Genular: Defining Cellular Identity and Function

Details for: Daxx

Gene ID: 13163

Symbol: Daxx

Ensembl ID: ENSMUSG00000002307

Description: Fas death domain-associated protein

Associated with

Cell cycle
(R-MMU-1640170)
Chromosome maintenance
(R-MMU-73886)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Inhibition of dna recombination at telomere
(R-MMU-9670095)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Telomere maintenance
(R-MMU-157579)
Transcriptional regulation by tp53
(R-MMU-3700989)
Androgen receptor signaling pathway
(GO:0030521)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Cell body
(GO:0044297)
Cell cortex
(GO:0005938)
Cell population proliferation
(GO:0008283)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to copper ion
(GO:0071280)
Cellular response to diamide
(GO:0072738)
Cellular response to heat
(GO:0034605)
Cellular response to sodium arsenite
(GO:1903936)
Cellular response to type ii interferon
(GO:0071346)
Cellular response to unfolded protein
(GO:0034620)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Heterochromatin
(GO:0000792)
Histone binding
(GO:0042393)
Jnk cascade
(GO:0007254)
Jun kinase binding
(GO:0008432)
Kinesin binding
(GO:0019894)
Microtubule
(GO:0005874)
Mitotic cytokinesis
(GO:0000281)
Molecular condensate scaffold activity
(GO:0140693)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cellular response to hypoxia
(GO:1900038)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0036480)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Pml body
(GO:0016605)
Pml body organization
(GO:0030578)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activator activity
(GO:0030295)
Protein kinase binding
(GO:0019901)
Protein localization to chromatin
(GO:0071168)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of multicellular organism growth
(GO:0040014)
Regulation of protein ubiquitination
(GO:0031396)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sumo-dependent protein binding
(GO:0140037)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)
Transcription regulator inhibitor activity
(GO:0140416)
Ubiquitin protein ligase binding
(GO:0031625)
Xy body
(GO:0001741)

Other Information

Proteins

Death domain-associated protein 6
Q3UKR0_MOUSE

Genular Protein ID: 4236816116

Symbol: DAXX_MOUSE

Name: Death domain-associated protein 6

UniProtKB Accession Codes:

O35613 Q9QWT8 Q9QWV3

Database IDs:

Citations:

PubMed ID: 9215629

Title: Daxx, a novel Fas-binding protein that activates JNK and apoptosis.

PubMed ID: 9215629

DOI: 10.1016/s0092-8674(00)80294-9

PubMed ID: 10684855

Title: Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.

PubMed ID: 10684855

DOI: 10.1084/jem.191.4.631

PubMed ID: 11034606

Title: FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation.

PubMed ID: 11034606

DOI: 10.1084/jem.192.8.1165

PubMed ID: 11799127

Title: The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells.

PubMed ID: 11799127

DOI: 10.1074/jbc.m111763200

PubMed ID: 12529400

Title: Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.

PubMed ID: 12529400

DOI: 10.1128/mcb.23.3.950-960.2003

PubMed ID: 16287980

Title: SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.

PubMed ID: 16287980

DOI: 10.1073/pnas.0504460102

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20504901

Title: The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.

PubMed ID: 20504901

DOI: 10.1101/gad.566910

PubMed ID: 20651253

Title: Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.

PubMed ID: 20651253

DOI: 10.1073/pnas.1008850107

PubMed ID: 22500635

Title: Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation.

PubMed ID: 22500635

DOI: 10.1016/j.neuron.2012.02.021

Sequence Information:

Length: 739
Mass: 81489
Checksum: 8407D5788528AC2D
Sequence:

MATDDSIIVL DDDDEDEAAA QPGPSNLPPN PASTGPGPGL SQQATGLSEP RVDGGSSNSG 
SRKCYKLDNE KLFEEFLELC KTETSDHPEV VPFLHKLQQR AQSVFLASAE FCNILSRVLA 
RSRKRPAKIY VYINELCTVL KAHSIKKKLN LAPAASTTSE ASGPNPPTEP PSDLTNTENT 
ASEASRTRGS RRQIQRLEQL LALYVAEIRR LQEKELDLSE LDDPDSSYLQ EARLKRKLIR 
LFGRLCELKD CSSLTGRVIE QRIPYRGTRY PEVNRRIERL INKPGLDTFP DYGDVLRAVE 
KAATRHSLGL PRQQLQLLAQ DAFRDVGVRL QERRHLDLIY NFGCHLTDDY RPGVDPALSD 
PTLARRLREN RTLAMNRLDE VISKYAMMQD KTEEGERQKR RARLLGTAPQ PSDPPQASSE 
SGEGPSGMAS QECPTTSKAE TDDDDDDDDD DDEDNEESEE EEEEEEEEKE ATEDEDEDLE 
QLQEDQGGDE EEEGGDNEGN ESPTSPSDFF HRRNSEPAEG LRTPEGQQKR GLTETPASPP 
GASLDPPSTD AESSGEQLLE PLLGDESPVS QLAELEMEAL PEERDISSPR KKSEDSLPTI 
LENGAAVVTS TSVNGRVSSH TWRDASPPSK RFRKEKKQLG SGLLGNSYIK EPMAQQDSGQ 
NTSVQPMPSP PLASVASVAD SSTRVDSPSH ELVTSSLCSP SPSLLLQTPQ AQSLRQCIYK 
TSVATQCDPE EIIVLSDSD

Genular Protein ID: 2331536909

Symbol: Q3UKR0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UKR0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 740
Mass: 81594
Checksum: 4965BFA754D88D85
Sequence:

MATDDSIIVL DDDDEDEAAA QPGPSNLPPN PASTGPGPGL SQQATGLSEP RVDGGSSNSG 
SRKCYKLDNE KLFEEFLELC KTETSDHPEV VPFLHKLQQR AQSVFLASAE FCNILSRVLA 
RSRKRPAKIY VYINELCTVL KAHSIKKKLN LAPAASTTSE ASGPNPPTEP PSDLTNTENT 
ASEASRTRGS RRQIQRLEQL LALYVAEIRR LQEKELDLSE LDDPDSSYLQ EARLKRKLIR 
LFGRLCELKD CSSLTGRVIE QRIPYRGTRY PEVNRRIERL INKPGLDTFP DYGDVLRAVE 
KAATRHSLGL PRQQLQLLAQ DAFRDVGVRL QERRHLDLIY NFGCHLTDDY RPGVDPALSD 
PTLARRLREN RTLAMNRLDE VISKYAMMQD KTEEGERQKR RARLLGTAPQ PSDPPKASSE 
SGEGPSGMAS QECPTTSKAE TDDDDDDDDD DDDEDNEESE EEEEEEEEEK EATEDEDEDL 
EQLQEDQGGD EEEEGGDNEG NESPTSPSDF FHRRNSEPAE GLRTPEGQQK RGLTETPASP 
PGASLDPPST DAESSGEQLL EPLLGDESPV SQLAELEMEA LPEERDISSS RKKSEDSLPT 
ILENGAAVVT STSVNGRVSS HTWRDASPPS KRFRKEKKQL GSGLLGNSYI KEPMAQQDSG 
QNTSVQPMPS PPLASVASVA DSSTRVDSPS HELVTSSLCS PSPSLLLQTP QAQSLRQCIY 
KTSVATQCDP EEIIVLSDSD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Daxx

Associated with

Other Information

Daxx, a novel Fas-binding protein that activates JNK and apoptosis. PubMed ID: 9215629

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. PubMed ID: 10684855

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation. PubMed ID: 11034606

The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. PubMed ID: 11799127

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. PubMed ID: 12529400

SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. PubMed ID: 16287980

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. PubMed ID: 20504901

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. PubMed ID: 20651253

Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. PubMed ID: 22500635

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 9215629

PubMed ID: 10684855

PubMed ID: 11034606

PubMed ID: 11799127

PubMed ID: 12529400

PubMed ID: 16287980

PubMed ID: 21183079

PubMed ID: 20504901

PubMed ID: 20651253

PubMed ID: 22500635

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 21183079