COPB1 | ENSG00000129083 | NCBI 1315

Details for: COPB1

Gene ID: 1315

Symbol: COPB1

Ensembl ID: ENSG00000129083

Description: COPI coat complex subunit beta 1

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Copi vesicle coat
(GO:0030126)
Cytosol
(GO:0005829)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Ficolin-1-rich granule membrane
(GO:0101003)
Golgi-associated vesicle
(GO:0005798)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Intra-golgi vesicle-mediated transport
(GO:0006891)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular protein transport
(GO:0006886)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Secretory granule membrane
(GO:0030667)
Structural molecule activity
(GO:0005198)
Tertiary granule membrane
(GO:0070821)
Transport vesicle
(GO:0030133)

Other Information

Proteins

Coatomer subunit beta

Genular Protein ID: 3512341529

Symbol: COPB_HUMAN

Name: Coatomer subunit beta

UniProtKB Accession Codes:

P53618 D3DQX0 Q6GTT7 Q9NTK2 Q9UNW7

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7982906

Title: Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

PubMed ID: 7982906

DOI: 10.1016/s0021-9258(18)43773-8

PubMed ID: 7573041

Title: The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex.

PubMed ID: 7573041

PubMed ID: 11056392

Title: Identification and characterization of novel isoforms of COP I subunits.

PubMed ID: 11056392

DOI: 10.1093/oxfordjournals.jbchem.a022817

PubMed ID: 11520457

Title: The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments.

PubMed ID: 11520457

DOI: 10.1016/s1074-7613(01)00179-0

PubMed ID: 12582157

Title: An essential function of tapasin in quality control of HLA-G molecules.

PubMed ID: 12582157

DOI: 10.1074/jbc.m212882200

PubMed ID: 17451557

Title: Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.

PubMed ID: 17451557

DOI: 10.1111/j.1600-0854.2007.00554.x

PubMed ID: 18385291

Title: Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1.

PubMed ID: 18385291

DOI: 10.1152/ajpcell.00010.2008

PubMed ID: 18556652

Title: Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.

PubMed ID: 18556652

DOI: 10.1074/jbc.m801869200

PubMed ID: 18725938

Title: HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.

PubMed ID: 18725938

DOI: 10.1371/journal.ppat.1000131

PubMed ID: 18356299

Title: COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro.

PubMed ID: 18356299

DOI: 10.1073/pnas.0710100105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19364919

Title: Early endosomes and endosomal coatomer are required for autophagy.

PubMed ID: 19364919

DOI: 10.1083/jcb.200810098

PubMed ID: 20362547

Title: Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.

PubMed ID: 20362547

DOI: 10.1016/j.bbrc.2010.03.171

PubMed ID: 20056612

Title: Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly.

PubMed ID: 20056612

DOI: 10.1074/jbc.m109.047084

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24806965

Title: TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport.

PubMed ID: 24806965

DOI: 10.1242/jcs.136754

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30352685

Title: Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

PubMed ID: 30352685

DOI: 10.1016/j.bbrc.2018.10.073

PubMed ID: 33632302

Title: Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly.

PubMed ID: 33632302

DOI: 10.1186/s13073-021-00850-w

Sequence Information:

Length: 953
Mass: 107142
Checksum: BE916C1C5A599D79
Sequence:

MTAAENVCYT LINVPMDSEP PSEISLKNDL EKGDVKSKTE ALKKVIIMIL NGEKLPGLLM 
TIIRFVLPLQ DHTIKKLLLV FWEIVPKTTP DGRLLHEMIL VCDAYRKDLQ HPNEFIRGST 
LRFLCKLKEA ELLEPLMPAI RACLEHRHSY VRRNAVLAIY TIYRNFEHLI PDAPELIHDF 
LVNEKDASCK RNAFMMLIHA DQDRALDYLS TCIDQVQTFG DILQLVIVEL IYKVCHANPS 
ERARFIRCIY NLLQSSSPAV KYEAAGTLVT LSSAPTAIKA AAQCYIDLII KESDNNVKLI 
VLDRLIELKE HPAHERVLQD LVMDILRVLS TPDLEVRKKT LQLALDLVSS RNVEELVIVL 
KKEVIKTNNV SEHEDTDKYR QLLVRTLHSC SVRFPDMAAN VIPVLMEFLS DNNEAAAADV 
LEFVREAIQR FDNLRMLIVE KMLEVFHAIK SVKIYRGALW ILGEYCSTKE DIQSVMTEIR 
RSLGEIPIVE SEIKKEAGEL KPEEEITVGP VQKLVTEMGT YATQSALSSS RPTKKEEDRP 
PLRGFLLDGD FFVAASLATT LTKIALRYVA LVQEKKKQNS FVAEAMLLMA TILHLGKSSL 
PKKPITDDDV DRISLCLKVL SECSPLMNDI FNKECRQSLS HMLSAKLEEE KLSQKKESEK 
RNVTVQPDDP ISFMQLTAKN EMNCKEDQFQ LSLLAAMGNT QRKEAADPLA SKLNKVTQLT 
GFSDPVYAEA YVHVNQYDIV LDVLVVNQTS DTLQNCTLEL ATLGDLKLVE KPSPLTLAPH 
DFANIKANVK VASTENGIIF GNIVYDVSGA ASDRNCVVLS DIHIDIMDYI QPATCTDAEF 
RQMWAEFEWE NKVTVNTNMV DLNDYLQHIL KSTNMKCLTP EKALSGYCGF MAANLYARSI 
FGEDALANVS IEKPIHQGPD AAVTGHIRIR AKSQGMALSL GDKINLSQKK TSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COPB1

Associated with

Other Information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic. PubMed ID: 7982906

The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex. PubMed ID: 7573041

Identification and characterization of novel isoforms of COP I subunits. PubMed ID: 11056392

The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments. PubMed ID: 11520457

An essential function of tapasin in quality control of HLA-G molecules. PubMed ID: 12582157

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. PubMed ID: 17451557

Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1. PubMed ID: 18385291

Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. PubMed ID: 18556652

HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PubMed ID: 18725938

COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro. PubMed ID: 18356299

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Early endosomes and endosomal coatomer are required for autophagy. PubMed ID: 19364919

Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP. PubMed ID: 20362547

Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly. PubMed ID: 20056612

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. PubMed ID: 24806965

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development. PubMed ID: 30352685

Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly. PubMed ID: 33632302