Gene KLF6 - ENSG00000067082 | NCBI Gene ID: 1316

Details for: KLF6

Gene ID: 1316

Symbol: KLF6

Ensembl ID: ENSG00000067082

Description: KLF transcription factor 6

Associated with

B cell differentiation
(GO:0030183)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Fibrillar center
(GO:0001650)
Intracellular membrane-bounded organelle
(GO:0043231)
Metal ion binding
(GO:0046872)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.08
Marker Score: 228419
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.95
Marker Score: 16957
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.92
Marker Score: 11006
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.91
Marker Score: 133131
Cell Name: mature T cell (CL0002419)
Fold Change: 3.87
Marker Score: 38297
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.83
Marker Score: 24413
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.79
Marker Score: 2871
Cell Name: memory T cell (CL0000813)
Fold Change: 3.75
Marker Score: 1610
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.69
Marker Score: 11638
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.65
Marker Score: 1874
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.63
Marker Score: 8848
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.62
Marker Score: 2629
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.62
Marker Score: 5336
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.57
Marker Score: 4299.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.51
Marker Score: 2748
Cell Name: blood cell (CL0000081)
Fold Change: 3.5
Marker Score: 40737
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.49
Marker Score: 3064.5
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.42
Marker Score: 2102
Cell Name: lymphocyte (CL0000542)
Fold Change: 3.39
Marker Score: 1714.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.36
Marker Score: 1970
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.35
Marker Score: 3149
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.33
Marker Score: 176157.5
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.29
Marker Score: 2584
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.28
Marker Score: 3964
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.25
Marker Score: 7927.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.2
Marker Score: 4414
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.17
Marker Score: 3126
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.16
Marker Score: 6616
Cell Name: granulocyte (CL0000094)
Fold Change: 3.15
Marker Score: 1414
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 3.13
Marker Score: 1960
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.09
Marker Score: 15187
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.08
Marker Score: 3525
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.06
Marker Score: 2503
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.04
Marker Score: 2230
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.02
Marker Score: 1771
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.01
Marker Score: 4364
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.01
Marker Score: 2567
Cell Name: reticular cell (CL0000432)
Fold Change: 3.01
Marker Score: 1097
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3
Marker Score: 2527
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3
Marker Score: 5846
Cell Name: neutrophil (CL0000775)
Fold Change: 2.99
Marker Score: 1820
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.97
Marker Score: 6742
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.96
Marker Score: 9309
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.96
Marker Score: 4849.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.93
Marker Score: 699
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.93
Marker Score: 8538
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.92
Marker Score: 8069
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.91
Marker Score: 2589
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 2.9
Marker Score: 2837
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.88
Marker Score: 11123
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.83
Marker Score: 977
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.83
Marker Score: 2446
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.8
Marker Score: 1687
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.78
Marker Score: 6266
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.78
Marker Score: 1136
Cell Name: basophil (CL0000767)
Fold Change: 2.78
Marker Score: 1320
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.77
Marker Score: 6698
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.76
Marker Score: 1895
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.76
Marker Score: 2670
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.76
Marker Score: 3002
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.76
Marker Score: 855
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 2.74
Marker Score: 1545
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.72
Marker Score: 1174
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.72
Marker Score: 2720.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.72
Marker Score: 2904
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.71
Marker Score: 11244
Cell Name: naive B cell (CL0000788)
Fold Change: 2.7
Marker Score: 2410
Cell Name: melanocyte (CL0000148)
Fold Change: 2.69
Marker Score: 1090
Cell Name: memory B cell (CL0000787)
Fold Change: 2.67
Marker Score: 2023
Cell Name: Unknown (CL0000548)
Fold Change: 2.67
Marker Score: 1947
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.67
Marker Score: 1817
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.66
Marker Score: 943
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.66
Marker Score: 2493
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 2.66
Marker Score: 578
Cell Name: oocyte (CL0000023)
Fold Change: 2.66
Marker Score: 657
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.66
Marker Score: 2858
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.64
Marker Score: 26801
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.64
Marker Score: 4475.5
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.64
Marker Score: 2330
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.6
Marker Score: 66703
Cell Name: supporting cell (CL0000630)
Fold Change: 2.6
Marker Score: 4890
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 2.59
Marker Score: 1090
Cell Name: stromal cell (CL0000499)
Fold Change: 2.59
Marker Score: 3033
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.58
Marker Score: 3743
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.57
Marker Score: 13508
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.56
Marker Score: 2453
Cell Name: pericyte (CL0000669)
Fold Change: 2.56
Marker Score: 1494
Cell Name: decidual cell (CL2000002)
Fold Change: 2.55
Marker Score: 11008
Cell Name: naive T cell (CL0000898)
Fold Change: 2.55
Marker Score: 1644
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 2.52
Marker Score: 627
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.51
Marker Score: 4380
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.51
Marker Score: 16358.5
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 2.51
Marker Score: 1348
Cell Name: enterocyte (CL0000584)
Fold Change: 2.5
Marker Score: 12021
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.5
Marker Score: 1248
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 2.5
Marker Score: 709
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.5
Marker Score: 4284
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 2.49
Marker Score: 1555
Cell Name: mature NK T cell (CL0000814)
Fold Change: 2.49
Marker Score: 1153
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.49
Marker Score: 19417

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**Key characteristics:** - KLF6 is a transcription factor belonging to the Krüppel-like factor (KLF) family. - It is expressed in high levels in B cells, dendritic cells, and macrophages. - KLF6 is a master regulator of B cell differentiation, promoting the development and survival of plasma cells. - It is involved in the regulation of B cell activation, differentiation, and survival. **Pathways and functions:** - KLF6 is a key regulator of B cell differentiation. - It is required for the development of B cells from hematopoietic stem cells. - It is also involved in the regulation of plasma cell differentiation and survival. - KLF6 promotes the transition of naive B cells into plasma cells by upregulating the expression of plasma cell-specific genes. - It also regulates the differentiation of other immune cells, such as dendritic cells and macrophages. **Clinical significance:** - Mutations in KLF6 have been linked to several human diseases, including autoimmune disorders, cancer, and inflammatory diseases. - In some cases, KLF6 mutations can lead to the development of leukemia, a cancer of the blood and bone marrow. - Targeting KLF6 has emerged as a promising therapeutic strategy for cancer and autoimmune diseases. **Additional notes:** - KLF6 is a highly conserved protein with homologs in other species. - It is a key regulator of the immune response and plays a critical role in maintaining immune homeostasis. - Dysregulation of KLF6 has been linked to a variety of diseases, highlighting its importance in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Krueppel-like factor 6
D3GC14_HUMAN

Genular Protein ID: 2699341844

Symbol: KLF6_HUMAN

Name: Krueppel-like factor 6

UniProtKB Accession Codes:

Q99612 B2RE86 B4DDN0 D3DRR1 F5H3M5 Q5VUT7 Q5VUT8 Q9BT79

Database IDs:

Citations:

PubMed ID: 9000136

Title: Identification of Bcd, a novel proto-oncogene expressed in B-cells.

PubMed ID: 9000136

PubMed ID: 9083102

Title: A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene.

PubMed ID: 9083102

DOI: 10.1074/jbc.272.14.9573

PubMed ID: 9689109

Title: Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.

PubMed ID: 9689109

DOI: 10.1073/pnas.95.16.9500

PubMed ID: 9685731

Title: Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter.

PubMed ID: 9685731

DOI: 10.1093/oxfordjournals.jbchem.a022124

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 11752579

Title: KLF6, a candidate tumor suppressor gene mutated in prostate cancer.

PubMed ID: 11752579

DOI: 10.1126/science.1066326

PubMed ID: 15824733

Title: Genetic alterations of the KLF6 gene in gastric cancer.

PubMed ID: 15824733

DOI: 10.1038/sj.onc.1208670

PubMed ID: 33227311

Title: ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like Factors.

PubMed ID: 33227311

DOI: 10.1016/j.jmb.2020.11.021

Sequence Information:

Length: 283
Mass: 31865
Checksum: 84294A7E6D0A0231
Sequence:

MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 
EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS 
PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS 
GKPGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR 
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL

Genular Protein ID: 2335292826

Symbol: D3GC14_HUMAN

Name: N/A

UniProtKB Accession Codes:

D3GC14

Database IDs:

Sequence Information:

Length: 241
Mass: 27110
Checksum: C3FFC72CF1B8FDE6
Sequence:

MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 
EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS 
PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS 
GKPGEKPYRC SWEGCEWRFA RSDELTRHFR KHTGAKPFKC SHCDRCFSRS DHLALHMKRH 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KLF6

Associated with

Cells (max top 100)

Other Information

Identification of Bcd, a novel proto-oncogene expressed in B-cells. PubMed ID: 9000136

A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. PubMed ID: 9083102

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. PubMed ID: 9689109

Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. PubMed ID: 9685731

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs. PubMed ID: 31375868

KLF6, a candidate tumor suppressor gene mutated in prostate cancer. PubMed ID: 11752579

Genetic alterations of the KLF6 gene in gastric cancer. PubMed ID: 15824733

ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like Factors. PubMed ID: 33227311