI 0.7rCSI 3.1%PRS 20.5%
-
CSI 0.7rCSI 1.1%PRS 20.4%
-
CSI 0.7rCSI 1.7%PRS 25.9%
-
CSI 0.7rCSI 1.1%PRS 22.6%
-
CSI 0.8rCSI 4.6%PRS 63.9%
-
CSI 0.8rCSI 0.6%PRS 34.9%
-
CSI 0.8rCSI 1.5%PRS 37.1%
-
CSI 0.8rCSI 1.7%PRS 33.4%
-
CSI 0.8rCSI 1.3%PRS 13.1%
-
CSI 0.8rCSI 1.5%PRS 49.2%
-
CSI 0.8rCSI 2.4%PRS 14.0%
-
CSI 0.8rCSI 1.3%PRS 14.3%
-
CSI 0.8rCSI 1.2%PRS 30.9%
-
CSI 0.8rCSI 0.6%PRS 30.7%
-
CSI 0.8rCSI 2.0%PRS 12.9%
-
CSI 0.8rCSI 1.1%PRS 33.4%
-
CSI 0.8rCSI 1.1%PRS 33.8%
-
CSI 0.9rCSI 1.5%PRS 18.9%
-
CSI 0.9rCSI 2.3%PRS 20.7%
-
CSI 0.9rCSI 2.8%PRS 23.1%
-
CSI 0.9rCSI 1.3%PRS 29.7%
-
CSI 0.9rCSI 1.0%PRS 37.5%
-
CSI 0.9rCSI 1.0%PRS 23.1%
-
CSI 0.9rCSI 0.5%PRS 31.2%
-
CSI 0.9rCSI 1.1%PRS 30.8%
-
CSI 0.9rCSI 1.3%PRS 17.2%
-
CSI 0.9rCSI 2.2%PRS 42.9%
-
CSI 1.0rCSI 3.0%PRS 31.0%
-
CSI 1.0rCSI 1.3%PRS 19.4%
-
CSI 1.0rCSI 0.8%PRS 20.7%
-
CSI 1.0rCSI 0.9%PRS 23.1%
-
CSI 1.0rCSI 0.8%PRS 22.3%
-
CSI 1.0rCSI 5.0%PRS 66.8%
-
CSI 1.0rCSI 1.4%PRS 20.5%
-
CSI 1.0rCSI 1.7%PRS 29.9%
-
CSI 1.0rCSI 5.1%PRS 66.3%
-
CSI 1.0rCSI 1.3%PRS 13.7%
-
CSI 1.0rCSI 3.9%PRS 30.2%
-
CSI 1.0rCSI 1.5%PRS 25.3%
-
CSI 1.0rCSI 2.5%PRS 57.1%
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CSI 1.0rCSI 4.0%PRS 36.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3512341529
Symbol: COPB_HUMAN
Name: Coatomer subunit beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7982906
Title: Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.
PubMed ID: 7982906
PubMed ID: 7573041
Title: The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex.
PubMed ID: 7573041
PubMed ID: 11056392
Title: Identification and characterization of novel isoforms of COP I subunits.
PubMed ID: 11056392
PubMed ID: 11520457
Title: The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments.
PubMed ID: 11520457
PubMed ID: 12582157
Title: An essential function of tapasin in quality control of HLA-G molecules.
PubMed ID: 12582157
PubMed ID: 17451557
Title: Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.
PubMed ID: 17451557
PubMed ID: 18385291
Title: Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1.
PubMed ID: 18385291
PubMed ID: 18556652
Title: Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.
PubMed ID: 18556652
PubMed ID: 18725938
Title: HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.
PubMed ID: 18725938
PubMed ID: 18356299
Title: COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro.
PubMed ID: 18356299
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19364919
Title: Early endosomes and endosomal coatomer are required for autophagy.
PubMed ID: 19364919
PubMed ID: 20362547
Title: Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.
PubMed ID: 20362547
PubMed ID: 20056612
Title: Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly.
PubMed ID: 20056612
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 24806965
Title: TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport.
PubMed ID: 24806965
DOI: 10.1242/jcs.136754
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30352685
Title: Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.
PubMed ID: 30352685
PubMed ID: 33632302
Title: Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly.
PubMed ID: 33632302
Sequence Information:
- Length: 953
- Mass: 107142
- Checksum: BE916C1C5A599D79
- Sequence:
MTAAENVCYT LINVPMDSEP PSEISLKNDL EKGDVKSKTE ALKKVIIMIL NGEKLPGLLM TIIRFVLPLQ DHTIKKLLLV FWEIVPKTTP DGRLLHEMIL VCDAYRKDLQ HPNEFIRGST LRFLCKLKEA ELLEPLMPAI RACLEHRHSY VRRNAVLAIY TIYRNFEHLI PDAPELIHDF LVNEKDASCK RNAFMMLIHA DQDRALDYLS TCIDQVQTFG DILQLVIVEL IYKVCHANPS ERARFIRCIY NLLQSSSPAV KYEAAGTLVT LSSAPTAIKA AAQCYIDLII KESDNNVKLI VLDRLIELKE HPAHERVLQD LVMDILRVLS TPDLEVRKKT LQLALDLVSS RNVEELVIVL KKEVIKTNNV SEHEDTDKYR QLLVRTLHSC SVRFPDMAAN VIPVLMEFLS DNNEAAAADV LEFVREAIQR FDNLRMLIVE KMLEVFHAIK SVKIYRGALW ILGEYCSTKE DIQSVMTEIR RSLGEIPIVE SEIKKEAGEL KPEEEITVGP VQKLVTEMGT YATQSALSSS RPTKKEEDRP PLRGFLLDGD FFVAASLATT LTKIALRYVA LVQEKKKQNS FVAEAMLLMA TILHLGKSSL PKKPITDDDV DRISLCLKVL SECSPLMNDI FNKECRQSLS HMLSAKLEEE KLSQKKESEK RNVTVQPDDP ISFMQLTAKN EMNCKEDQFQ LSLLAAMGNT QRKEAADPLA SKLNKVTQLT GFSDPVYAEA YVHVNQYDIV LDVLVVNQTS DTLQNCTLEL ATLGDLKLVE KPSPLTLAPH DFANIKANVK VASTENGIIF GNIVYDVSGA ASDRNCVVLS DIHIDIMDYI QPATCTDAEF RQMWAEFEWE NKVTVNTNMV DLNDYLQHIL KSTNMKCLTP EKALSGYCGF MAANLYARSI FGEDALANVS IEKPIHQGPD AAVTGHIRIR AKSQGMALSL GDKINLSQKK TSI