Details for: COPB1

Gene ID: 1315

Symbol: COPB1

Ensembl ID: ENSG00000129083

Description: COPI coat complex subunit beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.86
    Marker Score: 4229.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.75
    Marker Score: 60578
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2371
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.58
    Marker Score: 6112.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.57
    Marker Score: 4203
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.51
    Marker Score: 2671
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.48
    Marker Score: 596
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.48
    Marker Score: 418
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.46
    Marker Score: 2100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.45
    Marker Score: 829.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.45
    Marker Score: 419
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1529
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.45
    Marker Score: 3645
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.44
    Marker Score: 12551
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.42
    Marker Score: 351.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.42
    Marker Score: 410
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.41
    Marker Score: 15905
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.41
    Marker Score: 336
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.41
    Marker Score: 47813
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.4
    Marker Score: 1859
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4
    Marker Score: 663
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.4
    Marker Score: 385
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.4
    Marker Score: 1750
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.39
    Marker Score: 1442
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.38
    Marker Score: 11870
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.38
    Marker Score: 1618
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.37
    Marker Score: 1259
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.36
    Marker Score: 1307
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.36
    Marker Score: 1383
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.36
    Marker Score: 14036
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.36
    Marker Score: 83548
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.36
    Marker Score: 1367
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.35
    Marker Score: 1443
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.35
    Marker Score: 3066
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.35
    Marker Score: 1855
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.35
    Marker Score: 5479
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.34
    Marker Score: 5592
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.34
    Marker Score: 545
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.34
    Marker Score: 943
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.33
    Marker Score: 464
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.33
    Marker Score: 887
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.33
    Marker Score: 888
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.33
    Marker Score: 1550
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.33
    Marker Score: 426
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.32
    Marker Score: 12425
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.32
    Marker Score: 5187.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.32
    Marker Score: 4673
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.31
    Marker Score: 12460
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.31
    Marker Score: 763
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.31
    Marker Score: 4833.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.31
    Marker Score: 5629
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.3
    Marker Score: 887
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.29
    Marker Score: 8255
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.29
    Marker Score: 1669
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.29
    Marker Score: 12785
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.29
    Marker Score: 635
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1975
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.28
    Marker Score: 294
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.27
    Marker Score: 595
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.27
    Marker Score: 1274
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.26
    Marker Score: 8227
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.26
    Marker Score: 1333
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.26
    Marker Score: 4323
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.25
    Marker Score: 525
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.25
    Marker Score: 46199
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.25
    Marker Score: 466
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.25
    Marker Score: 1325
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.25
    Marker Score: 2373.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.25
    Marker Score: 2065
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.24
    Marker Score: 1996
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1422
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.23
    Marker Score: 2573
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.23
    Marker Score: 2598
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.23
    Marker Score: 1337
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.22
    Marker Score: 1177
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.21
    Marker Score: 1870
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.21
    Marker Score: 7350
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.21
    Marker Score: 754
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2
    Marker Score: 4654
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.2
    Marker Score: 1275
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.2
    Marker Score: 416
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.2
    Marker Score: 45477
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.2
    Marker Score: 500
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 577
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.19
    Marker Score: 1899
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.19
    Marker Score: 483
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.19
    Marker Score: 449
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.19
    Marker Score: 867
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.18
    Marker Score: 541
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.18
    Marker Score: 806
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.18
    Marker Score: 2157
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.18
    Marker Score: 366
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.18
    Marker Score: 677
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.18
    Marker Score: 258
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.18
    Marker Score: 5651
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.17
    Marker Score: 274
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.17
    Marker Score: 916
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.16
    Marker Score: 625
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.16
    Marker Score: 278
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.16
    Marker Score: 966

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Other Information

**Key characteristics:** * COPB1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including acinar cells of the salivary gland, urothelial cells of the bladder, neural progenitor cells, kidney loop of Henle cells, luminal epithelial cells of the mammary gland, type A enteroendocrine cells, preosteoblasts, oogonial cells, and fibroblasts of the breast. * COPB1 is a key component of the COPI coat complex, which is responsible for the sorting and transport of proteins between the ER and the Golgi apparatus. **Pathways and functions:** * COPB1 is involved in the assembly and transport of glycoproteins in the ER. * It is a key component of the COPI coat complex, which is responsible for the sorting and transport of proteins between the ER and the Golgi apparatus. * COPB1 is also involved in the regulation of protein trafficking between the ER and the cell surface. * It is involved in the degradation of proteins in the lysosome. **Clinical significance:** * COPB1 mutations can lead to a rare genetic disorder called coatomer-mediated protein-in-transit deficiency (CMPITD). * CMPITD is characterized by a variety of clinical symptoms, including growth retardation, intellectual disability, and liver disease. * Genetic testing for CMPITD can help to diagnose the condition and monitor the progression of the disease.

Genular Protein ID: 3512341529

Symbol: COPB_HUMAN

Name: Coatomer subunit beta

UniProtKB Accession Codes:

P53618 D3DQX0 Q6GTT7 Q9NTK2 Q9UNW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7982906

Title: Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

PubMed ID: 7982906

DOI: 10.1016/s0021-9258(18)43773-8

PubMed ID: 7573041

Title: The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex.

PubMed ID: 7573041

PubMed ID: 11056392

Title: Identification and characterization of novel isoforms of COP I subunits.

PubMed ID: 11056392

DOI: 10.1093/oxfordjournals.jbchem.a022817

PubMed ID: 11520457

Title: The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments.

PubMed ID: 11520457

DOI: 10.1016/s1074-7613(01)00179-0

PubMed ID: 12582157

Title: An essential function of tapasin in quality control of HLA-G molecules.

PubMed ID: 12582157

DOI: 10.1074/jbc.m212882200

PubMed ID: 17451557

Title: Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.

PubMed ID: 17451557

DOI: 10.1111/j.1600-0854.2007.00554.x

PubMed ID: 18385291

Title: Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1.

PubMed ID: 18385291

DOI: 10.1152/ajpcell.00010.2008

PubMed ID: 18556652

Title: Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.

PubMed ID: 18556652

DOI: 10.1074/jbc.m801869200

PubMed ID: 18725938

Title: HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.

PubMed ID: 18725938

DOI: 10.1371/journal.ppat.1000131

PubMed ID: 18356299

Title: COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro.

PubMed ID: 18356299

DOI: 10.1073/pnas.0710100105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19364919

Title: Early endosomes and endosomal coatomer are required for autophagy.

PubMed ID: 19364919

DOI: 10.1083/jcb.200810098

PubMed ID: 20362547

Title: Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.

PubMed ID: 20362547

DOI: 10.1016/j.bbrc.2010.03.171

PubMed ID: 20056612

Title: Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly.

PubMed ID: 20056612

DOI: 10.1074/jbc.m109.047084

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24806965

Title: TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport.

PubMed ID: 24806965

DOI: 10.1242/jcs.136754

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30352685

Title: Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

PubMed ID: 30352685

DOI: 10.1016/j.bbrc.2018.10.073

PubMed ID: 33632302

Title: Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly.

PubMed ID: 33632302

DOI: 10.1186/s13073-021-00850-w

Sequence Information:

  • Length: 953
  • Mass: 107142
  • Checksum: BE916C1C5A599D79
  • Sequence:
    • MTAAENVCYT LINVPMDSEP PSEISLKNDL EKGDVKSKTE ALKKVIIMIL NGEKLPGLLM 
TIIRFVLPLQ DHTIKKLLLV FWEIVPKTTP DGRLLHEMIL VCDAYRKDLQ HPNEFIRGST 
LRFLCKLKEA ELLEPLMPAI RACLEHRHSY VRRNAVLAIY TIYRNFEHLI PDAPELIHDF 
LVNEKDASCK RNAFMMLIHA DQDRALDYLS TCIDQVQTFG DILQLVIVEL IYKVCHANPS 
ERARFIRCIY NLLQSSSPAV KYEAAGTLVT LSSAPTAIKA AAQCYIDLII KESDNNVKLI 
VLDRLIELKE HPAHERVLQD LVMDILRVLS TPDLEVRKKT LQLALDLVSS RNVEELVIVL 
KKEVIKTNNV SEHEDTDKYR QLLVRTLHSC SVRFPDMAAN VIPVLMEFLS DNNEAAAADV 
LEFVREAIQR FDNLRMLIVE KMLEVFHAIK SVKIYRGALW ILGEYCSTKE DIQSVMTEIR 
RSLGEIPIVE SEIKKEAGEL KPEEEITVGP VQKLVTEMGT YATQSALSSS RPTKKEEDRP 
PLRGFLLDGD FFVAASLATT LTKIALRYVA LVQEKKKQNS FVAEAMLLMA TILHLGKSSL 
PKKPITDDDV DRISLCLKVL SECSPLMNDI FNKECRQSLS HMLSAKLEEE KLSQKKESEK 
RNVTVQPDDP ISFMQLTAKN EMNCKEDQFQ LSLLAAMGNT QRKEAADPLA SKLNKVTQLT 
GFSDPVYAEA YVHVNQYDIV LDVLVVNQTS DTLQNCTLEL ATLGDLKLVE KPSPLTLAPH 
DFANIKANVK VASTENGIIF GNIVYDVSGA ASDRNCVVLS DIHIDIMDYI QPATCTDAEF 
RQMWAEFEWE NKVTVNTNMV DLNDYLQHIL KSTNMKCLTP EKALSGYCGF MAANLYARSI 
FGEDALANVS IEKPIHQGPD AAVTGHIRIR AKSQGMALSL GDKINLSQKK TSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.