Details for: KLF6

Gene ID: 1316

Symbol: KLF6

Ensembl ID: ENSG00000067082

Description: KLF transcription factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 683.9811
    Cell Significance Index: -106.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 337.2451
    Cell Significance Index: -85.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 296.9795
    Cell Significance Index: -122.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 284.1058
    Cell Significance Index: -115.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 250.5917
    Cell Significance Index: -118.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 244.0972
    Cell Significance Index: -125.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 176.4025
    Cell Significance Index: -118.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 123.6144
    Cell Significance Index: -118.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 88.7542
    Cell Significance Index: -109.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.4479
    Cell Significance Index: -94.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.2806
    Cell Significance Index: -102.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.3626
    Cell Significance Index: -111.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.9841
    Cell Significance Index: -54.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.4455
    Cell Significance Index: 156.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.3805
    Cell Significance Index: 51.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.1657
    Cell Significance Index: 195.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.8833
    Cell Significance Index: 168.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.7537
    Cell Significance Index: 270.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.4147
    Cell Significance Index: 699.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.8947
    Cell Significance Index: 86.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.8904
    Cell Significance Index: 364.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.3196
    Cell Significance Index: 278.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.1484
    Cell Significance Index: 387.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.9468
    Cell Significance Index: 68.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9088
    Cell Significance Index: 135.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7648
    Cell Significance Index: 498.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5112
    Cell Significance Index: 130.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1426
    Cell Significance Index: 294.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0923
    Cell Significance Index: 45.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0076
    Cell Significance Index: 887.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8754
    Cell Significance Index: 221.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8130
    Cell Significance Index: 16.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7446
    Cell Significance Index: 19.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.6779
    Cell Significance Index: 28.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6222
    Cell Significance Index: 114.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5214
    Cell Significance Index: 830.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2675
    Cell Significance Index: 162.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.2028
    Cell Significance Index: 137.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1723
    Cell Significance Index: 53.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.8356
    Cell Significance Index: 95.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8318
    Cell Significance Index: 142.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7503
    Cell Significance Index: 677.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5976
    Cell Significance Index: 17.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5103
    Cell Significance Index: 101.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5075
    Cell Significance Index: 82.5500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4519
    Cell Significance Index: 2.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3716
    Cell Significance Index: 9.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3497
    Cell Significance Index: 34.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3415
    Cell Significance Index: 37.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3193
    Cell Significance Index: 60.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3068
    Cell Significance Index: 10.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2851
    Cell Significance Index: 57.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1284
    Cell Significance Index: 174.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0694
    Cell Significance Index: 24.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0686
    Cell Significance Index: 7.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0244
    Cell Significance Index: 1.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0169
    Cell Significance Index: 0.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0151
    Cell Significance Index: 1.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0149
    Cell Significance Index: 11.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0229
    Cell Significance Index: -0.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0234
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0528
    Cell Significance Index: -32.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0635
    Cell Significance Index: -117.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0684
    Cell Significance Index: -105.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0706
    Cell Significance Index: -52.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0751
    Cell Significance Index: -51.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0778
    Cell Significance Index: -49.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1525
    Cell Significance Index: -86.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1788
    Cell Significance Index: -81.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3303
    Cell Significance Index: -95.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3782
    Cell Significance Index: -6.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3830
    Cell Significance Index: -80.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4756
    Cell Significance Index: -12.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5037
    Cell Significance Index: -9.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6391
    Cell Significance Index: -22.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6487
    Cell Significance Index: -18.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6670
    Cell Significance Index: -35.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7176
    Cell Significance Index: -83.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7183
    Cell Significance Index: -104.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7988
    Cell Significance Index: -11.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8127
    Cell Significance Index: -19.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9404
    Cell Significance Index: -97.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9774
    Cell Significance Index: -24.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2555
    Cell Significance Index: -79.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2753
    Cell Significance Index: -17.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2782
    Cell Significance Index: -64.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3046
    Cell Significance Index: -73.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.3334
    Cell Significance Index: -81.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.3985
    Cell Significance Index: -57.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4362
    Cell Significance Index: -113.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.5468
    Cell Significance Index: -104.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6502
    Cell Significance Index: -101.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.6814
    Cell Significance Index: -48.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8396
    Cell Significance Index: -58.9200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.9640
    Cell Significance Index: -31.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9786
    Cell Significance Index: -49.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0077
    Cell Significance Index: -34.6100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -2.2936
    Cell Significance Index: -10.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF6 is a Krueppel-like factor transcription factor, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is a member of the Krüppel-like factor (KLF) family, which consists of 11 transcription factors that play crucial roles in various biological processes. KLF6 is specifically expressed in various immune cells, including classical monocytes, T-helper 22 cells, and natural T-regulatory cells, suggesting its involvement in immune regulation and tolerance. **Pathways and Functions:** KLF6 regulates gene expression through its interaction with specific DNA sequences, influencing various cellular processes. Some of the key signaling pathways and functions of KLF6 include: 1. **B cell differentiation:** KLF6 regulates the expression of genes involved in B cell development and differentiation, highlighting its role in immune system development and function. 2. **Chromatin remodeling:** KLF6 interacts with chromatin remodeling complexes, influencing the structure and function of chromatin and, consequently, gene expression. 3. **Transcriptional control:** KLF6 regulates the expression of genes involved in immune response, cell differentiation, and proliferation, acting as a transcriptional activator or repressor. 4. **Metal ion binding:** KLF6 binds to metal ions, which are essential for its DNA-binding activity and transcriptional regulation. **Clinical Significance:** KLF6 has been implicated in various diseases, including: 1. **Autoimmune diseases:** KLF6 has been shown to regulate the expression of genes involved in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** KLF6 has been identified as a tumor suppressor gene, with altered expression levels observed in various types of cancer, including breast, lung, and colon cancer. 3. **Immune disorders:** KLF6 has been implicated in immune disorders, such as multiple sclerosis and type 1 diabetes, where its expression and function are altered. In conclusion, KLF6 is a multifunctional transcription factor that plays a critical role in regulating immune response, cell differentiation, and transcriptional control. Its dysregulation has been implicated in various diseases, highlighting the importance of KLF6 in maintaining immune homeostasis and overall health. Further research is needed to elucidate the molecular mechanisms underlying KLF6's functions and its role in disease pathology.

Genular Protein ID: 2699341844

Symbol: KLF6_HUMAN

Name: Krueppel-like factor 6

UniProtKB Accession Codes:

Q99612 B2RE86 B4DDN0 D3DRR1 F5H3M5 Q5VUT7 Q5VUT8 Q9BT79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 3 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9000136

Title: Identification of Bcd, a novel proto-oncogene expressed in B-cells.

PubMed ID: 9000136

PubMed ID: 9083102

Title: A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene.

PubMed ID: 9083102

DOI: 10.1074/jbc.272.14.9573

PubMed ID: 9689109

Title: Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.

PubMed ID: 9689109

DOI: 10.1073/pnas.95.16.9500

PubMed ID: 9685731

Title: Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter.

PubMed ID: 9685731

DOI: 10.1093/oxfordjournals.jbchem.a022124

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 11752579

Title: KLF6, a candidate tumor suppressor gene mutated in prostate cancer.

PubMed ID: 11752579

DOI: 10.1126/science.1066326

PubMed ID: 15824733

Title: Genetic alterations of the KLF6 gene in gastric cancer.

PubMed ID: 15824733

DOI: 10.1038/sj.onc.1208670

PubMed ID: 33227311

Title: ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like Factors.

PubMed ID: 33227311

DOI: 10.1016/j.jmb.2020.11.021

Sequence Information:

  • Length: 283
  • Mass: 31865
  • Checksum: 84294A7E6D0A0231
  • Sequence:
    • MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 
EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS 
PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS 
GKPGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR 
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL

Genular Protein ID: 2335292826

Symbol: D3GC14_HUMAN

Name: N/A

UniProtKB Accession Codes:

D3GC14

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 241
  • Mass: 27110
  • Checksum: C3FFC72CF1B8FDE6
  • Sequence:
    • MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 
EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS 
PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS 
GKPGEKPYRC SWEGCEWRFA RSDELTRHFR KHTGAKPFKC SHCDRCFSRS DHLALHMKRH 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.