Genular: Defining Cellular Identity and Function

Details for: Dbh

Gene ID: 13166

Symbol: Dbh

Ensembl ID: ENSMUSG00000000889

Description: dopamine beta hydroxylase

Associated with

Catecholamine biosynthesis
(R-MMU-209905)
Metabolism
(R-MMU-1430728)
Metabolism of amine-derived hormones
(R-MMU-209776)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Apical part of cell
(GO:0045177)
Associative learning
(GO:0008306)
Axon
(GO:0030424)
Behavioral response to ethanol
(GO:0048149)
Blood vessel remodeling
(GO:0001974)
Catalytic activity
(GO:0003824)
Catecholamine biosynthetic process
(GO:0042423)
Centriolar satellite
(GO:0034451)
Copper ion binding
(GO:0005507)
Cytokine production
(GO:0001816)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Dopamine beta-monooxygenase activity
(GO:0004500)
Dopamine catabolic process
(GO:0042420)
Endoplasmic reticulum
(GO:0005783)
Extracellular space
(GO:0005615)
Fear response
(GO:0042596)
Glucose homeostasis
(GO:0042593)
Homoiothermy
(GO:0042309)
Intracellular membrane-bounded organelle
(GO:0043231)
L-ascorbic acid binding
(GO:0031418)
Leukocyte mediated immunity
(GO:0002443)
Leukocyte migration
(GO:0050900)
Locomotory behavior
(GO:0007626)
Maternal behavior
(GO:0042711)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Neuronal cell body
(GO:0043025)
Norepinephrine biosynthetic process
(GO:0042421)
Octopamine biosynthetic process
(GO:0006589)
Octopamine metabolic process
(GO:0046333)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
(GO:0016715)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of vasoconstriction
(GO:0045907)
Regulation of extrinsic apoptotic signaling pathway
(GO:2001236)
Regulation of vascular associated smooth muscle cell proliferation
(GO:1904705)
Regulation of vascular endothelial cell proliferation
(GO:1905562)
Response to amphetamine
(GO:0001975)
Response to pain
(GO:0048265)
Secretory granule lumen
(GO:0034774)
Secretory granule membrane
(GO:0030667)
Terminal bouton
(GO:0043195)
Varicosity
(GO:0043196)
Vasoconstriction
(GO:0042310)
Visual learning
(GO:0008542)

Other Information

Proteins

Dopamine beta-hydroxylase

Genular Protein ID: 2926634715

Symbol: DOPO_MOUSE

Name: Dopamine beta-hydroxylase

UniProtKB Accession Codes:

Q64237 Q3V1U4

Database IDs:

Citations:

PubMed ID: 1280432

Title: Mouse dopamine beta-hydroxylase: primary structure deduced from the cDNA sequence and exon/intron organization of the gene.

PubMed ID: 1280432

DOI: 10.1016/0006-291x(92)91598-k

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7961964

Title: Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice.

PubMed ID: 7961964

DOI: 10.1016/s0021-9258(18)43941-5

PubMed ID: 7715704

Title: Noradrenaline is essential for mouse fetal development.

PubMed ID: 7715704

DOI: 10.1038/374643a0

PubMed ID: 27148966

Title: Human bacterial artificial chromosome (BAC) transgenesis fully rescues noradrenergic function in dopamine beta-hydroxylase knockout mice.

PubMed ID: 27148966

DOI: 10.1371/journal.pone.0154864

Sequence Information:

Length: 622
Mass: 70314
Checksum: 7D9FA1B622F3FCA8
Sequence:

MQAHLSHQPC WSSLPSPSVR EAASMYGTAV AIFLVILVAA LRGSEPPESP FPYHIPLDPE 
GILELSWNVS YVQEIIHFQL QVQGLRAGVL FGMSDRGEME NADLIMLWTD GDRAYFADAW 
SDRKGQIHLD SQQDYQLLQA QRTRDGLSLL FKRPFVTCDP KDYVIEDDTV HLVYGILEEP 
FQSLEAINTS GLHTGLQRVQ LLKSEVPTPS MPEDVQTMDI RAPDILIPDN ETTYWCYITE 
LPPRFPRHHI IMYEAIVTEG NEALVHHMEV FQCAAESEDF PQFNGPCDSK MKPDRLNYCR 
HVLAAWALGA KAFYYPKEAG VPFGGPGSSP FLRLEVHYHN PRKIQGRQDS SGIRLHYTAT 
LRRYDAGIME LGLVYTPLMA IPPQETAFVL TGYCTDKCTQ MALQDSGIHI FASQLHTHLT 
GRKVVTVLAR DGQERKVVNR DNHYSPHFQE IRMLKKVVTV YPGDVLITSC TYNTENKTLA 
TVGGFGILEE MCVNYVHYYP QTELELCKSA VDDGFLQKYF HMVNRFSSEE VCTCPQASVP 
QQFSSVPWNS FNRDMLKALY DYAPISMHCN KTSAVRFPGE WNLQPLPKIT STLEEPTPRC 
PIRQTQSPAN PTVPITTEAD AE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dbh

Associated with

Other Information

Mouse dopamine beta-hydroxylase: primary structure deduced from the cDNA sequence and exon/intron organization of the gene. PubMed ID: 1280432

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. PubMed ID: 7961964

Noradrenaline is essential for mouse fetal development. PubMed ID: 7715704

Human bacterial artificial chromosome (BAC) transgenesis fully rescues noradrenergic function in dopamine beta-hydroxylase knockout mice. PubMed ID: 27148966