Details for: SLC31A2

Gene ID: 1318

Symbol: SLC31A2

Ensembl ID: ENSG00000136867

Description: solute carrier family 31 member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.73
    Marker Score: 6222
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.05
    Marker Score: 52537
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.84
    Marker Score: 733
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.81
    Marker Score: 3522
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.8
    Marker Score: 4302
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.76
    Marker Score: 4252
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.7
    Marker Score: 2047
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.59
    Marker Score: 9691
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.56
    Marker Score: 6139
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.54
    Marker Score: 1762
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.29
    Marker Score: 71868
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.28
    Marker Score: 599
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.19
    Marker Score: 496
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.16
    Marker Score: 1160
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.09
    Marker Score: 2817
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.08
    Marker Score: 1103.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251750
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47994
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 646
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.89
    Marker Score: 2224
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5038
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.88
    Marker Score: 10247
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12256
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.75
    Marker Score: 519
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1528
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.74
    Marker Score: 1572
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.72
    Marker Score: 799
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2828
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.67
    Marker Score: 669
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.65
    Marker Score: 1063
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 407.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.61
    Marker Score: 417
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.6
    Marker Score: 497
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.58
    Marker Score: 929
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.57
    Marker Score: 5824
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.57
    Marker Score: 377
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.57
    Marker Score: 19296
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.56
    Marker Score: 2338
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.56
    Marker Score: 982
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.55
    Marker Score: 302
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 176
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 346.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1016
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.54
    Marker Score: 340
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.53
    Marker Score: 360
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.52
    Marker Score: 681.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.52
    Marker Score: 267
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.51
    Marker Score: 1208
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.51
    Marker Score: 1243
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.5
    Marker Score: 170
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.49
    Marker Score: 897
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.49
    Marker Score: 710
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.49
    Marker Score: 121
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 437
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.48
    Marker Score: 167
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.48
    Marker Score: 736
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.46
    Marker Score: 283
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.46
    Marker Score: 116
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 450
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.45
    Marker Score: 155
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.44
    Marker Score: 255
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.44
    Marker Score: 220
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.44
    Marker Score: 180
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 649
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.43
    Marker Score: 1875
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.42
    Marker Score: 1642
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.41
    Marker Score: 1597
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.41
    Marker Score: 628
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4
    Marker Score: 425
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.39
    Marker Score: 109
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.38
    Marker Score: 253
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2280
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.37
    Marker Score: 73
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.37
    Marker Score: 80
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.37
    Marker Score: 232
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.36
    Marker Score: 220
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.35
    Marker Score: 127
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.35
    Marker Score: 1097

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Other Information

**Key characteristics:** * SLC31A2 is a type of copper transport protein. * It is expressed in a variety of cell types. * It is involved in the transport of copper ions across cellular membranes. * It is a significant protein in the regulation of copper ion homeostasis in cells. **Pathways and functions:** * SLC31A2 is involved in the copper ion import pathway. * It is responsible for the uptake of copper ions into cells from the extracellular environment. * It is also involved in the regulation of copper ion homeostasis in cells. **Clinical significance:** * SLC31A2 gene mutations have been linked to a number of human diseases, including Wilson's disease, which is caused by a deficiency of copper ions in the body. * SLC31A2 mutations can also cause other neurological disorders, such as amyotrophic lateral sclerosis and Alzheimer's disease. * Understanding the role of SLC31A2 in copper ion transport could lead to the development of new therapies for these diseases. **Additional information:** * The gene is located on chromosome 15q21.1. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a multi-pass protein, with a molecular weight of approximately 120 kDa.

Genular Protein ID: 2415589615

Symbol: COPT2_HUMAN

Name: Solute carrier family 31 member 2

UniProtKB Accession Codes:

O15432

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9207117

Title: hCTR1: a human gene for copper uptake identified by complementation in yeast.

PubMed ID: 9207117

DOI: 10.1073/pnas.94.14.7481

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17617060

Title: Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake.

PubMed ID: 17617060

DOI: 10.1042/bj20070705

PubMed ID: 17944601

Title: Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells.

PubMed ID: 17944601

DOI: 10.1042/bj20071025

PubMed ID: 26205368

Title: The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).

PubMed ID: 26205368

DOI: 10.1039/c5mt00131e

PubMed ID: 31083932

Title: Cu(II) Binding to the N-Terminal Model Peptide of the Human Ctr2 Transporter at Lysosomal and Extracellular pH.

PubMed ID: 31083932

DOI: 10.1021/acs.inorgchem.9b00711

Sequence Information:

  • Length: 143
  • Mass: 15681
  • Checksum: 0145EE8BE623443E
  • Sequence:
    • MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL LNQVLVNLPT 
SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH VIQVVIGYFI MLAVMSYNTW 
IFLGVVLGSA VGYYLAYPLL STA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.