Genular: Defining Cellular Identity and Function

Details for: Slc6a3

Gene ID: 13162

Symbol: Slc6a3

Ensembl ID: ENSMUSG00000021609

Description: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Associated with

Dopamine clearance from the synaptic cleft
(R-MMU-379401)
Na+/cl- dependent neurotransmitter transporters
(R-MMU-442660)
Neuronal system
(R-MMU-112316)
Neurotransmitter clearance
(R-MMU-112311)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transmission across chemical synapses
(R-MMU-112315)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Adenohypophysis development
(GO:0021984)
Amine binding
(GO:0043176)
Amino acid transport
(GO:0006865)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cognition
(GO:0050890)
Dopamine:sodium symporter activity
(GO:0005330)
Dopamine binding
(GO:0035240)
Dopamine biosynthetic process
(GO:0042416)
Dopamine catabolic process
(GO:0042420)
Dopaminergic synapse
(GO:0098691)
Dopamine transport
(GO:0015872)
Dopamine uptake
(GO:0090494)
Dopamine uptake involved in synaptic transmission
(GO:0051583)
Flotillin complex
(GO:0016600)
Heterocyclic compound binding
(GO:1901363)
Hyaloid vascular plexus regression
(GO:1990384)
Lactation
(GO:0007595)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Monoamine transmembrane transporter activity
(GO:0008504)
Monoamine transport
(GO:0015844)
Neuronal cell body
(GO:0043025)
Neuronal cell body membrane
(GO:0032809)
Neuron projection
(GO:0043005)
Neurotransmitter transmembrane transporter activity
(GO:0005326)
Neurotransmitter transport
(GO:0006836)
Neurotransmitter uptake
(GO:0001504)
Norepinephrine:sodium symporter activity
(GO:0005334)
Norepinephrine transport
(GO:0015874)
Plasma membrane
(GO:0005886)
Positive regulation of multicellular organism growth
(GO:0040018)
Postsynaptic membrane
(GO:0045211)
Prepulse inhibition
(GO:0060134)
Presynaptic membrane
(GO:0042734)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of dopamine metabolic process
(GO:0042053)
Response to camp
(GO:0051591)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Sensory perception of smell
(GO:0007608)
Signaling receptor binding
(GO:0005102)
Sodium ion transmembrane transport
(GO:0035725)
Symporter activity
(GO:0015293)

Other Information

Proteins

Sodium-dependent dopamine transporter

Genular Protein ID: 3217023540

Symbol: SC6A3_MOUSE

Name: Sodium-dependent dopamine transporter

UniProtKB Accession Codes:

Q61327 Q60719 Q9R1I2

Database IDs:

Citations:

PubMed ID: 10375632

Title: Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue.

PubMed ID: 10375632

DOI: 10.1016/s0378-1119(99)00143-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7637582

Title: Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures.

PubMed ID: 7637582

DOI: 10.1016/0169-328x(95)00018-n

PubMed ID: 12177201

Title: The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.

PubMed ID: 12177201

DOI: 10.1523/jneurosci.22-16-07045.2002

PubMed ID: 12606774

Title: Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter.

PubMed ID: 12606774

DOI: 10.1124/mol.63.3.653

PubMed ID: 17296554

Title: Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.

PubMed ID: 17296554

DOI: 10.1016/j.neuron.2007.01.019

PubMed ID: 19357284

Title: Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3.

PubMed ID: 19357284

DOI: 10.1523/jneurosci.4559-08.2009

PubMed ID: 30936473

Title: An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.

PubMed ID: 30936473

DOI: 10.1038/s41556-019-0301-x

Sequence Information:

Length: 619
Mass: 68805
Checksum: F436137BCE461E9B
Sequence:

MSKSKCSVGP MSSVVAPAKE PNAVGPREVE LILVKEQNGV QLTNSTLINP PQTPVEVQER 
ETWSKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 
GQFNREGAAG VWKICPVLKG VGFTVILISF YVGFFYNVII AWALHYFFSS FTMDLPWIHC 
NNTWNSPNCS DAHSSNSSDG LGLNDTFGTT PAAEYFERGV LHLHQSRGID DLGPPRWQLT 
ACLVLVIVLL YFSLWKGVKT SGKVVWITAT MPYVVLTALL LRGVTLPGAM DGIRAYLSVD 
FYRLCEASVW IDAATQVCFS LGVGFGVLIA FSSYNKFTNN CYRDAIITTS INSLTSFSSG 
FVVFSFLGYM AQKHNVPIRD VATDGPGLIF IIYPEAIATL PLSSAWAAVF FLMLLTLGID 
SAMGGMESVI TGLVDEFQLL HRHRELFTLG IVLATFLLSL FCVTNGGIYV FTLLDHFAAG 
TSILFGVLIE AIGVAWFYGV QQFSDDIKQM TGQRPNLYWR LCWKLVSPCF LLYVVVVSIV 
TFRPPHYGAY IFPDWANALG WIIATSSMAM VPIYATYKFC SLPGSFREKL AYAITPEKDR 
QLVDRGEVRQ FTLRHWLLV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc6a3

Associated with

Other Information

Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. PubMed ID: 10375632

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. PubMed ID: 7637582

The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. PubMed ID: 12177201

Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. PubMed ID: 12606774

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. PubMed ID: 17296554

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. PubMed ID: 19357284

An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. PubMed ID: 30936473