Details for: Dct

Gene ID: 13190

Symbol: Dct

Ensembl ID: ENSMUSG00000022129

Description: dopachrome tautomerase

Associated with

Other Information

Genular Protein ID: 3464750522

Symbol: TYRP2_MOUSE

Name: L-dopachrome Delta-isomerase

UniProtKB Accession Codes:

P29812 Q6NXI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EC 1 EMBL 5 Ensembl 1 GO 18 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1537334

Title: A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.

PubMed ID: 1537334

DOI: 10.1002/j.1460-2075.1992.tb05083.x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8530099

Title: Structure of the mouse tyrosinase-related protein-2/dopachrome tautomerase (Tyrp2/Dct) gene and sequence of two novel slaty alleles.

PubMed ID: 8530099

DOI: 10.1006/geno.1995.1212

PubMed ID: 1537333

Title: A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

PubMed ID: 1537333

DOI: 10.1002/j.1460-2075.1992.tb05082.x

PubMed ID: 7980602

Title: Dopachrome tautomerase is a zinc-containing enzyme.

PubMed ID: 7980602

DOI: 10.1006/bbrc.1994.2596

PubMed ID: 8573077

Title: Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.

PubMed ID: 8573077

DOI: 10.1042/bj3130447

PubMed ID: 26620560

Title: RUTBC1 functions as a GTPase-activating protein for Rab32/38 and regulates melanogenic enzyme trafficking in melanocytes.

PubMed ID: 26620560

DOI: 10.1074/jbc.m115.684043

PubMed ID: 33100333

Title: Dopachrome tautomerase variants in patients with oculocutaneous albinism.

PubMed ID: 33100333

DOI: 10.1038/s41436-020-00997-8

Sequence Information:

  • Length: 517
  • Mass: 58510
  • Checksum: BC21FE73BE392CEA
  • Sequence:
    • MGLVGWGLLL GCLGCGILLR ARAQFPRVCM TLDGVLNKEC CPPLGPEATN ICGFLEGRGQ 
CAEVQTDTRP WSGPYILRNQ DDREQWPRKF FNRTCKCTGN FAGYNCGGCK FGWTGPDCNR 
KKPAILRRNI HSLTAQEREQ FLGALDLAKK SIHPDYVITT QHWLGLLGPN GTQPQIANCS 
VYDFFVWLHY YSVRDTLLGP GRPYKAIDFS HQGPAFVTWH RYHLLWLERE LQRLTGNESF 
ALPYWNFATG KNECDVCTDE LLGAARQDDP TLISRNSRFS TWEIVCDSLD DYNRRVTLCN 
GTYEGLLRRN KVGRNNEKLP TLKNVQDCLS LQKFDSPPFF QNSTFSFRNA LEGFDKADGT 
LDSQVMNLHN LAHSFLNGTN ALPHSAANDP VFVVLHSFTD AIFDEWLKRN NPSTDAWPQE 
LAPIGHNRMY NMVPFFPPVT NEELFLTAEQ LGYNYAVDLS EEEAPVWSTT LSVVIGILGA 
FVLLLGLLAF LQYRRLRKGY APLMETGLSS KRYTEEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.