Details for: SLC31A1
Associated with
Other Information
Genular Protein ID: 2779579040
Symbol: COPT1_HUMAN
Name: Solute carrier family 31 member 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9207117
Title: hCTR1: a human gene for copper uptake identified by complementation in yeast.
PubMed ID: 9207117
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12023893
Title: Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1).
PubMed ID: 12023893
DOI: 10.1042/bj20011803
PubMed ID: 11734551
Title: Biochemical characterization of the human copper transporter Ctr1.
PubMed ID: 11734551
PubMed ID: 15326162
Title: Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: requirement for the extracellular methionine-rich clusters.
PubMed ID: 15326162
PubMed ID: 16135512
Title: The mechanism of copper uptake mediated by human CTR1: a mutational analysis.
PubMed ID: 16135512
PubMed ID: 17525160
Title: O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells.
PubMed ID: 17525160
PubMed ID: 19740744
Title: Copper-dependent recycling of hCTR1, the human high affinity copper transporter.
PubMed ID: 19740744
PubMed ID: 20451502
Title: The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin.
PubMed ID: 20451502
PubMed ID: 20569931
Title: Ctr1 transports silver into mammalian cells.
PubMed ID: 20569931
PubMed ID: 23658018
Title: Rate and regulation of copper transport by human copper transporter 1 (hCTR1).
PubMed ID: 23658018
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24167251
Title: Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
PubMed ID: 24167251
PubMed ID: 24837030
Title: Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain.
PubMed ID: 24837030
DOI: 10.1021/jp412589b
PubMed ID: 26205368
Title: The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).
PubMed ID: 26205368
DOI: 10.1039/c5mt00131e
PubMed ID: 26745413
Title: The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1.
PubMed ID: 26745413
PubMed ID: 27143361
Title: Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.
PubMed ID: 27143361
PubMed ID: 26945057
Title: Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu(+) uptake system.
PubMed ID: 26945057
DOI: 10.1242/jcs.173351
PubMed ID: 30489586
Title: The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.
PubMed ID: 30489586
DOI: 10.1039/c8mt00274f
PubMed ID: 31292775
Title: Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1.
PubMed ID: 31292775
PubMed ID: 32914794
Title: How trimerization of CTR1 N-terminal model peptides tunes Cu-binding and redox-chemistry.
PubMed ID: 32914794
DOI: 10.1039/d0cc04693k
PubMed ID: 33294387
Title: Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells.
PubMed ID: 33294387
PubMed ID: 35027734
Title: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.
PubMed ID: 35027734
PubMed ID: 35601835
Title: Multinuclear Metal-Binding Ability of the N-Terminal Region of Human Copper Transporter Ctr1: Dependence Upon pH and Metal Oxidation State.
PubMed ID: 35601835
PubMed ID: 16501047
Title: Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.
PubMed ID: 16501047
PubMed ID: 22615137
Title: Structural insights into the transmembrane domains of human copper transporter 1.
PubMed ID: 22615137
DOI: 10.1002/psc.2415
PubMed ID: 35913762
Title: Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter.
PubMed ID: 35913762
DOI: 10.1093/hmg/ddac156
PubMed ID: 36562171
Title: Fatal congenital copper transport defect caused by a homozygous likely pathogenic variant of SLC31A1.
PubMed ID: 36562171
DOI: 10.1111/cge.14289
Sequence Information:
- Length: 190
- Mass: 21091
- Checksum: 1E08FBAB72A9C014
- Sequence:
MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS IRYNSMPVPG PNGTILMETH KTVGQQMLSF PHLLQTVLHI IQVVISYFLM LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA VVVDITEHCH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.