Details for: SLC31A1

Gene ID: 1317

Symbol: SLC31A1

Ensembl ID: ENSG00000136868

Description: solute carrier family 31 member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.97
    Marker Score: 970
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.9
    Marker Score: 521
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9
    Marker Score: 4320
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.89
    Marker Score: 1264
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.77
    Marker Score: 3087
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.48
    Marker Score: 427
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.48
    Marker Score: 590
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.42
    Marker Score: 36431
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.4
    Marker Score: 1969
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.35
    Marker Score: 2464
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.33
    Marker Score: 622
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.2
    Marker Score: 697
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.18
    Marker Score: 389
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.11
    Marker Score: 665
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2186
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.06
    Marker Score: 1558
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.05
    Marker Score: 7811
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.02
    Marker Score: 4902
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.01
    Marker Score: 258
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1211
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71738
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47963
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.98
    Marker Score: 4211
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1502
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.97
    Marker Score: 3327
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.97
    Marker Score: 17167
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2145
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14215
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1472.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9
    Marker Score: 5755
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.89
    Marker Score: 665
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.87
    Marker Score: 594
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.86
    Marker Score: 427
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4854
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.84
    Marker Score: 532
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.84
    Marker Score: 674
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.84
    Marker Score: 1209
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.84
    Marker Score: 350
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.84
    Marker Score: 5097.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.83
    Marker Score: 402
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.82
    Marker Score: 1317
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 261
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6856
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.79
    Marker Score: 994.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.79
    Marker Score: 899
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 910
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.76
    Marker Score: 537
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.76
    Marker Score: 526
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.75
    Marker Score: 7167
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.75
    Marker Score: 7783
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.75
    Marker Score: 46068
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.75
    Marker Score: 748
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.74
    Marker Score: 504
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.73
    Marker Score: 3927
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.72
    Marker Score: 626
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.72
    Marker Score: 646
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3028
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.72
    Marker Score: 26479
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.71
    Marker Score: 751
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.71
    Marker Score: 482
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.7
    Marker Score: 1246
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.7
    Marker Score: 6055
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7
    Marker Score: 2916.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 635
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.69
    Marker Score: 4521
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.69
    Marker Score: 252
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.69
    Marker Score: 2164
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.69
    Marker Score: 38479
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.68
    Marker Score: 565
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.67
    Marker Score: 4280
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.66
    Marker Score: 385
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.65
    Marker Score: 316
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.65
    Marker Score: 1470
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.64
    Marker Score: 160
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.64
    Marker Score: 585.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 685
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.63
    Marker Score: 3335
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.63
    Marker Score: 843
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.63
    Marker Score: 665
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.63
    Marker Score: 13997
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.62
    Marker Score: 5813
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 408
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.61
    Marker Score: 684
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.61
    Marker Score: 601
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.61
    Marker Score: 1187
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.61
    Marker Score: 373
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.61
    Marker Score: 934
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.6
    Marker Score: 611

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Other Information

**Key characteristics:** - SLC31A1 is a protein of 261 amino acids. - It is a transmembrane protein that is expressed in the plasma membrane. - It is a copper-transporting protein. - It is a key regulator of copper ion homeostasis in the body. **Pathways and functions:** - SLC31A1 is involved in several important pathways, including the regulation of angiogenesis, copper ion binding, and copper ion transport. - It is involved in the regulation of vascular endothelial growth factor receptor-2 signaling pathway. - It is also involved in the transport of bile salts and organic acids. **Clinical significance:** - Mutations in SLC31A1 have been linked to several human diseases, including copper transport disorders. - These disorders can lead to a variety of symptoms, including neurological symptoms, cardiovascular disease, and kidney disease. - SLC31A1 is a promising target for the treatment of these disorders. **Additional information:** - SLC31A1 is a highly conserved protein, with a similar protein found in other mammals. - It is a member of the SLC31 family of ion transporters, which are responsible for the transport of various cations across cell membranes. - SLC31A1 is a relatively new protein, with the gene first identified in 2002.

Genular Protein ID: 2779579040

Symbol: COPT1_HUMAN

Name: Solute carrier family 31 member 1

UniProtKB Accession Codes:

O15431 A8K8Z6 Q53GR5 Q5T1M4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChEBI 2 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 7 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9207117

Title: hCTR1: a human gene for copper uptake identified by complementation in yeast.

PubMed ID: 9207117

DOI: 10.1073/pnas.94.14.7481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12023893

Title: Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1).

PubMed ID: 12023893

DOI: 10.1042/bj20011803

PubMed ID: 11734551

Title: Biochemical characterization of the human copper transporter Ctr1.

PubMed ID: 11734551

DOI: 10.1074/jbc.m104728200

PubMed ID: 15326162

Title: Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: requirement for the extracellular methionine-rich clusters.

PubMed ID: 15326162

DOI: 10.1074/jbc.m407777200

PubMed ID: 16135512

Title: The mechanism of copper uptake mediated by human CTR1: a mutational analysis.

PubMed ID: 16135512

DOI: 10.1074/jbc.m508822200

PubMed ID: 17525160

Title: O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells.

PubMed ID: 17525160

DOI: 10.1074/jbc.m701806200

PubMed ID: 19740744

Title: Copper-dependent recycling of hCTR1, the human high affinity copper transporter.

PubMed ID: 19740744

DOI: 10.1074/jbc.m109.000166

PubMed ID: 20451502

Title: The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin.

PubMed ID: 20451502

DOI: 10.1016/j.bcp.2010.04.030

PubMed ID: 20569931

Title: Ctr1 transports silver into mammalian cells.

PubMed ID: 20569931

DOI: 10.1016/j.jtemb.2010.01.009

PubMed ID: 23658018

Title: Rate and regulation of copper transport by human copper transporter 1 (hCTR1).

PubMed ID: 23658018

DOI: 10.1074/jbc.m112.442426

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24167251

Title: Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

PubMed ID: 24167251

DOI: 10.1073/pnas.1311749110

PubMed ID: 24837030

Title: Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain.

PubMed ID: 24837030

DOI: 10.1021/jp412589b

PubMed ID: 26205368

Title: The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).

PubMed ID: 26205368

DOI: 10.1039/c5mt00131e

PubMed ID: 26745413

Title: The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1.

PubMed ID: 26745413

DOI: 10.1016/j.bpj.2015.11.016

PubMed ID: 27143361

Title: Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

PubMed ID: 27143361

DOI: 10.1074/jbc.m116.731281

PubMed ID: 26945057

Title: Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu(+) uptake system.

PubMed ID: 26945057

DOI: 10.1242/jcs.173351

PubMed ID: 30489586

Title: The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.

PubMed ID: 30489586

DOI: 10.1039/c8mt00274f

PubMed ID: 31292775

Title: Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1.

PubMed ID: 31292775

DOI: 10.1007/s10534-019-00206-3

PubMed ID: 32914794

Title: How trimerization of CTR1 N-terminal model peptides tunes Cu-binding and redox-chemistry.

PubMed ID: 32914794

DOI: 10.1039/d0cc04693k

PubMed ID: 33294387

Title: Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells.

PubMed ID: 33294387

DOI: 10.1016/j.toxrep.2020.11.005

PubMed ID: 35027734

Title: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.

PubMed ID: 35027734

DOI: 10.1038/s41556-021-00822-7

PubMed ID: 35601835

Title: Multinuclear Metal-Binding Ability of the N-Terminal Region of Human Copper Transporter Ctr1: Dependence Upon pH and Metal Oxidation State.

PubMed ID: 35601835

DOI: 10.3389/fmolb.2022.897621

PubMed ID: 16501047

Title: Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.

PubMed ID: 16501047

DOI: 10.1073/pnas.0509929103

PubMed ID: 22615137

Title: Structural insights into the transmembrane domains of human copper transporter 1.

PubMed ID: 22615137

DOI: 10.1002/psc.2415

PubMed ID: 35913762

Title: Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter.

PubMed ID: 35913762

DOI: 10.1093/hmg/ddac156

PubMed ID: 36562171

Title: Fatal congenital copper transport defect caused by a homozygous likely pathogenic variant of SLC31A1.

PubMed ID: 36562171

DOI: 10.1111/cge.14289

Sequence Information:

  • Length: 190
  • Mass: 21091
  • Checksum: 1E08FBAB72A9C014
  • Sequence:
    • MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG 
LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS IRYNSMPVPG PNGTILMETH 
KTVGQQMLSF PHLLQTVLHI IQVVISYFLM LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA 
VVVDITEHCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.