Details for: SLC31A2

Gene ID: 1318

Symbol: SLC31A2

Ensembl ID: ENSG00000136867

Description: solute carrier family 31 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.8716
    Cell Significance Index: -17.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.3854
    Cell Significance Index: -15.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.4332
    Cell Significance Index: -16.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.4513
    Cell Significance Index: -18.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.7794
    Cell Significance Index: -16.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8448
    Cell Significance Index: -17.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9171
    Cell Significance Index: -18.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3740
    Cell Significance Index: -17.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.6544
    Cell Significance Index: 56.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1104
    Cell Significance Index: 145.0200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 2.5777
    Cell Significance Index: 53.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5009
    Cell Significance Index: 27.7400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.2558
    Cell Significance Index: 6.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8752
    Cell Significance Index: 61.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8067
    Cell Significance Index: 48.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6630
    Cell Significance Index: 17.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5014
    Cell Significance Index: 54.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4836
    Cell Significance Index: 47.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4332
    Cell Significance Index: 27.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3948
    Cell Significance Index: 174.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3384
    Cell Significance Index: 15.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3339
    Cell Significance Index: 301.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3185
    Cell Significance Index: 22.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2957
    Cell Significance Index: 48.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2644
    Cell Significance Index: 7.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2275
    Cell Significance Index: 10.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1845
    Cell Significance Index: 35.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1777
    Cell Significance Index: 5.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1646
    Cell Significance Index: 2.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1567
    Cell Significance Index: 20.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1537
    Cell Significance Index: 3.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1188
    Cell Significance Index: 13.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1100
    Cell Significance Index: 8.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0779
    Cell Significance Index: 2.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0775
    Cell Significance Index: 42.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0719
    Cell Significance Index: 14.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0698
    Cell Significance Index: 2.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0671
    Cell Significance Index: 46.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0656
    Cell Significance Index: 11.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0364
    Cell Significance Index: 0.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0235
    Cell Significance Index: 1.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0231
    Cell Significance Index: 3.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0164
    Cell Significance Index: 1.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0120
    Cell Significance Index: 0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0073
    Cell Significance Index: 2.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0043
    Cell Significance Index: -0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -8.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0110
    Cell Significance Index: -0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0160
    Cell Significance Index: -21.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0172
    Cell Significance Index: -13.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0206
    Cell Significance Index: -15.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0238
    Cell Significance Index: -15.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0244
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0288
    Cell Significance Index: -21.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0335
    Cell Significance Index: -20.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0363
    Cell Significance Index: -20.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0378
    Cell Significance Index: -10.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0387
    Cell Significance Index: -7.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0409
    Cell Significance Index: -18.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0476
    Cell Significance Index: -8.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0832
    Cell Significance Index: -12.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1042
    Cell Significance Index: -21.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1150
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1250
    Cell Significance Index: -14.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1286
    Cell Significance Index: -9.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1396
    Cell Significance Index: -16.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1477
    Cell Significance Index: -1.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1503
    Cell Significance Index: -2.0500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1612
    Cell Significance Index: -2.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1642
    Cell Significance Index: -17.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1682
    Cell Significance Index: -4.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1707
    Cell Significance Index: -10.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2078
    Cell Significance Index: -10.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2152
    Cell Significance Index: -17.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2205
    Cell Significance Index: -11.4900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2336
    Cell Significance Index: -2.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2364
    Cell Significance Index: -13.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2406
    Cell Significance Index: -16.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2665
    Cell Significance Index: -16.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2751
    Cell Significance Index: -11.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2869
    Cell Significance Index: -7.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2923
    Cell Significance Index: -8.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2948
    Cell Significance Index: -12.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3033
    Cell Significance Index: -9.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3228
    Cell Significance Index: -5.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3285
    Cell Significance Index: -14.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3357
    Cell Significance Index: -8.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3862
    Cell Significance Index: -8.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3923
    Cell Significance Index: -11.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3936
    Cell Significance Index: -14.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3996
    Cell Significance Index: -15.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4019
    Cell Significance Index: -14.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4029
    Cell Significance Index: -2.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4362
    Cell Significance Index: -8.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4452
    Cell Significance Index: -14.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4455
    Cell Significance Index: -15.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4464
    Cell Significance Index: -3.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transporter:** SLC31A2 is a transmembrane protein that facilitates the transport of copper ions across cellular membranes. 2. **Copper Ion Homeostasis:** The gene is involved in regulating copper ion homeostasis, ensuring the proper distribution of this essential metal ion within the body. 3. **Immune Function:** SLC31A2 is expressed in immune cells, such as macrophages and monocytes, highlighting its role in immune function and response. 4. **Cellular Localization:** The gene is localized to the plasma membrane, late endosome, and lysosome, indicating its involvement in various cellular processes. 5. **Signaling Pathways:** SLC31A2 modulates signaling pathways, including those involved in copper ion homeostasis, immune responses, and cellular signaling. **Pathways and Functions:** 1. **Copper Ion Homeostasis:** SLC31A2 regulates copper ion homeostasis by importing copper ions into cells and exporting them to extracellular compartments. 2. **Immune Response:** The gene plays a crucial role in regulating immune responses, particularly in macrophages and monocytes, which are essential for the recognition and elimination of pathogens. 3. **Cellular Signaling:** SLC31A2 modulates cellular signaling pathways, including those involved in copper ion homeostasis, immune responses, and cellular signaling. 4. **Lysosomal Function:** The gene is involved in lysosomal function, regulating the transport and storage of copper ions within lysosomes. 5. **Neurotransmission:** SLC31A2 has been implicated in neurotransmission, particularly in the regulation of copper ion homeostasis in neurons. **Clinical Significance:** 1. **Copper Deficiency Disorders:** Mutations in the SLC31A2 gene have been associated with copper deficiency disorders, such as Menkes disease and Wilson's disease. 2. **Immune System Dysfunction:** Dysregulation of SLC31A2 has been linked to immune system dysfunction, including autoimmune diseases and impaired immune responses. 3. **Cancer:** The gene's role in copper ion homeostasis and immune function makes it a potential target for cancer therapy. 4. **Neurological Disorders:** SLC31A2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, due to its involvement in copper ion homeostasis and neurotransmission. 5. **Pharmacological Applications:** Understanding the mechanisms of SLC31A2 may lead to the development of novel therapeutic strategies for copper-related disorders and immune system dysfunction. In conclusion, SLC31A2 plays a critical role in regulating copper ion homeostasis, immune function, and cellular signaling. Its dysregulation has been implicated in various diseases, including copper deficiency disorders, immune system dysfunction, and neurological disorders. Further research is necessary to fully elucidate the mechanisms of SLC31A2 and its potential therapeutic applications.

Genular Protein ID: 2415589615

Symbol: COPT2_HUMAN

Name: Solute carrier family 31 member 2

UniProtKB Accession Codes:

O15432

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9207117

Title: hCTR1: a human gene for copper uptake identified by complementation in yeast.

PubMed ID: 9207117

DOI: 10.1073/pnas.94.14.7481

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17617060

Title: Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake.

PubMed ID: 17617060

DOI: 10.1042/bj20070705

PubMed ID: 17944601

Title: Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells.

PubMed ID: 17944601

DOI: 10.1042/bj20071025

PubMed ID: 26205368

Title: The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).

PubMed ID: 26205368

DOI: 10.1039/c5mt00131e

PubMed ID: 31083932

Title: Cu(II) Binding to the N-Terminal Model Peptide of the Human Ctr2 Transporter at Lysosomal and Extracellular pH.

PubMed ID: 31083932

DOI: 10.1021/acs.inorgchem.9b00711

Sequence Information:

  • Length: 143
  • Mass: 15681
  • Checksum: 0145EE8BE623443E
  • Sequence:
    • MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL LNQVLVNLPT 
SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH VIQVVIGYFI MLAVMSYNTW 
IFLGVVLGSA VGYYLAYPLL STA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.