Genular: Defining Cellular Identity and Function

Details for: Ddb1

Gene ID: 13194

Symbol: Ddb1

Ensembl ID: ENSMUSG00000024740

Description: damage specific DNA binding protein 1

Associated with

Dna damage bypass
(R-MMU-73893)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Dual incision in gg-ner
(R-MMU-5696400)
Dual incision in tc-ner
(R-MMU-6782135)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Formation of tc-ner pre-incision complex
(R-MMU-6781823)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-MMU-6782210)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Nucleotide excision repair
(R-MMU-5696398)
Post-translational protein modification
(R-MMU-597592)
Recognition of dna damage by pcna-containing replication complex
(R-MMU-110314)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
Apoptotic process
(GO:0006915)
Biological process involved in interaction with symbiont
(GO:0051702)
Cellular response to uv
(GO:0034644)
Cul4-ring e3 ubiquitin ligase complex
(GO:0080008)
Cul4a-ring e3 ubiquitin ligase complex
(GO:0031464)
Cul4b-ring e3 ubiquitin ligase complex
(GO:0031465)
Cullin family protein binding
(GO:0097602)
Cytoplasm
(GO:0005737)
Damaged dna binding
(GO:0003684)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Ectopic germ cell programmed cell death
(GO:0035234)
Epigenetic programming in the zygotic pronuclei
(GO:0044725)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of reproductive process
(GO:2000242)
Nucleic acid binding
(GO:0003676)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation by virus of viral protein levels in host cell
(GO:0046726)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of viral genome replication
(GO:0045070)
Proteasomal protein catabolic process
(GO:0010498)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of circadian rhythm
(GO:0042752)
Regulation of mitotic cell cycle phase transition
(GO:1901990)
Rhythmic process
(GO:0048511)
Site of double-strand break
(GO:0035861)
Spindle assembly involved in female meiosis
(GO:0007056)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin ligase complex scaffold activity
(GO:0160072)
Uv-damage excision repair
(GO:0070914)
Viral release from host cell
(GO:0019076)
Wd40-repeat domain binding
(GO:0071987)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

DNA damage-binding protein 1

Genular Protein ID: 1331873123

Symbol: DDB1_MOUSE

Name: DNA damage-binding protein 1

UniProtKB Accession Codes:

Q3U1J4 Q3U4D0 Q3U8G3 Q3UJC4 Q99LV3 Q9QYK0 Q9WV39

Database IDs:

Citations:

PubMed ID: 10574459

Title: cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells.

PubMed ID: 10574459

DOI: 10.1093/dnares/6.5.319

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12107171

Title: Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase.

PubMed ID: 12107171

DOI: 10.1074/jbc.m204416200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24357321

Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.

PubMed ID: 24357321

DOI: 10.1126/science.1244587

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 27123980

Title: USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock.

PubMed ID: 27123980

DOI: 10.1371/journal.pone.0154263

PubMed ID: 28790135

Title: DDB1-mediated CRY1 degradation promotes FOXO1-driven gluconeogenesis in liver.

PubMed ID: 28790135

DOI: 10.2337/db16-1600

PubMed ID: 30111536

Title: DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

PubMed ID: 30111536

DOI: 10.15252/embj.201898981

PubMed ID: 31492966

Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.

PubMed ID: 31492966

DOI: 10.1007/s00018-019-03280-5

PubMed ID: 35178836

Title: DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression.

PubMed ID: 35178836

DOI: 10.1111/cas.15300

Sequence Information:

Length: 1140
Mass: 126853
Checksum: 9799298D52E60AE4
Sequence:

MSYNYVVTAQ KPTAVNGCVT GHFTSAEDLN LLIAKNTRLE IYVVTAEGLR PVKEVGMYGK 
IAVMELFRPK GESKDLLFIL TAKYNACILE YKQSGESIDI ITRAHGNVQD RIGRPSETGI 
IGIIDPECRM IGLRLYDGLF KVIPLDRDNK ELKAFNIRLE ELHVIDVKFL YGCQAPTICF 
VYQDPQGRHV KTYEVSLREK EFNKGPWKQE NVEAEASMVI AVPEPFGGAI IIGQESITYH 
NGDKYLAIAP PIIKQSTIVC HNRVDPNGSR YLLGDMEGRL FMLLLEKEEQ MDGTVTLKDL 
RVELLGETSI AECLTYLDNG VVFVGSRLGD SQLVKLNVDS NEQGSYVVAM ETFTNLGPIV 
DMCVVDLERQ GQGQLVTCSG AFKEGSLRII RNGIGIHEHA SIDLPGIKGL WPLRSDPGRE 
TDDTLVLSFV GQTRVLMLNG EEVEETELMG FVDDQQTFFC GNVAHQQLIQ ITSASVRLVS 
QEPKALVSEW KEPQGKNISV ASCNSSQVVV AVGRALYYLQ IHPQELRQIS HTEMEHEVAC 
LDITPLGDSN GLSPLCAIGL WTDISARILK LPSFELLHKE MLGGEIIPRS ILMTTFESSH 
YLLCALGDGA LFYFGLNIET GLLSDRKKVT LGTQPTVLRT FRSLSTTNVF ACSDRPTVIY 
SSNHKLVFSN VNLKEVNYMC PLNSDGYPDS LALANNSTLT IGTIDEIQKL HIRTVPLYES 
PRKICYQEVS QCFGVLSSRI EVQDSSGGTT ALRPSASTQA LSSSVSSSKL FSSSTAPHET 
SFGEEVEVHN LLIIDQHTFE VLHAHQFLQN EYALSLVSCK LGKDPNTYFI VGTAMVYPEE 
AEPKQGRIVV FQYSDGKLQT VAEKEVKGAV YSMVEFNGKL LASINSTVRL YEWTTEKELR 
TECNHYNNIM ALYLKTKGDF ILVGDLMRSV LLLAYKPMEG NFEEIARDFN PNWMSAVEIL 
DDDNFLGAEN AFNLFVCQKD SAATTDEERQ HLQEVGLFHL GEFVNVFCHG SLVMQNLGEA 
STPTQGSVLF GTVNGMIGLV TSLSESWYNL LLDMQNRLNK VIKSVGKIEH SFWRSFHTER 
KTEPATGFID GDLIESFLDI SRPKMQEVVA NLQYDDGSGM KREATADDLI KVVEELTRIH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ddb1

Associated with

Other Information

cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells. PubMed ID: 10574459

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase. PubMed ID: 12107171

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. PubMed ID: 24357321

CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1. PubMed ID: 26431207

USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock. PubMed ID: 27123980

DDB1-mediated CRY1 degradation promotes FOXO1-driven gluconeogenesis in liver. PubMed ID: 28790135

DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. PubMed ID: 30111536

The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. PubMed ID: 31492966

DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression. PubMed ID: 35178836